KEGG   Homo sapiens (human): 22800Help
Entry
22800             CDS       T01001                                 

Gene name
RRAS2, TC21
Definition
(RefSeq) RAS related 2
  KO
K07830  Ras-related protein R-Ras2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04024  cAMP signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04218  Cellular senescence
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    22800 (RRAS2)
   04010 MAPK signaling pathway
    22800 (RRAS2)
   04371 Apelin signaling pathway
    22800 (RRAS2)
   04072 Phospholipase D signaling pathway
    22800 (RRAS2)
   04024 cAMP signaling pathway
    22800 (RRAS2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    22800 (RRAS2)
   04137 Mitophagy - animal
    22800 (RRAS2)
  09143 Cell growth and death
   04218 Cellular senescence
    22800 (RRAS2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    22800 (RRAS2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    22800 (RRAS2)
 09160 Human Diseases
  09161 Cancers: Overview
   05205 Proteoglycans in cancer
    22800 (RRAS2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    22800 (RRAS2)
   04031 GTP-binding proteins [BR:hsa04031]
    22800 (RRAS2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   22800 (RRAS2)
  Exosomal proteins of bladder cancer cells
   22800 (RRAS2)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    22800 (RRAS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc Arf GTP_EFTU MMR_HSR1 RsgA_GTPase ATP_bind_1 DUF2075
Motif
Other DBs
NCBI-GeneID: 22800
NCBI-ProteinID: NP_036382
OMIM: 600098
HGNC: 17271
Ensembl: ENSG00000133818
Vega: OTTHUMG00000165756
Pharos: P62070(Tbio)
UniProt: P62070
Structure
PDB: 

Position
11p15.2
AA seq 204 aa AA seqDB search
MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR
AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF
PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE
QECPPSPEPTRKEKDKKGCHCVIF
NT seq 615 nt NT seq  +upstreamnt  +downstreamnt
atggccgcggccggctggcgggacggctccggccaggagaagtaccggctcgtggtggtc
ggcgggggcggcgtgggcaagtcggcgctcaccatccagttcatccagtcctattttgta
acggattatgatccaaccattgaagattcttacacaaagcagtgtgtgatagatgacaga
gcagcccggctagatattttggatacagcaggacaagaagagtttggagccatgagagaa
cagtatatgaggactggcgaaggcttcctgttggtcttttcagtcacagatagaggcagt
tttgaagaaatctataagtttcaaagacagattctcagagtaaaggatcgtgatgagttc
ccaatgattttaattggtaataaagcagatctggatcatcaaagacaggtaacacaggaa
gaaggacaacagttagcacggcagcttaaggtaacatacatggaggcatcagcaaagatt
aggatgaatgtagatcaagctttccatgaacttgtccgggttatcaggaaatttcaagag
caggaatgtcctccttcaccagaaccaacacggaaagaaaaagacaagaaaggctgccat
tgtgtcattttctag

KEGG   Homo sapiens (human): 22808Help
Entry
22808             CDS       T01001                                 

Gene name
MRAS, M-RAs, R-RAS3, RRAS3
Definition
(RefSeq) muscle RAS oncogene homolog
  KO
K07831  Ras-related protein M-Ras
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04218  Cellular senescence
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    22808 (MRAS)
   04015 Rap1 signaling pathway
    22808 (MRAS)
   04010 MAPK signaling pathway
    22808 (MRAS)
   04371 Apelin signaling pathway
    22808 (MRAS)
   04072 Phospholipase D signaling pathway
    22808 (MRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    22808 (MRAS)
   04137 Mitophagy - animal
    22808 (MRAS)
  09143 Cell growth and death
   04218 Cellular senescence
    22808 (MRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    22808 (MRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    22808 (MRAS)
 09160 Human Diseases
  09161 Cancers: Overview
   05205 Proteoglycans in cancer
    22808 (MRAS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    22808 (MRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    22808 (MRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc GTP_EFTU Arf RsgA_GTPase MMR_HSR1 ATP_bind_1 Gtr1_RagA AAA_16 MMR_HSR1_Xtn
Motif
Other DBs
NCBI-GeneID: 22808
NCBI-ProteinID: NP_001078518
OMIM: 608435
HGNC: 7227
Ensembl: ENSG00000158186
Vega: OTTHUMG00000159888
Pharos: O14807(Tbio)
UniProt: O14807 Q6FGP0 Q8WVM9
Position
3q22.3
AA seq 208 aa AA seqDB search
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW
AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP
MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP
EKSQKKKKKTKWRGDRATGTHKLQCVIL
NT seq 627 nt NT seq  +upstreamnt  +downstreamnt
atggcaaccagcgccgtccccagtgacaacctccccacatacaagctggtggtggtgggg
gatgggggtgtgggcaaaagtgccctcaccatccagtttttccagaagatctttgtgcct
gactatgaccccaccattgaagactcctacctgaaacatacggagattgacaatcaatgg
gccatcttggacgttctggacacagctgggcaggaggaattcagcgccatgcgggagcaa
tacatgcgcacgggggatggcttcctcatcgtctactccgtcactgacaaggccagcttt
gagcacgtggaccgcttccaccagcttatcctgcgcgtcaaagacagggagtcattcccg
atgatcctcgtggccaacaaggtcgatttgatgcacttgaggaagatcaccagggagcaa
ggaaaagaaatggcgaccaaacacaatattccgtacatagaaaccagtgccaaggaccca
cctctcaatgtcgacaaagccttccatgacctcgttagagtaattaggcaacagattccg
gaaaaaagccagaagaagaagaagaaaaccaaatggcggggagaccgggccacaggcacc
cacaaactgcaatgtgtgatcttgtga

KEGG   Homo sapiens (human): 3265Help
Entry
3265              CDS       T01001                                 

Gene name
HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, KRAS, KRAS2, Ki-Ras, RASH1, RASK2, c-K-ras, c-Ki-ras, p21ras
Definition
(RefSeq) HRas proto-oncogene, GTPase
  KO
K02833  GTPase HRas
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04144  Endocytosis
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04625  C-type lectin receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00077  HRAS-overexpression to RAS-ERK signaling pathway
N00078  Mutation-activated HRAS to RAS-ERK signaling pathway
N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
N00097  Loss of RASSF1 to EGF-EGFR-RAS-RASSF1 signaling pathway
N00103  EGF-EGFR-RAS-RalGDS signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00267  HBV HBx to host-cell-protein activation
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
 » show all
Disease
H00022  Bladder cancer
H00025  Penile cancer
H00030  Cervical cancer
H00032  Thyroid cancer
H00040  Squamous cell carcinoma
H00523  Noonan syndrome and related disorders
H01470  Giant cell tumor of bone
H01555  Merkel cell carcinoma
H01592  Medullary thyroid cancer
H01666  Angiosarcoma
H01747  Costello syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    3265 (HRAS)
   04015 Rap1 signaling pathway
    3265 (HRAS)
   04010 MAPK signaling pathway
    3265 (HRAS)
   04012 ErbB signaling pathway
    3265 (HRAS)
   04370 VEGF signaling pathway
    3265 (HRAS)
   04371 Apelin signaling pathway
    3265 (HRAS)
   04630 Jak-STAT signaling pathway
    3265 (HRAS)
   04068 FoxO signaling pathway
    3265 (HRAS)
   04072 Phospholipase D signaling pathway
    3265 (HRAS)
   04071 Sphingolipid signaling pathway
    3265 (HRAS)
   04151 PI3K-Akt signaling pathway
    3265 (HRAS)
   04150 mTOR signaling pathway
    3265 (HRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    3265 (HRAS)
   04140 Autophagy - animal
    3265 (HRAS)
   04137 Mitophagy - animal
    3265 (HRAS)
  09143 Cell growth and death
   04210 Apoptosis
    3265 (HRAS)
   04218 Cellular senescence
    3265 (HRAS)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    3265 (HRAS)
   04540 Gap junction
    3265 (HRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    3265 (HRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3265 (HRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    3265 (HRAS)
   04650 Natural killer cell mediated cytotoxicity
    3265 (HRAS)
   04660 T cell receptor signaling pathway
    3265 (HRAS)
   04662 B cell receptor signaling pathway
    3265 (HRAS)
   04664 Fc epsilon RI signaling pathway
    3265 (HRAS)
   04062 Chemokine signaling pathway
    3265 (HRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    3265 (HRAS)
   04912 GnRH signaling pathway
    3265 (HRAS)
   04915 Estrogen signaling pathway
    3265 (HRAS)
   04917 Prolactin signaling pathway
    3265 (HRAS)
   04921 Oxytocin signaling pathway
    3265 (HRAS)
   04926 Relaxin signaling pathway
    3265 (HRAS)
   04919 Thyroid hormone signaling pathway
    3265 (HRAS)
   04916 Melanogenesis
    3265 (HRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    3265 (HRAS)
   04726 Serotonergic synapse
    3265 (HRAS)
   04720 Long-term potentiation
    3265 (HRAS)
   04730 Long-term depression
    3265 (HRAS)
   04722 Neurotrophin signaling pathway
    3265 (HRAS)
  09158 Development
   04360 Axon guidance
    3265 (HRAS)
  09149 Aging
   04211 Longevity regulating pathway
    3265 (HRAS)
   04213 Longevity regulating pathway - multiple species
    3265 (HRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    3265 (HRAS)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    3265 (HRAS)
   05230 Central carbon metabolism in cancer
    3265 (HRAS)
   05231 Choline metabolism in cancer
    3265 (HRAS)
   05206 MicroRNAs in cancer
    3265 (HRAS)
   05205 Proteoglycans in cancer
    3265 (HRAS)
   05203 Viral carcinogenesis
    3265 (HRAS)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    3265 (HRAS)
   05225 Hepatocellular carcinoma
    3265 (HRAS)
   05226 Gastric cancer
    3265 (HRAS)
   05214 Glioma
    3265 (HRAS)
   05216 Thyroid cancer
    3265 (HRAS)
   05221 Acute myeloid leukemia
    3265 (HRAS)
   05220 Chronic myeloid leukemia
    3265 (HRAS)
   05218 Melanoma
    3265 (HRAS)
   05211 Renal cell carcinoma
    3265 (HRAS)
   05219 Bladder cancer
    3265 (HRAS)
   05215 Prostate cancer
    3265 (HRAS)
   05213 Endometrial cancer
    3265 (HRAS)
   05224 Breast cancer
    3265 (HRAS)
   05223 Non-small cell lung cancer
    3265 (HRAS)
  09165 Substance dependence
   05034 Alcoholism
    3265 (HRAS)
  09167 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    3265 (HRAS)
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    3265 (HRAS)
   05170 Human immunodeficiency virus 1 infection
    3265 (HRAS)
   05161 Hepatitis B
    3265 (HRAS)
   05160 Hepatitis C
    3265 (HRAS)
   05163 Human cytomegalovirus infection
    3265 (HRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3265 (HRAS)
   05165 Human papillomavirus infection
    3265 (HRAS)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    3265 (HRAS)
   01522 Endocrine resistance
    3265 (HRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3265 (HRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3265 (HRAS)
   04031 GTP-binding proteins [BR:hsa04031]
    3265 (HRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    3265 (HRAS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   3265 (HRAS)
  Exosomal proteins of colorectal cancer cells
   3265 (HRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    3265 (HRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA G-alpha ATP_bind_1 Septin Ldh_1_N AAA_25 AAA_16
Motif
Other DBs
NCBI-GeneID: 3265
NCBI-ProteinID: NP_001123914
OMIM: 190020
HGNC: 5173
Ensembl: ENSG00000174775
Vega: OTTHUMG00000131919
Pharos: P01112(Tchem)
UniProt: P01112 X5D945
Structure
PDB: 
2CE2 2EVW 2CLD 2CL6 5WDQ 2CL7 1CTQ 3OIW 3K8Y 3TGP 4DLR 3OIU 5WDP 2RGB 5P21 3I3S 5E95 3RS0 2RGE 3L8Z 2RGG 2QUZ 1ZW6 821P 3RS3 121P 5B2Z 5VBE 4DLV 4DLY 5B30 4DLU 3RRY 3RRZ 3RSO 2RGC 1QRA 4L9S 5WDO 4DLZ 6D55 6D56 3RS5 6D59 6D5L 4DLT 3RS4 3RS7 3RSL 2X1V 3KKM 1XJ0 1LF0 1LF5 1CLU 4DLW 4DLX 6D5E 6D5J 6BVI 6BVJ 6BVL 6D5H 6BVK 6BVM 3K9L 3DDC 1JAH 1JAI 4DLS 3RS2 3OIV 1XCM 3LBH 1GNR 3LBN 4XVQ 4EFL 4EFM 2RGA 2C5L 1RVD 4RSG 6D5G 4L9W 6Q21 5WFO 3K9N 2RGD 2UZI 1ZVQ 1P2T 1P2U 1IOZ 4Q21 721P 3L8Y 4XVR 6D5V 6D5M 5WFP 3LBI 3KKN 1LFD 5WPL 3KUD 4US0 1NVV 5VBZ 1NVU 1Q21 2Q21 421P 4URZ 5WFQ 4EFN 1P2V 1AGP 221P 4K81 621P 4G0N 1P2S 5WFR 4URY 4US2 4URX 6AMB 5X9S 1WQ1 1GNQ 3LO5 4URV 521P 4US1 2VH5 1XD2 1NVW 1GNP 4URW 1BKD 1PLJ 1PLK 1PLL 4URU 4NYJ 1IAQ 4NYI 1K8R 1HE8 1NVX 4G3X 6AXG 4NYM 5ZC6 2N46 2N42 2LWI 2LCF 2CLC 2CL0 1AA9 1CRP 1CRQ 1CRR
Thumbnails

Position
11p15.5
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgacggaatataagctggtggtggtgggcgccggcggtgtgggcaagagtgcgctgacc
atccagctgatccagaaccattttgtggacgaatacgaccccactatagaggattcctac
cggaagcaggtggtcattgatggggagacgtgcctgttggacatcctggataccgccggc
caggaggagtacagcgccatgcgggaccagtacatgcgcaccggggagggcttcctgtgt
gtgtttgccatcaacaacaccaagtcttttgaggacatccaccagtacagggagcagatc
aaacgggtgaaggactcggatgacgtgcccatggtgctggtggggaacaagtgtgacctg
gctgcacgcactgtggaatctcggcaggctcaggacctcgcccgaagctacggcatcccc
tacatcgagacctcggccaagacccggcagggagtggaggatgccttctacacgttggtg
cgtgagatccggcagcacaagctgcggaagctgaaccctcctgatgagagtggccccggc
tgcatgagctgcaagtgtgtgctctcctga

KEGG   Homo sapiens (human): 3845Help
Entry
3845              CDS       T01001                                 

Gene name
KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2
Definition
(RefSeq) KRAS proto-oncogene, GTPase
  KO
K07827  GTPase KRas
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04625  C-type lectin receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04960  Aldosterone-regulated sodium reabsorption
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
N00097  Loss of RASSF1 to EGF-EGFR-RAS-RASSF1 signaling pathway
N00103  EGF-EGFR-RAS-RalGDS signaling pathway
N00104  Mutation-activated KRAS to RalGDS signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00267  HBV HBx to host-cell-protein activation
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
 » show all
Disease
H00003  Acute myeloid leukemia (AML)
H00010  Multiple myeloma
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00030  Cervical cancer
H00032  Thyroid cancer
H00040  Squamous cell carcinoma
H00041  Kaposi sarcoma
H00046  Cholangiocarcinoma
H00047  Gallbladder cancer
H00458  Syndromic craniosynostoses
H00523  Noonan syndrome and related disorders
H01557  Hepatic angiosarcoma
H01592  Medullary thyroid cancer
H01666  Angiosarcoma
H01738  Noonan syndrome
H01745  Cardiofaciocutaneous syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    3845 (KRAS)
   04015 Rap1 signaling pathway
    3845 (KRAS)
   04010 MAPK signaling pathway
    3845 (KRAS)
   04012 ErbB signaling pathway
    3845 (KRAS)
   04370 VEGF signaling pathway
    3845 (KRAS)
   04371 Apelin signaling pathway
    3845 (KRAS)
   04068 FoxO signaling pathway
    3845 (KRAS)
   04072 Phospholipase D signaling pathway
    3845 (KRAS)
   04071 Sphingolipid signaling pathway
    3845 (KRAS)
   04151 PI3K-Akt signaling pathway
    3845 (KRAS)
   04150 mTOR signaling pathway
    3845 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    3845 (KRAS)
   04137 Mitophagy - animal
    3845 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    3845 (KRAS)
   04218 Cellular senescence
    3845 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    3845 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    3845 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    3845 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    3845 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    3845 (KRAS)
   04660 T cell receptor signaling pathway
    3845 (KRAS)
   04662 B cell receptor signaling pathway
    3845 (KRAS)
   04664 Fc epsilon RI signaling pathway
    3845 (KRAS)
   04062 Chemokine signaling pathway
    3845 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    3845 (KRAS)
   04912 GnRH signaling pathway
    3845 (KRAS)
   04915 Estrogen signaling pathway
    3845 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    3845 (KRAS)
   04917 Prolactin signaling pathway
    3845 (KRAS)
   04921 Oxytocin signaling pathway
    3845 (KRAS)
   04926 Relaxin signaling pathway
    3845 (KRAS)
   04919 Thyroid hormone signaling pathway
    3845 (KRAS)
   04916 Melanogenesis
    3845 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3845 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    3845 (KRAS)
   04726 Serotonergic synapse
    3845 (KRAS)
   04720 Long-term potentiation
    3845 (KRAS)
   04730 Long-term depression
    3845 (KRAS)
   04722 Neurotrophin signaling pathway
    3845 (KRAS)
  09158 Development
   04360 Axon guidance
    3845 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    3845 (KRAS)
   04213 Longevity regulating pathway - multiple species
    3845 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    3845 (KRAS)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    3845 (KRAS)
   05230 Central carbon metabolism in cancer
    3845 (KRAS)
   05231 Choline metabolism in cancer
    3845 (KRAS)
   05206 MicroRNAs in cancer
    3845 (KRAS)
   05205 Proteoglycans in cancer
    3845 (KRAS)
   05203 Viral carcinogenesis
    3845 (KRAS)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    3845 (KRAS)
   05212 Pancreatic cancer
    3845 (KRAS)
   05225 Hepatocellular carcinoma
    3845 (KRAS)
   05226 Gastric cancer
    3845 (KRAS)
   05214 Glioma
    3845 (KRAS)
   05216 Thyroid cancer
    3845 (KRAS)
   05221 Acute myeloid leukemia
    3845 (KRAS)
   05220 Chronic myeloid leukemia
    3845 (KRAS)
   05218 Melanoma
    3845 (KRAS)
   05211 Renal cell carcinoma
    3845 (KRAS)
   05219 Bladder cancer
    3845 (KRAS)
   05215 Prostate cancer
    3845 (KRAS)
   05213 Endometrial cancer
    3845 (KRAS)
   05224 Breast cancer
    3845 (KRAS)
   05223 Non-small cell lung cancer
    3845 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    3845 (KRAS)
  09167 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    3845 (KRAS)
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    3845 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    3845 (KRAS)
   05161 Hepatitis B
    3845 (KRAS)
   05160 Hepatitis C
    3845 (KRAS)
   05163 Human cytomegalovirus infection
    3845 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    3845 (KRAS)
   05165 Human papillomavirus infection
    3845 (KRAS)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    3845 (KRAS)
   01522 Endocrine resistance
    3845 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    3845 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    3845 (KRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    3845 (KRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    3845 (KRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 G-alpha FeoB_N ATP_bind_1 Septin AAA_25 CbiA
Motif
Other DBs
NCBI-GeneID: 3845
NCBI-ProteinID: NP_203524
OMIM: 190070
HGNC: 6407
Ensembl: ENSG00000133703
Vega: OTTHUMG00000171193
Pharos: P01116(Tbio)
UniProt: P01116 L7RSL8 I1SRC5
Structure
PDB: 

Position
12p12.1
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcattttgtggacgaatatgatccaacaatagaggattcctac
aggaagcaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaatt
aaaagagttaaggactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg
agggagatccgacaatacagattgaaaaaaatcagcaaagaagaaaagactcctggctgt
gtgaaaattaaaaaatgcattataatgtaa

KEGG   Homo sapiens (human): 4893Help
Entry
4893              CDS       T01001                                 

Gene name
NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6
Definition
(RefSeq) NRAS proto-oncogene, GTPase
  KO
K07828  GTPase NRas
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04540  Gap junction
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04625  C-type lectin receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04730  Long-term depression
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04926  Relaxin signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05034  Alcoholism
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05216  Thyroid cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
Network
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00004  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005  Mutation-activated MET to RAS-ERK signaling pathway
N00006  Amplified EGFR to RAS-ERK signaling pathway
N00007  EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  TRK fusion kinase to RAS-ERK signaling pathway
N00011  Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00016  PDGF-overexpression to RAS-ERK signaling pathway
N00018  Amplified PDGFR to RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00020  Amplified FGFR to RAS-ERK signaling pathway
N00021  EGF-ERBB2-RAS-ERK signaling pathway
N00022  ERBB2-overexpression to RAS-ERK signaling pathway
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00041  EGFR-overexpression to RAS-ERK signaling pathway
N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
N00097  Loss of RASSF1 to EGF-EGFR-RAS-RASSF1 signaling pathway
N00103  EGF-EGFR-RAS-RalGDS signaling pathway
N00152  CXCR-GNB/G-ERK signaling pathway
N00157  KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  KSHV K1 to RAS-ERK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00230  TGFA-overexpression to RAS-ERK signaling pathway
N00233  IGF2-IGF1R-RAS-ERK signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00246  HGF-overexpression to RAS-ERK signaling pathway
N00248  MET-overexpression to RAS-ERK signaling pathway
N00252  Amplified ERBB2 to RAS-ERK signaling pathway
N00259  Amplified MET to RAS-ERK signaling pathway
N00267  HBV HBx to host-cell-protein activation
N00276  EGF-overexpression to RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00278  EREG-overexpression to RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00280  AREG-overexpression to RAS-ERK signaling pathway
N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
N00369  HPV E5 to PDGFR-RAS-ERK signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
 » show all
Disease
H00003  Acute myeloid leukemia (AML)
H00010  Multiple myeloma
H00016  Oral cancer
H00018  Gastric cancer
H00032  Thyroid cancer
H00033  Adrenal carcinoma
H00038  Melanoma
H00108  Autoimmune lymphoproliferative syndromes
H00523  Noonan syndrome and related disorders
H01481  Myelodysplastic syndrome
H01666  Angiosarcoma
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    4893 (NRAS)
   04015 Rap1 signaling pathway
    4893 (NRAS)
   04010 MAPK signaling pathway
    4893 (NRAS)
   04012 ErbB signaling pathway
    4893 (NRAS)
   04370 VEGF signaling pathway
    4893 (NRAS)
   04371 Apelin signaling pathway
    4893 (NRAS)
   04068 FoxO signaling pathway
    4893 (NRAS)
   04072 Phospholipase D signaling pathway
    4893 (NRAS)
   04071 Sphingolipid signaling pathway
    4893 (NRAS)
   04151 PI3K-Akt signaling pathway
    4893 (NRAS)
   04150 mTOR signaling pathway
    4893 (NRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    4893 (NRAS)
   04137 Mitophagy - animal
    4893 (NRAS)
  09143 Cell growth and death
   04210 Apoptosis
    4893 (NRAS)
   04218 Cellular senescence
    4893 (NRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    4893 (NRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    4893 (NRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    4893 (NRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    4893 (NRAS)
   04650 Natural killer cell mediated cytotoxicity
    4893 (NRAS)
   04660 T cell receptor signaling pathway
    4893 (NRAS)
   04662 B cell receptor signaling pathway
    4893 (NRAS)
   04664 Fc epsilon RI signaling pathway
    4893 (NRAS)
   04062 Chemokine signaling pathway
    4893 (NRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    4893 (NRAS)
   04912 GnRH signaling pathway
    4893 (NRAS)
   04915 Estrogen signaling pathway
    4893 (NRAS)
   04917 Prolactin signaling pathway
    4893 (NRAS)
   04921 Oxytocin signaling pathway
    4893 (NRAS)
   04926 Relaxin signaling pathway
    4893 (NRAS)
   04919 Thyroid hormone signaling pathway
    4893 (NRAS)
   04916 Melanogenesis
    4893 (NRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    4893 (NRAS)
   04726 Serotonergic synapse
    4893 (NRAS)
   04720 Long-term potentiation
    4893 (NRAS)
   04730 Long-term depression
    4893 (NRAS)
   04722 Neurotrophin signaling pathway
    4893 (NRAS)
  09158 Development
   04360 Axon guidance
    4893 (NRAS)
  09149 Aging
   04211 Longevity regulating pathway
    4893 (NRAS)
   04213 Longevity regulating pathway - multiple species
    4893 (NRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    4893 (NRAS)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    4893 (NRAS)
   05230 Central carbon metabolism in cancer
    4893 (NRAS)
   05231 Choline metabolism in cancer
    4893 (NRAS)
   05206 MicroRNAs in cancer
    4893 (NRAS)
   05205 Proteoglycans in cancer
    4893 (NRAS)
   05203 Viral carcinogenesis
    4893 (NRAS)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    4893 (NRAS)
   05225 Hepatocellular carcinoma
    4893 (NRAS)
   05226 Gastric cancer
    4893 (NRAS)
   05214 Glioma
    4893 (NRAS)
   05216 Thyroid cancer
    4893 (NRAS)
   05221 Acute myeloid leukemia
    4893 (NRAS)
   05220 Chronic myeloid leukemia
    4893 (NRAS)
   05218 Melanoma
    4893 (NRAS)
   05211 Renal cell carcinoma
    4893 (NRAS)
   05219 Bladder cancer
    4893 (NRAS)
   05215 Prostate cancer
    4893 (NRAS)
   05213 Endometrial cancer
    4893 (NRAS)
   05224 Breast cancer
    4893 (NRAS)
   05223 Non-small cell lung cancer
    4893 (NRAS)
  09165 Substance dependence
   05034 Alcoholism
    4893 (NRAS)
  09167 Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    4893 (NRAS)
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    4893 (NRAS)
   05170 Human immunodeficiency virus 1 infection
    4893 (NRAS)
   05161 Hepatitis B
    4893 (NRAS)
   05160 Hepatitis C
    4893 (NRAS)
   05163 Human cytomegalovirus infection
    4893 (NRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    4893 (NRAS)
   05165 Human papillomavirus infection
    4893 (NRAS)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    4893 (NRAS)
   01522 Endocrine resistance
    4893 (NRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4893 (NRAS)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    4893 (NRAS)
   04031 GTP-binding proteins [BR:hsa04031]
    4893 (NRAS)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    4893 (NRAS)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   4893 (NRAS)
  Exosomal proteins of other body fluids (saliva and urine)
   4893 (NRAS)
  Exosomal proteins of breast cancer cells
   4893 (NRAS)
  Exosomal proteins of colorectal cancer cells
   4893 (NRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    4893 (NRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Septin Ldh_1_N ParA AAA_25
Motif
Other DBs
NCBI-GeneID: 4893
NCBI-ProteinID: NP_002515
OMIM: 164790
HGNC: 7989
Ensembl: ENSG00000213281
Vega: OTTHUMG00000012059
Pharos: P01111(Tchem)
UniProt: P01111 Q5U091
Structure
PDB: 

Position
1p13.2
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL
PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG
CMGLPCVVM
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgactgagtacaaactggtggtggttggagcaggtggtgttgggaaaagcgcactgaca
atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcttac
agaaaacaagtggttatagatggtgaaacctgtttgttggacatactggatacagctgga
caagaagagtacagtgccatgagagaccaatacatgaggacaggcgaaggcttcctctgt
gtatttgccatcaataatagcaagtcatttgcggatattaacctctacagggagcagatt
aagcgagtaaaagactcggatgatgtacctatggtgctagtgggaaacaagtgtgatttg
ccaacaaggacagttgatacaaaacaagcccacgaactggccaagagttacgggattcca
ttcattgaaacctcagccaagaccagacagggtgttgaagatgctttttacacactggta
agagaaatacgccagtaccgaatgaaaaaactcaacagcagtgatgatgggactcagggt
tgtatgggattgccatgtgtggtgatgtaa

KEGG   Homo sapiens (human): 6237Help
Entry
6237              CDS       T01001                                 

Gene name
RRAS, R-Ras
Definition
(RefSeq) RAS related
  KO
K07829  Ras-related protein R-Ras
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04024  cAMP signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04218  Cellular senescence
hsa04360  Axon guidance
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    6237 (RRAS)
   04015 Rap1 signaling pathway
    6237 (RRAS)
   04010 MAPK signaling pathway
    6237 (RRAS)
   04371 Apelin signaling pathway
    6237 (RRAS)
   04072 Phospholipase D signaling pathway
    6237 (RRAS)
   04024 cAMP signaling pathway
    6237 (RRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    6237 (RRAS)
   04137 Mitophagy - animal
    6237 (RRAS)
  09143 Cell growth and death
   04218 Cellular senescence
    6237 (RRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    6237 (RRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    6237 (RRAS)
  09158 Development
   04360 Axon guidance
    6237 (RRAS)
 09160 Human Diseases
  09161 Cancers: Overview
   05205 Proteoglycans in cancer
    6237 (RRAS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    6237 (RRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    6237 (RRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc Arf GTP_EFTU ATP_bind_1 MMR_HSR1 AAA_22
Motif
Other DBs
NCBI-GeneID: 6237
NCBI-ProteinID: NP_006261
OMIM: 165090
HGNC: 10447
Ensembl: ENSG00000126458
Vega: OTTHUMG00000183247
Pharos: P10301(Tbio)
UniProt: P10301 A0A024QZF2
Structure
PDB: 

Position
19q13.33
AA seq 218 aa AA seqDB search
MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP
TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG
KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD
EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL
NT seq 657 nt NT seq  +upstreamnt  +downstreamnt
atgagcagcggggcggcgtccgggacagggcgggggcggccccggggcgggggacctggg
cccggggaccccccgcccagcgagacacacaagctggtggtcgtgggcggcggcggcgtg
ggcaagagcgcgctgaccatccagttcatccagtcctacttcgtgtctgactacgacccc
actattgaggactcctacacgaagatctgcagtgtggatggcatcccagcccggctggac
atcctggacaccgcgggccaggaagagttcggggccatgagagagcagtacatgcgtgct
ggccacggcttcctgctggtgttcgccattaacgaccggcagagtttcaacgaggtgggc
aagctcttcacgcagattctgcgggtcaaggaccgcgacgacttccccgttgtgttggtc
gggaacaaggcagatctggagtcacagcgccaggtcccccgatcagaagcctctgccttc
ggcgcctcccaccacgtggcctactttgaggcctcggccaaactgcgtctcaacgtggac
gaggcttttgagcagctggtgcgggctgtccggaaataccaggaacaagagctcccaccg
agccctcccagtgcccccaggaagaagggcgggggctgcccctgcgtcctcctgtag

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