KEGG   Homo sapiens (human): 1981
Entry
1981              CDS       T01001                                 
Symbol
EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
Name
(RefSeq) eukaryotic translation initiation factor 4 gamma 1
  KO
K03260  translation initiation factor 4G
Organism
hsa  Homo sapiens (human)
Pathway
hsa05416  Viral myocarditis
Disease
H00057  Parkinson disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09166 Cardiovascular disease
   05416 Viral myocarditis
    1981 (EIF4G1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1981 (EIF4G1)
   03012 Translation factors [BR:hsa03012]
    1981 (EIF4G1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     1981 (EIF4G1)
   mRNA cycle factors
    Stress granule specific factors
     1981 (EIF4G1)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-4
    1981 (EIF4G1)
SSDB
Motif
Pfam: MIF4G MA3 W2 eIF4G1-like_eIF4E-bd RabGAP-TBC
Other DBs
NCBI-GeneID: 1981
NCBI-ProteinID: NP_937884
OMIM: 600495
HGNC: 3296
Ensembl: ENSG00000114867
UniProt: Q04637 Q96I65
Structure
Position
3:184314606..184335358
AA seq 1599 aa
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
NT seq 4800 nt   +upstreamnt  +downstreamnt
atgaacaaagctccacagtccacaggccccccacccgccccatcccccggactcccacag
ccagcgtttcccccggggcagacagcgccggtggtgttcagtacgccacaagcgacacaa
atgaacacgccttctcagccccgccagcacttctaccctagccgggcccagcccccgagc
agtgcagcctcccgagtgcagagtgcagcccctgcccgccctggcccagctgcccatgtc
taccctgctggatcccaagtaatgatgatcccttcccagatctcctacccagcctcccag
ggggcctactacatccctggacaggggcgttccacatacgttgtcccgacacagcagtac
cctgtgcagccaggagccccaggcttctatccaggtgcaagccctacagaatttgggacc
tacgctggcgcctactatccagcccaaggggtgcagcagtttcccactggcgtggccccc
accccagttttgatgaaccagccaccccagattgctcccaagagggagcgtaagacgatc
cgaattcgagatccaaaccaaggaggaaaggatatcacagaggagatcatgtctggggcc
cgcactgcctccacacccacccctccccagacgggaggcggtctggagcctcaagctaat
ggggagacgccccaggttgctgtcattgtccggccagatgaccggtcacagggagcaatc
attgctgaccggccagggctgcctggcccagagcatagcccttcagaatcccagccttcg
tcgccttctccgaccccatcaccatccccagtcttggaaccggggtctgagcctaatctc
gcagtcctctctattcctggggacactatgacaactatacaaatgtctgtagaagaatca
acccccatctcccgtgaaactggggagccatatcgcctctctccagaacccactcctctc
gccgaacccatactggaagtagaagtgacacttagcaaaccggttccagaatctgagttt
tcttccagtcctctccaggctcccacccctttggcatctcacacagtggaaattcatgag
cctaatggcatggtcccatctgaagatctggaaccagaggtggagtcaagcccagagctt
gctcctcccccagcttgcccctccgaatcccctgtgcccattgctccaactgcccaacct
gaggaactgctcaacggagccccctcgccaccagctgtggacttaagcccagtcagtgag
ccagaggagcaggccaaggaggtgacagcatcaatggcgccccccaccatcccctctgct
actccagctacggctccttcagctacttccccagctcaggaggaggaaatggaagaagaa
gaagaagaggaagaaggagaagcaggagaagcaggagaagctgagagtgagaaaggagga
gaggaactgctccccccagagagtacccctattccagccaacttgtctcagaatttggag
gcagcagcagccactcaagtggcagtatctgtgccaaagaggagacggaaaattaaggag
ctaaataagaaggaggctgttggagaccttctggatgccttcaaggaggcgaacccggca
gtaccagaggtggaaaatcagcctcctgcaggcagcaatccaggcccagagtctgagggc
agtggtgtgcccccacgtcctgaggaagcagatgagacctgggactcaaaggaagacaaa
attcacaatgctgagaacatccagcccggggaacagaagtatgaatataagtcagatcag
tggaagcctctaaacctagaggagaaaaaacgttacgaccgtgagttcctgcttggtttt
cagttcatctttgccagtatgcagaagccagagggattgccacatatcagtgacgtggtg
ctggacaaggccaataaaacaccactgcggccactggatcccactagactacaaggcata
aattgtggcccagacttcactccatcctttgccaaccttggccggacaacccttagcacc
cgtgggcccccaaggggtgggccaggtggggagctgccccgtgggccggctggcctggga
ccccggcgctctcagcagggaccccgaaaagaaccacgcaagatcattgccacagtgtta
atgaccgaagatataaaactgaacaaagcagagaaagcctggaaacccagcagcaagcgg
acggcggctgataaggatcgaggggaagaagatgctgatggcagcaaaacccaggaccta
ttccgcagggtgcgctccatcctgaataaactgacaccccagatgttccagcagctgatg
aagcaagtgacgcagctggccatcgacaccgaggaacgcctcaaaggggtcattgacctc
atttttgagaaggccatttcagagcccaacttctctgtggcctatgccaacatgtgccgc
tgcctcatggcgctgaaagtgcccactacggaaaagccaacagtgactgtgaacttccga
aagctgttgttgaatcgatgtcagaaggagtttgagaaagacaaagatgatgatgaggtt
tttgagaagaagcaaaaagagatggatgaagctgctacggcagaggaacgaggacgcctg
aaggaagagctggaagaggctcgggacatagcccggcggcgctctttagggaatatcaag
tttattggagagttgttcaaactgaagatgttaacagaggcaataatgcatgactgtgtg
gtcaaactgcttaagaaccatgatgaagagtcccttgagtgcctttgtcgtctgctcacc
accattggcaaagacctggactttgaaaaagccaagccccgaatggatcagtatttcaac
cagatggaaaaaatcattaaagaaaagaagacgtcatcccgcatccgctttatgctgcag
gacgtgctggatctgcgagggagcaattgggtgccacgccgaggggatcagggtcccaag
accattgaccagatccataaggaggctgagatggaagaacatcgagagcacatcaaagtg
cagcagctcatggccaagggcagtgacaagcgtcggggcggtcctccaggccctcccatc
agccgtggacttccccttgtggatgatggtggctggaacacagttcccatcagcaaaggt
agccgccccattgacacctcacgactcaccaagatcaccaagcctggctccatcgattct
aacaaccagctctttgcacctggagggcgactgagctggggcaagggcagcagcggaggc
tcaggagccaagccctcagacgcagcatcagaagctgctcgcccagctactagtactttg
aatcgcttctcagcccttcaacaagcggtacccacagaaagcacagataatagacgtgtg
gtgcagaggagtagcttgagccgagaacgaggcgagaaagctggagaccgaggagaccgc
ctagagcggagtgaacggggaggggaccgtggggaccggcttgatcgtgcgcggacacct
gctaccaagcggagcttcagcaaggaagtggaggagcggagtagagaacggccctcccag
cctgaggggctgcgcaaggcagctagcctcacggaggatcgggaccgtgggcgggatgcc
gtgaagcgagaagctgccctacccccagtgagccccctgaaggcggctctctctgaggag
gagttagagaagaaatccaaggctatcattgaggaatatctccatctcaatgacatgaaa
gaggcagtccagtgcgtgcaggagctggcctcaccctccttgctcttcatctttgtacgg
catggtgtcgagtctacgctggagcgcagtgccattgctcgtgagcatatggggcagctg
ctgcaccagctgctctgtgctgggcatctgtctactgctcagtactaccaagggttgtat
gaaatcttggaattggctgaggacatggaaattgacatcccccacgtgtggctctaccta
gcggaactggtaacacccattctgcaggaaggtggggtgcccatgggggagctgttcagg
gagattacaaagcctctgagaccgttgggcaaagctgcttccctgttgctggagatcctg
ggcctcctgtgcaaaagcatgggtcctaaaaaggtggggacgctgtggcgagaagccggg
cttagctggaaggaatttctacctgaaggccaggacattggtgcattcgtcgctgaacag
aaggtggagtataccctgggagaggagtcggaagcccctggccagagggcactcccctcc
gaggagctgaacaggcagctggagaagctgctgaaggagggcagcagtaaccagcgggtg
ttcgactggatagaggccaacctgagtgagcagcagatagtatccaacacgttagttcga
gccctcatgacggctgtctgctattctgcaattatttttgagactcccctccgagtggac
gttgcagtgctgaaagcgcgagcgaagctgctgcagaaatacctgtgtgacgagcagaag
gagctacaggcgctctacgccctccaggcccttgtagtgaccttagaacagcctcccaac
ctgctgcggatgttctttgacgcactgtatgacgaggacgtggtgaaggaggatgccttc
tacagttgggagagtagcaaggaccccgctgagcagcagggcaagggtgtggcccttaaa
tctgtcacagccttcttcaagtggctccgtgaagcagaggaggagtctgaccacaactga

  All links  
Disease (2)   
   OMIM (2)   
Gene (32)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (80)   
   RefSeq(nuc) (8)   
   GenBank (36)   
   EMBL (36)   
3D Structure (14)   
   PDB (14)   
Protein domain (5)   
   Pfam (5)   
All databases (144)   

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