KEGG   Homo sapiens (human): 23175
Entry
23175             CDS       T01001                                 

Gene name
LPIN1, PAP1
Definition
(RefSeq) lipin 1
  KO
K15728  phosphatidate phosphatase LPIN [EC:3.1.3.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00561  Glycerolipid metabolism
hsa00564  Glycerophospholipid metabolism
hsa01100  Metabolic pathways
hsa04150  mTOR signaling pathway
Module
hsa_M00089  Triacylglycerol biosynthesis
Disease
H01290  Acute recurrent myoglobinuria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    23175 (LPIN1)
   00564 Glycerophospholipid metabolism
    23175 (LPIN1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    23175 (LPIN1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    23175 (LPIN1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     23175 (LPIN1)
Protein phosphatases and associated proteins [BR:hsa01009]
 HAD phosphatases
  Other HAD phosphatases
   23175 (LPIN1)
SSDB
Motif
Pfam: LNS2 Lipin_N Lipin_mid WRNPLPNID
Other DBs
NCBI-GeneID: 23175
NCBI-ProteinID: NP_663731
OMIM: 605518
HGNC: 13345
Ensembl: ENSG00000134324
Vega: OTTHUMG00000119082
Pharos: Q14693(Tbio)
UniProt: Q14693
Position
2p25.1
AA seq 890 aa
MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRS
REKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQL
KRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDED
MFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTP
SPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRK
ICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPM
IEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDP
SGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITK
DAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVES
IMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSS
SDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCR
CEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFL
YCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCL
TDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYV
RLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHSASA
NT seq 2673 nt   +upstreamnt  +downstreamnt
atgaattacgtggggcagttagccggccaggtgtttgtcaccgtgaaggagctctacaag
gggctgaatcccgccacactctcagggtgcattgacatcattgtcatccgccagcccaat
ggaaacctccaatgctcccctttccacgtccgctttgggaagatgggggtcctgcgctcc
cgagagaaagtggttgacatagaaatcaatggggaatctgtggatttgcatatgaaattg
ggagataatggagaagcattttttgttcaagaaacagataatgatcaggaagttatccct
atgcacctggccacctcccccatcctgtcagaaggagcttcgagaatggaatgccagctg
aaaaggggctctgtggacaggatgagaggcctggaccccagcacgccagcccaagtgatc
gctcccagcgagacgccgtcaagcagctctgtagtaaagaagagaagaaaaaggaggaga
aagtcacagctggacagcctgaagagagatgacaacatgaacacatctgaggatgaggac
atgttccccatcgagatgagctcggatgaggccatggagctgctggagagcagcagaact
cttcctaatgatatacctccattccaagatgatattcctgaggaaaacctctccctggct
gtgatttaccctcagtcagcctcataccctaattcggatagagagtggtcacccactccc
agtccttccggttcccgaccttcaacacctaaaagtgattcagaattggtcagcaagtcc
acggaaaggacagggcagaagaacccagaaatgctttggctgtggggagagctgccgcag
gctgctaagtcttcttctccacacaagatgaaagagtccagcccattgagcagtagaaaa
atttgtgataaaagtcactttcaggccattcacagcgaatcttcagacacttttagtgac
caatcgccaactctggtcggtggggcacttttggaccagaacaagcctcagacagaaatg
cagtttgtgaatgaagaagacctggagaccttaggagcagcagcgccactcttgcccatg
atcgaggagctcaaacccccctctgccagtgtagtccagacagcaaacaagacggattct
ccttccaggaaaagagataaacgaagccgacatcttggtgctgacggcgtctacttggat
gacctcacagacatggatcctgaagtggcggccctgtattttcccaaaaacggagatcct
tccggactcgcaaaacatgcaagcgacaacggagcccggtcagccaaccagtccccgcag
tcggtgggcagctcgggcgtggacagtggcgtggagagcacctcggacgggctgagggac
ctcccttccatcgccatctccctctgcgggggcctcagcgaccaccgggagatcacgaaa
gatgcattcctggagcaagctgtgtcatatcaacagtttgtggacaaccccgctattatc
gatgaccccaatctcgtggtaaagattgggagtaaatattataactggacaacagcagca
cccctcctcctggcaatgcaggccttccagaaacctttgccaaaggccactgtggaatct
atcatgagggataaaatgcccaaaaagggaggaagatggtggttttcatggaggggaaga
aacaccacaatcaaggaggaaagtaagccagagcagtgcttggctggcaaggcccatagc
accggagagcaaccgccgcagctcagcttggccaccagggtaaagcatgaatcatcctcc
agtgatgaggagcgcgcagctgccaagccatcaaacgcaggccacctccctcttctgcct
aatgtcagctacaagaagactctccggctgacttccgagcagcttaaaagcttgaagttg
aagaatggccccaacgacgtggttttcagtgtcaccacgcagtaccaaggcacgtgccgc
tgtgagggcaccatctatctgtggaactgggatgataaagtcatcatttctgatattgat
gggacaattaccagatcagatactcttggccacattttgcccacccttgggaaggattgg
acccatcagggcatcgctaagctgtaccataaagtgagccagaatggatataaatttctc
tactgttctgcccgtgccatcgggatggcggacatgacgcggggctacctgcactgggtc
aacgagaggggcacggtgctgccccaggggcccctgctgctgagtcccagcagcctcttc
tctgccctgcacagagaagtgattgaaaagaagccagaaaagtttaaagtccagtgtttg
acagacatcaaaaacctgtttttccccaacacagaacccttttatgctgcttttggaaac
cgaccagctgatgtgtattcatacaagcaagtaggagtgtctttgaatagaatatttacc
gtcaaccctaaaggagagctggtacaggaacatgcaaagaccaacatctcttcgtatgtg
agactctgtgaagtagtcgaccacgttttcccgttgctgaaaagaagccattcttcagac
tttccctgttcggataccttcagtaacttcaccttttggagagagccactgccacctttt
gaaaaccaggacattcattctgcctcagcgtaa

KEGG   Homo sapiens (human): 64900
Entry
64900             CDS       T01001                                 

Gene name
LPIN3, LIPN3L, SMP2, dJ620E11.2
Definition
(RefSeq) lipin 3
  KO
K15728  phosphatidate phosphatase LPIN [EC:3.1.3.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00561  Glycerolipid metabolism
hsa00564  Glycerophospholipid metabolism
hsa01100  Metabolic pathways
hsa04150  mTOR signaling pathway
Module
hsa_M00089  Triacylglycerol biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    64900 (LPIN3)
   00564 Glycerophospholipid metabolism
    64900 (LPIN3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    64900 (LPIN3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    64900 (LPIN3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     64900 (LPIN3)
Protein phosphatases and associated proteins [BR:hsa01009]
 HAD phosphatases
  Other HAD phosphatases
   64900 (LPIN3)
SSDB
Motif
Pfam: LNS2 Lipin_N Lipin_mid WRNPLPNID
Other DBs
NCBI-GeneID: 64900
NCBI-ProteinID: NP_001288789
OMIM: 605520
HGNC: 14451
Ensembl: ENSG00000132793
Vega: OTTHUMG00000033056
Pharos: Q9BQK8(Tbio)
UniProt: Q9BQK8
Position
20q12
AA seq 852 aa
MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRS
REKVVDIELNGEPVDLHMKLGDSGEAFFVQELESDDEHVPPGLCTSPIPWGGLSGFPSDS
QLGTASEPEGLVMAGTASTGRRKRRRRRKPKQKEDAVATDSSPEELEAGAESELSLPEKL
RPEPPGSVQLEEKSSLQPKDIYPYSDGEWPPQASLSAGELTSPKSDSELEVRTPEPSPLR
AESHMQWAWGRLPKVARAERPESSVVLEGRAGATSPPRGGPSTPSTSVAGGVDPLGLPIQ
QTEAGADLQPDTEDPTLVGPPLHTPETEESKTQSSGDMGLPPASKSWSWATLEVPVPTGQ
PERVSRGKGSPKRSQHLGPSDIYLDDLPSLDSENAALYFPQSDSGLGARRWSEPSSQKSL
RDPNPEHEPEPTLDTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTKNPGLLDDPNL
VVKINGKHYNWAVAAPMILSLQAFQKNLPKSTMDKLEREKMPRKGGRWWFSWRRRDFLAE
ERSAQKEKTAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPSTPPSTPTYKKSLRLSSD
QIRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDDKVVISDIDGTITKSDALGHIL
PQLGKDWTHQGITSLYHKIQLNGYKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGPIL
LSPSSLFSALHREVIEKKPEVFKVACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQVGL
PESRIFTVNPRGELIQELIKNHKSTYERLGEVVELLFPPVARGPSTDLANPEYSNFCYWR
EPLPAVDLDTLD
NT seq 2559 nt   +upstreamnt  +downstreamnt
atgaactacgtggggcagctggcggagacggtgtttgggacggtgaaggagctgtaccgg
ggcctgaacccagccacactgagcggcggcattgacgtgctggtggtgaagcaggtggac
ggctcgttccggtgctcacccttccacgtgcgttttggcaagctgggcgtcctgcggtcg
cgggagaaggtggtagacattgagctcaatggggagcctgtggacttgcacatgaagctt
ggggacagcggggaggccttctttgttcaggagctggagagcgatgatgaacatgtgcct
cccggcctgtgcacctcacccatcccttgggggggtctgtctggcttcccctcggactcc
cagctgggcactgccagtgagcctgagggcctcgtcatggcaggcacggcctccactggg
cggaggaagaggcgtcgcaggaggaaacccaagcagaaagaggatgcagtggcaactgat
tctagtccagaggaactggaggcaggcgctgagagtgagctatccctgccggaaaagctg
aggccagagcccccaggcagtgtccagttggaagagaagtcttcactgcagcccaaagac
atctacccctactcggatggcgagtggcccccccaggccagcctctcagcaggtgagcta
acatcccctaagagcgactcggagctggaggtgcggaccccggagcccagtcccctaaga
gccgagtcccacatgcagtgggcctgggggaggctgcctaaggtggccagagctgagcgg
cccgagtcctcagtggtccttgaaggcagagctggggcaacctctcctcctcggggagga
cccagcactccctctacctctgtggctggcggcgtggaccctttgggactcccaatccag
caaacagaggctggtgccgaccttcagcctgacacagaggatcccactctagtgggtccc
cctctccacaccccagagacagaggaaagcaagactcagagctctggggacatgggcctc
cctcctgcctccaagtcatggagctgggccactctggaggttccagttcccaccgggcag
ccagagagggtctccagggggaaaggctccccaaagagaagccagcacctgggccccagt
gacatctacctggatgacttgccctccctggactctgagaatgcagcgctttacttcccc
caaagtgactctgggctgggggccagaagatggagtgaacccagcagtcagaagtccctg
agggaccccaaccctgaacatgaacctgaacccactctggacacagtggatacaatagca
ctgtccctctgtggtggactggctgacagccgggacatctccctagagaaattcaaccag
cacagcgtctcttaccaggacctcaccaaaaaccccggacttttggatgacccaaaccta
gtggtgaaaatcaatggaaagcattataactgggctgtggctgcccccatgatcctctcc
ctgcaagccttccagaaaaacttgcccaagagcaccatggacaagctggagagggagaag
atgccccggaagggtgggcgatggtggttttcctggcgacgcagggacttcctggccgag
gagcgcagtgcccagaaggagaagactgcagccaaggagcagcagggggagaagacagaa
gtcctgagcagtgatgacgatgccccagacagccctgtgatcctggagatcccctccttg
ccaccctccactccaccctccactcctacctacaagaagtccctccgcctctcctccgat
cagatccggcgcctgaacctgcaagaaggtgccaatgatgtggtcttcagcgtgaccact
cagtaccagggcacctgccgctgcaaggccaccatctacctgtggaaatgggacgacaag
gtggtcatctctgacatcgacggcaccatcaccaagtcagatgctctgggccatatcctg
ccccagctggggaaagactggacacaccagggcatcaccagtctctatcacaaaatccaa
ctaaatgggtacaagttcctgtactgctcggcgcgggccattggcatggcggacctcacc
aaggggtacctgcagtgggtgagcgaggggggctgtagcctccccaagggccccatcctt
ctgtctcccagcagcctcttctctgccctccacagagaggtgatcgagaagaaaccagag
gtgttcaaggtcgcctgcctgagtgacatccagcagctgtttctgccccacggacagccc
ttctatgctgcctttgggaataggcccaatgatgtctttgcctaccggcaggtgggcctg
cctgagtcacgcatcttcacagtcaacccccggggagagctcatccaggagctcataaag
aaccacaaatccacgtatgagcggcttggtgaagtggtcgagctcctcttcccacctgtg
gcccgtggccccagcacagacctggccaaccctgaatacagtaacttctgctactggcgg
gagccactgcctgctgtggaccttgataccctggactga

KEGG   Homo sapiens (human): 9663
Entry
9663              CDS       T01001                                 

Gene name
LPIN2
Definition
(RefSeq) lipin 2
  KO
K15728  phosphatidate phosphatase LPIN [EC:3.1.3.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00561  Glycerolipid metabolism
hsa00564  Glycerophospholipid metabolism
hsa01100  Metabolic pathways
hsa04150  mTOR signaling pathway
Module
hsa_M00089  Triacylglycerol biosynthesis
Disease
H01117  Chronic recurrent multifocal osteomyelitis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    9663 (LPIN2)
   00564 Glycerophospholipid metabolism
    9663 (LPIN2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    9663 (LPIN2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    9663 (LPIN2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     9663 (LPIN2)
Protein phosphatases and associated proteins [BR:hsa01009]
 HAD phosphatases
  Other HAD phosphatases
   9663 (LPIN2)
SSDB
Motif
Pfam: LNS2 Lipin_N Lipin_mid WRNPLPNID
Other DBs
NCBI-GeneID: 9663
NCBI-ProteinID: NP_055461
OMIM: 605519
HGNC: 14450
Ensembl: ENSG00000101577
Vega: OTTHUMG00000131508
Pharos: Q92539(Tbio)
UniProt: Q92539
Position
18p11.31
AA seq 896 aa
MNYVGQLAGQVIVTVKELYKGINQATLSGCIDVIVVQQQDGSYQCSPFHVRFGKLGVLRS
KEKVIDIEINGSAVDLHMKLGDNGEAFFVEETEEEYEKLPAYLATSPIPTEDQFFKDIDT
PLVKSGGDETPSQSSDISHVLETETIFTPSSVKKKKRRRKKYKQDSKKEEQAASAAAEDT
CDVGVSSDDDKGAQAARGSSNASLKEEECKEPLLFHSGDHYPLSDGDWSPLETTYPQTAC
PKSDSELEVKPAESLLRSESHMEWTWGGFPESTKVSKRERSDHHPRTATITPSENTHFRV
IPSEDNLISEVEKDASMEDTVCTIVKPKPRALGTQMSDPTSVAELLEPPLESTQISSMLD
ADHLPNAALAEAPSESKPAAKVDSPSKKKGVHKRSQHQGPDDIYLDDLKGLEPEVAALYF
PKSESEPGSRQWPESDTLSGSQSPQSVGSAAADSGTECLSDSAMDLPDVTLSLCGGLSEN
GEISKEKFMEHIITYHEFAENPGLIDNPNLVIRIYNRYYNWALAAPMILSLQVFQKSLPK
ATVESWVKDKMPKKSGRWWFWRKRESMTKQLPESKEGKSEAPPASDLPSSSKEPAGARPA
ENDSSSDEGSQELEESITVDPIPTEPLSHGSTTSYKKSLRLSSDQIAKLKLHDGPNDVVF
SITTQYQGTCRCAGTIYLWNWNDKIIISDIDGTITKSDALGQILPQLGKDWTHQGIAKLY
HSINENGYKFLYCSARAIGMADMTRGYLHWVNDKGTILPRGPLMLSPSSLFSAFHREVIE
KKPEKFKIECLNDIKNLFAPSKQPFYAAFGNRPNDVYAYTQVGVPDCRIFTVNPKGELIQ
ERTKGNKSSYHRLSELVEHVFPLLSKEQNSAFPCPEFSSFCYWRDPIPEVDLDDLS
NT seq 2691 nt   +upstreamnt  +downstreamnt
atgaattatgtgggacagctggctgggcaggtgattgtcactgtgaaggaactctacaag
ggcattaaccaggccaccctctctgggtgcattgatgtcatcgtggtacagcagcaggat
ggcagctatcagtgttcaccttttcacgttcggtttggaaagctgggagtcctgagatcc
aaagagaaagtgattgatatagaaatcaacggcagtgcagtggatcttcacatgaagttg
ggtgataacggagaagctttctttgttgaggagactgaagaagaatatgaaaagcttcct
gcttaccttgccacctcaccaattcctactgaagatcagttctttaaagatattgacacc
cctttggtgaaatcgggtggagatgaaacaccatctcagagttcagacatctcacacgtc
ttggaaacagagacaatttttactccaagttctgtgaaaaagaaaaaacgaaggagaaag
aaatacaaacaggacagtaagaaggaagagcaggccgcatctgctgctgcagaagacaca
tgtgatgtaggcgtgagctccgatgatgacaagggggcccaggcagcacgaggatcttca
aatgcttccttgaaagaagaagaatgtaaagagcctttgctcttccattctggggatcat
taccccttatctgatggagattggtcccctttagagaccacctatccccagacagcgtgt
cctaagagtgattcagagctggaggtgaaacctgcggagagcctgctcagatcagagtct
cacatggagtggacgtggggcggattcccagagtccaccaaggtcagcaaaagagaacga
tctgaccatcatcctaggacagctacaattacaccatcagaaaatactcattttcgggta
attcccagtgaggacaacctcatcagtgaagttgagaaggatgcttccatggaagacact
gtctgtaccatagtgaagcccaaacccagagccctgggtacacagatgagcgacccaaca
tctgtggcagagcttctcgaacctcctcttgagagtactcagatttcatctatgttagat
gctgaccaccttcccaacgcagccttagcggaggcgccctcagaatccaaaccggcagct
aaagtagactcgccgtcaaagaagaaaggtgttcacaaaagaagccaacaccagggacct
gatgatatttaccttgatgacttaaagggtctagaacctgaagttgcagctctttatttc
cctaaaagtgaatcggagcccggttccaggcagtggcccgagtctgacacactctctggc
tcccagtccccacagtccgtgggaagcgcagctgcagatagcggcaccgagtgcctctca
gattctgccatggacttgcctgacgttaccctctccctttgcgggggcctcagtgaaaat
ggagaaatttcaaaagaaaaattcatggagcatatcattacttatcacgaatttgcagaa
aaccctggacttatagacaatcctaaccttgtaataaggatatataatcgttactataac
tgggctttggcagctcccatgatccttagcttgcaagtattccagaagagcttgcctaag
gccacagttgagtcctgggtgaaagacaagatgccaaagaaatctggtcgctggtggttt
tggcgaaagagagaaagcatgaccaaacagctgccagaatccaaggagggaaaatctgag
gcaccgccagccagtgacctgccatccagctccaaggagccggccggtgccaggccggcc
gagaatgactcctcgagtgacgagggatcacaggagctcgaagaatccatcacagtggac
cccatccccacagagcccctgagccacggcagcacaacttcatataagaagtctctccgc
ctctcctcagaccagatcgcaaaactgaagctccacgatggcccaaatgatgttgtgttt
agtattacaacccagtatcaaggcacctgtcgctgtgcagggaccatttacctgtggaac
tggaatgacaagatcatcatttctgatattgatgggacaataaccaagtcggatgctttg
ggacagattctcccacagctgggcaaagactggacccaccagggtatagcaaagctctac
cattccatcaatgagaatggctacaagtttctgtactgctcggctcgtgccatcggcatg
gccgacatgacccgtggctacctgcactgggtcaatgacaagggcacaatcttgccccgg
ggccccctgatgctgtcccccagcagcttgttctccgccttccacagagaagtgatagaa
aagaaaccagagaagttcaaaattgagtgtctaaatgatatcaagaatctgtttgccccg
tctaagcagcccttctatgctgcctttggaaaccgtccaaatgatgtctatgcctacaca
caagttggagttccagactgtagaatattcaccgtgaaccccaagggtgaattaatacaa
gaaagaaccaaaggaaacaagtcatcgtatcacaggctgagtgagctcgtggagcatgtg
ttcccccttctcagtaaggagcagaattccgcttttccctgcccggagttcagctccttc
tgctactggcgagacccgatccctgaagtggacctggatgacctgtcttga

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