KEGG   Homo sapiens (human): 2122Help
Entry
2122              CDS       T01001                                 

Gene name
MECOM, AML1-EVI-1, EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3, RUSAT2
Definition
(RefSeq) MDS1 and EVI1 complex locus
  KO
K04462  ecotropic virus integration site 1 protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05200  Pathways in cancer
hsa05220  Chronic myeloid leukemia
Network
N00107  EVI-1 overexpression to TGF-beta signaling pathway
Disease
H00004  Chronic myeloid leukemia (CML)
H00867  Radioulnar synostosis with amegakaryocytic thrombocytopenia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2122 (MECOM)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    2122 (MECOM)
  09162 Cancers: Specific types
   05220 Chronic myeloid leukemia
    2122 (MECOM)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2122 (MECOM)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  Zinc finger
   Cys2His2 developmental/cell cycle regulators, Krueppel-like
    2122 (MECOM)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: zf-C2H2 zf-H2C2_2 zf-C2H2_4 zf-C2H2_6 zf-C2H2_jaz zf-H2C2_5 zf-BED zf-C2H2_8 Zn-ribbon_8 zf-C2H2_11 zf-met PyrI_C SET
Motif
Other DBs
NCBI-GeneID: 2122
NCBI-ProteinID: NP_004982
OMIM: 165215
HGNC: 3498
Ensembl: ENSG00000085276
Vega: OTTHUMG00000158596
Pharos: Q03112(Tbio)
UniProt: Q03112
Position
3q26.2
AA seq 1239 aa AA seqDB search
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKE
GSPYKAPIYIPDDIPIPAEFELRESNMPGAGLGIWTKRKIEVGEKFGPYVGEQRSNLKDP
SYGWEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIA
PGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFS
MVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAF
NWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATS
SGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSL
NKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLT
FPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQD
ILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSD
LESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVND
SIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPL
KMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSR
SRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPL
EALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMF
NFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSI
SSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELEST
GAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEE
VEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEY
KSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMM
LSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV
NT seq 3720 nt NT seq  +upstreamnt  +downstreamnt
atgagatccaaaggcagggcaaggaaactggccacaaataatgagtgtgtatatggcaac
taccctgaaatacctttggaagaaatgccagatgcagatggagtagccagcactccctcc
ctcaatattcaagagccatgctctcctgccacatccagtgaagcattcactccaaaggag
ggttctccttacaaagcccccatctacatccctgatgatatccccattcctgctgagttt
gaacttcgagagtcaaatatgcctggggcaggactaggaatatggaccaaaaggaagatc
gaagtaggtgaaaagtttgggccttatgtgggagagcagaggtcaaacctgaaagacccc
agttatggatgggagatcttagacgaattttacaatgtgaagttctgcatagatgccagt
caaccagatgttggaagctggctcaagtacattagattcgctggctgttatgatcagcac
aaccttgttgcatgccagataaatgatcagatattctatagagtagttgcagacattgcg
ccgggagaggagcttctgctgttcatgaagagcgaagactatccccatgaaactatggcg
ccggatatccacgaagaacggcaatatcgctgcgaagactgtgaccagctctttgaatct
aaggctgaactagcagatcaccaaaagtttccatgcagtactcctcactcagcattttca
atggttgaagaggactttcagcaaaaactcgaaagcgagaatgatctccaagagatacac
acgatccaggagtgtaaggaatgtgaccaagtttttcctgatttgcaaagcctggagaaa
cacatgctgtcacatactgaagagagggaatacaagtgtgatcagtgtcccaaggcattt
aactggaagtccaatttaattcgccaccagatgtcacatgacagtggaaagcactatgaa
tgtgaaaactgtgccaaggttttcacggaccctagcaaccttcagcggcacattcgctct
cagcatgtcggtgcccgggcccatgcatgcccggagtgtggcaaaacgtttgccacttcg
tcgggcctcaaacaacacaagcacatccacagcagtgtgaagccctttatctgtgaggtc
tgccataaatcctatactcagttttcaaacctttgccgtcataagcgcatgcatgctgat
tgcagaacccaaatcaagtgcaaagactgtggacaaatgttcagcactacgtcttcctta
aataaacacaggaggttttgtgagggcaagaaccattttgcggcaggtggattttttggc
caaggcatttcacttcctggaaccccagctatggataaaacgtccatggttaatatgagt
catgccaacccgggccttgctgactattttggcgccaataggcatcctgctggtcttacc
tttccaacagctcctggattttcttttagcttccctggtctgtttccttccggcttgtac
cacaggcctcctttgatacctgctagttctcctgttaaaggactatcaagtactgaacag
acaaacaaaagtcaaagtcccctcatgacacatcctcagatactgccagctacacaggat
attttgaaggcactatctaaacacccatctgtaggggacaataagccagtggagctccag
cccgagaggtcctctgaagagaggccctttgagaaaatcagtgaccagtcagagagtagt
gaccttgatgatgtcagtacaccaagtggcagtgacctggaaacaacctcgggctctgat
ctggaaagtgacattgaaagtgataaagagaaatttaaagaaaatggtaaaatgttcaaa
gacaaagtaagccctcttcagaatctggcttcaataaataataagaaagaatacagcaat
cattccattttctcaccatctttagaggagcagactgcggtgtcaggagctgtgaatgat
tctataaaggctattgcttctattgctgaaaaatactttggttcaacaggactggtgggg
ctgcaagacaaaaaagttggagctttaccttacccttccatgtttcccctcccatttttt
ccagcattctctcaatcaatgtacccatttcctgatagagacttgagatcgttacctttg
aaaatggaaccccaatcaccaggtgaagtaaagaaactgcagaagggcagctctgagtcc
ccctttgatctcaccactaagcgaaaggatgagaagcccttgactccagtcccctccaag
cctccagtgacacctgccacaagccaagaccagcccctggatctaagtatgggcagtagg
agtagagccagtgggacaaagctgactgagcctcgaaaaaaccacgtgtttgggggaaaa
aaaggaagcaacgtcgaatcaagacctgcttcagatggttccttgcagcatgcaagaccc
actcctttctttatggaccctatttacagagtagagaaaagaaaactaactgacccactt
gaagctttaaaagagaaatacttgaggccttctccaggattcttgtttcacccacaattc
caactgcctgatcagagaacttggatgtcagctattgaaaacatggcagaaaagctagag
agcttcagtgccctgaaacctgaggccagtgagctcttacagtcagtgccctctatgttc
aacttcagggcgcctcccaatgccctgccagagaaccttctgcggaagggaaaggagcgc
tatacctgcagatactgtggcaagatttttccaaggtctgcaaacctaacacggcacttg
agaacccacacaggagagcagccttacagatgcaaatactgtgacagatcatttagcata
tcttctaacttgcaaaggcatgttcgcaacatccacaataaagagaagccatttaagtgt
cacttatgtgataggtgttttggtcaacaaaccaatttagacagacacctaaagaaacat
gagaatgggaacatgtccggtacagcaacatcgtcgcctcattctgaactggaaagtaca
ggtgcgattctggatgacaaagaagatgcttacttcacagaaattcgaaatttcattggg
aacagcaaccatggcagccaatctcccaggaatgtggaggagagaatgaatggcagtcat
tttaaagatgaaaaggctttggtgaccagtcaaaattcagacttgctggatgatgaagaa
gttgaagatgaggtgttgttagatgaggaggatgaagacaatgatattactggaaaaaca
ggaaaggaaccagtgacaagtaatttacatgaaggaaaccctgaggatgactatgaagaa
accagtgccctggagatgagttgcaagacatccccagtgaggtataaagaggaagaatat
aaaagtggactttctgctctagatcatataaggcacttcacagatagcctcaaaatgagg
aaaatggaagataatcaatattctgaagctgagctgtcttcttttagtacttcccatgtg
ccagaggaacttaagcagccgttacacagaaagtccaaatcgcaggcatatgctatgatg
ctgtcactgtctgacaaggagtccctccattctacatcccacagttcttccaacgtgtgg
cacagtatggccagggctgcggcggaatccagtgctatccagtccataagccacgtatga

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