KEGG   Homo sapiens (human): 200734
Entry
200734            CDS       T01001                                 
Symbol
SPRED2, NS14, Spred-2
Name
(RefSeq) sprouty related EVH1 domain containing 2
  KO
K04703  sprouty-related, EVH1 domain-containing protein
Organism
hsa  Homo sapiens (human)
Network
nt06526  MAPK signaling
  Element
N01597  Regulation of GF-RTK-RAS-ERK signaling, SPRED and NF1
Disease
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    200734 (SPRED2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     200734 (SPRED2)
SSDB
Motif
Pfam: Sprouty WH1
Other DBs
NCBI-GeneID: 200734
NCBI-ProteinID: NP_861449
OMIM: 609292
HGNC: 17722
Ensembl: ENSG00000198369
UniProt: Q7Z698 B3KPL5
Structure
Position
2:complement(65307175..65432599)
AA seq 418 aa
MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR
KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD
YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA
NT seq 1257 nt   +upstreamnt  +downstreamnt
atgaccgaagaaacacacccagacgatgacagctatattgtgcgtgtcaaggctgtggtt
atgaccagagatgactccagcgggggatggttcccacaggaaggaggcgggatcagtcgc
gtcggggtctgtaaggtcatgcaccccgaaggcaatggacgaagcggctttctcatccat
ggtgaacgacagaaagacaaactggtggtattggaatgctatgtaagaaaggacttggtc
tacaccaaagccaatccaacgtttcatcactggaaggtcgataataggaagtttggactt
actttccaaagccctgctgatgcccgagcctttgacaggggagtaaggaaagcaatcgaa
gaccttatagaaggttcaacaacgtcatcttccaccatccataatgaagctgagcttggc
gatgatgacgtttttacaacagctacagacagttcttctaattcctctcagaagagagag
caacctactcggacaatctcctctcccacatcctgtgagcaccggaggatttataccctg
ggccacctccacgactcataccccacagaccactatcacctcgatcagccgatgccaagg
ccctaccgccaggtgagcttcccggacgacgacgaggagatcgtgcgcatcaacccccgg
gagaagatctggatgacggggtacgaggattaccggcacgcacccgtcaggggcaagtac
ccggacccctcggaggacgcggactcctcctacgtgcgcttcgccaagggcgaggtcccc
aagcatgactacaactacccctacgtggactcctcagactttggcctaggcgaggacccc
aaaggccgcgggggcagcgtgatcaagacgcagccctcccggggcaagtcgcggcggcgg
aaggaggacggagagcgctcgcggtgcgtgtactgcagggacatgttcaaccacgaggag
aaccgccggggccactgccaggacgcgcccgactccgtgagaacttgcatccgccgggtg
agctgcatgtggtgcgcggacagcatgctctatcactgtatgtcggaccccgagggagac
tatacagacccttgctcgtgcgatactagcgacgagaagttttgcctccggtggatggct
cttattgccttgtctttcctggccccctgtatgtgctgttacctgccccttcgggcctgc
taccactgcggagtgatgtgcaggtgctgtggcgggaagcacaaagcggccgcgtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (9)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (19)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (40)   
   RefSeq(nuc) (16)   
   GenBank (12)   
   EMBL (12)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (74)   

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