KEGG   Homo sapiens (human): 200959
Entry
200959            CDS       T01001                                 

Gene name
GABRR3
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit rho3
  KO
K05190  gamma-aminobutyric acid receptor subunit rho
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    200959 (GABRR3)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    200959 (GABRR3)
   04723 Retrograde endocannabinoid signaling
    200959 (GABRR3)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    200959 (GABRR3)
   05033 Nicotine addiction
    200959 (GABRR3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    200959 (GABRR3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   200959 (GABRR3)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 200959
NCBI-ProteinID: NP_001099050
OMIM: 618668
HGNC: 17969
Ensembl: ENSG00000183185
Vega: OTTHUMG00000159135
Pharos: A8MPY1(Tdark)
UniProt: A8MPY1
Position
3q11.2
AA seq 467 aa
MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQK
YEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLS
FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITV
SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFS
ASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARV
SLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEER
KQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS
RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV
NT seq 1404 nt   +upstreamnt  +downstreamnt
atggtcctggctttccagttagtctccttcacctacatctggatcatattgaaaccaaat
gtttgtgctgcttctaacatcaagatgacacaccagcggtgctcctcttcaatgaaacaa
acctgcaaacaagaaactagaatgaagaaagatgacagtaccaaagcgcggcctcagaaa
tatgagcaacttctccatatagaggacaacgatttcgcaatgagacctggatttggaggg
tctccagtgccagtaggtatagatgtccatgttgaaagcattgacagcatttcagagact
aacatggactttacaatgactttttatctcaggcattactggaaagacgagaggctctcc
tttcctagcacagcaaacaaaagcatgacatttgatcatagattgaccagaaagatctgg
gtgcctgatatcttttttgtccactctaaaagatccttcatccatgatacaactatggag
aatatcatgctgcgcgtacaccctgatggaaacgtcctcctaagtctcaggataacggtt
tcggccatgtgctttatggatttcagcaggtttcctcttgacactcaaaattgttctctt
gaactggaaagctatgcctacaatgaggatgacctaatgctatactggaaacacggaaac
aagtccttaaatactgaagaacatatgtccctttctcagttcttcattgaagacttcagt
gcatctagtggattagctttctatagcagcacaggttggtacaataggcttttcatcaac
tttgtgctaaggaggcatgttttcttctttgtgctgcaaacctatttcccagccatattg
atggtgatgctttcatgggtttcattttggattgaccgaagagctgttcctgcaagagtt
tccctgggaatcaccacagtgctgaccatgtccacaatcatcactgctgtgagcgcctcc
atgccccaggtgtcctacctcaaggctgtggatgtgtacctgtgggtcagctccctcttt
gtgttcctgtcagtcattgagtatgcagctgtgaactacctcaccacagtggaagagcgg
aaacaattcaagaagacaggaaagatttctaggatgtacaatattgatgcagttcaagct
atggcctttgatggttgttaccatgacagcgagattgacatggaccagacttccctctct
ctaaactcagaagacttcatgagaagaaaatcgatatgcagccccagcaccgattcatct
cggataaagagaagaaaatccctaggaggacatgttggtagaatcattctggaaaacaac
catgtcattgacacctattctaggattttattccccattgtgtatattttatttaatttg
ttttactggggtgtatatgtatga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (2)   
   Pfam (2)   
All databases (40)   

Download RDF
KEGG   Homo sapiens (human): 2554
Entry
2554              CDS       T01001                                 

Gene name
GABRA1, DEE19, ECA4, EIEE19, EJM, EJM5
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha1
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
H00808  Idiopathic generalized epilepsies
H02215  Childhood absence epilepsy
H02217  Juvenile myoclonic epilepsy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clomethiazole (DG00923): D07330 D07725
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Etomidate: D00548<US>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methohexital (DG00789): D00712<US> D04985
Methylphenobarbital: D00700
Methyprylon: D01150
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Progabide: D05621
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zaleplon: D00530<US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2554 (GABRA1)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2554 (GABRA1)
   04723 Retrograde endocannabinoid signaling
    2554 (GABRA1)
  09157 Sensory system
   04742 Taste transduction
    2554 (GABRA1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2554 (GABRA1)
   05033 Nicotine addiction
    2554 (GABRA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2554 (GABRA1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2554 (GABRA1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2554
NCBI-ProteinID: NP_000797
OMIM: 137160
HGNC: 4075
Ensembl: ENSG00000022355
Vega: OTTHUMG00000163586
Pharos: P14867(Tclin)
UniProt: P14867 A8K177
Structure
PDB: 
6I53 5O8F 6D6T 6D6U

Position
5q34
AA seq 456 aa
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
NT seq 1371 nt   +upstreamnt  +downstreamnt
atgaggaaaagtccaggtctgtctgactgtctttgggcctggatcctccttctgagcaca
ctgactggaagaagctatggacagccgtcattacaagatgaacttaaagacaataccact
gtcttcaccaggattttggacagactcctagatggttatgacaatcgcctgagaccagga
ttgggagagcgtgtaaccgaagtgaagactgatatcttcgtcaccagtttcggacccgtt
tcagaccatgatatggaatatacaatagatgtatttttccgtcaaagctggaaggatgaa
aggttaaaatttaaaggacctatgacagtcctccggttaaataacctaatggcaagtaaa
atctggactccggacacatttttccacaatggaaagaagtcagtggcccacaacatgacc
atgcccaacaaactcctgcggatcacagaggatggcaccttgctgtacaccatgaggctg
acagtgagagctgaatgtccgatgcatttggaggacttccctatggatgcccatgcttgc
ccactaaaatttggaagttatgcttatacaagagcagaagttgtttatgaatggaccaga
gagccagcacgctcagtggttgtagcagaagatggatcacgtctaaaccagtatgacctt
cttggacaaacagtagactctggaattgtccagtcaagtacaggagaatatgttgttatg
accactcatttccacttgaagagaaagattggctactttgttattcaaacatacctgcca
tgcataatgacagtgattctctcacaagtctccttctggctcaacagagagtctgtacca
gcaagaactgtctttggagtaacaactgtgctcaccatgacaacattgagcatcagtgcc
agaaactccctccctaaggtggcttatgcaacagctatggattggtttattgccgtgtgc
tatgcctttgtgttctcagctctgattgagtttgccacagtaaactatttcactaagaga
ggttatgcatgggatggcaaaagtgtggttccagaaaagccaaagaaagtaaaggatcct
cttattaagaaaaacaacacttacgctccaacagcaaccagctacacccctaatttggcc
aggggcgacccgggcttagccaccattgctaaaagtgcaaccatagaacctaaagaggtc
aagcccgaaacaaaaccaccagaacccaagaaaacctttaacagtgtcagcaaaattgac
cgactgtcaagaatagccttcccgctgctatttggaatctttaacttagtctactgggct
acgtatttaaacagagagcctcagctaaaagcccccacaccacatcaatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (7)   
   KEGG DISEASE (4)   
   OMIM (3)   
Drug (113)   
   KEGG DRUG (113)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (43)   
   RefSeq(nuc) (7)   
   GenBank (18)   
   EMBL (18)   
Protein domain (2)   
   Pfam (2)   
All databases (196)   

Download RDF
KEGG   Homo sapiens (human): 2555
Entry
2555              CDS       T01001                                 

Gene name
GABRA2, DEE78, EIEE78
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha2
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
H01611  Alcohol dependence
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2555 (GABRA2)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2555 (GABRA2)
   04723 Retrograde endocannabinoid signaling
    2555 (GABRA2)
  09157 Sensory system
   04742 Taste transduction
    2555 (GABRA2)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2555 (GABRA2)
   05033 Nicotine addiction
    2555 (GABRA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2555 (GABRA2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2555 (GABRA2)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb CytochromB561_N DUF5522
Other DBs
NCBI-GeneID: 2555
NCBI-ProteinID: NP_000798
OMIM: 137140
HGNC: 4076
Ensembl: ENSG00000151834
Vega: OTTHUMG00000044266
Pharos: P47869(Tclin)
UniProt: P47869 A0A024R9X6
Structure
PDB: 
5O8F

Position
4p12
AA seq 451 aa
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
NT seq 1356 nt   +upstreamnt  +downstreamnt
atgaagacaaaattgaacatctacaacatgcagttcctgctttttgttttcttggtgtgg
gaccctgccaggttggtgctggctaacatccaagaagatgaggctaaaaataacattacc
atctttacgagaattcttgacagacttctggatggttacgataatcggcttagaccagga
ctgggagacagtattactgaagtcttcactaacatctacgtgaccagttttggccctgtc
tcagatacagatatggaatatacaattgatgttttctttcgacaaaaatggaaagatgaa
cgtttaaaatttaaaggtcctatgaatatccttcgactaaacaatttaatggctagcaaa
atctggactccagataccttttttcacaatgggaaaaaatcagtagctcataatatgaca
atgccaaataagttgcttcgaattcaggatgatgggactctgctgtataccatgaggctt
acagttcaagctgaatgcccaatgcacttggaggatttcccaatggatgctcattcatgt
cctctgaaatttggcagctatgcatatacaacttcagaggtcacttatatttggacttac
aatgcatctgattcagtacaggttgctcctgatggctctaggttaaatcaatatgacctg
ctgggccaatcaatcggaaaggagacaattaaatccagtacaggtgaatatactgtaatg
acagctcatttccacctgaaaagaaaaattgggtattttgtgattcaaacctatctgcct
tgcatcatgactgtcattctctcccaagtttcattctggcttaacagagaatctgtgcct
gcaagaactgtgtttggagtaacaactgtcctaacaatgacaactctaagcatcagtgct
cggaattctctccccaaagtggcttatgcaactgccatggactggtttattgctgtttgt
tatgcatttgtgttctctgccctaattgaatttgcaactgttaattacttcaccaaaaga
ggatgggcttgggatgggaagagtgtagtaaatgacaagaaaaaagaaaaggcttccgtt
atgatacagaacaacgcttatgcagtggctgttgccaattatgccccgaatctttcaaaa
gatccagttctctccaccatctccaagagtgcaaccacgccagaacccaacaagaagcca
gaaaacaagccagctgaagcaaagaaaactttcaacagtgttagcaaaattgacagaatg
tccagaatagtttttccagttttgtttggtacctttaatttagtttactgggctacatat
ttaaacagagaacctgtattaggggtcagtccttga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (23)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (58)   
   RefSeq(nuc) (20)   
   GenBank (19)   
   EMBL (19)   
Protein domain (4)   
   Pfam (4)   
All databases (215)   

Download RDF
KEGG   Homo sapiens (human): 2556
Entry
2556              CDS       T01001                                 

Gene name
GABRA3
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha3
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2556 (GABRA3)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2556 (GABRA3)
   04723 Retrograde endocannabinoid signaling
    2556 (GABRA3)
  09157 Sensory system
   04742 Taste transduction
    2556 (GABRA3)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2556 (GABRA3)
   05033 Nicotine addiction
    2556 (GABRA3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2556 (GABRA3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2556 (GABRA3)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2556
NCBI-ProteinID: NP_000799
OMIM: 305660
HGNC: 4077
Ensembl: ENSG00000011677
Vega: OTTHUMG00000024183
Pharos: P34903(Tclin)
UniProt: P34903
Structure
PDB: 
5O8F

Position
Xq28
AA seq 492 aa
MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS
TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ
TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL
YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL
NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN
RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN
YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA
APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN
RESAIKGMIRKQ
NT seq 1479 nt   +upstreamnt  +downstreamnt
atgataatcacacaaacaagtcactgttacatgaccagccttgggattcttttcctgatt
aatattctccctggaaccactggtcaaggggaatcaagacgacaagaacccggggacttt
gtgaagcaggacattggcgggctgtctcctaagcatgccccagatattcctgatgacagc
actgacaacatcactatcttcaccagaatcttggatcgtcttctggacggctatgacaac
cggctgcgacctgggcttggagatgcagtgactgaagtgaagactgacatctacgtgacc
agttttggccctgtgtcagacactgacatggagtacactattgatgtattttttcggcag
acatggcatgatgaaagactgaaatttgatggccccatgaagatccttccactgaacaat
ctcctggctagtaagatctggacaccggacaccttcttccacaatggcaagaaatcagtg
gctcataacatgaccacgcccaacaagctgctcagattggtggacaacggaaccctcctc
tatacaatgaggttaacaattcatgctgagtgtcccatgcatttggaagattttcccatg
gatgtgcatgcctgcccactgaagtttggaagctatgcctatacaacagctgaagtggtt
tattcttggactctcggaaagaacaaatccgtggaagtggcacaggatggttctcgcttg
aaccagtatgaccttttgggccatgttgttgggacagagataatccggtctagtacagga
gaatatgtcgtcatgacaacccacttccatctcaagcgaaaaattggctactttgtgatc
cagacctacttgccatgtatcatgactgtcattctgtcacaagtgtcgttctggctcaac
agagagtctgttcctgcccgtacagtctttggtgtcaccactgtgcttaccatgaccacc
ttgagtatcagtgccagaaattccttacctaaagtggcatatgcgacggccatggactgg
ttcatagccgtctgttatgcctttgtattttctgcactgattgaatttgccactgtcaac
tatttcaccaagcggagttgggcttgggaaggcaagaaggtgccagaggccctggagatg
aagaagaaaacaccagcagccccagcaaagaaaaccagcactaccttcaacatcgtgggg
accacctatcccatcaacctggccaaggacactgaattttccaccatctccaagggcgct
gctcccagtgcctcctcaaccccaacaatcattgcttcacccaaggccacctacgtgcag
gacagcccgactgagaccaagacctacaacagtgtcagcaaggttgacaaaatttcccgc
atcatctttcctgtgctctttgccatattcaatctggtctattgggccacatatgtcaac
cgggagtcagctatcaagggcatgatccgcaaacagtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (14)   
   RefSeq(nuc) (2)   
   GenBank (6)   
   EMBL (6)   
Protein domain (2)   
   Pfam (2)   
All databases (145)   

Download RDF
KEGG   Homo sapiens (human): 2557
Entry
2557              CDS       T01001                                 

Gene name
GABRA4
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha4
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2557 (GABRA4)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2557 (GABRA4)
   04723 Retrograde endocannabinoid signaling
    2557 (GABRA4)
  09157 Sensory system
   04742 Taste transduction
    2557 (GABRA4)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2557 (GABRA4)
   05033 Nicotine addiction
    2557 (GABRA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2557 (GABRA4)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2557 (GABRA4)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb OAD_gamma
Other DBs
NCBI-GeneID: 2557
NCBI-ProteinID: NP_000800
OMIM: 137141
HGNC: 4078
Ensembl: ENSG00000109158
Vega: OTTHUMG00000099431
Pharos: P48169(Tclin)
UniProt: P48169 X5D7F5
Position
4p12
AA seq 554 aa
MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ
EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES
SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG
SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV
YLSKDTMEKSESLM
NT seq 1665 nt   +upstreamnt  +downstreamnt
atggtttctgccaagaaggtacccgcgatcgctctgtccgccggggtcagtttcgccctc
ctgcgcttcctgtgcctggcggtttgtttaaacgaatccccaggacagaaccaaaaggag
gagaaattgtgcacagaaaatttcacccgcatcctggacagtttgctcgatggttatgac
aacaggctgcgtcctggatttgggggtcctgttacagaagtgaaaactgacatatatgtc
accagctttggacctgtttctgatgttgaaatggaatacacaatggatgtgttcttcagg
cagacatggattgacaaaagattaaaatatgacggccccattgaaattttgagattgaac
aatatgatggtaacgaaagtgtggacccctgatactttcttcaggaatggaaagaaatct
gtctcacataatatgacagctccaaataagctttttagaattatgagaaatggtactatt
ttatacacaatgagactcaccataagtgcggagtgtcccatgagattggtggattttccc
atggatggtcatgcatgccctttgaaattcgggagttatgcctatccaaagagtgagatg
atctatacctggacaaaaggtcctgagaaatcagttgaagttccgaaggagtcttccagc
ttagttcaatatgatttgattgggcaaaccgtatcaagtgaaaccatcaaatcaattacg
ggtgaatatattgttatgacggtttacttccacctcagacggaagatgggttattttatg
attcagacctatattccgtgcattatgacagtgattctttctcaagtttcattttggata
aataaagaatcagttcccgctaggactgtatttggaataacaactgtcctcaccatgacc
acactaagcatcagtgcacgacattctttgcccaaagtgtcctatgctaccgccatggac
tggttcatagctgtctgctttgcttttgtattttcggcccttatcgagtttgctgctgtc
aactatttcaccaatattcaaatggaaaaagccaaaaggaagacatcaaagccccctcag
gaagttcccgctgctccagtgcagagagagaagcatcctgaagcccctctgcagaataca
aatgccaatttgaacatgagaaaaagaacaaatgctttggttcactctgaatctgatgtt
ggcaacagaactgaggtgggaaaccattcaagcaaatcttccacagttgttcaagaatct
tctaaaggcacacctcggtcttacttagcttccagtccaaacccattcagccgtgcaaat
gcagctgaaaccatatctgcagcaagagcacttccatctgcttctcctacttctatccga
actggatatatgcctcgaaaggcttcagttggatctgcttctactcgtcacgtgtttgga
tcaagactgcagaggataaagaccacagttaataccataggggctactgggaagttgtca
gctactcctcctccatcggctccaccaccttctggatctggcacaagtaaaatagacaaa
tatgcccgtattctctttccagtcacatttggggcatttaacatggtttattgggttgtt
tatttatctaaggacactatggagaaatcagaaagtctaatgtaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (27)   
   RefSeq(nuc) (3)   
   GenBank (12)   
   EMBL (12)   
Protein domain (3)   
   Pfam (3)   
All databases (166)   

Download RDF
KEGG   Homo sapiens (human): 2558
Entry
2558              CDS       T01001                                 

Gene name
GABRA5, DEE79, EIEE79
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha5
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2558 (GABRA5)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2558 (GABRA5)
   04723 Retrograde endocannabinoid signaling
    2558 (GABRA5)
  09157 Sensory system
   04742 Taste transduction
    2558 (GABRA5)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2558 (GABRA5)
   05033 Nicotine addiction
    2558 (GABRA5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2558 (GABRA5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2558 (GABRA5)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb CytochromB561_N
Other DBs
NCBI-GeneID: 2558
NCBI-ProteinID: NP_000801
OMIM: 137142
HGNC: 4079
Ensembl: ENSG00000186297
Vega: OTTHUMG00000171824
Pharos: P31644(Tclin)
UniProt: P31644
Structure
PDB: 
5O8F 6A96

Position
15q12
AA seq 462 aa
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggacaatggaatgttctctggttttatcatgatcaaaaacctccttctcttttgtatt
tccatgaacttatccagtcactttggcttttcacagatgccaaccagttcagtgaaagat
gagaccaatgacaacatcacgatatttaccaggatcttggatgggctcttggatggctac
gacaacagacttcggcccgggctgggagagcgcatcactcaggtgaggaccgacatctac
gtcaccagcttcggcccggtgtccgacacggaaatggagtacaccatagacgtgtttttc
cgacaaagctggaaagatgaaaggcttcggtttaaggggcccatgcagcgcctccctctc
aacaacctccttgccagcaagatctggaccccagacacgttcttccacaacgggaagaag
tccatcgctcacaacatgaccacgcccaacaagctgctgcggctggaggacgacggcacc
ctgctctacaccatgcgcttgaccatctctgcagagtgccccatgcagcttgaggacttc
ccgatggatgcgcacgcttgccctctgaaatttggcagctatgcgtaccctaattctgaa
gtcgtttacgtctggaccaacggctccaccaagtcggtggtggtggcggaagatggctcc
agactgaaccagtaccacctgatggggcagacggtgggcactgagaacatcagcaccagc
acaggcgaatacacaatcatgacagctcacttccacctgaaaaggaagattggctacttt
gtcatccagacctaccttccctgcataatgaccgtgatcttatcacaggtgtccttttgg
ctgaaccgggaatcagtcccagccaggacagtttttggggtcaccacggtgctgaccatg
acgaccctcagcatcagcgccaggaactctctgcccaaagtggcctacgccaccgccatg
gactggttcatagccgtgtgctatgccttcgtcttctcggcgctgatagagtttgccacg
gtcaattactttaccaagagaggctgggcctgggatggcaaaaaagccttggaagcagcc
aagatcaagaaaaagcgtgaagtcatactaaataagtcaacaaacgcttttacaactggg
aagatgtctcaccccccaaacattccgaaggaacagaccccagcagggacgtcgaataca
acctcagtctcagtaaaaccctctgaagagaagacttctgaaagcaaaaagacttacaac
agtatcagcaaaattgacaaaatgtcccgaatcgtattcccagtcttgttcggcactttc
aacttagtttactgggcaacgtatttgaatagggagccggtgataaaaggagccgcctct
ccaaaataa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (34)   
   RefSeq(nuc) (6)   
   GenBank (14)   
   EMBL (14)   
Protein domain (3)   
   Pfam (3)   
All databases (172)   

Download RDF
KEGG   Homo sapiens (human): 2559
Entry
2559              CDS       T01001                                 

Gene name
GABRA6
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha6
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2559 (GABRA6)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2559 (GABRA6)
   04723 Retrograde endocannabinoid signaling
    2559 (GABRA6)
  09157 Sensory system
   04742 Taste transduction
    2559 (GABRA6)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2559 (GABRA6)
   05033 Nicotine addiction
    2559 (GABRA6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2559 (GABRA6)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2559 (GABRA6)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb DUF4396
Other DBs
NCBI-GeneID: 2559
NCBI-ProteinID: NP_000802
OMIM: 137143
HGNC: 4080
Ensembl: ENSG00000145863
Vega: OTTHUMG00000130351
Pharos: Q16445(Tclin)
UniProt: Q16445
Position
5q34
AA seq 453 aa
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI
VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY
SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
NT seq 1362 nt   +upstreamnt  +downstreamnt
atggcgtcgtctctgccctggctgtgcattattctgtggctagaaaatgccctagggaaa
ctcgaagttgaaggcaacttctactcagaaaacgtcagtcggatcctggacaacttgctt
gaaggctatgacaatcggctgcggccgggatttggaggtgctgtcactgaagtcaaaaca
gacatttatgtgaccagttttgggcccgtgtcagatgtggagatggagtatacgatggat
gtttttttccgccagacctggactgatgagaggttgaagtttggggggccaactgagatt
ctgagtctgaataatttgatggtcagtaaaatctggacgcctgacacctttttcagaaat
ggtaaaaagtccattgctcacaacatgacaactcctaataaactcttcagaataatgcag
aatggaaccattttatacaccatgaggcttaccatcaatgctgactgtcccatgaggctg
gttaactttcctatggatgggcatgcttgtccactcaagtttgggagctatgcttatccc
aaaagtgaaatcatatatacgtggaaaaaaggaccactttactcagtagaagtcccagaa
gaatcttcaagccttctccagtatgatctgattggacaaacagtatctagtgagacaatt
aaatctaacacaggtgaatacgttataatgacagtttacttccacttgcaaaggaagatg
ggctacttcatgatacagatatacactccttgcattatgacagtcattctttcccaggtg
tctttctggattaataaggagtccgtcccagcaagaactgtttttgggatcaccactgtt
ttaactatgaccactttgagcatcagtgcccggcactctttgccaaaagtgtcatatgcc
actgccatggattggttcatagctgtttgctttgcattcgtcttctctgcgcttatcgag
ttcgcagctgtcaactactttaccaatcttcagacacagaaggccaaaaggaaggcacag
tttgcagccccacccacagtgacaatatcaaaagctactgaacctttggaagctgagatt
gttttgcatcctgactccaaatatcatctgaagaaaaggatcacttctctgtctttgcca
atagtttcatcttccgaggccaataaagtgctcacgagagcgcccatcttacaatcaaca
cctgtcacacccccaccactctcgccagcctttggaggcaccagtaaaatagaccagtat
tctcgaattctcttcccagttgcatttgcaggattcaaccttgtgtactgggtagtttat
ctttccaaagatacaatggaagtcagtagcagtgttgaatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
Protein domain (3)   
   Pfam (3)   
All databases (148)   

Download RDF
KEGG   Homo sapiens (human): 2560
Entry
2560              CDS       T01001                                 

Gene name
GABRB1, DEE45, EIEE45
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit beta1
  KO
K05181  gamma-aminobutyric acid receptor subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2560 (GABRB1)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2560 (GABRB1)
   04726 Serotonergic synapse
    2560 (GABRB1)
   04723 Retrograde endocannabinoid signaling
    2560 (GABRB1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2560 (GABRB1)
   05033 Nicotine addiction
    2560 (GABRB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2560 (GABRB1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2560 (GABRB1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb OAD_gamma
Other DBs
NCBI-GeneID: 2560
NCBI-ProteinID: NP_000803
OMIM: 137190
HGNC: 4081
Ensembl: ENSG00000163288
Vega: OTTHUMG00000044269
Pharos: P18505(Tclin)
UniProt: P18505 X5DNL6
Position
4p12
AA seq 474 aa
MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ
VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR
HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
NT seq 1425 nt   +upstreamnt  +downstreamnt
atgtggacagtacaaaatcgagagagtctggggcttctctctttccctgtgatgattacc
atggtctgttgtgcacacagcaccaatgaacccagcaacatgtcatacgtgaaagagaca
gtggacagattgctcaaaggatatgacattcgcttgcggccggacttcggagggcccccc
gtcgacgttgggatgcggatcgatgtcgccagcatagacatggtctccgaagtgaatatg
gattatacactcaccatgtatttccagcagtcttggaaagacaaaaggctttcttattct
ggaatcccactgaacctcaccctagacaatagggtagctgaccaactctgggtaccagac
acctactttctgaatgacaagaaatcatttgtgcatggggtcacagtgaaaaatcgaatg
attcgactgcatcctgatggaacagttctctatggactccgaatcacaaccacagctgca
tgtatgatggatcttcgaagatatccattggatgagcagaactgcaccctggagatcgaa
agttatggctataccactgatgacattgaattttactggaatggaggagaaggggcagtc
actggtgttaataaaatcgaacttcctcaattttcaattgttgactacaagatggtgtct
aagaaggtggagttcacaacaggagcgtatccacgactgtcactaagttttcgtctaaag
agaaacattggttacttcattttgcaaacctacatgccttctacactgattacaattctg
tcctgggtgtctttttggatcaactatgatgcatctgcagccagagtcgcactaggaatc
acgacagtgcttacaatgacaaccatcagcacccacctcagggagaccctgccaaagatc
ccttatgtcaaagcgattgatatttatctgatgggttgctttgtgtttgtgttcctggct
ctgctggagtatgcctttgtaaattacatcttctttgggaaaggccctcagaaaaaggga
gctagcaaacaagaccagagtgccaatgagaagaataaactggagatgaataaagtccag
gtcgacgcccacggtaacattctcctcagcaccctggaaatccggaatgagacgagtggc
tcggaagtgctcacgagcgtgagcgaccccaaggccaccatgtactcctatgacagcgcc
agcatccagtaccgcaagcccctgagcagccgcgaggcctacgggcgcgccctggaccgg
cacggggtacccagcaaggggcgcatccgcaggcgtgcctcccagctcaaagtcaagatc
cccgacttgactgatgtgaattccatagacaagtggtcccgaatgtttttccccatcacc
ttttctctttttaatgtcgtctattggctttactatgtacactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (36)   
   RefSeq(nuc) (6)   
   GenBank (15)   
   EMBL (15)   
Protein domain (3)   
   Pfam (3)   
All databases (178)   

Download RDF
KEGG   Homo sapiens (human): 2561
Entry
2561              CDS       T01001                                 

Gene name
GABRB2, ICEE2
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit beta2
  KO
K05181  gamma-aminobutyric acid receptor subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H02150  Infantile or early childhood epileptic encephalopathy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2561 (GABRB2)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2561 (GABRB2)
   04726 Serotonergic synapse
    2561 (GABRB2)
   04723 Retrograde endocannabinoid signaling
    2561 (GABRB2)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2561 (GABRB2)
   05033 Nicotine addiction
    2561 (GABRB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2561 (GABRB2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2561 (GABRB2)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2561
NCBI-ProteinID: NP_068711
OMIM: 600232
HGNC: 4082
Ensembl: ENSG00000145864
Vega: OTTHUMG00000130349
Pharos: P47870(Tclin)
UniProt: P47870
Structure
PDB: 
6D6T 6D6U

Position
5q34
AA seq 512 aa
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV
AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT
YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES
YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR
NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP
YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI
FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA
VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD
LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
NT seq 1539 nt   +upstreamnt  +downstreamnt
atgtggagagtgcggaaaaggggctactttgggatttggtccttccccttaataatcgcc
gctgtctgtgcgcagagtgtcaatgaccctagtaatatgtcgctggttaaagagacggtg
gatagactcctgaaaggctatgacattcgtctgagaccagattttggaggtccccccgtg
gctgtggggatgaacattgacattgccagcatcgatatggtttctgaagtcaatatggat
tataccttgacaatgtactttcaacaagcctggagagataagaggctgtcctataatgta
atacctttaaacttgactctggacaacagagtggcagaccagctctgggtgcctgatacc
tatttcctgaacgataagaagtcatttgtgcacggagtgactgttaagaaccgcatgatt
cgcctgcatcctgatggcaccgtcctttatggactcagaatcacaaccacagctgcctgc
atgatggacctaaggaggtacccactggatgaacaaaactgcaccttggaaattgagagc
tatggatacacaactgatgacattgagttttactggcgtggcgatgataatgcagtaaca
ggagtaacgaaaattgaacttccacagttctctattgtagattacaaacttatcaccaag
aaggttgttttttccacaggttcctatcccaggttatccctcagctttaagcttaagaga
aacattggctactttatcctgcaaacatacatgccttccatcctgattaccatcctctcc
tgggtctccttctggattaattacgatgcttcagctgcaagggtggcattaggaatcaca
actgtcctcacaatgaccacaatcaacacccacctccgggaaactctccctaaaatcccc
tatgtgaaggccattgacatgtacctgatggggtgctttgtcttcgttttcatggccctt
ctggaatatgccctagtcaactacatcttctttgggagggggccccaacgccaaaagaaa
gcagctgagaaggctgccagtgccaacaatgagaagatgcgcctggatgtcaacaagatt
ttttataaagatattaaacaaaatgggacccaatatcgatccttgtgggaccctactgga
aacctctccccaactagacggactaccaattacgatttctctctgtatacgatggacccc
catgagaacatcttactgagcactctcgagataaaaaatgaaatggccacatctgaggct
gtgatgggacttggagaccccagaagcacaatgctagcctatgatgcctccagcatccag
tatcggaaagctgggttgcccaggcatagttttggccgaaatgctctggaacgacatgtg
gcgcaaaagaaaagtcgcctgaggagacgcgcctcccaactgaaaatcaccatccctgac
ttgactgatgtgaatgccatagatcggtggtcccgcatattcttcccagtggttttttcc
ttcttcaacatcgtctattggctttattatgtgaactaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
Protein domain (2)   
   Pfam (2)   
All databases (167)   

Download RDF
KEGG   Homo sapiens (human): 2562
Entry
2562              CDS       T01001                                 

Gene name
GABRB3, DEE43, ECA5, EIEE43
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit beta3
  KO
K05181  gamma-aminobutyric acid receptor subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
H02215  Childhood absence epilepsy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2562 (GABRB3)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2562 (GABRB3)
   04726 Serotonergic synapse
    2562 (GABRB3)
   04723 Retrograde endocannabinoid signaling
    2562 (GABRB3)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2562 (GABRB3)
   05033 Nicotine addiction
    2562 (GABRB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2562 (GABRB3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2562 (GABRB3)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb OAD_gamma
Other DBs
NCBI-GeneID: 2562
NCBI-ProteinID: NP_000805
OMIM: 137192
HGNC: 4083
Ensembl: ENSG00000166206
Vega: OTTHUMG00000129231
Pharos: P28472(Tclin)
UniProt: P28472
Structure
PDB: 

Position
15q12
AA seq 473 aa
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP
VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK
RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR
VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS
LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
NT seq 1422 nt   +upstreamnt  +downstreamnt
atgtggggccttgcgggaggaaggcttttcggcatcttctcggccccggtgctggtggct
gtggtgtgctgcgcccagagtgtgaacgatcccgggaacatgtcctttgtgaaggagacg
gtggacaagctgttgaaaggctacgacattcgcctaagacccgacttcgggggtcccccg
gtctgcgtggggatgaacatcgacatcgccagcatcgacatggtttccgaagtcaacatg
gattataccttaaccatgtattttcaacaatattggagagataaaaggctcgcctattct
gggatccctctcaacctcacgcttgacaatcgagtggctgaccagctatgggtgcccgac
acatatttcttaaatgacaaaaagtcatttgtgcatggagtgacagtgaaaaaccgcatg
atccgtcttcaccctgatgggacagtgctgtatgggctcagaatcaccacgacagcagca
tgcatgatggacctcaggagataccccctggacgagcagaactgcactctggaaattgaa
agctatggctacaccacggatgacattgagttttactggcgaggcggggacaaggctgtt
accggagtggaaaggattgagctcccgcagttctccatcgtggagcaccgtctggtctcg
aggaatgttgtcttcgccacaggtgcctatcctcgactgtcactgagctttcggttgaag
aggaacattggatacttcattcttcagacttatatgccctctatactgataacgattctg
tcgtgggtgtccttctggatcaattatgatgcatctgctgctagagttgccctcgggatc
acaactgtgctgacaatgacaaccatcaacacccaccttcgggagaccttgcccaaaatc
ccctatgtcaaagccattgacatgtaccttatgggctgcttcgtctttgtgttcctggcc
cttctggagtatgcctttgtcaactacattttctttggaagaggccctcaaaggcagaag
aagcttgcagaaaagacagccaaggcaaagaatgaccgttcaaagagcgaaagcaaccgg
gtggatgctcatggaaatattctgttgacatcgctggaagttcacaatgaaatgaatgag
gtctcaggcggcattggcgataccaggaattcagcaatatcctttgacaactcaggaatc
cagtacaggaaacagagcatgcctcgagaagggcatgggcgattcctgggggacagaagc
ctcccgcacaagaagacccatctacggaggaggtcttcacagctcaaaattaaaatacct
gatctaaccgatgtgaatgccatagacagatggtccaggatcgtgtttccattcactttt
tctcttttcaacttagtttactggctgtactatgttaactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (47)   
   RefSeq(nuc) (7)   
   GenBank (20)   
   EMBL (20)   
Protein domain (3)   
   Pfam (3)   
All databases (193)   

Download RDF
KEGG   Homo sapiens (human): 2563
Entry
2563              CDS       T01001                                 

Gene name
GABRD, EIG10, EJM7, GEFSP5
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit delta
  KO
K05184  gamma-aminobutyric acid receptor subunit delta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00783  Febrile seizures
H00808  Idiopathic generalized epilepsies
H02217  Juvenile myoclonic epilepsy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2563 (GABRD)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2563 (GABRD)
   04723 Retrograde endocannabinoid signaling
    2563 (GABRD)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2563 (GABRD)
   05033 Nicotine addiction
    2563 (GABRD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2563 (GABRD)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2563 (GABRD)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2563
NCBI-ProteinID: NP_000806
OMIM: 137163
HGNC: 4084
Ensembl: ENSG00000187730
Vega: OTTHUMG00000041064
Pharos: O14764(Tclin)
UniProt: O14764 A8K496
Position
1p36.33
AA seq 452 aa
MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG
GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW
LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML
DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH
FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS
LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI
VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR
PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM
NT seq 1359 nt   +upstreamnt  +downstreamnt
atggacgcgcccgcccggctgctggccccgctcctgctcctctgcgcgcagcagctccgc
ggcaccagagcgatgaatgacatcggcgactacgtgggctccaacctggagatctcctgg
ctccccaacctggacgggctgatagccggctacgcccgcaacttccggcctggcatcgga
ggcccccccgtgaatgtggcccttgccctggaggtggccagcatcgaccacatctcagag
gccaacatggagtacaccatgacggtgttcctgcaccagagctggcgggacagcaggctc
tcctacaaccacaccaacgagaccctgggtctggacagccgcttcgtggacaagctgtgg
ctgcccgacaccttcatcgtgaacgccaagtcggcctggttccacgacgtgacggtggag
aacaagctcatccggctgcagcccgacggcgtgatcctgtacagcatccgaatcacctcc
actgtggcctgcgacatggacctggccaaataccccatggacgagcaggagtgcatgctg
gacctggagagctacggttactcatcggaggacatcgtctactactggtcggagagccag
gagcacatccacgggctggacaagctgcagctggcgcagttcaccatcaccagctaccgc
ttcaccacggagctgatgaacttcaagtccgctggccagttcccacggctcagcctgcac
ttccacctgcggaggaaccgcggcgtgtacatcatccaatcctacatgccctccgtcctg
ctggtcgccatgtcctgggtctccttctggatcagccaggcggcggtgcccgccagggtg
tctctaggcatcaccacggtgctgacgatgaccacgctcatggtcagtgcccgctcctcc
ctgccacgggcatcagccatcaaggcactggacgtctacttctggatctgctatgtcttc
gtgtttgccgccctggtggagtacgcctttgctcatttcaacgccgactacaggaagaag
cagaaggccaaggtcaaggtctccaggccgagggcagagatggacgtgaggaacgccatt
gtcctcttctccctctctgctgccggcgtcacgcaggagctggccatctcccgccggcag
cgccgcgtcccggggaacctgatgggctcctacaggtcggtgggggtggagacaggggag
acgaagaaggagggggcagcccgctcaggaggccaggggggcatccgtgcccggctcagg
cccatcgacgcagacaccattgacatttacgcccgcgctgtgttccctgcggcgtttgcg
gccgtcaatgtcatctactgggcggcatacgccatgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (5)   
   KEGG DISEASE (3)   
   OMIM (2)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
Protein domain (2)   
   Pfam (2)   
All databases (161)   

Download RDF
KEGG   Homo sapiens (human): 2564
Entry
2564              CDS       T01001                                 

Gene name
GABRE
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit epsilon
  KO
K05185  gamma-aminobutyric acid receptor subunit epsilon
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2564 (GABRE)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2564 (GABRE)
   04723 Retrograde endocannabinoid signaling
    2564 (GABRE)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2564 (GABRE)
   05033 Nicotine addiction
    2564 (GABRE)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2564 (GABRE)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2564 (GABRE)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2564
NCBI-ProteinID: NP_004952
OMIM: 300093
HGNC: 4085
Ensembl: ENSG00000102287
Vega: OTTHUMG00000024176
Pharos: P78334(Tclin)
UniProt: P78334
Position
Xq28
AA seq 506 aa
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE
TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI
IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD
GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW
KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW
IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV
LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER
PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL
DNYSRVVFPVTFFFFNVLYWLVCLNL
NT seq 1521 nt   +upstreamnt  +downstreamnt
atgttgtccaaagttcttccagtcctcctaggcatcttattgatcctccagtcgagggtc
gagggacctcagactgaatcaaagaatgaagcctcttcccgtgatgttgtctatggcccc
cagccccagcctctggaaaatcagctcctctctgaggaaacaaagtcaactgagactgag
actgggagcagagttggcaaactgccagaagcctctcgcatcctgaacactatcctgagt
aattatgaccacaaactgcgccctggcattggagagaagcccactgtggtcactgttgag
atctccgtcaacagccttggtcctctctctatcctagacatggaatacaccattgacatc
atcttctcccagacctggtacgacgaacgcctctgttacaacgacacctttgagtctctt
gttctgaatggcaatgtggtgagccagctatggatcccggacaccttttttaggaattct
aagaggacccacgagcatgagatcaccatgcccaaccagatggtccgcatctacaaggat
ggcaaggtgttgtacacaattaggatgaccattgatgccggatgctcactccacatgctc
agatttccaatggattctcactcttgccctctatctttctctagcttttcctatcctgag
aatgagatgatctacaagtgggaaaatttcaagcttgaaatcaatgagaagaactcctgg
aagctcttccagtttgattttacaggagtgagcaacaaaactgaaataatcacaacccca
gttggtgacttcatggtcatgacgattttcttcaatgtgagcaggcggtttggctatgtt
gcctttcaaaactatgtcccttcttccgtgaccacgatgctctcctgggtttccttttgg
atcaagacagagtctgctccagcccggacctctctagggatcacctctgttctgaccatg
accacgttgggcaccttttctcgtaagaatttcccgcgtgtctcctatatcacagccttg
gatttctatatcgccatctgcttcgtcttctgcttctgcgctctgttggagtttgctgtg
ctcaacttcctgatctacaaccagacaaaagcccatgcttctcctaaactccgccatcct
cgtatcaatagccgtgcccatgcccgtacccgtgcacgttcccgagcctgtgcccgccaa
catcaggaagcttttgtgtgccagattgtcaccactgagggaagtgatggagaggagcgc
ccgtcttgctcagcccagcagccccctagcccaggtagccctgagggtccccgcagcctc
tgctccaagctggcctgctgtgagtggtgcaagcgttttaagaagtacttctgcatggtc
cccgattgtgagggcagtacctggcagcagggccgcctctgcatccatgtctaccgcctg
gataactactcgagagttgttttcccagtgactttcttcttcttcaatgtgctctactgg
cttgtttgccttaacttgtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (33)   
   RefSeq(nuc) (9)   
   GenBank (12)   
   EMBL (12)   
Protein domain (2)   
   Pfam (2)   
All databases (184)   

Download RDF
KEGG   Homo sapiens (human): 2565
Entry
2565              CDS       T01001                                 

Gene name
GABRG1
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit gamma1
  KO
K05186  gamma-aminobutyric acid receptor subunit gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2565 (GABRG1)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2565 (GABRG1)
   04723 Retrograde endocannabinoid signaling
    2565 (GABRG1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2565 (GABRG1)
   05033 Nicotine addiction
    2565 (GABRG1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2565 (GABRG1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2565 (GABRG1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2565
NCBI-ProteinID: NP_775807
OMIM: 137166
HGNC: 4086
Ensembl: ENSG00000163285
Vega: OTTHUMG00000128609
Pharos: Q8N1C3(Tclin)
UniProt: Q8N1C3
Position
4p12
AA seq 465 aa
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgggtcctttgaaagcttttctcttctccccttttcttctgcggagtcaaagtagaggg
gtgaggttggtcttcttgttactgaccctgcatttgggaaactgtgttgataaggcagat
gatgaagatgatgaggatttaacggtgaacaaaacctgggtcttggccccaaaaattcat
gaaggagatatcacacaaattctgaattcattgcttcaaggctatgacaataaacttcgt
ccagatataggagtgaggcccacagtaattgaaactgatgtttatgtaaacagcattgga
ccagttgatccaattaatatggaatatacaatagatataatttttgcccaaacctggttt
gacagtcgtttaaaattcaatagtaccatgaaagtgcttatgcttaacagtaatatggtt
ggaaaaatttggattcctgacactttcttcagaaactcaagaaaatctgatgctcactgg
ataacaactcctaatcgtctgcttcgaatttggaatgatggacgagttctgtatactcta
agattgacaattaatgcagaatgttatcttcagcttcataactttcccatggatgaacat
tcctgtccactggaattttcaagctatggataccctaaaaatgaaattgagtataagtgg
aaaaagccctccgtagaagtggctgatcctaaatactggagattatatcagtttgcattt
gtagggttacggaactcaactgaaatcactcacacgatctctggggattatgttatcatg
acaattttttttgacctgagcagaagaatgggatatttcactattcagacctacattcca
tgcattctgacagttgttctttcttgggtgtctttttggatcaataaagatgcagtgcct
gcaagaacatcgttgggtatcactacagttctgactatgacaaccctgagtacaattgcc
aggaagtctttacctaaggtttcttatgtgactgcgatggatctctttgtttctgtttgt
ttcatttttgtttttgcagccttgatggaatatggaaccttgcattattttaccagcaac
caaaaaggaaagactgctactaaagacagaaagctaaaaaataaagcctcgatgactcct
ggtctccatcctggatccactctgattccaatgaataatatttctgtgccgcaagaagat
gattatgggtatcagtgtttggagggcaaagattgtgccagcttcttctgttgctttgaa
gactgcagaacaggatcttggagggaaggaaggatacacatacgcattgccaaaattgac
tcttattctagaatatttttcccaaccgcttttgccctgttcaacttggtttattgggtt
ggctatctttacttataa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (16)   
   RefSeq(nuc) (2)   
   GenBank (7)   
   EMBL (7)   
Protein domain (2)   
   Pfam (2)   
All databases (147)   

Download RDF
KEGG   Homo sapiens (human): 2566
Entry
2566              CDS       T01001                                 

Gene name
GABRG2, CAE2, DEE74, ECA2, EIEE74, FEB8, GEFSP3
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit gamma2
  KO
K05186  gamma-aminobutyric acid receptor subunit gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
H00783  Febrile seizures
H02215  Childhood absence epilepsy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2566 (GABRG2)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2566 (GABRG2)
   04723 Retrograde endocannabinoid signaling
    2566 (GABRG2)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2566 (GABRG2)
   05033 Nicotine addiction
    2566 (GABRG2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2566 (GABRG2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2566 (GABRG2)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2566
NCBI-ProteinID: NP_000807
OMIM: 137164
HGNC: 4087
Ensembl: ENSG00000113327
Vega: OTTHUMG00000130350
Pharos: P18507(Tclin)
UniProt: P18507
Structure
PDB: 

Position
5q34
AA seq 467 aa
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC
FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
NT seq 1404 nt   +upstreamnt  +downstreamnt
atgagttcgccaaatatatggagcacaggaagctcagtctactcgactcctgtattttca
cagaaaatgacggtgtggattctgctcctgctgtcgctctaccctggcttcactagccag
aaatctgatgatgactatgaagattatgcttctaacaaaacatgggtcttgactccaaaa
gttcctgagggtgatgtcactgtcatcttaaacaacctgctggaaggatatgacaataaa
cttcggcctgatataggagtgaagccaacgttaattcacacagacatgtatgtgaatagc
attggtccagtgaacgctatcaatatggaatacactattgatatattttttgcgcaaacg
tggtatgacagacgtttgaaatttaacagcaccattaaagtcctccgattgaacagcaac
atggtggggaaaatctggattccagacactttcttcagaaattccaaaaaagctgatgca
cactggatcaccacccccaacaggatgctgagaatttggaatgatggtcgagtgctctac
accctaaggttgacaattgatgctgagtgccaattacaattgcacaactttccaatggat
gaacactcctgccccttggagttctccagttatggctatccacgtgaagaaattgtttat
caatggaagcgaagttctgttgaagtgggcgacacaagatcctggaggctttatcaattc
tcatttgttggtctaagaaataccaccgaagtagtgaagacaacttccggagattatgtg
gtcatgtctgtctactttgatctgagcagaagaatgggatactttaccatccagacctat
atcccctgcacactcattgtcgtcctatcctgggtgtctttctggatcaataaggatgct
gttccagccagaacatctttaggtatcaccactgtcctgacaatgaccaccctcagcacc
attgcccggaaatcgctccccaaggtctcctatgtcacagcgatggatctctttgtatct
gtttgtttcatctttgtcttctctgctctggtggagtatggcaccttgcattattttgtc
agcaaccggaaaccaagcaaggacaaagataaaaagaagaaaaaccctgcccctaccatt
gatatccgcccaagatcagcaaccattcaaatgaataatgctacacaccttcaagagaga
gatgaagagtacggctatgagtgtctggacggcaaggactgtgccagttttttctgctgt
tttgaagattgtcgaacaggagcttggagacatgggaggatacatatccgcattgccaaa
atggactcctatgctcggatcttcttccccactgccttctgcctgtttaatctggtctat
tgggtctcctacctctacctgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (17)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (15)   
DNA sequence (39)   
   RefSeq(nuc) (15)   
   GenBank (12)   
   EMBL (12)   
Protein domain (2)   
   Pfam (2)   
All databases (209)   

Download RDF
KEGG   Homo sapiens (human): 2567
Entry
2567              CDS       T01001                                 

Gene name
GABRG3
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit gamma3
  KO
K05186  gamma-aminobutyric acid receptor subunit gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2567 (GABRG3)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2567 (GABRG3)
   04723 Retrograde endocannabinoid signaling
    2567 (GABRG3)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2567 (GABRG3)
   05033 Nicotine addiction
    2567 (GABRG3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2567 (GABRG3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2567 (GABRG3)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2567
NCBI-ProteinID: NP_150092
OMIM: 600233
HGNC: 4088
Ensembl: ENSG00000182256
Vega: OTTHUMG00000044462
Pharos: Q99928(Tclin)
UniProt: Q99928
Position
15q12
AA seq 467 aa
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK
KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS
NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM
DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY
VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS
TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS
SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC
YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
NT seq 1404 nt   +upstreamnt  +downstreamnt
atggccccgaagctgctgctcctcctctgcctgttctcgggcttgcacgcgcggtccaga
aaggtggaagaggatgaatatgaagattcatcatcaaaccaaaagtgggtcttggctcca
aaatcccaagacaccgacgtgactcttattctcaacaagttgctaagagaatatgataaa
aagctgaggccagatattggaataaaaccgaccgtaattgacgttgacatttatgttaac
agcattggtcctgtgtcatcaataaacatggaataccaaattgacatattttttgctcag
acctggacagatagtcgccttcgattcaacagcacaatgaaaattcttactctgaacagc
aacatggtggggttaatctggatcccagacaccatcttccgcaattctaaaaccgcagag
gctcactggatcaccacacccaatcagctcctccggatttggaatgacgggaaaatcctt
tacactttgaggctcaccatcaatgctgagtgccagctgcagctgcacaacttccccatg
gacgaacactcctgcccgctgattttctccagctatggctatcccaaagaagaaatgatt
tatagatggagaaaaaattcagtggaggcagctgaccagaaatcatggcggctttatcag
tttgacttcatgggcctcagaaacaccacagaaatcgtgacaacgtctgcaggtgattat
gttgtcatgactatatattttgaattgagtagaagaatgggatacttcaccattcagaca
tacattccctgtatactgactgtggttttatcctgggtgtcattttggatcaaaaaagat
gctacgccagcaagaacagcattaggcatcaccacggtgctgaccatgaccaccctgagc
accatcgccaggaagtccttgccacgcgtgtcctacgtgaccgccatggacctttttgtg
accgtgtgcttcctgtttgtcttcgccgcgctgatggagtatgccaccctcaactactat
tccagctgtagaaaaccaaccaccacgaagaagacaacatcgttactacatccagattcc
tcaagatggattcctgagcgaataagcctacaagccccttccaactattccctcctggac
atgaggccaccaccaactgcgatgatcactttaaacaattccgtttactggcaggaattt
gaagatacctgtgtctatgagtgtctggatggcaaagactgtcagagcttcttctgctgc
tatgaagaatgtaaatcaggatcctggaggaaagggcgtattcacatagacatcttggag
ctggactcgtactcccgggtctttttccccacgtccttcctgctctttaacctggtctac
tgggttggatacctgtatctctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (20)   
   RefSeq(nuc) (8)   
   GenBank (6)   
   EMBL (6)   
Protein domain (2)   
   Pfam (2)   
All databases (157)   

Download RDF
KEGG   Homo sapiens (human): 2568
Entry
2568              CDS       T01001                                 

Gene name
GABRP
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit pi
  KO
K05189  gamma-aminobutyric acid receptor subunit pi
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2568 (GABRP)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2568 (GABRP)
   04723 Retrograde endocannabinoid signaling
    2568 (GABRP)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2568 (GABRP)
   05033 Nicotine addiction
    2568 (GABRP)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2568 (GABRP)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2568 (GABRP)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2568
NCBI-ProteinID: NP_055026
OMIM: 602729
HGNC: 4089
Ensembl: ENSG00000094755
Vega: OTTHUMG00000130443
Pharos: O00591(Tclin)
UniProt: O00591
Position
5q35.1
AA seq 440 aa
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP
VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT
YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES
WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR
NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN
CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS
SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL
LFPLIFMLANVFYWAYYMYF
NT seq 1323 nt   +upstreamnt  +downstreamnt
atgaactacagcctccacttggccttcgtgtgtctgagtctcttcactgagaggatgtgc
atccaggggagtcagttcaacgtcgaggtcggcagaagtgacaagctttccctgcctggc
tttgagaacctcacagcaggatataacaaatttctcaggcccaattttggtggagaaccc
gtacagatagcgctgactctggacattgcaagtatctctagcatttcagagagtaacatg
gactacacagccaccatatacctccgacagcgctggatggaccagcggctggtgtttgaa
ggcaacaagagcttcactctggatgcccgcctcgtggagttcctctgggtgccagatact
tacattgtggagtccaagaagtccttcctccatgaagtcactgtgggaaacaggctcatc
cgcctcttctccaatggcacggtcctgtatgccctcagaatcacgacaactgttgcatgt
aacatggatctgtctaaataccccatggacacacagacatgcaagttgcagctggaaagc
tggggctatgatggaaatgatgtggagttcacctggctgagagggaacgactctgtgcgt
ggactggaacacctgcggcttgctcagtacaccatagagcggtatttcaccttagtcacc
agatcgcagcaggagacaggaaattacactagattggtcttacagtttgagcttcggagg
aatgttctgtatttcattttggaaacctacgttccttccactttcctggtggtgttgtcc
tgggtttcattttggatctctctcgattcagtccctgcaagaacctgcattggagtgacg
accgtgttatcaatgaccacactgatgatcgggtcccgcacttctcttcccaacaccaac
tgcttcatcaaggccatcgatgtgtacctggggatctgctttagctttgtgtttggggcc
ttgctagaatatgcagttgctcactacagttccttacagcagatggcagccaaagatagg
gggacaacaaaggaagtagaagaagtcagtattactaatatcatcaacagctccatctcc
agctttaaacggaagatcagctttgccagcattgaaatttccagcgacaacgttgactac
agtgacttgacaatgaaaaccagcgacaagttcaagtttgtcttccgagaaaagatgggc
aggattgttgattatttcacaattcaaaaccccagtaatgttgatcactattccaaacta
ctgtttcctttgatttttatgctagccaatgtattttactgggcatactacatgtatttt
tga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
Protein domain (2)   
   Pfam (2)   
All databases (156)   

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KEGG   Homo sapiens (human): 2569
Entry
2569              CDS       T01001                                 

Gene name
GABRR1
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit rho1
  KO
K05190  gamma-aminobutyric acid receptor subunit rho
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2569 (GABRR1)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2569 (GABRR1)
   04723 Retrograde endocannabinoid signaling
    2569 (GABRR1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2569 (GABRR1)
   05033 Nicotine addiction
    2569 (GABRR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2569 (GABRR1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2569 (GABRR1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2569
NCBI-ProteinID: NP_002033
OMIM: 137161
HGNC: 4090
Ensembl: ENSG00000146276
Vega: OTTHUMG00000015195
Pharos: P24046(Tchem)
UniProt: P24046
Position
6q15
AA seq 479 aa
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgttggctgtcccaaatatgagatttggcatctttcttttgtggtggggatgggttttg
gccactgaaagcagaatgcactggcccggaagagaagtccacgagatgtctaagaaaggc
aggccccaaagacaaagacgagaagtacatgaagatgcccacaagcaagtcagcccaatt
ctgagacgaagtcctgacatcaccaaatcgcctctgacaaagtcagaacagcttctgagg
atagatgaccatgatttcagcatgaggcctggctttggaggccctgccattcctgttggt
gtggatgtgcaggtggagagtttggatagcatctcagaggttgacatggactttacgatg
accctctacctgaggcactactggaaggacgagaggctgtcttttccaagcaccaacaac
ctcagcatgacgtttgacggccggctggtcaagaagatctgggtccctgacatgtttttc
gtgcactccaaacgctccttcatccacgacaccaccacagacaacgtcatgttgcgggtc
cagcctgatgggaaagtgctctatagtctcagggttacagtaactgcaatgtgcaacatg
gacttcagccgatttcccttggacacacaaacgtgctctcttgaaattgaaagctatgcc
tatacagaagatgacctcatgctgtactggaaaaagggcaatgactccttaaagacagat
gaacggatctcactctcccagttcctcattcaggaattccacaccaccaccaaactggct
ttctacagcagcacaggctggtacaaccgtctctacattaatttcacgttgcgtcgccac
atcttcttcttcttgctccaaacttatttccccgctaccctgatggtcatgctgtcctgg
gtgtccttctggatcgaccgcagagccgtgcctgccagagtccccttaggtatcacaacg
gtgctgaccatgtccaccatcatcacgggcgtgaatgcctccatgccgcgcgtctcctac
atcaaggccgtggacatctacctctgggtcagctttgtgttcgtgttcctctcggtgctg
gagtatgcggccgtcaactacctgaccactgtgcaggagaggaaggaacagaagctgcgg
gagaagcttccctgcaccagcggattacctccgccccgcactgcgatgctggacggcaac
tacagtgatggggaggtgaatgacctggacaactacatgccagagaatggagagaagccc
gacaggatgatggtgcagctgaccctggcctcagagaggagctccccacagaggaaaagt
cagagaagcagctatgtgagcatgagaatcgacacccacgccattgataaatactccagg
atcatctttccagcagcatacattttattcaatttaatatactggtctattttctcctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (21)   
   RefSeq(nuc) (5)   
   GenBank (8)   
   EMBL (8)   
Protein domain (2)   
   Pfam (2)   
All databases (51)   

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KEGG   Homo sapiens (human): 2570
Entry
2570              CDS       T01001                                 

Gene name
GABRR2
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit rho2
  KO
K05190  gamma-aminobutyric acid receptor subunit rho
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2570 (GABRR2)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2570 (GABRR2)
   04723 Retrograde endocannabinoid signaling
    2570 (GABRR2)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2570 (GABRR2)
   05033 Nicotine addiction
    2570 (GABRR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2570 (GABRR2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2570 (GABRR2)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2570
NCBI-ProteinID: NP_002034
OMIM: 137162
HGNC: 4091
Ensembl: ENSG00000111886
Vega: OTTHUMG00000015198
Pharos: P28476(Tbio)
UniProt: P28476
Position
6q15
AA seq 465 aa
MPYFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLR
VDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASN
KSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNM
DFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLA
FYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITT
VLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLR
EKFPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA
RKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgccttattttacaagactcattttgttcttgttttgcttgatggttctcgtggagagc
agaaaacccaagaggaagcgatggacagggcaggtggaaatgcccaagccaagtcactta
tataagaagaaccttgatgtgaccaagatccggaagggaaagcctcagcagcttctcaga
gtggacgagcacgacttcagcatgagacccgccttcggaggccctgccatcccggtgggc
gtggacgtacaggtggagagcctggacagcatctccgaggtggacatggacttcactatg
accctgtacctgcggcattactggaaggatgagaggctagctttctccagcgccagcaac
aagagcatgaccttcgatggccggctggtgaagaagatctgggtccctgatgtcttcttt
gttcactccaaaagatcgttcactcatgacaccaccactgacaacatcatgctgagggtg
ttcccagatggacacgtgctgtacagcatgaggattacggtcactgccatgtgcaacatg
gacttcagccactttcccctggactcccagacctgttctttggagctggagagctatgcc
tatacagatgaagatctaatgctgtactggaagaatggggatgaatccctaaaaacagat
gagaagatctccttgtctcagtttctgattcagaaatttcacacaacttccaggctggcc
ttctacagcagcactggctggtacaaccgtctgtacattaacttcacgttgcgtcgccac
atcttcttcttcttgctccaaacatatttccctgccactctgatggtcatgctgtcctgg
gtgtccttctggatcgaccgcagagctgtgcctgccagagtttcactgggtatcacgacg
gtgctgaccatgaccaccatcatcacgggcgtgaatgcctccatgccgcgcgtctcctac
gtcaaggccgtggacatctacctctgggtcagctttgtgttcgtgttcctctcggtgctg
gagtatgcggctgtcaactacctgaccaccgtgcaggagcgcaaggaacggaagctgcgg
gagaagttcccgtgcatgtgtggaatgcttcattcaaaaaccatgatgctggatggaagc
tacagtgagtctgaggccaacagcctggctgggtaccccagaagccatatcctgacagaa
gaagaaaggcaagacaaaatagtggtccacctgggcctgagtggtgaagccaacgctgcc
agaaagaaggggcttctgaagggccagacgggttttcgtatcttccagaatacccatgcc
attgacaaatactctaggttgatattccctgcctcctacatatttttcaacttaatttat
tggtcagtgttttcctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (20)   
   RefSeq(nuc) (6)   
   GenBank (7)   
   EMBL (7)   
Protein domain (2)   
   Pfam (2)   
All databases (51)   

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KEGG   Homo sapiens (human): 55879
Entry
55879             CDS       T01001                                 

Gene name
GABRQ, THETA
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit theta
  KO
K05192  gamma-aminobutyric acid receptor subunit theta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    55879 (GABRQ)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    55879 (GABRQ)
   04723 Retrograde endocannabinoid signaling
    55879 (GABRQ)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    55879 (GABRQ)
   05033 Nicotine addiction
    55879 (GABRQ)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    55879 (GABRQ)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   55879 (GABRQ)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 55879
NCBI-ProteinID: NP_061028
OMIM: 300349
HGNC: 14454
Ensembl: ENSG00000268089
Vega: OTTHUMG00000022649
Pharos: Q9UN88(Tclin)
UniProt: Q9UN88
Position
Xq28
AA seq 632 aa
MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ
KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA
YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT
AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI
TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI
GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR
QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST
SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPT
EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK
SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN
PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
NT seq 1899 nt   +upstreamnt  +downstreamnt
atgggcatccgaggcatgctgcgagccgcagtgatcctgctgctcatcaggacctggctc
gcggagggcaactaccccagtcccatcccgaaattccacttcgagttctcctctgctgtg
cccgaagtcgtcctgaacctcttcaactgcaaaaattgtgcaaatgaagctgtggttcaa
aagattttggacagggtgctgtcaagatacgatgtccgcctgagaccgaattttggaggt
gcccctgtgcctgtgagaatatctatttatgtcacgagcattgaacagatctcagaaatg
aatatggactacacgatcacgatgttttttcatcagacttggaaagattcacgcttagca
tactatgagaccaccctgaacttgaccctggactatcggatgcatgagaagttgtgggtc
cctgactgctactttctgaacagcaaggatgctttcgtgcatgatgtgactgtggagaat
cgcgtgtttcagcttcacccagatggaacggtgcggtacggcatccgactcaccactaca
gcagcttgttccctggatctgcataaattccctatggacaagcaggcctgcaacctggtg
gtagagagctatggttacacggttgaagacatcatattattctgggatgacaatgggaac
gccatccacatgactgaggagctgcatatccctcagttcactttcctgggaaggacgatt
actagcaaggaggtgtatttctacacaggttcctacatacgcctgatactgaagttccag
gttcagagggaagttaacagctaccttgtgcaagtctactggcctactgtcctcaccact
attacctcttggatatcgttttggatgaactatgattcctctgcagccagggtgacaatt
ggcttaacttcaatgctcatcctgaccaccatcgactcacatctgcgggataagctcccc
aacatttcctgtatcaaggccattgatatctatatcctcgtgtgcttgttctttgtgttc
ctgtccttgctggagtatgtctacatcaactatcttttctacagtcgaggacctcggcgc
cagcctaggcgacacaggagaccccgaagagtcattgcccgctaccgctaccagcaagtg
gtggtaggaaacgtgcaggatggcctgattaacgtggaagacggagtcagctctctcccc
atcaccccagcgcaggcccccctggcaagcccggaaagcctcggttctttgacgtccacc
tccgagcaggcccagctggccacctcggaaagcctcagcccactcacttctctctcaggc
caggcccccctggccactggagaaagcctgagcgatctcccctccacctcagagcaggcc
cggcacagctatggtgttcgctttaatggtttccaggctgatgacagtattattcctacc
gaaatccgcaaccgtgtcgaagcccatggccatggtgttacccatgaccatgaagattcc
aatgagagcttgagctcggatgagcgccatggccatggccccagtgggaagcccatgctt
caccatggcgagaagggtgtgcaagaagcaggctgggaccttgatgacaacaatgacaag
agcgactgccttgccattaaggagcaattcaagtgtgatactaacagtacctggggcctt
aatgatgatgagctcatggcccatggccaagagaaggacagtagctcagagtctgaggat
agttgccccccaagccctgggtgctccttcactgaagggttctccttcgatctctttaat
cctgactacgtcccaaaggtcgacaagtggtcccggttcctcttccctctggcctttggg
ttgttcaacattgtttactgggtataccatatgtattag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (105)   
   KEGG DRUG (105)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (12)   
   RefSeq(nuc) (2)   
   GenBank (5)   
   EMBL (5)   
Protein domain (2)   
   Pfam (2)   
All databases (162)   

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