KEGG   Homo sapiens (human): 1977Help
Entry
1977              CDS       T01001                                 

Gene name
EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
Definition
(RefSeq) eukaryotic translation initiation factor 4E
  KO
K03259  translation initiation factor 4E
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa03013  RNA transport
hsa04066  HIF-1 signaling pathway
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04910  Insulin signaling pathway
Module
hsa_M00428  eIF4F complex
Disease
H02111  Autism
Drug target
Briciclib (DG01851): D10614 D10694
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 RNA transport
    1977 (EIF4E)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    1977 (EIF4E)
   04151 PI3K-Akt signaling pathway
    1977 (EIF4E)
   04150 mTOR signaling pathway
    1977 (EIF4E)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    1977 (EIF4E)
  09149 Aging
   04211 Longevity regulating pathway
    1977 (EIF4E)
 09160 Human Diseases
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    1977 (EIF4E)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1977 (EIF4E)
   03012 Translation factors [BR:hsa03012]
    1977 (EIF4E)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic Type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     1977 (EIF4E)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     1977 (EIF4E)
Translation factors [BR:hsa03012]
 Eukaryotic Type
  Initiation factors
   eIF-4
    1977 (EIF4E)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IF4E
Motif
Other DBs
NCBI-GeneID: 1977
NCBI-ProteinID: NP_001959
OMIM: 133440
HGNC: 3287
Ensembl: ENSG00000151247
Vega: OTTHUMG00000161090
Pharos: P06730(Tchem)
UniProt: P06730
Structure
PDB: 

Position
4q23
AA seq 217 aa AA seqDB search
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
NT seq 654 nt NT seq  +upstreamnt  +downstreamnt
atggcgactgtcgaaccggaaaccacccctactcctaatcccccgactacagaagaggag
aaaacggaatctaatcaggaggttgctaacccagaacactatattaaacatcccctacag
aacagatgggcactctggttttttaaaaatgataaaagcaaaacttggcaagcaaacctg
cggctgatctccaagtttgatactgttgaagacttttgggctctgtacaaccatatccag
ttgtctagtaatttaatgcctggctgtgactactcactttttaaggatggtattgagcct
atgtgggaagatgagaaaaacaaacggggaggacgatggctaattacattgaacaaacag
cagagacgaagtgacctcgatcgcttttggctagagacacttctgtgccttattggagaa
tcttttgatgactacagtgatgatgtatgtggcgctgttgttaatgttagagctaaaggt
gataagatagcaatatggactactgaatgtgaaaacagagaagctgttacacatataggg
agggtatacaaggaaaggttaggacttcctccaaagatagtgattggttatcagtcccac
gcagacacagctactaagagcggctccaccactaaaaataggtttgttgtttaa

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