KEGG   Homo sapiens (human): 2213
Entry
2213              CDS       T01001                                 
Symbol
FCGR2B, CD32, CD32B, FCG2, FCGR2, FCGR2C, FcGRIIB, FcRII-c, FcgammaRIIb, IGFR2
Name
(RefSeq) Fc gamma receptor IIb
  KO
K12560  low affinity immunoglobulin gamma Fc receptor II-b
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagosome
hsa04380  Osteoclast differentiation
hsa04662  B cell receptor signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa05150  Staphylococcus aureus infection
hsa05152  Tuberculosis
hsa05162  Measles
Disease
H00080  Systemic lupus erythematosus
H00361  Malaria
Drug target
Valziflocept: D11339
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    2213 (FCGR2B)
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    2213 (FCGR2B)
   04666 Fc gamma R-mediated phagocytosis
    2213 (FCGR2B)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    2213 (FCGR2B)
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    2213 (FCGR2B)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    2213 (FCGR2B)
   05152 Tuberculosis
    2213 (FCGR2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2213 (FCGR2B)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    2213 (FCGR2B)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    2213 (FCGR2B)
CD molecules [BR:hsa04090]
 Proteins
  2213 (FCGR2B)
SSDB
Motif
Pfam: Ig_2 Ig_3 ig Ig_4 I-set V-set Ig_5 Big_7 7tm_3 C1-set CD34_antigen ECSCR V-set_CD47 Amnionless Adeno_E3_CR2 DUF3827
Other DBs
NCBI-GeneID: 2213
NCBI-ProteinID: NP_003992
OMIM: 604590
HGNC: 3618
Ensembl: ENSG00000072694
Pharos: P31994(Tbio)
UniProt: P31994
Structure
Position
1:161647243..161678654
AA seq 310 aa
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWIN
VLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSL
SDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPN
FSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAA
VVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDA
LEEPDDQNRI
NT seq 933 nt   +upstreamnt  +downstreamnt
atgggaatcctgtcattcttacctgtccttgccactgagagtgactgggctgactgcaag
tccccccagccttggggtcatatgcttctgtggacagctgtgctattcctggctcctgtt
gctgggacacctgcagctcccccaaaggctgtgctgaaactcgagccccagtggatcaac
gtgctccaggaggactctgtgactctgacatgccgggggactcacagccctgagagcgac
tccattcagtggttccacaatgggaatctcattcccacccacacgcagcccagctacagg
ttcaaggccaacaacaatgacagcggggagtacacgtgccagactggccagaccagcctc
agcgaccctgtgcatctgactgtgctttctgagtggctggtgctccagacccctcacctg
gagttccaggagggagaaaccatcgtgctgaggtgccacagctggaaggacaagcctctg
gtcaaggtcacattcttccagaatggaaaatccaagaaattttcccgttcggatcccaac
ttctccatcccacaagcaaaccacagtcacagtggtgattaccactgcacaggaaacata
ggctacacgctgtactcatccaagcctgtgaccatcactgtccaagctcccagctcttca
ccgatggggatcattgtggctgtggtcactgggattgctgtagcggccattgttgctgct
gtagtggccttgatctactgcaggaaaaagcggatttcagctctcccaggataccctgag
tgcagggaaatgggagagaccctccctgagaaaccagccaatcccactaatcctgatgag
gctgacaaagttggggctgagaacacaatcacctattcacttctcatgcacccggatgct
ctggaagagcctgatgaccagaaccgtatttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (95)   
   RefSeq(nuc) (15)   
   GenBank (40)   
   EMBL (40)   
3D Structure (3)   
   PDB (3)   
Protein domain (16)   
   Pfam (16)   
All databases (159)   

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