KEGG   Homo sapiens (human): 23072
Entry
23072             CDS       T01001                                 
Symbol
HECW1, NEDL1
Name
(RefSeq) E3 ubiquitin-protein ligase HECW1 isoform a
  KO
K12167  E3 ubiquitin-protein ligase HECW1 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    23072 (HECW1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     23072 (HECW1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   23072 (HECW1)
SSDB
Motif
Pfam: HECT HECW_N HECW1_helix WW C2 Keratin_B2_2
Other DBs
NCBI-GeneID: 23072
NCBI-ProteinID: NP_055867
OMIM: 610384
HGNC: 22195
Ensembl: ENSP00000379228.1
UniProt: Q76N89
Structure
Position
7:43112647..43566001
AA seq 1606 aa
MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG
VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV
LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK
NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI
FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK
LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE
SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA
VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA
STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS
ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL
SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS
SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS
SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV
ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID
SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED
SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN
PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL
PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS
EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA
RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC
SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL
EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN
DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL
EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI
ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE
YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE
KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE
NT seq 4821 nt   +upstreamnt  +downstreamnt
atgctgctgcacctgtgtagtgtgaagaatctgtaccagaacaggtttttaggcctggcc
gccatggcgtctccttctagaaactcccagagccgacgccggtgcaaggagccgctccga
tacagctacaaccccgaccagttccacaacatggacctcaggggcggcccccacgatggc
gtcaccattccccgctccaccagcgacactgacctggtcacctcggacagccgctccacg
ctcatggtcagcagctcctactattccatcgggcactctcaggacctggtcatccactgg
gacataaaggaggaagtggacgctggggactggattggcatgtacctcattgatgaggtc
ttgtccgaaaactttctggactataaaaaccgtggagtcaatggttctcatcggggccag
atcatctggaagatcgatgccagctcgtactttgtggaacctgaaactaagatctgcttc
aaatactaccatggagtgagtggggccctgcgagcaaccacccccagtgtcacggtcaaa
aactcggcagctcctatttttaaaagcattggtgctgatgagaccgtccaaggacaagga
agtcggaggctgatcagcttctctctctcagatttccaagccatggggttgaagaaaggg
atgtttttcaacccagacccttatctgaagatttccattcagcctgggaaacacagcatc
ttccccgccctccctcaccatggacaggagaggagatccaagatcataggcaacaccgtg
aaccccatctggcaggccgagcaattcagttttgtgtccttgcccactgacgtgctggaa
attgaggtgaaggacaagtttgccaagagccgccccatcatcaagcgcttcttgggaaag
ctgtcgatgcccgttcaaagactcctggagagacacgccataggggatagggtggtcagc
tacacacttggccgcaggcttccaacagatcatgtgagtggacagctgcaattccgattt
gagatcacttcctccatccacccagatgatgaggagatttccctgagtaccgagcctgag
tcagcccaaattcaggacagccccatgaacaacctgatggaaagcggcagtggggaacct
cggtctgaggcaccagagtcctctgagagctggaagccagagcagctgggtgagggcagt
gtccccgatggtccagggaaccaaagcatagagctttccagaccagctgaggaagcagca
gtcatcacggaggcaggagaccagggcatggtctctgtgggacctgaaggggctggggag
ctcctggcccaggtgcaaaaggacatccagcctgcccccagtgcagaagagctggccgag
cagctggacctgggtgaggaggcatcagcactgctgctggaagacggtgaagccccagcc
agcaccaaggaggagcccttggaggaggaagcaacgacccagagccgggctggaagggaa
gaagaggagaaggagcaggaggaggagggagatgtgtctaccctggagcagggagagggc
aggctgcagctgcgggcctcggtgaagagaaaaagcaggccctgctccttgcctgtgtcc
gagctggagacggtgatcgcgtcagcctgcggggaccccgagaccccgcggacacactac
atccgcatccacaccctgctgcacagcatgccctccgcccagggcggcagcgcggcagag
gaggaggacggcgcggaggaggagtccaccctcaaggactcctcggagaaggatgggctc
agcgaggtggacacggtggccgctgacccgtctgccctggaagaggacagagaagagccc
gagggggctactccaggcacggcgcaccctggccactccgggggccacttccccagcctg
gccaatggcgcggcccaggatggcgacacgcaccccagcaccgggagcgagagcgactcc
agccccaggcaaggcggggaccacagttgcgagggctgtgacgcgtcctgctgcagcccc
tcgtgctacagctcctcgtgctacagcacgtcctgctacagcagctcgtgctacagcgcc
tcgtgctacagcccctcctgctacaacggcaacaggttcgccagccacacgcgcttctcc
tccgtggacagcgccaagatctccgagagcacggtcttctcctcgcaagacgacgaggag
gaggagaacagcgcgttcgagtcggtacccgactccatgcagagccctgagctggacccg
gagtccacgaacggcgctgggccgtggcaagacgagctggccgcccctagcgggcacgtg
gaaagaagcccggaaggtctggaatcccccgtggcaggtccaagcaatcggagagaaggt
gaatgtcctatactccataattcccagccagtaagccagcttccttccctgaggcctgaa
catcatcactacccaacaatcgatgagcctcttccaccaaactgggaagctcgaattgac
agccacgggcgggtcttttatgtggaccacgtgaaccgcacaaccacctggcagcgtccg
acggcagcagccaccccggatggcatgcggagatcggggtccatccagcagatggagcaa
ctcaacaggcggtatcaaaacattcagcgaaccattgcaacagagaggtccgaagaagat
tctggcagccaaagctgcgagcaagccccagcaggaggaggcggaggtggagggagtgac
tcagaagccgaatcttcccagtccagcttagatctaaggagagaagggtcactttctcca
gtgaactcacaaaaaatcaccttgctgctgcagtccccagcggtcaagttcatcaccaac
cccgagttcttcactgtgctacatgccaattatagtgcctaccgagtcttcaccagtagc
acctgcttaaagcacatgattctgaaagtccgacgggatgctcgcaattttgaacgctac
cagcacaaccgggacttggtgaatttcatcaacatgttcgcagacactcggctggaactg
ccccggggctgggagatcaaaacggaccagcagggaaagtcttttttcgtggaccacaac
agtcgagctaccactttcattgacccccgaatccctcttcagaacggtcgtcttcccaat
catctaactcaccgacagcacctccagaggctccgaagttacagcgctggagaggcctca
gaagtttctagaaacagaggagcctctttactggccaggccaggacacagcttagtagct
gctattcgaagccaacatcaacatgagtcattgccactggcatataatgacaagattgtg
gcatttcttcgccagccaaacatttttgaaatgctgcaagagcgtcagccaagcttagca
agaaaccacacactcagggagaaaatccattacattcggactgagggtaatcacgggctt
gagaagttgtcctgtgatgcggatctggtcattttgctgagtctctttgaagaagagatt
atgtcctacgtccccctgcaggctgccttccaccctgggtatagcttctctccccgatgt
tcaccctgttcttcacctcagaactccccaggtttacagagagccagtgcaagagcccct
tccccctaccgaagagactttgaggccaagctccgcaatttctacagaaaactggaagcc
aaaggatttggtcagggtccggggaaaattaagctcattattcgccgggatcatttgttg
gagggaaccttcaatcaggtgatggcctattcgcggaaagagctccagcgaaacaagctc
tacgtcacctttgttggagaggagggcctggactacagtggcccctcgcgggagttcttc
ttccttctgtctcaggagctcttcaacccttactatggactctttgagtactcggcaaat
gatacttacacggtgcagatcagccccatgtccgcatttgtagaaaaccatcttgagtgg
ttcaggtttagcggtcgcatcctgggtctggctctgatccatcagtaccttcttgacgct
ttcttcacgaggcccttctacaaggcactcctgagactgccctgtgatttgagtgacctg
gaatatttggatgaggaattccaccagagtttgcagtggatgaaggacaacaacatcaca
gacatcttagacctcactttcactgttaatgaagaggtttttggacaggtcacggaaagg
gagttgaagtctggaggagccaacacacaggtgacggagaaaaacaagaaggagtacatc
gagcgcatggtgaagtggcgggtggagcgcggcgtggtacagcagaccgaggcgctggtg
cgcggcttctacgaggttgtagactcgaggctggtgtccgtgtttgatgccagggagctg
gagctggtgatagctggcaccgcggaaatcgacctaaatgactggcggaataacactgag
taccggggaggttaccacgatgggcatcttgtgatccgctggttctgggctgcggtggag
cgcttcaataatgagcagaggctgagattactgcagtttgtcacgggaacatccagcgtg
ccctacgaaggcttcgcagccctccgtgggagcaatgggcttcggcgcttctgcatagag
aaatgggggaaaattacttctctccccagggcacacacatgcttcaaccgactggatctt
ccaccgtatccctcgtactccatgttgtatgaaaagctgttaacagcagtagaggaaacc
agcacctttggacttgagtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (32)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (38)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (36)   
DNA sequence (52)   
   RefSeq(nuc) (36)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   Pfam (6)   
All databases (130)   

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