KEGG   Homo sapiens (human): 2048Help
Entry
2048              CDS       T01001                                 

Gene name
EPHB2, BDPLT22, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Definition
(RefSeq) EPH receptor B2
  KO
K05111  Eph receptor B2 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Drug target
Sitravatinib (DG03045): D11140 D11541
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    2048 (EPHB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2048 (EPHB2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2048 (EPHB2)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  EPH family [OT]
   2048 (EPHB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase_Tyr Ephrin_lbd Pkinase fn3 EphA2_TM SAM_1 SAM_2 Ephrin_rec_like Pur_ac_phosph_N SusE cEGF Haspin_kinase Kdo
Motif
Other DBs
NCBI-GeneID: 2048
NCBI-ProteinID: NP_001296122
OMIM: 600997
HGNC: 3393
Ensembl: ENSG00000133216
Vega: OTTHUMG00000002881
Pharos: P29323(Tchem)
UniProt: P29323 Q6NVW1 Q4LE53
Structure
PDB: 

Position
1p36.12
AA seq 1055 aa AA seqDB search
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ
VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF
DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY
CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI
ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF
SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE
YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK
LPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF
TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT
EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV
IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY
TSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE
QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGI
NLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTL
AGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKK
GMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG
NT seq 3168 nt NT seq  +upstreamnt  +downstreamnt
atggctctgcggaggctgggggccgcgctgctgctgctgccgctgctcgccgccgtggaa
gaaacgctaatggactccactacagcgactgctgagctgggctggatggtgcatcctcca
tcagggtgggaagaggtgagtggctacgatgagaacatgaacacgatccgcacgtaccag
gtgtgcaacgtgtttgagtcaagccagaacaactggctacggaccaagtttatccggcgc
cgtggcgcccaccgcatccacgtggagatgaagttttcggtgcgtgactgcagcagcatc
cccagcgtgcctggctcctgcaaggagaccttcaacctctattactatgaggctgacttt
gactcggccaccaagaccttccccaactggatggagaatccatgggtgaaggtggatacc
attgcagccgacgagagcttctcccaggtggacctgggtggccgcgtcatgaaaatcaac
accgaggtgcggagcttcggacctgtgtcccgcagcggcttctacctggccttccaggac
tatggcggctgcatgtccctcatcgccgtgcgtgtcttctaccgcaagtgcccccgcatc
atccagaatggcgccatcttccaggaaaccctgtcgggggctgagagcacatcgctggtg
gctgcccggggcagctgcatcgccaatgcggaagaggtggatgtacccatcaagctctac
tgtaacggggacggcgagtggctggtgcccatcgggcgctgcatgtgcaaagcaggcttc
gaggccgttgagaatggcaccgtctgccgaggttgtccatctgggactttcaaggccaac
caaggggatgaggcctgtacccactgtcccatcaacagccggaccacttctgaaggggcc
accaactgtgtctgccgcaatggctactacagagcagacctggaccccctggacatgccc
tgcacaaccatcccctccgcgccccaggctgtgatttccagtgtcaatgagacctccctc
atgctggagtggacccctccccgcgactccggaggccgagaggacctcgtctacaacatc
atctgcaagagctgtggctcgggccggggtgcctgcacccgctgcggggacaatgtacag
tacgcaccacgccagctaggcctgaccgagccacgcatttacatcagtgacctgctggcc
cacacccagtacaccttcgagatccaggctgtgaacggcgttactgaccagagccccttc
tcgcctcagttcgcctctgtgaacatcaccaccaaccaggcagctccatcggcagtgtcc
atcatgcatcaggtgagccgcaccgtggacagcattaccctgtcgtggtcccagccggac
cagcccaatggcgtgatcctggactatgagctgcagtactatgagaaggagctcagtgag
tacaacgccacagccataaaaagccccaccaacacggtcaccgtgcagggcctcaaagcc
ggcgccatctatgtcttccaggtgcgggcacgcaccgtggcaggttacgggcgctacagc
ggcaagatgtacttccagaccatgacagaagccgagtaccagacaagcatccaggagaag
ttgccactcatcatcggctcctcggccgctggcctggtcttcctcattgctgtggttgtc
atcgccatcgtgtgtaacagacgggggtttgagcgtgctgactcggagtacacggacaag
ctgcaacactacaccagtggccacatgaccccaggcatgaagatctacatcgatcctttc
acctacgaggaccccaacgaggcagtgcgggagtttgccaaggaaattgacatctcctgt
gtcaaaattgagcaggtgatcggagcaggggagtttggcgaggtctgcagtggccacctg
aagctgccaggcaagagagagatctttgtggccatcaagacgctcaagtcgggctacacg
gagaagcagcgccgggacttcctgagcgaagcctccatcatgggccagttcgaccatccc
aacgtcatccacctggagggtgtcgtgaccaagagcacacctgtgatgatcatcaccgag
ttcatggagaatggctccctggactcctttctccggcaaaacgatgggcagttcacagtc
atccagctggtgggcatgcttcggggcatcgcagctggcatgaagtacctggcagacatg
aactatgttcaccgtgacctggctgcccgcaacatcctcgtcaacagcaacctggtctgc
aaggtgtcggactttgggctctcacgctttctagaggacgatacctcagaccccacctac
accagtgccctgggcggaaagatccccatccgctggacagccccggaagccatccagtac
cggaagttcacctcggccagtgatgtgtggagctacggcattgtcatgtgggaggtgatg
tcctatggggagcggccctactgggacatgaccaaccaggatgtaatcaatgccattgag
caggactatcggctgccaccgcccatggactgcccgagcgccctgcaccaactcatgctg
gactgttggcagaaggaccgcaaccaccggcccaagttcggccaaattgtcaacacgcta
gacaagatgatccgcaatcccaacagcctcaaagccatggcgcccctctcctctggcatc
aacctgccgctgctggaccgcacgatccccgactacaccagctttaacacggtggacgag
tggctggaggccatcaagatggggcagtacaaggagagcttcgccaatgccggcttcacc
tcctttgacgtcgtgtctcagatgatgatggaggacattctccgggttggggtcactttg
gctggccaccagaaaaaaatcctgaacagtatccaggtgatgcgggcgcagatgaaccag
attcagtctgtggagggccagccactcgccaggaggccacgggccacgggaagaaccaag
cggtgccagccacgagacgtcaccaagaaaacatgcaactcaaacgacggaaaaaaaaag
ggaatgggaaaaaagaaaacagatcctgggagggggcgggaaatacaaggaatatttttt
aaagaggattctcataaggaaagcaatgactgttcttgcgggggataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   OMIM (3)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (11)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (47)   
   RefSeq(nuc) (7)   
   GenBank (20)   
   EMBL (20)   
Protein domain (13)   
   Pfam (13)   
All databases (102)   

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