| Entry |
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| Gene name |
EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
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| Definition |
(RefSeq) eukaryotic translation initiation factor 2 subunit alpha
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| KO |
| K03237 | translation initiation factor 2 subunit 1 |
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| Organism |
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| Pathway |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
| hsa05168 | Herpes simplex virus 1 infection |
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| Network |
nt06138 PKR-eIF2alpha signaling (viruses) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06412 Unfolded protein response (UPR) signaling nt06460 Alzheimer disease |
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| Element |
| N00571 | PKR-eIF2alpha signaling pathway |
| N00572 | HSV ICP34.5 to PKR-eIF2alpha signaling pathway |
| N00573 | HSV US11 to PKR-eIF2alpha signaling pathway |
| N00696 | MV C to PKR-eIF2alpha signaling pathway |
| N00725 | IAV NS1 to PKR-eIF2alpha signaling pathway |
| N00726 | IAV NP to PKR-eIF2alpha signaling pathway |
| N01009 | PERK-ATF4 signaling pathway |
| N01010 | Mutation-caused aberrant PSEN1 to PERK-ATF4 signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09122 Translation
03013 RNA transport
1965 (EIF2S1)
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
1965 (EIF2S1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
1965 (EIF2S1)
09143 Cell growth and death
04210 Apoptosis
1965 (EIF2S1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
1965 (EIF2S1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease (NAFLD)
1965 (EIF2S1)
09172 Infectious disease: viral
05162 Measles
1965 (EIF2S1)
05164 Influenza A
1965 (EIF2S1)
05160 Hepatitis C
1965 (EIF2S1)
05168 Herpes simplex virus 1 infection
1965 (EIF2S1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03012 Translation factors [BR:hsa03012]
1965 (EIF2S1)
Translation factors [BR:hsa03012]
Eukaryotic type
Initiation factors
eIF-2
1965 (EIF2S1)
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
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| Structure |
PDB: |
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| Position |
14q23.3
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| AA seq |
315 aa  
MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSIN
KLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLE
YTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNI
NRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTT
TLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEV
DGDDDAEEMEAKAED |
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| NT seq |
948 nt  +upstreamnt +downstreamnt
atgccgggtctaagttgtagattttatcaacacaaatttcctgaggtggaagatgtagtg
atggtgaatgtcagatccattgctgaaatgggggcttatgtcagcttgctggaatacaac
aacattgaaggcatgattcttcttagtgaattatccagaaggcgtatccgttctatcaac
aaactcatccgaattggcaggaatgagtgtgtggttgtcattagggtggacaaagaaaaa
ggatatattgatttgtcaaaaagaagagtttctccagaggaagcaatcaaatgtgaagac
aaattcacaaaatccaaaactgtttatagcattcttcgtcatgttgctgaggtgttagaa
tacaccaaggatgagcagctggaaagcctattccagaggactgcctgggtctttgatgac
aagtacaagagacctggatatggtgcctatgatgcatttaagcatgcagtctcagaccca
tctattttggatagtttagatttgaatgaagatgaacgggaagtactcattaataatatt
aataggcgcttgaccccacaggctgtcaaaattcgagcagatattgaagtggcttgttat
ggttatgaaggcattgatgctgtaaaagaagccctaagagcaggtttgaattgttctaca
gaaaacatgcccattaagattaatctaatagctcctcctcggtatgtaatgactacgaca
accctggagagaacagaaggcctttctgtcctcagtcaagctatggctgttatcaaagag
aagattgaggaaaagaggggtgtgttcaatgttcaaatggagcccaaagtggtcacagat
acagatgagactgaacttgcgaggcagatggagaggcttgaaagagaaaatgccgaagtg
gatggagatgatgatgcagaagaaatggaagccaaagctgaagattaa |
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