KEGG   Homo sapiens (human): 2309
Entry
2309              CDS       T01001                                 
Symbol
FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Name
(RefSeq) forkhead box O3
  KO
K09408  forkhead box protein O3
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04062  Chemokine signaling pathway
hsa04068  FoxO signaling pathway
hsa04137  Mitophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04722  Neurotrophin signaling pathway
hsa04917  Prolactin signaling pathway
hsa04936  Alcoholic liver disease
hsa05131  Shigellosis
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05213  Endometrial cancer
hsa05223  Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    2309 (FOXO3)
   04151 PI3K-Akt signaling pathway
    2309 (FOXO3)
   04152 AMPK signaling pathway
    2309 (FOXO3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    2309 (FOXO3)
  09143 Cell growth and death
   04218 Cellular senescence
    2309 (FOXO3)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2309 (FOXO3)
  09152 Endocrine system
   04917 Prolactin signaling pathway
    2309 (FOXO3)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    2309 (FOXO3)
  09149 Aging
   04211 Longevity regulating pathway
    2309 (FOXO3)
   04213 Longevity regulating pathway - multiple species
    2309 (FOXO3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    2309 (FOXO3)
  09162 Cancer: specific types
   05213 Endometrial cancer
    2309 (FOXO3)
   05223 Non-small cell lung cancer
    2309 (FOXO3)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    2309 (FOXO3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    2309 (FOXO3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    2309 (FOXO3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2309 (FOXO3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix other regulators
    2309 (FOXO3)
SSDB
Motif
Pfam: FOXO_KIX_bdg Forkhead FOXO-TAD
Other DBs
NCBI-GeneID: 2309
NCBI-ProteinID: NP_001446
OMIM: 602681
HGNC: 3821
Ensembl: ENSG00000118689
UniProt: O43524
Structure
Position
6:108559825..108684774
AA seq 673 aa
MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE
EDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS
GGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTL
SQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDG
GKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSS
DELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSK
PCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKG
SGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLS
HSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQT
QGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLP
VMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFT
GAKQASSQSWVPG
NT seq 2022 nt   +upstreamnt  +downstreamnt
atggcagaggcaccggcttccccggccccgctctctccgctcgaagtggagctggacccg
gagttcgagccccagagccgtccgcgatcctgtacgtggcccctgcaaaggccggagctc
caagcgagccctgccaagccctcgggggagacggccgccgactccatgatccccgaggag
gaggacgatgaagacgacgaggacggcgggggacgggccggctcggccatggcgatcggc
ggcggcggcgggagcggcacgctgggctccgggctgctccttgaggactcggcccgggtg
ctggcacccggagggcaagaccccgggtctgggccagccaccgcggcgggcgggctgagc
gggggtacacaggcgctgctgcagcctcagcaaccgctgccaccgccgcagccgggggcg
gctgggggctccgggcagccgaggaaatgttcgtcgcggcggaacgcctggggaaacctg
tcctacgcggacctgatcacccgcgccatcgagagctccccggacaaacggctcactctg
tcccagatctacgagtggatggtgcgttgcgtgccctacttcaaggataagggcgacagc
aacagctctgccggctggaagaactccatccggcacaacctgtcactgcatagtcgattc
atgcgggtccagaatgagggaactggcaagagctcttggtggatcatcaaccctgatggg
gggaagagcggaaaagccccccggcggcgggctgtctccatggacaatagcaacaagtat
accaagagccgtggccgcgcagccaagaagaaggcagccctgcagacagcccccgaatca
gctgacgacagtccctcccagctctccaagtggcctggcagccccacgtcacgcagcagt
gatgagctggatgcgtggacggacttccgttcacgcaccaattctaacgccagcacagtc
agtggccgcctgtcgcccatcatggcaagcacagagttggatgaagtccaggacgatgat
gcgcctctctcgcccatgctctacagcagctcagccagcctgtcaccttcagtaagcaag
ccgtgcacggtggaactgccacggctgactgatatggcaggcaccatgaatctgaatgat
gggctgactgaaaacctcatggacgacctgctggataacatcacgctcccgccatcccag
ccatcgcccactgggggactcatgcagcggagctctagcttcccgtataccaccaagggc
tcgggcctgggctccccaaccagctcctttaacagcacggtgttcggaccttcatctctg
aactccctacgccagtctcccatgcagaccatccaagagaacaagccagctaccttctct
tccatgtcacactatggtaaccagacactccaggacctgctcacttcggactcacttagc
cacagcgatgtcatgatgacacagtcggaccccttgatgtctcaggccagcaccgctgtg
tctgcccagaattcccgccggaacgtgatgcttcgcaatgatccgatgatgtcctttgct
gcccagcctaaccagggaagtttggtcaatcagaacttgctccaccaccagcaccaaacc
cagggcgctcttggtggcagccgtgccttgtcgaattctgtcagcaacatgggcttgagt
gagtccagcagccttgggtcagccaaacaccagcagcagtctcctgtcagccagtctatg
caaaccctctcggactctctctcaggctcctccttgtactcaactagtgcaaacctgccc
gtcatgggccatgagaagttccccagcgacttggacctggacatgttcaatgggagcttg
gaatgtgacatggagtccattatccgtagtgaactcatggatgctgatgggttggatttt
aactttgattccctcatctccacacagaatgttgttggtttgaacgtggggaacttcact
ggtgctaagcaggcctcatctcagagctgggtgccaggctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (19)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (18)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (54)   
   RefSeq(nuc) (16)   
   GenBank (19)   
   EMBL (19)   
3D Structure (6)   
   PDB (6)   
Protein domain (3)   
   Pfam (3)   
All databases (101)   

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