KEGG   Homo sapiens (human): 2155
Entry
2155              CDS       T01001                                 
Symbol
F7, SPCA
Name
(RefSeq) coagulation factor VII
  KO
K01320  coagulation factor VII [EC:3.4.21.21]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
  Element
N01503  Extrinsic pathway of coagulation cascade, F7 activation
Disease
H01730  Myocardial infarction
H02256  Factor VII deficiency
Drug target
Coagulation factor VII (DG00172): D00172<JP/US> D10139
Factor VIII inhibitor bypassing activity: D12421<JP>
Tifacogin: D06142
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    2155 (F7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    2155 (F7)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.21  coagulation factor VIIa
     2155 (F7)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   2155 (F7)
SSDB
Motif
Pfam: Trypsin Gla FXa_inhibition DUF1986 EGF cEGF hEGF
Other DBs
NCBI-GeneID: 2155
NCBI-ProteinID: NP_000122
OMIM: 613878
HGNC: 3544
Ensembl: ENSG00000057593
CPD: C03378
UniProt: P08709
Structure
Position
13:113105788..113120685
AA seq 466 aa
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
NT seq 1401 nt   +upstreamnt  +downstreamnt
atggtctcccaggccctcaggctcctctgccttctgcttgggcttcagggctgcctggct
gcaggcggggtcgctaaggcctcaggaggagaaacacgggacatgccgtggaagccgggg
cctcacagagtcttcgtaacccaggaggaagcccacggcgtcctgcaccggcgccggcgc
gccaacgcgttcctggaggagctgcggccgggctccctggagagggagtgcaaggaggag
cagtgctccttcgaggaggcccgggagatcttcaaggacgcggagaggacgaagctgttc
tggatttcttacagtgatggggaccagtgtgcctcaagtccatgccagaatgggggctcc
tgcaaggaccagctccagtcctatatctgcttctgcctccctgccttcgagggccggaac
tgtgagacgcacaaggatgaccagctgatctgtgtgaacgagaacggcggctgtgagcag
tactgcagtgaccacacgggcaccaagcgctcctgtcggtgccacgaggggtactctctg
ctggcagacggggtgtcctgcacacccacagttgaatatccatgtggaaaaatacctatt
ctagaaaaaagaaatgccagcaaaccccaaggccgaattgtggggggcaaggtgtgcccc
aaaggggagtgtccatggcaggtcctgttgttggtgaatggagctcagttgtgtgggggg
accctgatcaacaccatctgggtggtctccgcggcccactgtttcgacaaaatcaagaac
tggaggaacctgatcgcggtgctgggcgagcacgacctcagcgagcacgacggggatgag
cagagccggcgggtggcgcaggtcatcatccccagcacgtacgtcccgggcaccaccaac
cacgacatcgcgctgctccgcctgcaccagcccgtggtcctcactgaccatgtggtgccc
ctctgcctgcccgaacggacgttctctgagaggacgctggccttcgtgcgcttctcattg
gtcagcggctggggccagctgctggaccgtggcgccacggccctggagctcatggtcctc
aacgtgccccggctgatgacccaggactgcctgcagcagtcacggaaggtgggagactcc
ccaaatatcacggagtacatgttctgtgccggctactcggatggcagcaaggactcctgc
aagggggacagtggaggcccacatgccacccactaccggggcacgtggtacctgacgggc
atcgtcagctggggccagggctgcgcaaccgtgggccactttggggtgtacaccagggtc
tcccagtacatcgagtggctgcaaaagctcatgcgctcagagccacgcccaggagtcctc
ctgcgagccccatttccctag

  All links  
Disease (3)   
   OMIM (3)   
Gene (21)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PROTHERM (6)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (38)   
   RefSeq(nuc) (14)   
   GenBank (12)   
   EMBL (12)   
3D Structure (108)   
   PDB (108)   
Protein domain (7)   
   Pfam (7)   
All databases (192)   

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