KEGG   Homo sapiens (human): 22953
Entry
22953             CDS       T01001                                 

Gene name
P2RX2, DFNA41, P2X2
Definition
(RefSeq) purinergic receptor P2X 2
  KO
K05216  P2X purinoceptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04742  Taste transduction
Disease
H00604  Deafness, autosomal dominant
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    22953 (P2RX2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    22953 (P2RX2)
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    22953 (P2RX2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    22953 (P2RX2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   22953 (P2RX2)
SSDB
Motif
Pfam: P2X_receptor WAP
Other DBs
NCBI-GeneID: 22953
NCBI-ProteinID: NP_733782
OMIM: 600844
HGNC: 15459
Ensembl: ENSG00000187848
Vega: OTTHUMG00000168018
Pharos: Q9UBL9(Tbio)
UniProt: Q9UBL9 Q32MC3
Position
12q24.33
AA seq 471 aa
MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
NT seq 1416 nt   +upstreamnt  +downstreamnt
atggccgccgcccagcccaagtaccccgccggggcgaccgcccggcgcctggcccggggc
tgctggtccgccctctgggactacgagacgcccaaggtgatcgtggtgaggaaccggcgc
ctgggggtcctgtaccgcgccgtgcagctgctcatcctgctctacttcgtgtggtacgta
ttcatcgtgcagaaaagctaccaggagagcgagacgggccccgagagctccatcatcacc
aaggtcaaggggatcaccacgtccgagcacaaagtgtgggacgtggaggagtacgtgaag
ccccccgaggggggcagcgtgttcagcatcatcaccagggtcgaggccacccactcccag
acccagggaacctgccccgagagcataagggtccacaacgccacctgcctctccgacgcc
gactgcgtggctggggagctggacatgctgggaaacggcctgaggactgggcgctgtgtg
ccctattaccaggggccctccaagacctgcgaggtgttcggctggtgcccggtggaagat
ggggcctctgtcagccaatttctgggtacgatggccccaaatttcaccatcctcatcaag
aacagcatccactaccccaaattccacttctccaagggcaacatcgccgaccgcacagac
gggtacctgaagcgctgcacgttccacgaggcctccgacctctactgccccatcttcaag
ctgggctttatcgtggagaaggctggggagagcttcacagagctcgcacacaagggtggt
gtcatcggggtcattatcaactgggactgtgacctggacctgcctgcatcggagtgcaac
cccaagtactccttccggaggcttgaccccaagcacgtgcctgcctcgtcaggctacaac
ttcaggtttgccaaatactacaagatcaatggcaccaccacccgcacgctcatcaaggcc
tacgggatccgcattgacgtcattgtgcatggacaggccgggaagttcagcctgattccc
accattattaatctggccacagctctgacttccgtcggggtgggctccttcctgtgcgac
tggatcttgctaacattcatgaacaaaaacaaggtctacagccataagaaatttgacaag
gtgtgtacgccgagccacccctcaggtagctggcctgtgacccttgcccgtgtattgggc
caggcccctcccgaacccggccaccgctccgaggaccagcaccccagccctccatcaggc
caggagggccaacaaggggcagagtgtggcccagccttcccgcccctgcggccttgcccc
atctctgccccttctgagcagatggtggacactcctgcctccgagcctgcccaagcctcc
acacccacagaccccaaaggtttggctcaactctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (39)   
   RefSeq(nuc) (13)   
   GenBank (13)   
   EMBL (13)   
Protein domain (2)   
   Pfam (2)   
All databases (85)   

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KEGG   Homo sapiens (human): 5023
Entry
5023              CDS       T01001                                 

Gene name
P2RX1, P2X1
Definition
(RefSeq) purinergic receptor P2X 1
  KO
K05215  P2X purinoceptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04611  Platelet activation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5023 (P2RX1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5023 (P2RX1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5023 (P2RX1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5023 (P2RX1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5023 (P2RX1)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 5023
NCBI-ProteinID: NP_002549
OMIM: 600845
HGNC: 8533
Ensembl: ENSG00000108405
Vega: OTTHUMG00000177673
Pharos: P51575(Tchem)
UniProt: P51575
Position
17p13.2
AA seq 399 aa
MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
NT seq 1200 nt   +upstreamnt  +downstreamnt
atggcacggcggttccaggaggagctggccgccttcctcttcgagtatgacaccccccgc
atggtgctggtgcgtaataagaaggtgggcgttatcttccgactgatccagctggtggtc
ctggtctacgtcatcgggtgggtgtttctctatgagaagggctaccagacctcgagcggc
ctcatcagcagtgtctctgtgaaactcaagggcctggccgtgacccagctccctggcctc
ggcccccaggtctgggatgtggctgactacgtcttcccagcccagggggacaactccttc
gtggtcatgaccaatttcatcgtgaccccgaagcagactcaaggctactgcgcagagcac
ccagaagggggcatatgcaaggaagacagtggctgtacccctgggaaggccaagaggaag
gcccaaggcatccgcacgggcaagtgtgtggccttcaacgacactgtgaagacgtgtgag
atctttggctggtgccccgtggaggtggatgacgacatcccgcgccctgcccttctccga
gaggccgagaacttcactcttttcatcaagaacagcatcagctttccacgcttcaaggtc
aacaggcgcaacctggtggaggaggtgaatgctgcccacatgaagacctgcctctttcac
aagaccctgcaccccctgtgcccagtcttccagcttggctacgtggtgcaagagtcaggc
cagaacttcagcaccctggctgagaagggtggagtggttggcatcaccatcgactggcac
tgtgacctggactggcacgtacggcactgcagacccatctatgagttccatgggctgtac
gaagagaaaaatctctccccaggcttcaacttcaggtttgccaggcactttgtggagaac
gggaccaactaccgtcacctcttcaaggtgtttgggattcgctttgacatcctggtggac
ggcaaggccgggaagtttgacatcatccctacaatgaccaccatcggctctggaattggc
atctttggggtggccacagttctctgtgacctgctgctgcttcacatcctgcctaagagg
cactactacaagcagaagaagttcaaatacgctgaggacatggggccaggggcggctgag
cgtgacctcgcagctaccagctccaccctgggcctgcaggagaacatgaggacatcctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (27)   
   RefSeq(nuc) (9)   
   GenBank (9)   
   EMBL (9)   
Protein domain (1)   
   Pfam (1)   
All databases (56)   

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KEGG   Homo sapiens (human): 5024
Entry
5024              CDS       T01001                                 

Gene name
P2RX3, P2X3
Definition
(RefSeq) purinergic receptor P2X 3
  KO
K05217  P2X purinoceptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04742  Taste transduction
Drug target
Gefapixant (DG03083): D11349 D11693
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5024 (P2RX3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5024 (P2RX3)
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    5024 (P2RX3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5024 (P2RX3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5024 (P2RX3)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 5024
NCBI-ProteinID: NP_002550
OMIM: 600843
HGNC: 8534
Ensembl: ENSG00000109991
Vega: OTTHUMG00000167025
Pharos: P56373(Tchem)
UniProt: P56373
Structure
PDB: 

Position
11q12.1
AA seq 397 aa
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
NT seq 1194 nt   +upstreamnt  +downstreamnt
atgaactgcatatccgacttcttcacctatgagaccaccaagtcggtggttgtgaagagc
tggaccatcgggatcatcaaccgagtagttcagcttctgatcatctcctactttgtaggg
tgggttttcttgcacgagaaggcttaccaggtacgggacacagccattgagtcctcggtg
gtaaccaaggtgaagggctccggactctacgccaacagagtcatggatgtgtctgattac
gtgacgccacctcagggcacctcggtctttgtcatcatcaccaagatgattgttactgaa
aatcagatgcaaggattctgcccagagagtgaggagaaataccgctgtgtatcagacagc
cagtgcgggcctgagcgcttgccaggtggggggatcctcactggccgctgcgtgaactac
agctctgtgctccggacctgtgagatccagggctggtgccccacggaggtggacacagtg
gaaacgcccatcatgatggaagctgagaacttcactattttcatcaagaacagcatccgt
ttccccctcttcaactttgagaagggaaacctccttcccaacctgacagccagggacatg
aagacctgccgcttccacccggacaaggaccctttctgccccatcttgcgggtaggggac
gtggtcaagtttgcggggcaggattttgccaaactggcgcgcacggggggagttctgggc
attaagatcggctgggtgtgcgacttggacaaggcctgggaccagtgcatccccaaatac
tccttcacccggctcgacagcgtttctgagaaaagcagcgtgtccccaggctacaacttc
aggtttgccaagtactacaaaatggaaaatggcagtgagtaccgcaccctcctgaaggct
tttggcatccgcttcgacgtgctggtatacgggaatgctggcaagttcaacatcatcccc
accatcatcagctctgtggcggcctttacttctgtgggagtgggaactgttctctgtgac
atcatcctgctcaacttcctcaagggggccgaccagtacaaagccaagaagtttgaggag
gtgaatgagactacgctgaaaatcgcggctttgaccaacccagtgtaccccagcgaccag
accacagcggagaagcagtccaccgattcgggggccttctccataggccactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (23)   
   RefSeq(nuc) (7)   
   GenBank (8)   
   EMBL (8)   
Protein domain (1)   
   Pfam (1)   
All databases (51)   

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KEGG   Homo sapiens (human): 5025
Entry
5025              CDS       T01001                                 

Gene name
P2RX4, P2X4, P2X4R
Definition
(RefSeq) purinergic receptor P2X 4
  KO
K05218  P2X purinoceptor 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5025 (P2RX4)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5025 (P2RX4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5025 (P2RX4)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5025 (P2RX4)
SSDB
Motif
Pfam: P2X_receptor DUF3624
Other DBs
NCBI-GeneID: 5025
NCBI-ProteinID: NP_002551
OMIM: 600846
HGNC: 8535
Ensembl: ENSG00000135124
Vega: OTTHUMG00000169155
Pharos: Q99571(Tchem)
UniProt: Q99571
Position
12q24.31
AA seq 388 aa
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
NT seq 1167 nt   +upstreamnt  +downstreamnt
atggcgggctgctgcgccgcgctggcggccttcctgttcgagtacgacacgccgcgcatc
gtgctcatccgcagccgcaaagtggggctcatgaaccgcgccgtgcaactgctcatcctg
gcctacgtcatcgggtgggtgtttgtgtgggaaaagggctaccaggaaactgactccgtg
gtcagctccgttacgaccaaggtcaagggcgtggctgtgaccaacacttctaaacttgga
ttccggatctgggatgtggcggattatgtgataccagctcaggaggaaaactccctcttc
gtcatgaccaacgtgatcctcaccatgaaccagacacagggcctgtgccccgagattcca
gatgcgaccactgtgtgtaaatcagatgccagctgtactgccggctctgccggcacccac
agcaacggagtctcaacaggcaggtgcgtagctttcaacgggtctgtcaagacgtgtgag
gtggcggcctggtgcccggtggaggatgacacacacgtgccacaacctgcttttttaaag
gctgcagaaaacttcactcttttggttaagaacaacatctggtatcccaaatttaatttc
agcaagaggaatatccttcccaacatcaccactacttacctcaagtcgtgcatttatgat
gctaaaacagatcccttctgccccatattccgtcttggcaaaatagtggagaacgcagga
cacagtttccaggacatggccgtggagggaggcatcatgggcatccaggtcaactgggac
tgcaacctggacagagccgcctccctctgcttgcccaggtactccttccgccgcctcgat
acacgggacgttgagcacaacgtatctcctggctacaatttcaggtttgccaagtactac
agagacctggctggcaacgagcagcgcacgctcatcaaggcctatggcatccgcttcgac
atcattgtgtttgggaaggcagggaaatttgacatcatccccactatgatcaacatcggc
tctggcctggcactgctaggcatggcgaccgtgctgtgtgacatcatagtcctctactgc
atgaagaaaagactctactatcgggagaagaaatataaatatgtggaagattacgagcag
ggtcttgctagtgagctggaccagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (54)   
   RefSeq(nuc) (14)   
   GenBank (20)   
   EMBL (20)   
Protein domain (2)   
   Pfam (2)   
All databases (91)   

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KEGG   Homo sapiens (human): 5026
Entry
5026              CDS       T01001                                 

Gene name
P2RX5, LRH-1, P2X5, P2X5R
Definition
(RefSeq) purinergic receptor P2X 5
  KO
K05219  P2X purinoceptor 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5026 (P2RX5)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5026 (P2RX5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5026 (P2RX5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5026 (P2RX5)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 5026
NCBI-ProteinID: NP_002552
OMIM: 602836
HGNC: 8536
Ensembl: ENSG00000083454
Vega: OTTHUMG00000090700
Pharos: Q93086(Tbio)
UniProt: Q93086
Position
17p13.2
AA seq 422 aa
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
ST
NT seq 1269 nt   +upstreamnt  +downstreamnt
atggggcaggcgggctgcaaggggctctgcctgtcgctgttcgactacaagaccgagaag
tatgtcatcgccaagaacaagaaggtgggcctgctgtaccggctgctgcaggcctccatc
ctggcgtacctggtcgtatgggtgttcctgataaagaagggttaccaagacgtcgacacc
tccctgcagagtgctgtcatcaccaaagtcaagggcgtggccttcaccaacacctcggat
cttgggcagcggatctgggatgtcgccgactacgtcattccagcccagggagagaacgtc
ttttttgtggtcaccaacctgattgtgacccccaaccagcggcagaacgtctgtgctgag
aatgaaggcattcctgatggcgcgtgctccaaggacagcgactgccacgctggggaagcg
gttacagctggaaacggagtgaagaccggccgctgcctgcggagagagaacttggccagg
ggcacctgtgagatctttgcctggtgcccgttggagacaagctccaggccggaggagcca
ttcctgaaggaggccgaagacttcaccattttcataaagaaccacatccgtttccccaaa
ttcaacttctccaaaagcaatgtgatggacgtcaaggacagatctttcctgaaatcatgc
cactttggccccaagaaccactactgccccatcttccgactgggctccgtgatccgctgg
gccgggagcgacttccaggatatagccctggagggtggcgtgataggaattaatattgaa
tggaactgtgatcttgataaagctgcctctgagtgccaccctcactattcttttagccgt
ctggacaataaactttcaaagtctgtctcctccgggtacaacttcagatttgccagatat
taccgagacgcagccggggtggagttccgcaccctgatgaaagcctacgggatccgcttt
gacgtgatggtgaacggcaagggtgctttcttctgcgacctggtactcatctacctcatc
aaaaagagagagttttaccgtgacaagaagtacgaggaagtgaggggcctagaagacagt
tcccaggaggccgaggacgaggcatcggggctggggctatctgagcagctcacatctggg
ccagggctgctggggatgccggagcagcaggagctgcaggagccacccgaggcgaagcgt
ggaagcagcagtcagaaggggaacggatctgtgtgcccacagctcctggagccccacagg
agcacgtga

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Pathway (2)   
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Disease (1)   
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Gene (18)   
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Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (39)   
   RefSeq(nuc) (5)   
   GenBank (17)   
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Protein domain (1)   
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KEGG   Homo sapiens (human): 5027
Entry
5027              CDS       T01001                                 

Gene name
P2RX7, P2X7
Definition
(RefSeq) purinergic receptor P2X 7
  KO
K05220  P2X purinoceptor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04621  NOD-like receptor signaling pathway
Drug target
Brilliant blue G: D10799<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5027 (P2RX7)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5027 (P2RX7)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    5027 (P2RX7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5027 (P2RX7)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5027 (P2RX7)
SSDB
Motif
Pfam: P2X_receptor Keratin_matx Ribosomal_L5_C
Other DBs
NCBI-GeneID: 5027
NCBI-ProteinID: NP_002553
OMIM: 602566
HGNC: 8537
Ensembl: ENSG00000089041
Vega: OTTHUMG00000169153
Pharos: Q99572(Tchem)
UniProt: Q99572
Position
12q24.31
AA seq 595 aa
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
NT seq 1788 nt   +upstreamnt  +downstreamnt
atgccggcctgctgcagctgcagtgatgttttccagtatgagacgaacaaagtcactcgg
atccagagcatgaattatggcaccattaagtggttcttccacgtgatcatcttttcctac
gtttgctttgctctggtgagtgacaagctgtaccagcggaaagagcctgtcatcagttct
gtgcacaccaaggtgaaggggatagcagaggtgaaagaggagatcgtggagaatggagtg
aagaagttggtgcacagtgtctttgacaccgcagactacaccttccctttgcaggggaac
tctttcttcgtgatgacaaactttctcaaaacagaaggccaagagcagcggttgtgtccc
gagtatcccacccgcaggacgctctgttcctctgaccgaggttgtaaaaagggatggatg
gacccgcagagcaaaggaattcagaccggaaggtgtgtagtgtatgaagggaaccagaag
acctgtgaagtctctgcctggtgccccatcgaggcagtggaagaggccccccggcctgct
ctcttgaacagtgccgaaaacttcactgtgctcatcaagaacaatatcgacttccccggc
cacaactacaccacgagaaacatcctgccaggtttaaacatcacttgtaccttccacaag
actcagaatccacagtgtcccattttccgactaggagacatcttccgagaaacaggcgat
aatttttcagatgtggcaattcagggcggaataatgggcattgagatctactgggactgc
aacctagaccgttggttccatcactgccgtcccaaatacagtttccgtcgccttgacgac
aagaccaccaacgtgtccttgtaccctggctacaacttcagatacgccaagtactacaag
gaaaacaatgttgagaaacggactctgataaaagtcttcgggatccgttttgacatcctg
gtttttggcaccggaggaaaatttgacattatccagctggttgtgtacatcggctcaacc
ctctcctacttcggtctggccgctgtgttcatcgacttcctcatcgacacttactccagt
aactgctgtcgctcccatatttatccctggtgcaagtgctgtcagccctgtgtggtcaac
gaatactactacaggaagaagtgcgagtccattgtggagccaaagccgacattaaagtat
gtgtcctttgtggatgaatcccacattaggatggtgaaccagcagctactagggagaagt
ctgcaagatgtcaagggccaagaagtcccaagacctgcgatggacttcacagatttgtcc
aggctgcccctggccctccatgacacacccccgattcctggacaaccagaggagatacag
ctgcttagaaaggaggcgactcctagatccagggatagccccgtctggtgccagtgtgga
agctgcctcccatctcaactccctgagagccacaggtgcctggaggagctgtgctgccgg
aaaaagccgggggcctgcatcaccacctcagagctgttcaggaagctggtcctgtccaga
cacgtcctgcagttcctcctgctctaccaggagcccttgctggcgctggatgtggattcc
accaacagccggctgcggcactgtgcctacaggtgctacgccacctggcgcttcggctcc
caggacatggctgactttgccatcctgcccagctgctgccgctggaggatccggaaagag
tttccgaagagtgaagggcagtacagtggcttcaagagtccttactga

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Ontology (2)   
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Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (77)   
   RefSeq(nuc) (17)   
   GenBank (30)   
   EMBL (30)   
Protein domain (3)   
   Pfam (3)   
All databases (121)   

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KEGG   Homo sapiens (human): 9127
Entry
9127              CDS       T01001                                 

Gene name
P2RX6, P2RXL1, P2X6, P2XM
Definition
(RefSeq) purinergic receptor P2X 6
  KO
K05221  P2X purinoceptor 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    9127 (P2RX6)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    9127 (P2RX6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    9127 (P2RX6)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   9127 (P2RX6)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 9127
NCBI-ProteinID: NP_005437
OMIM: 608077
HGNC: 8538
Ensembl: ENSG00000099957
Vega: OTTHUMG00000150689
Pharos: O15547(Tbio)
UniProt: O15547
Position
22q11.21
AA seq 441 aa
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA
KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP
AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE
SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV
FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT
HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL
YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT
QTPGWPCPSSDTHLPTHSGSL
NT seq 1326 nt   +upstreamnt  +downstreamnt
atgtgcccgcagctagcaggagctggcagcatgggctccccaggggctacgacaggctgg
gggcttctggattataagacggagaagtatgtgatgaccaggaactggcgggtgggcgcc
ctgcagaggctgctgcagtttgggatcgtggtctatgtggtagggtgggctctcctcgcc
aaaaaaggctaccaggagcgggacctggaaccccagttttccatcatcaccaaactcaaa
ggggtttccgtcactcagatcaaggagcttggaaaccggctgtgggatgtggccgacttc
gtgaagccacctcagggagagaacgtgttcttcttggtgaccaacttccttgtgacgcca
gcccaagttcagggcagatgcccagagcacccgtccgtcccactggctaactgctgggtc
gacgaggactgccccgaaggggagggaggcacacacagccacggtgtaaaaacaggccag
tgtgtggtgttcaatgggacccacaggacctgtgagatctggagttggtgccccgtggag
agtggcgttgtgccctcgaggcccctgctggcccaggcccagaacttcacactgttcatc
aaaaacacagtcaccttcagcaagttcaacttctctaagtccaatgccttggagacctgg
gaccccacctattttaagcactgccgctatgaaccacaattcagcccctactgtcccgtg
ttccgcattggggacctcgtggccaaggctggagggaccttcgaggacctggcgttgctg
ggtggctctgtaggcatcagagttcactgggattgtgacctggacaccggggactctggc
tgctggcctcactactccttccagctgcaggagaagagctacaacttcaggacagccact
cactggtgggagcaaccgggtgtggaggcccgcaccctgctcaagctctatggaatccgc
ttcgacatcctcgtcaccgggcaggcagggaagttcgggctcatccccacggccgtcaca
ctgggcaccggggcagcttggctgggcgtggtcacctttttctgtgacctgctactgctg
tatgtggatagagaagcccatttctactggaggacaaagtatgaggaggccaaggccccg
aaagcaaccgccaactctgtgtggagggagctggcccttgcatcccaagcccgactggcc
gagtgcctcagacggagctcagcacctgcacccacggccactgctgctgggagtcagaca
cagacaccaggatggccctgtccaagttctgacacccacttgccaacccattccgggagc
ctgtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (44)   
   RefSeq(nuc) (22)   
   GenBank (11)   
   EMBL (11)   
Protein domain (1)   
   Pfam (1)   
All databases (97)   

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