KEGG   Homo sapiens (human): 22978
Entry
22978             CDS       T01001                                 
Symbol
NT5C2, GMP, NT5B, PNT5, SPG45, SPG65, cN-II
Name
(RefSeq) 5'-nucleotidase, cytosolic II
  KO
K01081  5'-nucleotidase [EC:3.1.3.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
Module
hsa_M00958  Adenine ribonucleotide degradation, AMP => Urate
hsa_M00959  Guanine ribonucleotide degradation, GMP => Urate
Network
nt06027  Purine salvage pathway
  Element
N01418  Purine salvage pathway, adenine to AMP
N01421  Purine salvage pathway, hypoxanthine/guanine to IMP/GMP
Disease
H00266  Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    22978 (NT5C2)
   00240 Pyrimidine metabolism
    22978 (NT5C2)
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    22978 (NT5C2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.5  5'-nucleotidase
     22978 (NT5C2)
SSDB
Motif
Pfam: 5_nucleotid
Other DBs
NCBI-GeneID: 22978
NCBI-ProteinID: NP_001127845
OMIM: 600417
HGNC: 8022
Ensembl: ENSG00000076685
Pharos: P49902(Tbio)
UniProt: P49902 A0A384MED8 A8K6K2
Structure
Position
10:complement(103088017..103193272)
AA seq 561 aa
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE
NT seq 1686 nt   +upstreamnt  +downstreamnt
atgtcaacctcctggagtgatcggttacagaatgcagcagatatgcctgctaacatggat
aagcatgccctgaaaaagtatcgtcgagaagcctatcatcgggtgtttgtgaaccgaagt
ttagcaatggaaaagataaagtgttttggttttgatatggattatacccttgctgtgtac
aagtccccagagtatgagtcccttggttttgagcttactgtggagagattagtttctatt
ggctatccccaggagttgctcagctttgcttatgattctacattccctaccaggggactt
gtctttgacacactgtatggaaatcttttgaaagtcgatgcctatggaaacctcttggtc
tgtgcacatggatttaactttataaggggaccagaaactagagaacagtatccaaataaa
tttatccagcgagatgatactgaaagattttacattctgaacacactattcaacctacca
gagacctacctgttggcctgcctagtagatttttttactaattgtcccagatataccagt
tgtgaaacaggatttaaagatggggacctcttcatgtcctaccggagtatgttccaggat
gtaagagatgctgttgactgggttcattacaagggctcccttaaggaaaagacagttgaa
aatcttgagaagtatgtagtcaaagatggaaaactgcctttgcttctgagccggatgaag
gaagtagggaaagtatttcttgctaccaacagtgactataaatatacagataaaattatg
acttacctgtttgacttcccacatggccccaagcctgggagctcccatcgaccatggcag
tcctactttgacttgatcttggtggatgcacggaaaccactcttttttggagaaggcaca
gtactgcgtcaggtggatactaaaactggcaagctgaaaattggtacctacacagggccc
ctacagcatggtatcgtctactcaggaggttcttctgatacgatctgtgacctgttggga
gccaagggaaaagacattttgtatattggagatcacatttttggggacattttaaaatca
aagaaacggcaagggtggcgaacttttttggtgattcctgaactcgcacaggagctacat
gtctggactgacaagagttcacttttcgaagaacttcagagcttggatattttcttggct
gaactctacaagcatcttgacagcagtagcaatgagcgtccagacatcagttccatccag
agacgtattaagaaagtaactcatgacatggacatgtgctatgggatgatgggaagcctg
tttcgcagtggctcccggcagaccctttttgccagtcaagtgatgcgttatgctgacctc
tatgcagcatctttcatcaacctgctgtattaccctttcagctacctcttcagggctgcc
catgtcttgatgcctcatgaatcaacggtggagcacacacacgtagatatcaatgagatg
gagtctcctcttgccacccggaaccgcacatcagtggatttcaaagacactgactacaag
cggcaccagctgacacggtcaattagtgagattaaacctcccaacctcttcccactggcc
ccccaggaaattacacactgccatgacgaagatgatgatgaagaggaggaggaggaggaa
gaataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (30)   
   KEGG COMPOUND (30)   
Chemical reaction (15)   
   KEGG ENZYME (1)   
   KEGG REACTION (14)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   PHAROS (1)   
Protein sequence (78)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (74)   
DNA sequence (146)   
   RefSeq(nuc) (74)   
   GenBank (36)   
   EMBL (36)   
3D Structure (43)   
   PDB (43)   
Protein domain (1)   
   Pfam (1)   
All databases (344)   

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