KEGG   Homo sapiens (human): 203068Help
Entry
203068            CDS       T01001                                 

Gene name
TUBB, CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
Definition
(RefSeq) tubulin beta class I
  KO
K07375  tubulin beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection
Disease
H01579  Congenital symmetric circumferential skin creases
H01881  Complex cortical dysplasia with other brain malformations
Drug target
Batabulin (DG01412): D03059 D06560
Brentuximab vedotin: D09587
Cabazitaxel (DG00695): D09755 D10452
Cevipabulin (DG01413): D06576 D08889
Colchicine: D00570
Docetaxel (DG00694): D02165 D07866
Eribulin: D08914
Estramustine (DG00724): D02398 D04066 D06397
Glembatumumab vedotin: D09912
Indibulin: D10013
Ixabepilone: D04645
Lexibulin: D10073
Maytansine: D04864
Mivobulin isethionate: D05062
Paclitaxel: D00491
Paclitaxel poliglumex: D05333
Podophyllotoxin: D05529
Soblidotin: D01919
Taltobulin: D06001
Tasidotin hydrochloride: D06009
Trastuzumab emtansine: D09980
Verubulin (DG01411): D10029 D10030
Vinblastine (DG00689): D01068 D08675
Vincristine (DG00690): D02197 D08679
Vindesine (DG00691): D01769 D06304
Vinepidine sulfate: D06305
Vinflunine: D09032
Vinglycinate sulfate: D06306
Vinleurosine sulfate: D06307
Vinorelbine (DG00692): D01935 D08680
Vinrosidine sulfate: D06308
Vinzolidine sulfate: D06309
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    203068 (TUBB)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    203068 (TUBB)
 09160 Human Diseases
  09171 Infectious diseases: Bacterial
   05130 Pathogenic Escherichia coli infection
    203068 (TUBB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    203068 (TUBB)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    203068 (TUBB)
   04147 Exosome [BR:hsa04147]
    203068 (TUBB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Microtubules and associated factors
    Other tubulins
     203068 (TUBB)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulins
    203068 (TUBB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   203068 (TUBB)
  Exosomal proteins of colorectal cancer cells
   203068 (TUBB)
  Exosomal proteins of bladder cancer cells
   203068 (TUBB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Tubulin Tubulin_C Misat_Tub_SegII Tubulin_3 Tubulin_2
Motif
Other DBs
NCBI-GeneID: 203068
NCBI-ProteinID: NP_821133
OMIM: 191130
HGNC: 20778
Ensembl: ENSG00000196230
Vega: OTTHUMG00000031059
Pharos: P07437(Tclin)
UniProt: P07437 Q5SU16
Structure
PDB: 

Position
6p21.33
AA seq 444 aa AA seqDB search
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA
NT seq 1335 nt NT seq  +upstreamnt  +downstreamnt
atgagggaaatcgtgcacatccaggctggtcagtgtggcaaccagatcggtgccaagttc
tgggaggtgatcagtgatgaacatggcatcgaccccaccggcacctaccacggggacagc
gacctgcagctggaccgcatctctgtgtactacaatgaagccacaggtggcaaatatgtt
cctcgtgccatcctggtggatctagaacctgggaccatggactctgttcgctcaggtcct
tttggccagatctttagaccagacaactttgtatttggtcagtctggggcaggtaacaac
tgggccaaaggccactacacagagggcgccgagctggttgattctgtcctggatgtggta
cggaaggaggcagagagctgtgactgcctgcagggcttccagctgacccactcactgggc
gggggcacaggctctggaatgggcactctccttatcagcaagatccgagaagaataccct
gatcgcatcatgaataccttcagtgtggtgccttcacccaaagtgtctgacaccgtggtc
gagccctacaatgccaccctctccgtccatcagttggtagagaatactgatgagacctat
tgcattgacaacgaggccctctatgatatctgcttccgcactctgaagctgaccacacca
acctacggggatctgaaccaccttgtctcagccaccatgagtggtgtcaccacctgcctc
cgtttccctggccagctcaatgctgacctccgcaagttggcagtcaacatggtccccttc
ccacgtctccatttctttatgcctggctttgcccctctcaccagccgtggaagccagcag
tatcgagctctcacagtgccggaactcacccagcaggtcttcgatgccaagaacatgatg
gctgcctgtgacccccgccacggccgatacctcaccgtggctgctgtcttccgtggtcgg
atgtccatgaaggaggtcgatgagcagatgcttaacgtgcagaacaagaacagcagctac
tttgtggaatggatccccaacaatgtcaagacagccgtctgtgacatcccacctcgtggc
ctcaagatggcagtcaccttcattggcaatagcacagccatccaggagctcttcaagcgc
atctcggagcagttcactgccatgttccgccggaaggccttcctccactggtacacaggc
gagggcatggacgagatggagttcaccgaggctgagagcaacatgaacgacctcgtctct
gagtatcagcagtaccaggatgccaccgcagaagaggaggaggatttcggtgaggaggcc
gaagaggaggcctaa

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