KEGG   Homo sapiens (human): 221178
Entry
221178            CDS       T01001                                 

Gene name
SPATA13, ARHGEF29, ASEF2
Definition
(RefSeq) spermatogenesis associated 13
  KO
K05769  Rho guanine nucleotide exchange factor 4/29
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    221178 (SPATA13)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    221178 (SPATA13)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    221178 (SPATA13)
SSDB
Motif
Pfam: RhoGEF SH3_1 PH SH3_9 SH3_2
Other DBs
NCBI-GeneID: 221178
NCBI-ProteinID: NP_694568
OMIM: 613324
HGNC: 23222
Ensembl: ENSG00000182957 ENSG00000228741 ENSG00000273167
Vega: OTTHUMG00000016578 OTTHUMG00000186016
Pharos: Q96N96(Tbio)
UniProt: Q96N96 A0A024RDM6
Position
13q12.12
AA seq 652 aa
MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQV
PPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSY
EDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEAS
NKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQM
RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL
KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEA
CRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL
INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD
HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYL
FCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCP
VAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK
NT seq 1959 nt   +upstreamnt  +downstreamnt
atgacttctgccagccctgaagaccagaatgctccagtgggctgccccaaaggagcccgg
agaaggcgccccatttccgtgataggtggggtcagcttgtatgggaccaaccagacggag
gaactggacaatcttctgacccaaccggcttccaggccgcccatgcctgctcaccaggtg
ccaccctacaaggctgtgtcggcccggttccggcccttcacattctcccagagcaccccc
attgggttggaccgtgtgggacgccggcggcagatgagagcatccaacgtttcttcagat
ggaggtactgagccctctgccttagtggatgacaacggtagtgaggaggacttcagctat
gaagacctctgccaggccagccctcggtacctgcagcccggcggggagcagctggccatc
aatgagctgatcagtgatggcaacgtggtctgcgcagaagccctgtgggaccatgtgacc
atggatgaccaggaactgggcttcaaagccggggatgtcatccaggttctggaagcctcc
aacaaggactggtggtggggccgcagtgaagataaggaagcctggttccccgcgagcttc
gtcagattgcgagtgaatcaggaagagctgtcggaaaactccagcagcacccccagtgag
gagcaggacgaggaggccagccagagccgccacagacactgtgagaacaagcagcagatg
cggaccaacgtcatccgggagatcatggacaccgagcgggtgtacatcaaacacctcagg
gacatctgtgagggctatatccgacagtgccgcaagcacacaggaatgttcaccgttgcg
cagctagccactatttttggaaacattgaagatatttacaaattccaaagaaagtttctg
aaagaccttgagaaacagtacaacaaagaggaacctcacttaagtgaaataggatcttgc
tttcttcaaaatcaagagggctttgccatctattccgagtactgcaacaaccacccgggc
gcctgcctggagctcgccaacctcatgaagcagggcaagtacagacatttctttgaagcc
tgccgcctgctgcagcagatgattgacatcgccatcgacgggttcctgctcacaccagtg
cagaagatctgcaaatacccgctgcagctggccgagctgctcaagtataccacacaggaa
cacggtgattacagcaacataaaggcagcatatgaggccatgaagaatgtggcctgtctg
atcaacgagcgcaagcgcaagctggagagcatcgacaagatagctcgctggcaggtgtct
atcgtgggctgggagggactggatatcttagaccgaagctcagaattgattcattctggg
gagctgaccaaaatcactaagcaaggcaaaagccagcagcggacgttcttcctgtttgac
caccagctggtgtcctgcaagaaggacctgctgcgcagggacatgctgtactacaagggc
cggctggacatggatgagatggagcttgtggacctgggggatgggcgcgacaaggactgc
aacctcagcgtgaaaaatgccttcaagctcgtcagtaggaccacagacgaggtttatttg
ttttgtgccaaaaaacaagaagacaaggcgaggtggctgcaggcctgtgcagatgaaagg
aggcgggtgcaagaggacaaggagatgggaatggaaatttcagaaaaccagaagaaactt
gccatgttaaatgctcaaaaggcaggacatggaaagtcaaaaggctacaacaggtgccct
gtggccccaccgcaccagggcctgcaccccatccaccagcgccacatcactatgcccaca
agcgtcccccagcagcaggtctttggcctggcggaacccaagaggaagtcctcgctcttc
tggcacaccttcaacaggctcacccccttccggaaatga

KEGG   Homo sapiens (human): 50649
Entry
50649             CDS       T01001                                 

Gene name
ARHGEF4, ASEF, ASEF1, GEF4, SMIM39, STM6
Definition
(RefSeq) Rho guanine nucleotide exchange factor 4
  KO
K05769  Rho guanine nucleotide exchange factor 4/29
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    50649 (ARHGEF4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    50649 (ARHGEF4)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    50649 (ARHGEF4)
SSDB
Motif
Pfam: RhoGEF SH3_1 PH SH3_2 SH3_9
Other DBs
NCBI-GeneID: 50649
NCBI-ProteinID: NP_056135
OMIM: 605216
HGNC: 684
Ensembl: ENSG00000136002
Vega: OTTHUMG00000131657
Pharos: Q9NR80(Tbio)
UniProt: Q9NR80 Q9NTG0
Structure
PDB: 
2PZ1 3NMX 2DX1 3NMZ

Position
2q21.1
AA seq 690 aa
MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH
RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH
PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG
GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE
GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI
KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE
LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL
LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ
WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV
LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA
FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHPALPSNR
PQQQVLVLAEPRRKPSTFWHSISRLAPFRK
NT seq 2073 nt   +upstreamnt  +downstreamnt
atgccctgggaagaaccagcaggtgagaagcccagttgctctcacagtcagaaggcgttc
cacatggagcctgcccagaagccctgcttcaccactgacatggtgacatgggccctcctc
tgcatctctgcagagactgtgcgtggggaggctccttcacagcctaggggcatccctcac
cgctcgcccgtcagtgtggatgacctgtggctggagaagacacagagaaagaagttgcag
aagcaggcccacgtcgaaaggaggctgcacataggggcagtgcacaaagatggagtcaag
tgctggagaaagacgatcattacctctccagagtctttgaatctccctagaagaagccat
ccactctcccagagtgctccaacgggactgaaccacatgggctggccagagcacacacca
ggcactgccatgcctgatggagctctggacacagctgtctgcgctgacgaagtggggagc
gaggaggacctgtatgatgacctgcacagctccagccaccactacagccaccctggaggg
ggtggggagcagctggctatcaatgagctcatcagcgatggcagtgtggtctgcgctgaa
gcactctgggaccatgtcaccatggacgaccaggagctgggcttcaaagctggggacgtc
atcgaagtgatggatgccaccaacagagagtggtggtggggccgggtcgccgatggcgag
ggctggtttccagccagcttcgttcggctgagggtgaatcaggacgagcccgcggatgac
gacgcccctctggccgggaacagcggagcggaggacggcggggcggaggcgcagagcagc
aaggaccagatgcggaccaacgtcatcaacgagatcctcagcactgagcgggactacatc
aagcacctgcgcgacatctgcgagggctacgtccggcagtgccgcaagcgcgcagacatg
ttcagcgaggagcagctgcgtaccatcttcgggaacatcgaggacatctaccgctgccag
aaggccttcgtgaaggccctggagcagaggttcaaccgcgagcgcccacacctgagcgag
ctgggtgcctgcttcctggagcatcaagccgacttccagatctactcggagtactgcaat
aaccaccccaacgcctgcgtggagctctcccggctcaccaagctcagcaagtacgtgtac
ttcttcgaggcctgccggctgctgcagaagatgattgacatctccctggatggcttcctg
ctgactccggtgcagaagatctgcaagtaccctctgcagctggccgagctgctcaaatac
acgcacccccagcacagggacttcaaggatgttgaagccgccttgcatgccatgaagaac
gtggcccagctcatcaacgagcggaagcggagacttgagaacatcgacaagattgctcag
tggcagagctccatagaggactgggagggagaagatctcttggtcaggagctcagaactc
atctactcgggggagctgactcgagttacacagcctcaagccaaaagccagcagcgaatg
ttctttctctttgaccaccagctcatctactgtaagaaggacctgctccgccgcgacgtg
ttgtactacaagggccggctggacatggacggcctggaggtggtggacctggaggacggg
aaggacagagacctccatgtgagcatcaagaacgccttccggctgcaccgtggcgccaca
ggggacagccacctgctgtgcaccaggaagcccgagcagaagcagcgctggctcaaggcc
tttgccagggagagggagcaggtgcagctggaccaggagacaggcttctccatcactgaa
ctgcagaggaagcaggccatgctgaatgccagcaagcagcaggtcacagggaagcccaaa
gctgttggccggccctgctacctgacgcgccagaagcacccagccctgcccagcaaccgg
ccccagcagcaggtcctggtgctggcggagcccaggcgcaagccatctaccttctggcac
agcatcagccggctggcacccttccgcaagtga

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