KEGG T01001: 200959

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

HGNC:

Ensembl:

Vega:

Pharos:

A8MPY1(Tdark)

UniProt:

A8MPY1

Position

3q11.2

AA seq 467 aa
MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQK
YEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLS
FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITV
SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFS
ASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARV
SLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEER
KQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS
RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV

NT seq 1404 nt +upstreamnt +downstreamnt
atggtcctggctttccagttagtctccttcacctacatctggatcatattgaaaccaaat
gtttgtgctgcttctaacatcaagatgacacaccagcggtgctcctcttcaatgaaacaa
acctgcaaacaagaaactagaatgaagaaagatgacagtaccaaagcgcggcctcagaaa
tatgagcaacttctccatatagaggacaacgatttcgcaatgagacctggatttggaggg
tctccagtgccagtaggtatagatgtccatgttgaaagcattgacagcatttcagagact
aacatggactttacaatgactttttatctcaggcattactggaaagacgagaggctctcc
tttcctagcacagcaaacaaaagcatgacatttgatcatagattgaccagaaagatctgg
gtgcctgatatcttttttgtccactctaaaagatccttcatccatgatacaactatggag
aatatcatgctgcgcgtacaccctgatggaaacgtcctcctaagtctcaggataacggtt
tcggccatgtgctttatggatttcagcaggtttcctcttgacactcaaaattgttctctt
gaactggaaagctatgcctacaatgaggatgacctaatgctatactggaaacacggaaac
aagtccttaaatactgaagaacatatgtccctttctcagttcttcattgaagacttcagt
gcatctagtggattagctttctatagcagcacaggttggtacaataggcttttcatcaac
tttgtgctaaggaggcatgttttcttctttgtgctgcaaacctatttcccagccatattg
atggtgatgctttcatgggtttcattttggattgaccgaagagctgttcctgcaagagtt
tccctgggaatcaccacagtgctgaccatgtccacaatcatcactgctgtgagcgcctcc
atgccccaggtgtcctacctcaaggctgtggatgtgtacctgtgggtcagctccctcttt
gtgttcctgtcagtcattgagtatgcagctgtgaactacctcaccacagtggaagagcgg
aaacaattcaagaagacaggaaagatttctaggatgtacaatattgatgcagttcaagct
atggcctttgatggttgttaccatgacagcgagattgacatggaccagacttccctctct
ctaaactcagaagacttcatgagaagaaaatcgatatgcagccccagcaccgattcatct
cggataaagagaagaaaatccctaggaggacatgttggtagaatcattctggaaaacaac
catgtcattgacacctattctaggattttattccccattgtgtatattttatttaatttg
ttttactggggtgtatatgtatga

Homo sapiens (human): 2554

Entry

2554 CDS T01001

Gene name

GABRA1, ECA4, EIEE19, EJM, EJM5

Definition

(RefSeq) gamma-aminobutyric acid type A receptor alpha1 subunit

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H00606

Early infantile epileptic encephalopathy

H00808

Idiopathic generalized epilepsies

H02215

Childhood absence epilepsy

H02217

Juvenile myoclonic epilepsy

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

D00267 D00693

Cinolazepam:

D07328

Clobazam:

D01253

Clomethiazole (DG00923):

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Etomidate:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methohexital (DG00789):

Methylphenobarbital:

Methyprylon:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Progabide:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zaleplon:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2554 (GABRA1)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2554 (GABRA1)
   04723 Retrograde endocannabinoid signaling
    2554 (GABRA1)
  09157 Sensory system
   04742 Taste transduction
    2554 (GABRA1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2554 (GABRA1)
   05033 Nicotine addiction
    2554 (GABRA1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2554 (GABRA1)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2554 (GABRA1)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P14867(Tclin)

UniProt:

P14867 A8K177

Structure

PDB:

6I53 5O8F 6D6T 6D6U

Position

5q34

AA seq 456 aa
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ

NT seq 1371 nt +upstreamnt +downstreamnt
atgaggaaaagtccaggtctgtctgactgtctttgggcctggatcctccttctgagcaca
ctgactggaagaagctatggacagccgtcattacaagatgaacttaaagacaataccact
gtcttcaccaggattttggacagactcctagatggttatgacaatcgcctgagaccagga
ttgggagagcgtgtaaccgaagtgaagactgatatcttcgtcaccagtttcggacccgtt
tcagaccatgatatggaatatacaatagatgtatttttccgtcaaagctggaaggatgaa
aggttaaaatttaaaggacctatgacagtcctccggttaaataacctaatggcaagtaaa
atctggactccggacacatttttccacaatggaaagaagtcagtggcccacaacatgacc
atgcccaacaaactcctgcggatcacagaggatggcaccttgctgtacaccatgaggctg
acagtgagagctgaatgtccgatgcatttggaggacttccctatggatgcccatgcttgc
ccactaaaatttggaagttatgcttatacaagagcagaagttgtttatgaatggaccaga
gagccagcacgctcagtggttgtagcagaagatggatcacgtctaaaccagtatgacctt
cttggacaaacagtagactctggaattgtccagtcaagtacaggagaatatgttgttatg
accactcatttccacttgaagagaaagattggctactttgttattcaaacatacctgcca
tgcataatgacagtgattctctcacaagtctccttctggctcaacagagagtctgtacca
gcaagaactgtctttggagtaacaactgtgctcaccatgacaacattgagcatcagtgcc
agaaactccctccctaaggtggcttatgcaacagctatggattggtttattgccgtgtgc
tatgcctttgtgttctcagctctgattgagtttgccacagtaaactatttcactaagaga
ggttatgcatgggatggcaaaagtgtggttccagaaaagccaaagaaagtaaaggatcct
cttattaagaaaaacaacacttacgctccaacagcaaccagctacacccctaatttggcc
aggggcgacccgggcttagccaccattgctaaaagtgcaaccatagaacctaaagaggtc
aagcccgaaacaaaaccaccagaacccaagaaaacctttaacagtgtcagcaaaattgac
cgactgtcaagaatagccttcccgctgctatttggaatctttaacttagtctactgggct
acgtatttaaacagagagcctcagctaaaagcccccacaccacatcaatag

Homo sapiens (human): 2555

Entry

2555 CDS T01001

Gene name

GABRA2

Definition

(RefSeq) gamma-aminobutyric acid type A receptor alpha2 subunit

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H01611

Alcohol dependence

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Neur_chan_LBD Neur_chan_memb CytochromB561_N DUF5522

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2555 (GABRA2)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2555 (GABRA2)
   04723 Retrograde endocannabinoid signaling
    2555 (GABRA2)
  09157 Sensory system
   04742 Taste transduction
    2555 (GABRA2)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2555 (GABRA2)
   05033 Nicotine addiction
    2555 (GABRA2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2555 (GABRA2)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2555 (GABRA2)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P47869(Tclin)

UniProt:

P47869 A0A024R9X6

Structure

PDB:

5O8F

Position

4p12

AA seq 451 aa
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP

NT seq 1356 nt +upstreamnt +downstreamnt
atgaagacaaaattgaacatctacaacatgcagttcctgctttttgttttcttggtgtgg
gaccctgccaggttggtgctggctaacatccaagaagatgaggctaaaaataacattacc
atctttacgagaattcttgacagacttctggatggttacgataatcggcttagaccagga
ctgggagacagtattactgaagtcttcactaacatctacgtgaccagttttggccctgtc
tcagatacagatatggaatatacaattgatgttttctttcgacaaaaatggaaagatgaa
cgtttaaaatttaaaggtcctatgaatatccttcgactaaacaatttaatggctagcaaa
atctggactccagataccttttttcacaatgggaaaaaatcagtagctcataatatgaca
atgccaaataagttgcttcgaattcaggatgatgggactctgctgtataccatgaggctt
acagttcaagctgaatgcccaatgcacttggaggatttcccaatggatgctcattcatgt
cctctgaaatttggcagctatgcatatacaacttcagaggtcacttatatttggacttac
aatgcatctgattcagtacaggttgctcctgatggctctaggttaaatcaatatgacctg
ctgggccaatcaatcggaaaggagacaattaaatccagtacaggtgaatatactgtaatg
acagctcatttccacctgaaaagaaaaattgggtattttgtgattcaaacctatctgcct
tgcatcatgactgtcattctctcccaagtttcattctggcttaacagagaatctgtgcct
gcaagaactgtgtttggagtaacaactgtcctaacaatgacaactctaagcatcagtgct
cggaattctctccccaaagtggcttatgcaactgccatggactggtttattgctgtttgt
tatgcatttgtgttctctgccctaattgaatttgcaactgttaattacttcaccaaaaga
ggatgggcttgggatgggaagagtgtagtaaatgacaagaaaaaagaaaaggcttccgtt
atgatacagaacaacgcttatgcagtggctgttgccaattatgccccgaatctttcaaaa
gatccagttctctccaccatctccaagagtgcaaccacgccagaacccaacaagaagcca
gaaaacaagccagctgaagcaaagaaaactttcaacagtgttagcaaaattgacagaatg
tccagaatagtttttccagttttgtttggtacctttaatttagtttactgggctacatat
ttaaacagagaacctgtattaggggtcagtccttga

Homo sapiens (human): 2556

Entry

2556 CDS T01001

Gene name

GABRA3

Definition

(RefSeq) gamma-aminobutyric acid type A receptor alpha3 subunit

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2556 (GABRA3)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2556 (GABRA3)
   04723 Retrograde endocannabinoid signaling
    2556 (GABRA3)
  09157 Sensory system
   04742 Taste transduction
    2556 (GABRA3)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2556 (GABRA3)
   05033 Nicotine addiction
    2556 (GABRA3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2556 (GABRA3)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2556 (GABRA3)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P34903(Tclin)

UniProt:

P34903

Structure

PDB:

5O8F

Position

Xq28

AA seq 492 aa
MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS
TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ
TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL
YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL
NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN
RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN
YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA
APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN
RESAIKGMIRKQ

NT seq 1479 nt +upstreamnt +downstreamnt
atgataatcacacaaacaagtcactgttacatgaccagccttgggattcttttcctgatt
aatattctccctggaaccactggtcaaggggaatcaagacgacaagaacccggggacttt
gtgaagcaggacattggcgggctgtctcctaagcatgccccagatattcctgatgacagc
actgacaacatcactatcttcaccagaatcttggatcgtcttctggacggctatgacaac
cggctgcgacctgggcttggagatgcagtgactgaagtgaagactgacatctacgtgacc
agttttggccctgtgtcagacactgacatggagtacactattgatgtattttttcggcag
acatggcatgatgaaagactgaaatttgatggccccatgaagatccttccactgaacaat
ctcctggctagtaagatctggacaccggacaccttcttccacaatggcaagaaatcagtg
gctcataacatgaccacgcccaacaagctgctcagattggtggacaacggaaccctcctc
tatacaatgaggttaacaattcatgctgagtgtcccatgcatttggaagattttcccatg
gatgtgcatgcctgcccactgaagtttggaagctatgcctatacaacagctgaagtggtt
tattcttggactctcggaaagaacaaatccgtggaagtggcacaggatggttctcgcttg
aaccagtatgaccttttgggccatgttgttgggacagagataatccggtctagtacagga
gaatatgtcgtcatgacaacccacttccatctcaagcgaaaaattggctactttgtgatc
cagacctacttgccatgtatcatgactgtcattctgtcacaagtgtcgttctggctcaac
agagagtctgttcctgcccgtacagtctttggtgtcaccactgtgcttaccatgaccacc
ttgagtatcagtgccagaaattccttacctaaagtggcatatgcgacggccatggactgg
ttcatagccgtctgttatgcctttgtattttctgcactgattgaatttgccactgtcaac
tatttcaccaagcggagttgggcttgggaaggcaagaaggtgccagaggccctggagatg
aagaagaaaacaccagcagccccagcaaagaaaaccagcactaccttcaacatcgtgggg
accacctatcccatcaacctggccaaggacactgaattttccaccatctccaagggcgct
gctcccagtgcctcctcaaccccaacaatcattgcttcacccaaggccacctacgtgcag
gacagcccgactgagaccaagacctacaacagtgtcagcaaggttgacaaaatttcccgc
atcatctttcctgtgctctttgccatattcaatctggtctattgggccacatatgtcaac
cgggagtcagctatcaagggcatgatccgcaaacagtag

Homo sapiens (human): 2557

Entry

2557 CDS T01001

Gene name

GABRA4

Definition

(RefSeq) gamma-aminobutyric acid type A receptor alpha4 subunit

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Neur_chan_LBD Neur_chan_memb OAD_gamma

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2557 (GABRA4)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2557 (GABRA4)
   04723 Retrograde endocannabinoid signaling
    2557 (GABRA4)
  09157 Sensory system
   04742 Taste transduction
    2557 (GABRA4)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2557 (GABRA4)
   05033 Nicotine addiction
    2557 (GABRA4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2557 (GABRA4)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2557 (GABRA4)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P48169(Tclin)

UniProt:

P48169 X5D7F5

Position

4p12

AA seq 554 aa
MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ
EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES
SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG
SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV
YLSKDTMEKSESLM

NT seq 1665 nt +upstreamnt +downstreamnt
atggtttctgccaagaaggtacccgcgatcgctctgtccgccggggtcagtttcgccctc
ctgcgcttcctgtgcctggcggtttgtttaaacgaatccccaggacagaaccaaaaggag
gagaaattgtgcacagaaaatttcacccgcatcctggacagtttgctcgatggttatgac
aacaggctgcgtcctggatttgggggtcctgttacagaagtgaaaactgacatatatgtc
accagctttggacctgtttctgatgttgaaatggaatacacaatggatgtgttcttcagg
cagacatggattgacaaaagattaaaatatgacggccccattgaaattttgagattgaac
aatatgatggtaacgaaagtgtggacccctgatactttcttcaggaatggaaagaaatct
gtctcacataatatgacagctccaaataagctttttagaattatgagaaatggtactatt
ttatacacaatgagactcaccataagtgcggagtgtcccatgagattggtggattttccc
atggatggtcatgcatgccctttgaaattcgggagttatgcctatccaaagagtgagatg
atctatacctggacaaaaggtcctgagaaatcagttgaagttccgaaggagtcttccagc
ttagttcaatatgatttgattgggcaaaccgtatcaagtgaaaccatcaaatcaattacg
ggtgaatatattgttatgacggtttacttccacctcagacggaagatgggttattttatg
attcagacctatattccgtgcattatgacagtgattctttctcaagtttcattttggata
aataaagaatcagttcccgctaggactgtatttggaataacaactgtcctcaccatgacc
acactaagcatcagtgcacgacattctttgcccaaagtgtcctatgctaccgccatggac
tggttcatagctgtctgctttgcttttgtattttcggcccttatcgagtttgctgctgtc
aactatttcaccaatattcaaatggaaaaagccaaaaggaagacatcaaagccccctcag
gaagttcccgctgctccagtgcagagagagaagcatcctgaagcccctctgcagaataca
aatgccaatttgaacatgagaaaaagaacaaatgctttggttcactctgaatctgatgtt
ggcaacagaactgaggtgggaaaccattcaagcaaatcttccacagttgttcaagaatct
tctaaaggcacacctcggtcttacttagcttccagtccaaacccattcagccgtgcaaat
gcagctgaaaccatatctgcagcaagagcacttccatctgcttctcctacttctatccga
actggatatatgcctcgaaaggcttcagttggatctgcttctactcgtcacgtgtttgga
tcaagactgcagaggataaagaccacagttaataccataggggctactgggaagttgtca
gctactcctcctccatcggctccaccaccttctggatctggcacaagtaaaatagacaaa
tatgcccgtattctctttccagtcacatttggggcatttaacatggtttattgggttgtt
tatttatctaaggacactatggagaaatcagaaagtctaatgtaa

Homo sapiens (human): 2558

Entry

2558 CDS T01001

Gene name

GABRA5

Definition

(RefSeq) gamma-aminobutyric acid type A receptor alpha5 subunit

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Neur_chan_LBD Neur_chan_memb CytochromB561_N

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2558 (GABRA5)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2558 (GABRA5)
   04723 Retrograde endocannabinoid signaling
    2558 (GABRA5)
  09157 Sensory system
   04742 Taste transduction
    2558 (GABRA5)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2558 (GABRA5)
   05033 Nicotine addiction
    2558 (GABRA5)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2558 (GABRA5)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2558 (GABRA5)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P31644(Tclin)

UniProt:

P31644

Structure

PDB:

5O8F 6A96

Position

15q12

AA seq 462 aa
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK

NT seq 1389 nt +upstreamnt +downstreamnt
atggacaatggaatgttctctggttttatcatgatcaaaaacctccttctcttttgtatt
tccatgaacttatccagtcactttggcttttcacagatgccaaccagttcagtgaaagat
gagaccaatgacaacatcacgatatttaccaggatcttggatgggctcttggatggctac
gacaacagacttcggcccgggctgggagagcgcatcactcaggtgaggaccgacatctac
gtcaccagcttcggcccggtgtccgacacggaaatggagtacaccatagacgtgtttttc
cgacaaagctggaaagatgaaaggcttcggtttaaggggcccatgcagcgcctccctctc
aacaacctccttgccagcaagatctggaccccagacacgttcttccacaacgggaagaag
tccatcgctcacaacatgaccacgcccaacaagctgctgcggctggaggacgacggcacc
ctgctctacaccatgcgcttgaccatctctgcagagtgccccatgcagcttgaggacttc
ccgatggatgcgcacgcttgccctctgaaatttggcagctatgcgtaccctaattctgaa
gtcgtttacgtctggaccaacggctccaccaagtcggtggtggtggcggaagatggctcc
agactgaaccagtaccacctgatggggcagacggtgggcactgagaacatcagcaccagc
acaggcgaatacacaatcatgacagctcacttccacctgaaaaggaagattggctacttt
gtcatccagacctaccttccctgcataatgaccgtgatcttatcacaggtgtccttttgg
ctgaaccgggaatcagtcccagccaggacagtttttggggtcaccacggtgctgaccatg
acgaccctcagcatcagcgccaggaactctctgcccaaagtggcctacgccaccgccatg
gactggttcatagccgtgtgctatgccttcgtcttctcggcgctgatagagtttgccacg
gtcaattactttaccaagagaggctgggcctgggatggcaaaaaagccttggaagcagcc
aagatcaagaaaaagcgtgaagtcatactaaataagtcaacaaacgcttttacaactggg
aagatgtctcaccccccaaacattccgaaggaacagaccccagcagggacgtcgaataca
acctcagtctcagtaaaaccctctgaagagaagacttctgaaagcaaaaagacttacaac
agtatcagcaaaattgacaaaatgtcccgaatcgtattcccagtcttgttcggcactttc
aacttagtttactgggcaacgtatttgaatagggagccggtgataaaaggagccgcctct
ccaaaataa

Homo sapiens (human): 2559

Entry

2559 CDS T01001

Gene name

GABRA6

Definition

(RefSeq) gamma-aminobutyric acid type A receptor alpha6 subunit

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Neur_chan_LBD Neur_chan_memb DUF4396

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2559 (GABRA6)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2559 (GABRA6)
   04723 Retrograde endocannabinoid signaling
    2559 (GABRA6)
  09157 Sensory system
   04742 Taste transduction
    2559 (GABRA6)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2559 (GABRA6)
   05033 Nicotine addiction
    2559 (GABRA6)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2559 (GABRA6)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2559 (GABRA6)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q16445(Tclin)

UniProt:

Q16445

Position

5q34

AA seq 453 aa
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI
VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY
SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE

NT seq 1362 nt +upstreamnt +downstreamnt
atggcgtcgtctctgccctggctgtgcattattctgtggctagaaaatgccctagggaaa
ctcgaagttgaaggcaacttctactcagaaaacgtcagtcggatcctggacaacttgctt
gaaggctatgacaatcggctgcggccgggatttggaggtgctgtcactgaagtcaaaaca
gacatttatgtgaccagttttgggcccgtgtcagatgtggagatggagtatacgatggat
gtttttttccgccagacctggactgatgagaggttgaagtttggggggccaactgagatt
ctgagtctgaataatttgatggtcagtaaaatctggacgcctgacacctttttcagaaat
ggtaaaaagtccattgctcacaacatgacaactcctaataaactcttcagaataatgcag
aatggaaccattttatacaccatgaggcttaccatcaatgctgactgtcccatgaggctg
gttaactttcctatggatgggcatgcttgtccactcaagtttgggagctatgcttatccc
aaaagtgaaatcatatatacgtggaaaaaaggaccactttactcagtagaagtcccagaa
gaatcttcaagccttctccagtatgatctgattggacaaacagtatctagtgagacaatt
aaatctaacacaggtgaatacgttataatgacagtttacttccacttgcaaaggaagatg
ggctacttcatgatacagatatacactccttgcattatgacagtcattctttcccaggtg
tctttctggattaataaggagtccgtcccagcaagaactgtttttgggatcaccactgtt
ttaactatgaccactttgagcatcagtgcccggcactctttgccaaaagtgtcatatgcc
actgccatggattggttcatagctgtttgctttgcattcgtcttctctgcgcttatcgag
ttcgcagctgtcaactactttaccaatcttcagacacagaaggccaaaaggaaggcacag
tttgcagccccacccacagtgacaatatcaaaagctactgaacctttggaagctgagatt
gttttgcatcctgactccaaatatcatctgaagaaaaggatcacttctctgtctttgcca
atagtttcatcttccgaggccaataaagtgctcacgagagcgcccatcttacaatcaaca
cctgtcacacccccaccactctcgccagcctttggaggcaccagtaaaatagaccagtat
tctcgaattctcttcccagttgcatttgcaggattcaaccttgtgtactgggtagtttat
ctttccaaagatacaatggaagtcagtagcagtgttgaatag

Homo sapiens (human): 2560

Entry

2560 CDS T01001

Gene name

GABRB1, EIEE45

Definition

(RefSeq) gamma-aminobutyric acid type A receptor beta1 subunit

K05181

gamma-aminobutyric acid receptor subunit beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04726

Serotonergic synapse

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H00606

Early infantile epileptic encephalopathy

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Neur_chan_LBD Neur_chan_memb OAD_gamma

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2560 (GABRB1)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2560 (GABRB1)
   04726 Serotonergic synapse
    2560 (GABRB1)
   04723 Retrograde endocannabinoid signaling
    2560 (GABRB1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2560 (GABRB1)
   05033 Nicotine addiction
    2560 (GABRB1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2560 (GABRB1)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2560 (GABRB1)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P18505(Tclin)

UniProt:

P18505 X5DNL6

Position

4p12

AA seq 474 aa
MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ
VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR
HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH

NT seq 1425 nt +upstreamnt +downstreamnt
atgtggacagtacaaaatcgagagagtctggggcttctctctttccctgtgatgattacc
atggtctgttgtgcacacagcaccaatgaacccagcaacatgtcatacgtgaaagagaca
gtggacagattgctcaaaggatatgacattcgcttgcggccggacttcggagggcccccc
gtcgacgttgggatgcggatcgatgtcgccagcatagacatggtctccgaagtgaatatg
gattatacactcaccatgtatttccagcagtcttggaaagacaaaaggctttcttattct
ggaatcccactgaacctcaccctagacaatagggtagctgaccaactctgggtaccagac
acctactttctgaatgacaagaaatcatttgtgcatggggtcacagtgaaaaatcgaatg
attcgactgcatcctgatggaacagttctctatggactccgaatcacaaccacagctgca
tgtatgatggatcttcgaagatatccattggatgagcagaactgcaccctggagatcgaa
agttatggctataccactgatgacattgaattttactggaatggaggagaaggggcagtc
actggtgttaataaaatcgaacttcctcaattttcaattgttgactacaagatggtgtct
aagaaggtggagttcacaacaggagcgtatccacgactgtcactaagttttcgtctaaag
agaaacattggttacttcattttgcaaacctacatgccttctacactgattacaattctg
tcctgggtgtctttttggatcaactatgatgcatctgcagccagagtcgcactaggaatc
acgacagtgcttacaatgacaaccatcagcacccacctcagggagaccctgccaaagatc
ccttatgtcaaagcgattgatatttatctgatgggttgctttgtgtttgtgttcctggct
ctgctggagtatgcctttgtaaattacatcttctttgggaaaggccctcagaaaaaggga
gctagcaaacaagaccagagtgccaatgagaagaataaactggagatgaataaagtccag
gtcgacgcccacggtaacattctcctcagcaccctggaaatccggaatgagacgagtggc
tcggaagtgctcacgagcgtgagcgaccccaaggccaccatgtactcctatgacagcgcc
agcatccagtaccgcaagcccctgagcagccgcgaggcctacgggcgcgccctggaccgg
cacggggtacccagcaaggggcgcatccgcaggcgtgcctcccagctcaaagtcaagatc
cccgacttgactgatgtgaattccatagacaagtggtcccgaatgtttttccccatcacc
ttttctctttttaatgtcgtctattggctttactatgtacactga

Homo sapiens (human): 2561

Entry

2561 CDS T01001

Gene name

GABRB2, ICEE2

Definition

(RefSeq) gamma-aminobutyric acid type A receptor beta2 subunit

K05181

gamma-aminobutyric acid receptor subunit beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04726

Serotonergic synapse

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H02150

Infantile or early childhood epileptic encephalopathy

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2561 (GABRB2)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2561 (GABRB2)
   04726 Serotonergic synapse
    2561 (GABRB2)
   04723 Retrograde endocannabinoid signaling
    2561 (GABRB2)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2561 (GABRB2)
   05033 Nicotine addiction
    2561 (GABRB2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2561 (GABRB2)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2561 (GABRB2)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P47870(Tclin)

UniProt:

P47870

Structure

PDB:

6D6T 6D6U

Position

5q34

AA seq 512 aa
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV
AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT
YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES
YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR
NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP
YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI
FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA
VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD
LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN

NT seq 1539 nt +upstreamnt +downstreamnt
atgtggagagtgcggaaaaggggctactttgggatttggtccttccccttaataatcgcc
gctgtctgtgcgcagagtgtcaatgaccctagtaatatgtcgctggttaaagagacggtg
gatagactcctgaaaggctatgacattcgtctgagaccagattttggaggtccccccgtg
gctgtggggatgaacattgacattgccagcatcgatatggtttctgaagtcaatatggat
tataccttgacaatgtactttcaacaagcctggagagataagaggctgtcctataatgta
atacctttaaacttgactctggacaacagagtggcagaccagctctgggtgcctgatacc
tatttcctgaacgataagaagtcatttgtgcacggagtgactgttaagaaccgcatgatt
cgcctgcatcctgatggcaccgtcctttatggactcagaatcacaaccacagctgcctgc
atgatggacctaaggaggtacccactggatgaacaaaactgcaccttggaaattgagagc
tatggatacacaactgatgacattgagttttactggcgtggcgatgataatgcagtaaca
ggagtaacgaaaattgaacttccacagttctctattgtagattacaaacttatcaccaag
aaggttgttttttccacaggttcctatcccaggttatccctcagctttaagcttaagaga
aacattggctactttatcctgcaaacatacatgccttccatcctgattaccatcctctcc
tgggtctccttctggattaattacgatgcttcagctgcaagggtggcattaggaatcaca
actgtcctcacaatgaccacaatcaacacccacctccgggaaactctccctaaaatcccc
tatgtgaaggccattgacatgtacctgatggggtgctttgtcttcgttttcatggccctt
ctggaatatgccctagtcaactacatcttctttgggagggggccccaacgccaaaagaaa
gcagctgagaaggctgccagtgccaacaatgagaagatgcgcctggatgtcaacaagatt
ttttataaagatattaaacaaaatgggacccaatatcgatccttgtgggaccctactgga
aacctctccccaactagacggactaccaattacgatttctctctgtatacgatggacccc
catgagaacatcttactgagcactctcgagataaaaaatgaaatggccacatctgaggct
gtgatgggacttggagaccccagaagcacaatgctagcctatgatgcctccagcatccag
tatcggaaagctgggttgcccaggcatagttttggccgaaatgctctggaacgacatgtg
gcgcaaaagaaaagtcgcctgaggagacgcgcctcccaactgaaaatcaccatccctgac
ttgactgatgtgaatgccatagatcggtggtcccgcatattcttcccagtggttttttcc
ttcttcaacatcgtctattggctttattatgtgaactaa

Homo sapiens (human): 2562

Entry

2562 CDS T01001

Gene name

GABRB3, ECA5, EIEE43

Definition

(RefSeq) gamma-aminobutyric acid type A receptor beta3 subunit

K05181

gamma-aminobutyric acid receptor subunit beta

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04726

Serotonergic synapse

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H00606

Early infantile epileptic encephalopathy

H01813

Lennox-Gastaut syndrome

H02215

Childhood absence epilepsy

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Neur_chan_LBD Neur_chan_memb OAD_gamma

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2562 (GABRB3)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2562 (GABRB3)
   04726 Serotonergic synapse
    2562 (GABRB3)
   04723 Retrograde endocannabinoid signaling
    2562 (GABRB3)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2562 (GABRB3)
   05033 Nicotine addiction
    2562 (GABRB3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2562 (GABRB3)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2562 (GABRB3)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P28472(Tclin)

UniProt:

P28472

Structure

PDB:

4COF 6HUJ 6HUG 6I53 6HUO 6A96 6HUP 6HUK

Position

15q12

AA seq 473 aa
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP
VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK
RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR
VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS
LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN

NT seq 1422 nt +upstreamnt +downstreamnt
atgtggggccttgcgggaggaaggcttttcggcatcttctcggccccggtgctggtggct
gtggtgtgctgcgcccagagtgtgaacgatcccgggaacatgtcctttgtgaaggagacg
gtggacaagctgttgaaaggctacgacattcgcctaagacccgacttcgggggtcccccg
gtctgcgtggggatgaacatcgacatcgccagcatcgacatggtttccgaagtcaacatg
gattataccttaaccatgtattttcaacaatattggagagataaaaggctcgcctattct
gggatccctctcaacctcacgcttgacaatcgagtggctgaccagctatgggtgcccgac
acatatttcttaaatgacaaaaagtcatttgtgcatggagtgacagtgaaaaaccgcatg
atccgtcttcaccctgatgggacagtgctgtatgggctcagaatcaccacgacagcagca
tgcatgatggacctcaggagataccccctggacgagcagaactgcactctggaaattgaa
agctatggctacaccacggatgacattgagttttactggcgaggcggggacaaggctgtt
accggagtggaaaggattgagctcccgcagttctccatcgtggagcaccgtctggtctcg
aggaatgttgtcttcgccacaggtgcctatcctcgactgtcactgagctttcggttgaag
aggaacattggatacttcattcttcagacttatatgccctctatactgataacgattctg
tcgtgggtgtccttctggatcaattatgatgcatctgctgctagagttgccctcgggatc
acaactgtgctgacaatgacaaccatcaacacccaccttcgggagaccttgcccaaaatc
ccctatgtcaaagccattgacatgtaccttatgggctgcttcgtctttgtgttcctggcc
cttctggagtatgcctttgtcaactacattttctttggaagaggccctcaaaggcagaag
aagcttgcagaaaagacagccaaggcaaagaatgaccgttcaaagagcgaaagcaaccgg
gtggatgctcatggaaatattctgttgacatcgctggaagttcacaatgaaatgaatgag
gtctcaggcggcattggcgataccaggaattcagcaatatcctttgacaactcaggaatc
cagtacaggaaacagagcatgcctcgagaagggcatgggcgattcctgggggacagaagc
ctcccgcacaagaagacccatctacggaggaggtcttcacagctcaaaattaaaatacct
gatctaaccgatgtgaatgccatagacagatggtccaggatcgtgtttccattcactttt
tctcttttcaacttagtttactggctgtactatgttaactga

Homo sapiens (human): 2563

Entry

2563 CDS T01001

Gene name

GABRD, EIG10, EJM7, GEFSP5

Definition

(RefSeq) gamma-aminobutyric acid type A receptor delta subunit

K05184

gamma-aminobutyric acid receptor subunit delta

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H00783

Febrile seizures

H00808

Idiopathic generalized epilepsies

H02217

Juvenile myoclonic epilepsy

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2563 (GABRD)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2563 (GABRD)
   04723 Retrograde endocannabinoid signaling
    2563 (GABRD)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2563 (GABRD)
   05033 Nicotine addiction
    2563 (GABRD)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2563 (GABRD)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2563 (GABRD)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

O14764(Tclin)

UniProt:

O14764 A8K496

Position

1p36.33

AA seq 452 aa
MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG
GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW
LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML
DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH
FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS
LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI
VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR
PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM

NT seq 1359 nt +upstreamnt +downstreamnt
atggacgcgcccgcccggctgctggccccgctcctgctcctctgcgcgcagcagctccgc
ggcaccagagcgatgaatgacatcggcgactacgtgggctccaacctggagatctcctgg
ctccccaacctggacgggctgatagccggctacgcccgcaacttccggcctggcatcgga
ggcccccccgtgaatgtggcccttgccctggaggtggccagcatcgaccacatctcagag
gccaacatggagtacaccatgacggtgttcctgcaccagagctggcgggacagcaggctc
tcctacaaccacaccaacgagaccctgggtctggacagccgcttcgtggacaagctgtgg
ctgcccgacaccttcatcgtgaacgccaagtcggcctggttccacgacgtgacggtggag
aacaagctcatccggctgcagcccgacggcgtgatcctgtacagcatccgaatcacctcc
actgtggcctgcgacatggacctggccaaataccccatggacgagcaggagtgcatgctg
gacctggagagctacggttactcatcggaggacatcgtctactactggtcggagagccag
gagcacatccacgggctggacaagctgcagctggcgcagttcaccatcaccagctaccgc
ttcaccacggagctgatgaacttcaagtccgctggccagttcccacggctcagcctgcac
ttccacctgcggaggaaccgcggcgtgtacatcatccaatcctacatgccctccgtcctg
ctggtcgccatgtcctgggtctccttctggatcagccaggcggcggtgcccgccagggtg
tctctaggcatcaccacggtgctgacgatgaccacgctcatggtcagtgcccgctcctcc
ctgccacgggcatcagccatcaaggcactggacgtctacttctggatctgctatgtcttc
gtgtttgccgccctggtggagtacgcctttgctcatttcaacgccgactacaggaagaag
cagaaggccaaggtcaaggtctccaggccgagggcagagatggacgtgaggaacgccatt
gtcctcttctccctctctgctgccggcgtcacgcaggagctggccatctcccgccggcag
cgccgcgtcccggggaacctgatgggctcctacaggtcggtgggggtggagacaggggag
acgaagaaggagggggcagcccgctcaggaggccaggggggcatccgtgcccggctcagg
cccatcgacgcagacaccattgacatttacgcccgcgctgtgttccctgcggcgtttgcg
gccgtcaatgtcatctactgggcggcatacgccatgtga

Homo sapiens (human): 2564

Entry

2564 CDS T01001

Gene name

GABRE

Definition

(RefSeq) gamma-aminobutyric acid type A receptor epsilon subunit

K05185

gamma-aminobutyric acid receptor subunit epsilon

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2564 (GABRE)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2564 (GABRE)
   04723 Retrograde endocannabinoid signaling
    2564 (GABRE)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2564 (GABRE)
   05033 Nicotine addiction
    2564 (GABRE)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2564 (GABRE)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2564 (GABRE)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P78334(Tclin)

UniProt:

P78334

Position

Xq28

AA seq 506 aa
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE
TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI
IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD
GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW
KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW
IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV
LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER
PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL
DNYSRVVFPVTFFFFNVLYWLVCLNL

NT seq 1521 nt +upstreamnt +downstreamnt
atgttgtccaaagttcttccagtcctcctaggcatcttattgatcctccagtcgagggtc
gagggacctcagactgaatcaaagaatgaagcctcttcccgtgatgttgtctatggcccc
cagccccagcctctggaaaatcagctcctctctgaggaaacaaagtcaactgagactgag
actgggagcagagttggcaaactgccagaagcctctcgcatcctgaacactatcctgagt
aattatgaccacaaactgcgccctggcattggagagaagcccactgtggtcactgttgag
atctccgtcaacagccttggtcctctctctatcctagacatggaatacaccattgacatc
atcttctcccagacctggtacgacgaacgcctctgttacaacgacacctttgagtctctt
gttctgaatggcaatgtggtgagccagctatggatcccggacaccttttttaggaattct
aagaggacccacgagcatgagatcaccatgcccaaccagatggtccgcatctacaaggat
ggcaaggtgttgtacacaattaggatgaccattgatgccggatgctcactccacatgctc
agatttccaatggattctcactcttgccctctatctttctctagcttttcctatcctgag
aatgagatgatctacaagtgggaaaatttcaagcttgaaatcaatgagaagaactcctgg
aagctcttccagtttgattttacaggagtgagcaacaaaactgaaataatcacaacccca
gttggtgacttcatggtcatgacgattttcttcaatgtgagcaggcggtttggctatgtt
gcctttcaaaactatgtcccttcttccgtgaccacgatgctctcctgggtttccttttgg
atcaagacagagtctgctccagcccggacctctctagggatcacctctgttctgaccatg
accacgttgggcaccttttctcgtaagaatttcccgcgtgtctcctatatcacagccttg
gatttctatatcgccatctgcttcgtcttctgcttctgcgctctgttggagtttgctgtg
ctcaacttcctgatctacaaccagacaaaagcccatgcttctcctaaactccgccatcct
cgtatcaatagccgtgcccatgcccgtacccgtgcacgttcccgagcctgtgcccgccaa
catcaggaagcttttgtgtgccagattgtcaccactgagggaagtgatggagaggagcgc
ccgtcttgctcagcccagcagccccctagcccaggtagccctgagggtccccgcagcctc
tgctccaagctggcctgctgtgagtggtgcaagcgttttaagaagtacttctgcatggtc
cccgattgtgagggcagtacctggcagcagggccgcctctgcatccatgtctaccgcctg
gataactactcgagagttgttttcccagtgactttcttcttcttcaatgtgctctactgg
cttgtttgccttaacttgtag

Homo sapiens (human): 2565

Entry

2565 CDS T01001

Gene name

GABRG1

Definition

(RefSeq) gamma-aminobutyric acid type A receptor gamma1 subunit

K05186

gamma-aminobutyric acid receptor subunit gamma

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2565 (GABRG1)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2565 (GABRG1)
   04723 Retrograde endocannabinoid signaling
    2565 (GABRG1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2565 (GABRG1)
   05033 Nicotine addiction
    2565 (GABRG1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2565 (GABRG1)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2565 (GABRG1)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q8N1C3(Tclin)

UniProt:

Q8N1C3

Position

4p12

AA seq 465 aa
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL

NT seq 1398 nt +upstreamnt +downstreamnt
atgggtcctttgaaagcttttctcttctccccttttcttctgcggagtcaaagtagaggg
gtgaggttggtcttcttgttactgaccctgcatttgggaaactgtgttgataaggcagat
gatgaagatgatgaggatttaacggtgaacaaaacctgggtcttggccccaaaaattcat
gaaggagatatcacacaaattctgaattcattgcttcaaggctatgacaataaacttcgt
ccagatataggagtgaggcccacagtaattgaaactgatgtttatgtaaacagcattgga
ccagttgatccaattaatatggaatatacaatagatataatttttgcccaaacctggttt
gacagtcgtttaaaattcaatagtaccatgaaagtgcttatgcttaacagtaatatggtt
ggaaaaatttggattcctgacactttcttcagaaactcaagaaaatctgatgctcactgg
ataacaactcctaatcgtctgcttcgaatttggaatgatggacgagttctgtatactcta
agattgacaattaatgcagaatgttatcttcagcttcataactttcccatggatgaacat
tcctgtccactggaattttcaagctatggataccctaaaaatgaaattgagtataagtgg
aaaaagccctccgtagaagtggctgatcctaaatactggagattatatcagtttgcattt
gtagggttacggaactcaactgaaatcactcacacgatctctggggattatgttatcatg
acaattttttttgacctgagcagaagaatgggatatttcactattcagacctacattcca
tgcattctgacagttgttctttcttgggtgtctttttggatcaataaagatgcagtgcct
gcaagaacatcgttgggtatcactacagttctgactatgacaaccctgagtacaattgcc
aggaagtctttacctaaggtttcttatgtgactgcgatggatctctttgtttctgtttgt
ttcatttttgtttttgcagccttgatggaatatggaaccttgcattattttaccagcaac
caaaaaggaaagactgctactaaagacagaaagctaaaaaataaagcctcgatgactcct
ggtctccatcctggatccactctgattccaatgaataatatttctgtgccgcaagaagat
gattatgggtatcagtgtttggagggcaaagattgtgccagcttcttctgttgctttgaa
gactgcagaacaggatcttggagggaaggaaggatacacatacgcattgccaaaattgac
tcttattctagaatatttttcccaaccgcttttgccctgttcaacttggtttattgggtt
ggctatctttacttataa

Homo sapiens (human): 2566

Entry

2566 CDS T01001

Gene name

GABRG2, CAE2, ECA2, EIEE74, FEB8, GEFSP3

Definition

(RefSeq) gamma-aminobutyric acid type A receptor gamma2 subunit

K05186

gamma-aminobutyric acid receptor subunit gamma

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Disease

H00783

Febrile seizures

H02215

Childhood absence epilepsy

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2566 (GABRG2)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2566 (GABRG2)
   04723 Retrograde endocannabinoid signaling
    2566 (GABRG2)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2566 (GABRG2)
   05033 Nicotine addiction
    2566 (GABRG2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2566 (GABRG2)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2566 (GABRG2)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P18507(Tclin)

UniProt:

P18507

Structure

PDB:

6HUJ 6HUG 6I53 6HUO 6HUP 6HUK 6D6T 6D6U

Position

5q34

AA seq 467 aa
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC
FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

NT seq 1404 nt +upstreamnt +downstreamnt
atgagttcgccaaatatatggagcacaggaagctcagtctactcgactcctgtattttca
cagaaaatgacggtgtggattctgctcctgctgtcgctctaccctggcttcactagccag
aaatctgatgatgactatgaagattatgcttctaacaaaacatgggtcttgactccaaaa
gttcctgagggtgatgtcactgtcatcttaaacaacctgctggaaggatatgacaataaa
cttcggcctgatataggagtgaagccaacgttaattcacacagacatgtatgtgaatagc
attggtccagtgaacgctatcaatatggaatacactattgatatattttttgcgcaaacg
tggtatgacagacgtttgaaatttaacagcaccattaaagtcctccgattgaacagcaac
atggtggggaaaatctggattccagacactttcttcagaaattccaaaaaagctgatgca
cactggatcaccacccccaacaggatgctgagaatttggaatgatggtcgagtgctctac
accctaaggttgacaattgatgctgagtgccaattacaattgcacaactttccaatggat
gaacactcctgccccttggagttctccagttatggctatccacgtgaagaaattgtttat
caatggaagcgaagttctgttgaagtgggcgacacaagatcctggaggctttatcaattc
tcatttgttggtctaagaaataccaccgaagtagtgaagacaacttccggagattatgtg
gtcatgtctgtctactttgatctgagcagaagaatgggatactttaccatccagacctat
atcccctgcacactcattgtcgtcctatcctgggtgtctttctggatcaataaggatgct
gttccagccagaacatctttaggtatcaccactgtcctgacaatgaccaccctcagcacc
attgcccggaaatcgctccccaaggtctcctatgtcacagcgatggatctctttgtatct
gtttgtttcatctttgtcttctctgctctggtggagtatggcaccttgcattattttgtc
agcaaccggaaaccaagcaaggacaaagataaaaagaagaaaaaccctgcccctaccatt
gatatccgcccaagatcagcaaccattcaaatgaataatgctacacaccttcaagagaga
gatgaagagtacggctatgagtgtctggacggcaaggactgtgccagttttttctgctgt
tttgaagattgtcgaacaggagcttggagacatgggaggatacatatccgcattgccaaa
atggactcctatgctcggatcttcttccccactgccttctgcctgtttaatctggtctat
tgggtctcctacctctacctgtga

Homo sapiens (human): 2567

Entry

2567 CDS T01001

Gene name

GABRG3

Definition

(RefSeq) gamma-aminobutyric acid type A receptor gamma3 subunit

K05186

gamma-aminobutyric acid receptor subunit gamma

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2567 (GABRG3)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2567 (GABRG3)
   04723 Retrograde endocannabinoid signaling
    2567 (GABRG3)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2567 (GABRG3)
   05033 Nicotine addiction
    2567 (GABRG3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2567 (GABRG3)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2567 (GABRG3)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q99928(Tclin)

UniProt:

Q99928

Position

15q12

AA seq 467 aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK
KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS
NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM
DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY
VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS
TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS
SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC
YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL

NT seq 1404 nt +upstreamnt +downstreamnt
atggccccgaagctgctgctcctcctctgcctgttctcgggcttgcacgcgcggtccaga
aaggtggaagaggatgaatatgaagattcatcatcaaaccaaaagtgggtcttggctcca
aaatcccaagacaccgacgtgactcttattctcaacaagttgctaagagaatatgataaa
aagctgaggccagatattggaataaaaccgaccgtaattgacgttgacatttatgttaac
agcattggtcctgtgtcatcaataaacatggaataccaaattgacatattttttgctcag
acctggacagatagtcgccttcgattcaacagcacaatgaaaattcttactctgaacagc
aacatggtggggttaatctggatcccagacaccatcttccgcaattctaaaaccgcagag
gctcactggatcaccacacccaatcagctcctccggatttggaatgacgggaaaatcctt
tacactttgaggctcaccatcaatgctgagtgccagctgcagctgcacaacttccccatg
gacgaacactcctgcccgctgattttctccagctatggctatcccaaagaagaaatgatt
tatagatggagaaaaaattcagtggaggcagctgaccagaaatcatggcggctttatcag
tttgacttcatgggcctcagaaacaccacagaaatcgtgacaacgtctgcaggtgattat
gttgtcatgactatatattttgaattgagtagaagaatgggatacttcaccattcagaca
tacattccctgtatactgactgtggttttatcctgggtgtcattttggatcaaaaaagat
gctacgccagcaagaacagcattaggcatcaccacggtgctgaccatgaccaccctgagc
accatcgccaggaagtccttgccacgcgtgtcctacgtgaccgccatggacctttttgtg
accgtgtgcttcctgtttgtcttcgccgcgctgatggagtatgccaccctcaactactat
tccagctgtagaaaaccaaccaccacgaagaagacaacatcgttactacatccagattcc
tcaagatggattcctgagcgaataagcctacaagccccttccaactattccctcctggac
atgaggccaccaccaactgcgatgatcactttaaacaattccgtttactggcaggaattt
gaagatacctgtgtctatgagtgtctggatggcaaagactgtcagagcttcttctgctgc
tatgaagaatgtaaatcaggatcctggaggaaagggcgtattcacatagacatcttggag
ctggactcgtactcccgggtctttttccccacgtccttcctgctctttaacctggtctac
tgggttggatacctgtatctctaa

Homo sapiens (human): 2568

Entry

2568 CDS T01001

Gene name

GABRP

Definition

(RefSeq) gamma-aminobutyric acid type A receptor pi subunit

K05189

gamma-aminobutyric acid receptor subunit pi

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2568 (GABRP)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2568 (GABRP)
   04723 Retrograde endocannabinoid signaling
    2568 (GABRP)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2568 (GABRP)
   05033 Nicotine addiction
    2568 (GABRP)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2568 (GABRP)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2568 (GABRP)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

O00591(Tclin)

UniProt:

O00591

Position

5q35.1

AA seq 440 aa
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP
VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT
YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES
WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR
NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN
CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS
SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL
LFPLIFMLANVFYWAYYMYF

NT seq 1323 nt +upstreamnt +downstreamnt
atgaactacagcctccacttggccttcgtgtgtctgagtctcttcactgagaggatgtgc
atccaggggagtcagttcaacgtcgaggtcggcagaagtgacaagctttccctgcctggc
tttgagaacctcacagcaggatataacaaatttctcaggcccaattttggtggagaaccc
gtacagatagcgctgactctggacattgcaagtatctctagcatttcagagagtaacatg
gactacacagccaccatatacctccgacagcgctggatggaccagcggctggtgtttgaa
ggcaacaagagcttcactctggatgcccgcctcgtggagttcctctgggtgccagatact
tacattgtggagtccaagaagtccttcctccatgaagtcactgtgggaaacaggctcatc
cgcctcttctccaatggcacggtcctgtatgccctcagaatcacgacaactgttgcatgt
aacatggatctgtctaaataccccatggacacacagacatgcaagttgcagctggaaagc
tggggctatgatggaaatgatgtggagttcacctggctgagagggaacgactctgtgcgt
ggactggaacacctgcggcttgctcagtacaccatagagcggtatttcaccttagtcacc
agatcgcagcaggagacaggaaattacactagattggtcttacagtttgagcttcggagg
aatgttctgtatttcattttggaaacctacgttccttccactttcctggtggtgttgtcc
tgggtttcattttggatctctctcgattcagtccctgcaagaacctgcattggagtgacg
accgtgttatcaatgaccacactgatgatcgggtcccgcacttctcttcccaacaccaac
tgcttcatcaaggccatcgatgtgtacctggggatctgctttagctttgtgtttggggcc
ttgctagaatatgcagttgctcactacagttccttacagcagatggcagccaaagatagg
gggacaacaaaggaagtagaagaagtcagtattactaatatcatcaacagctccatctcc
agctttaaacggaagatcagctttgccagcattgaaatttccagcgacaacgttgactac
agtgacttgacaatgaaaaccagcgacaagttcaagtttgtcttccgagaaaagatgggc
aggattgttgattatttcacaattcaaaaccccagtaatgttgatcactattccaaacta
ctgtttcctttgatttttatgctagccaatgtattttactgggcatactacatgtatttt
tga

Homo sapiens (human): 2569

Entry

2569 CDS T01001

Gene name

GABRR1

Definition

(RefSeq) gamma-aminobutyric acid type A receptor rho1 subunit

K05190

gamma-aminobutyric acid receptor subunit rho

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2569 (GABRR1)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2569 (GABRR1)
   04723 Retrograde endocannabinoid signaling
    2569 (GABRR1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2569 (GABRR1)
   05033 Nicotine addiction
    2569 (GABRR1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2569 (GABRR1)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2569 (GABRR1)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P24046(Tchem)

UniProt:

P24046

Position

6q15

AA seq 479 aa
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS

NT seq 1440 nt +upstreamnt +downstreamnt
atgttggctgtcccaaatatgagatttggcatctttcttttgtggtggggatgggttttg
gccactgaaagcagaatgcactggcccggaagagaagtccacgagatgtctaagaaaggc
aggccccaaagacaaagacgagaagtacatgaagatgcccacaagcaagtcagcccaatt
ctgagacgaagtcctgacatcaccaaatcgcctctgacaaagtcagaacagcttctgagg
atagatgaccatgatttcagcatgaggcctggctttggaggccctgccattcctgttggt
gtggatgtgcaggtggagagtttggatagcatctcagaggttgacatggactttacgatg
accctctacctgaggcactactggaaggacgagaggctgtcttttccaagcaccaacaac
ctcagcatgacgtttgacggccggctggtcaagaagatctgggtccctgacatgtttttc
gtgcactccaaacgctccttcatccacgacaccaccacagacaacgtcatgttgcgggtc
cagcctgatgggaaagtgctctatagtctcagggttacagtaactgcaatgtgcaacatg
gacttcagccgatttcccttggacacacaaacgtgctctcttgaaattgaaagctatgcc
tatacagaagatgacctcatgctgtactggaaaaagggcaatgactccttaaagacagat
gaacggatctcactctcccagttcctcattcaggaattccacaccaccaccaaactggct
ttctacagcagcacaggctggtacaaccgtctctacattaatttcacgttgcgtcgccac
atcttcttcttcttgctccaaacttatttccccgctaccctgatggtcatgctgtcctgg
gtgtccttctggatcgaccgcagagccgtgcctgccagagtccccttaggtatcacaacg
gtgctgaccatgtccaccatcatcacgggcgtgaatgcctccatgccgcgcgtctcctac
atcaaggccgtggacatctacctctgggtcagctttgtgttcgtgttcctctcggtgctg
gagtatgcggccgtcaactacctgaccactgtgcaggagaggaaggaacagaagctgcgg
gagaagcttccctgcaccagcggattacctccgccccgcactgcgatgctggacggcaac
tacagtgatggggaggtgaatgacctggacaactacatgccagagaatggagagaagccc
gacaggatgatggtgcagctgaccctggcctcagagaggagctccccacagaggaaaagt
cagagaagcagctatgtgagcatgagaatcgacacccacgccattgataaatactccagg
atcatctttccagcagcatacattttattcaatttaatatactggtctattttctcctag

Homo sapiens (human): 2570

Entry

2570 CDS T01001

Gene name

GABRR2

Definition

(RefSeq) gamma-aminobutyric acid type A receptor rho2 subunit

K05190

gamma-aminobutyric acid receptor subunit rho

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2570 (GABRR2)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2570 (GABRR2)
   04723 Retrograde endocannabinoid signaling
    2570 (GABRR2)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2570 (GABRR2)
   05033 Nicotine addiction
    2570 (GABRR2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2570 (GABRR2)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2570 (GABRR2)

SSDB

Motif

Pfam:

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P28476(Tbio)

UniProt:

P28476

Position

6q15

AA seq 465 aa
MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLR
VDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASN
KSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNM
DFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLA
FYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITT
VLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLR
EKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA
RKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS

NT seq 1398 nt +upstreamnt +downstreamnt
atgccttattttacaagactcattttgttcttgttttgcttgatggttctcgtggagagc
agaaaacccaagaggaagcgatggacagggcaggtggaaatgcccaagccaagtcactta
tataagaagaaccttgatgtgaccaagatccggaagggaaagcctcagcagcttctcaga
gtggacgagcacgacttcagcatgagacccgccttcggaggccctgccatcccggtgggc
gtggacgtacaggtggagagcctggacagcatctccgaggtggacatggacttcactatg
accctgtacctgcggcattactggaaggatgagaggctagctttctccagcgccagcaac
aagagcatgaccttcgatggccggctggtgaagaagatctgggtccctgatgtcttcttt
gttcactccaaaagatcgttcactcatgacaccaccactgacaacatcatgctgagggtg
ttcccagatggacacgtgctgtacagcatgaggattacggtcactgccatgtgcaacatg
gacttcagccactttcccctggactcccagacctgttctttggagctggagagctatgcc
tatacagatgaagatctaatgctgtactggaagaatggggatgaatccctaaaaacagat
gagaagatctccttgtctcagtttctgattcagaaatttcacacaacttccaggctggcc
ttctacagcagcactggctggtacaaccgtctgtacattaacttcacgttgcgtcgccac
atcttcttcttcttgctccaaacatatttccctgccactctgatggtcatgctgtcctgg
gtgtccttctggatcgaccgcagagctgtgcctgccagagtttcactgggtatcacgacg
gtgctgaccatgaccaccatcatcacgggcgtgaatgcctccatgccgcgcgtctcctac
gtcaaggccgtggacatctacctctgggtcagctttgtgttcgtgttcctctcggtgctg
gagtatgcggctgtcaactacctgaccaccgtgcaggagcgcaaggaacggaagctgcgg
gagaagttcccgtgcatgtgtggaatgcttcattcaaaaaccatgatgctggatggaagc
tacagtgagtctgaggccaacagcctggctgggtaccccagaagccatatcctgacagaa
gaagaaaggcaagacaaaatagtggtccacctgggcctgagtggtgaagccaacgctgcc
agaaagaaggggcttctgaagggccagacgggttttcgtatcttccagaatacccatgcc
attgacaaatactctaggttgatattccctgcctcctacatatttttcaacttaatttat
tggtcagtgttttcctag

Homo sapiens (human): 55879

Entry

55879 CDS T01001

Gene name

GABRQ, THETA

Definition

(RefSeq) gamma-aminobutyric acid type A receptor theta subunit

K05192

gamma-aminobutyric acid receptor subunit theta

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

Adinazolam (DG00911):

Adipiplon:

Alpidem:

Alprazolam:

Aminobutyric acid:

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

Brotizolam:

Butabarbital (DG01308):

Butobarbital:

Chlordiazepoxide (DG00908):

Cinolazepam:

Clobazam:

Clonazepam:

Clotiazepam:

Cloxazolam:

Delorazepam:

Dextofisopam:

Diazepam:

Estazolam:

Eszopiclone:

Ethyl loflazepate:

Etizolam:

Fludiazepam:

Flumazenil:

Flunitrazepam:

Flurazepam (DG00919):

Flutazolam:

Flutoprazepam:

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

Hexobarbital:

Indiplon:

Iomazenil:

Ketazolam:

Levotofisopam:

Loprazolam (DG00921):

Lorazepam:

Lormetazepam:

Medazepam (DG00909):

Meprobamate:

Metharbital:

Methylphenobarbital:

Mexazolam:

Midazolam (DG00920):

Nimetazepam:

Nitrazepam:

Nordazepam:

Ocinaplon:

Oxazepam:

Oxazolam:

Pagoclone:

Panadiplon:

Pazinaclone:

Pentobarbital (DG00915):

Phenobarbital (DG00845):

Potassium clorazepate (DG01218):

Prazepam:

Propofol (DG00797):

Quazepam:

Remimazolam besilate:

Rilmazafone (DG01307):

Sarmazenil:

Secobarbital (DG00917):

Suritozole:

Talbutal:

Temazepam:

Thiamylal (DG01377):

Thiopental (DG00790):

Tofisopam:

Topiramate:

Triazolam:

Zolpidem (DG00922):

Zopiclone:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    55879 (GABRQ)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    55879 (GABRQ)
   04723 Retrograde endocannabinoid signaling
    55879 (GABRQ)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    55879 (GABRQ)
   05033 Nicotine addiction
    55879 (GABRQ)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    55879 (GABRQ)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   55879 (GABRQ)

SSDB

Motif

Pfam: