KEGG   Homo sapiens (human): 2308
Entry
2308              CDS       T01001                                 
Symbol
FOXO1, FKH1, FKHR, FOXO1A
Name
(RefSeq) forkhead box O1
  KO
K07201  forkhead box protein O1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04910  Insulin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04922  Glucagon signaling pathway
hsa04931  Insulin resistance
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05131  Shigellosis
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05215  Prostate cancer
Network
nt06240  Transcription (cancer)
  Element
N00141  PAX3-FOXO1 fusion to transcriptional activation
Disease
H00037  Rhabdomyosarcoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    2308 (FOXO1)
   04152 AMPK signaling pathway
    2308 (FOXO1)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    2308 (FOXO1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    2308 (FOXO1)
   04922 Glucagon signaling pathway
    2308 (FOXO1)
   04919 Thyroid hormone signaling pathway
    2308 (FOXO1)
  09149 Aging
   04211 Longevity regulating pathway
    2308 (FOXO1)
   04213 Longevity regulating pathway - multiple species
    2308 (FOXO1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2308 (FOXO1)
   05202 Transcriptional misregulation in cancer
    2308 (FOXO1)
  09162 Cancer: specific types
   05215 Prostate cancer
    2308 (FOXO1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    2308 (FOXO1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    2308 (FOXO1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    2308 (FOXO1)
   04931 Insulin resistance
    2308 (FOXO1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    2308 (FOXO1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2308 (FOXO1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix other regulators
    2308 (FOXO1)
SSDB
Motif
Pfam: FOXO_KIX_bdg Forkhead FOXO-TAD
Other DBs
NCBI-GeneID: 2308
NCBI-ProteinID: NP_002006
OMIM: 136533
HGNC: 3819
Ensembl: ENSG00000150907
UniProt: Q12778
Structure
Position
13:complement(40555667..40666641)
AA seq 655 aa
MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPS
ASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHP
APPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKR
LTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLN
PEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPG
SHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLP
SLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPN
YQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPV
DPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLP
HTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPS
DLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG
NT seq 1968 nt   +upstreamnt  +downstreamnt
atggccgaggcgcctcaggtggtggagatcgacccggacttcgagccgctgccccggccg
cgctcgtgcacctggccgctgcccaggccggagtttagccagtccaactcggccacctcc
agcccggcgccgtcgggcagcgcggctgccaaccccgacgccgcggcgggcctgccctcg
gcctcggctgccgctgtcagcgccgacttcatgagcaacctgagcttgctggaggagagc
gaggacttcccgcaggcgcccggctccgtggcggcggcggtggcggcggcggccgccgcg
gccgccaccggggggctgtgcggggacttccagggcccggaggcgggctgcctgcaccca
gcgccaccgcagcccccgccgcccgggccgctgtcgcagcacccgccggtgccccccgcc
gccgctgggccgctcgcggggcagccgcgcaagagcagctcgtcccgccgcaacgcgtgg
ggcaacctgtcctacgccgacctcatcaccaaggccatcgagagctcggcggagaagcgg
ctcacgctgtcgcagatctacgagtggatggtcaagagcgtgccctacttcaaggataag
ggtgacagcaacagctcggcgggctggaagaattcaattcgtcataatctgtccctacac
agcaagttcattcgtgtgcagaatgaaggaactggaaaaagttcttggtggatgctcaat
ccagagggtggcaagagcgggaaatctcctaggagaagagctgcatccatggacaacaac
agtaaatttgctaagagccgaagccgagctgccaagaagaaagcatctctccagtctggc
caggagggtgctggggacagccctggatcacagttttccaaatggcctgcaagccctggc
tctcacagcaatgatgactttgataactggagtacatttcgccctcgaactagctcaaat
gctagtactattagtgggagactctcacccattatgaccgaacaggatgatcttggagaa
ggggatgtgcattctatggtgtacccgccatctgccgcaaagatggcctctactttaccc
agtctgtctgagataagcaatcccgaaaacatggaaaatcttttggataatctcaacctt
ctctcatcaccaacatcattaactgtttcgacccagtcctcacctggcaccatgatgcag
cagacgccgtgctactcgtttgcgccaccaaacaccagtttgaattcacccagcccaaac
taccaaaaatatacatatggccaatccagcatgagccctttgccccagatgcctatacaa
acacttcaggacaataagtcgagttatggaggtatgagtcagtataactgtgcgcctgga
ctcttgaaggagttgctgacttctgactctcctccccataatgacattatgacaccagtt
gatcctggggtagcccagcccaacagccgggttctgggccagaacgtcatgatgggccct
aattcggtcatgtcaacctatggcagccaggcatctcataacaaaatgatgaatcccagc
tcccatacccaccctggacatgctcagcagacatctgcagttaacgggcgtcccctgccc
cacacggtaagcaccatgccccacacctcgggtatgaaccgcctgacccaagtgaagaca
cctgtacaagtgcctctgccccaccccatgcagatgagtgccctggggggctactcctcc
gtgagcagctgcaatggctatggcagaatgggccttctccaccaggagaagctcccaagt
gacttggatggcatgttcattgagcgcttagactgtgacatggaatccatcattcggaat
gacctcatggatggagatacattggattttaactttgacaatgtgttgcccaaccaaagc
ttcccacacagtgtcaagacaacgacacatagctgggtgtcaggctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (19)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (21)   
   RefSeq(nuc) (5)   
   GenBank (8)   
   EMBL (8)   
3D Structure (11)   
   PDB (11)   
Protein domain (3)   
   Pfam (3)   
All databases (63)   

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