KEGG   Homo sapiens (human): 2100
Entry
2100              CDS       T01001                                 
Symbol
ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8
Name
(RefSeq) estrogen receptor 2
  KO
K08551  estrogen receptor beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04081  Hormone signaling
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04929  GnRH secretion
hsa05200  Pathways in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05224  Breast cancer
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
  Element
N00286  Nuclear-initiated estrogen signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01352  BPA to RAS-ERK signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01364  E2 to nuclear-initiated estrogen signaling pathway
Disease
H00599  Ovarian dysgenesis
Drug target
Acolbifene hydrochloride: D02758
Afimoxifene: D06551
Alfatradiol: D07121
Arzoxifene hydrochloride: D02993
Bazedoxifene: D03062<JP>
Brilanestrant: D11264
Chlorotrianisene: D00269
Clometherone: D03551
Clomifene (DG00474): D00962<JP/US> D07726
Delmadinone (DG02935): D07783
Dienestrol: D00898
Diethylstilbestrol (DG00466): D00577 D00946 D07826
Droloxifene (DG01265): D03911 D03912
Enclomiphene (DG01992): D08910 D10876
Epitiostanol: D01265
Equilin: D04041
Erteberel: D09899
Estetrol (DG03027): D11513 D11514
Estradiol (DG00462): D00105<JP/US> D01413<JP/US> D01617 D01953 D04061<US> D04063<US> D04064 D04065 D07918<US> D07919
Estriol (DG00463): D00185<JP> D01986 D01989 D07920 D07921
Estrogens, esterified: D04071<US>
Estrone (DG00464): D00067 D00312 D00948
Fispemifene: D10008
Fluoroestradiol (18F): D11829<US>
Fulvestrant: D01161<JP/US>
Hexestrol (DG02847): D01641 D02018
Idoxifene: D04496
Lasofoxifene: D04672
Levormeloxifene fumarate: D09834
Mepitiostane: D01602
Mestranol: D00575
Miproxifene phosphate: D01853
Nafoxidine hydrochloride: D05106
Nitromifene citrate: D05192
Ormeloxifene: D08301
Prasterone (DG00141): D01616 D08409<US>
Prinaberel: D06631
Promestriene: D07221
Raloxifene (DG00476): D02217<JP/US> D08465 D10606<JP>
Tamoxifen (DG00734): D00966<JP/US> D08559
Toremifene (DG00735): D00967<JP/US> D08620
Trioxifene mesylate: D06245
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    2100 (ESR2)
 09150 Organismal Systems
  09152 Endocrine system
   04929 GnRH secretion
    2100 (ESR2)
   04915 Estrogen signaling pathway
    2100 (ESR2)
   04917 Prolactin signaling pathway
    2100 (ESR2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2100 (ESR2)
   05207 Chemical carcinogenesis - receptor activation
    2100 (ESR2)
  09162 Cancer: specific types
   05224 Breast cancer
    2100 (ESR2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    2100 (ESR2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2100 (ESR2)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2100 (ESR2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    2100 (ESR2)
Nuclear receptors [BR:hsa03310]
 3. Estrogen like
  3A. Estrogen receptor
   2100 (ESR2)
SSDB
Motif
Pfam: ERbeta_N zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 2100
NCBI-ProteinID: NP_001428
OMIM: 601663
HGNC: 3468
Ensembl: ENSG00000140009
UniProt: Q92731 Q7LCB3
Structure
Position
14:complement(64226707..64338613)
AA seq 530 aa
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
NT seq 1593 nt   +upstreamnt  +downstreamnt
atggatataaaaaactcaccatctagccttaattctccttcctcctacaactgcagtcaa
tccatcttacccctggagcacggctccatatacataccttcctcctatgtagacagccac
catgaatatccagccatgacattctatagccctgctgtgatgaattacagcattcccagc
aatgtcactaacttggaaggtgggcctggtcggcagaccacaagcccaaatgtgttgtgg
ccaacacctgggcacctttctcctttagtggtccatcgccagttatcacatctgtatgcg
gaacctcaaaagagtccctggtgtgaagcaagatcgctagaacacaccttacctgtaaac
agagagacactgaaaaggaaggttagtgggaaccgttgcgccagccctgttactggtcca
ggttcaaagagggatgctcacttctgcgctgtctgcagcgattacgcatcgggatatcac
tatggagtctggtcgtgtgaaggatgtaaggccttttttaaaagaagcattcaaggacat
aatgattatatttgtccagctacaaatcagtgtacaatcgataaaaaccggcgcaagagc
tgccaggcctgccgacttcggaagtgttacgaagtgggaatggtgaagtgtggctcccgg
agagagagatgtgggtaccgccttgtgcggagacagagaagtgccgacgagcagctgcac
tgtgccggcaaggccaagagaagtggcggccacgcgccccgagtgcgggagctgctgctg
gacgccctgagccccgagcagctagtgctcaccctcctggaggctgagccgccccatgtg
ctgatcagccgccccagtgcgcccttcaccgaggcctccatgatgatgtccctgaccaag
ttggccgacaaggagttggtacacatgatcagctgggccaagaagattcccggctttgtg
gagctcagcctgttcgaccaagtgcggctcttggagagctgttggatggaggtgttaatg
atggggctgatgtggcgctcaattgaccaccccggcaagctcatctttgctccagatctt
gttctggacagggatgaggggaaatgcgtagaaggaattctggaaatctttgacatgctc
ctggcaactacttcaaggtttcgagagttaaaactccaacacaaagaatatctctgtgtc
aaggccatgatcctgctcaattccagtatgtaccctctggtcacagcgacccaggatgct
gacagcagccggaagctggctcacttgctgaacgccgtgaccgatgctttggtttgggtg
attgccaagagcggcatctcctcccagcagcaatccatgcgcctggctaacctcctgatg
ctcctgtcccacgtcaggcatgcgagtaacaagggcatggaacatctgctcaacatgaag
tgcaaaaatgtggtcccagtgtatgacctgctgctggagatgctgaatgcccacgtgctt
cgcgggtgcaagtcctccatcacggggtccgagtgcagcccggcagaggacagtaaaagc
aaagagggctcccagaacccacagtctcagtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (19)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (17)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (124)   
   RefSeq(nuc) (18)   
   GenBank (53)   
   EMBL (53)   
3D Structure (37)   
   PDB (37)   
Protein domain (3)   
   Pfam (3)   
All databases (202)   

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