KEGG T01001: 2322

Homo sapiens (human): 2322

Entry

2322              CDS       T01001

Symbol

FLT3, CD135, FLK-2, FLK2, STK1

Name

(RefSeq) fms related receptor tyrosine kinase 3

K05092

fms-related tyrosine kinase 3 [EC:2.7.10.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04151

PI3K-Akt signaling pathway

hsa04640

Hematopoietic cell lineage

hsa05200

Pathways in cancer

hsa05202

Transcriptional misregulation in cancer

hsa05221

Acute myeloid leukemia

hsa05230

Central carbon metabolism in cancer

Network

nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06219  JAK-STAT signaling (cancer)
nt06240  Transcription (cancer)
nt06262  Pancreatic cancer
nt06275  Acute myeloid leukemia
nt06526  MAPK signaling
nt06530  PI3K signaling

Element

N00004

Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway

N00031

Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway

N00054

Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway

N00119

MLL-AF4 fusion to transcriptional activation

N00217

FLT3LG-FLT3-RAS-ERK signaling pathway

N00218

FLT3LG-FLT3-RAS-PI3K signaling pathway

N00219

FLT3LG-FLT3-STAT5 signaling pathway

N01592

GF-RTK-RAS-ERK signaling pathway

N01599

Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL

N01656

GF-RTK-PI3K signaling pathway

N01658

GF-RTK-RAS-PI3K signaling pathway

Disease

H00003

Acute myeloid leukemia

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

Drug target

Crenolanib (DG01361):

D10102 D10103

Dovitinib lactate:

D08907

Emirodatamab:

D12641

Gilteritinib (DG01948):

D10709 D10800<JP/US>

Lestaurtinib:

D04696

Midostaurin:

D05029<US>

Pacritinib:

D11768<US>

Pexidartinib (DG02960):

D11270 D11271<US>

Quizartinib (DG01364):

D09955 D09956<JP/US>

Semaxanib:

D05819

Sorafenib (DG00713):

D06272<JP/US> D08524

Sunitinib (DG00712):

D06402<JP/US> D08552

Tandutinib:

D06005

Tozasertib (DG01365):

D08279 D08344

Tuspetinib:

D12476

Zotiraciclib (DG03058):

D11599 D11600

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    2322 (FLT3)
   04014 Ras signaling pathway
    2322 (FLT3)
   04151 PI3K-Akt signaling pathway
    2322 (FLT3)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    2322 (FLT3)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2322 (FLT3)
   05202 Transcriptional misregulation in cancer
    2322 (FLT3)
   05230 Central carbon metabolism in cancer
    2322 (FLT3)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    2322 (FLT3)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2322 (FLT3)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    2322 (FLT3)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     2322 (FLT3)
Protein kinases [BR:hsa01001]
Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   2322 (FLT3)
CD molecules [BR:hsa04090]
Proteins
  2322 (FLT3)

SSDB

Motif

Pfam:

PK_Tyr_Ser-Thr Pkinase ig I-set Ig_3 Ig_2 Haspin_kinase APH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

13:complement(28003274..28100576)

AA seq 993 aa
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS

NT seq 2982 nt +upstreamnt +downstreamnt
atgccggcgttggcgcgcgacggcggccagctgccgctgctcgttgttttttctgcaatg
atatttgggactattacaaatcaagatctgcctgtgatcaagtgtgttttaatcaatcat
aagaacaatgattcatcagtggggaagtcatcatcatatcccatggtatcagaatccccg
gaagacctcgggtgtgcgttgagaccccagagctcagggacagtgtacgaagctgccgct
gtggaagtggatgtatctgcttccatcacactgcaagtgctggtcgacgccccagggaac
atttcctgtctctgggtctttaagcacagctccctgaattgccagccacattttgattta
caaaacagaggagttgtttccatggtcattttgaaaatgacagaaacccaagctggagaa
tacctactttttattcagagtgaagctaccaattacacaatattgtttacagtgagtata
agaaataccctgctttacacattaagaagaccttactttagaaaaatggaaaaccaggac
gccctggtctgcatatctgagagcgttccagagccgatcgtggaatgggtgctttgcgat
tcacagggggaaagctgtaaagaagaaagtccagctgttgttaaaaaggaggaaaaagtg
cttcatgaattatttgggacggacataaggtgctgtgccagaaatgaactgggcagggaa
tgcaccaggctgttcacaatagatctaaatcaaactcctcagaccacattgccacaatta
tttcttaaagtaggggaacccttatggataaggtgcaaagctgttcatgtgaaccatgga
ttcgggctcacctgggaattagaaaacaaagcactcgaggagggcaactactttgagatg
agtacctattcaacaaacagaactatgatacggattctgtttgcttttgtatcatcagtg
gcaagaaacgacaccggatactacacttgttcctcttcaaagcatcccagtcaatcagct
ttggttaccatcgtagaaaagggatttataaatgctaccaattcaagtgaagattatgaa
attgaccaatatgaagagttttgtttttctgtcaggtttaaagcctacccacaaatcaga
tgtacgtggaccttctctcgaaaatcatttccttgtgagcaaaagggtcttgataacgga
tacagcatatccaagttttgcaatcataagcaccagccaggagaatatatattccatgca
gaaaatgatgatgcccaatttaccaaaatgttcacgctgaatataagaaggaaacctcaa
gtgctcgcagaagcatcggcaagtcaggcgtcctgtttctcggatggatacccattacca
tcttggacctggaagaagtgttcagacaagtctcccaactgcacagaagagatcacagaa
ggagtctggaatagaaaggctaacagaaaagtgtttggacagtgggtgtcgagcagtact
ctaaacatgagtgaagccataaaagggttcctggtcaagtgctgtgcatacaattccctt
ggcacatcttgtgagacgatccttttaaactctccaggccccttccctttcatccaagac
aacatctcattctatgcaacaattggtgtttgtctcctcttcattgtcgttttaaccctg
ctaatttgtcacaagtacaaaaagcaatttaggtatgaaagccagctacagatggtacag
gtgaccggctcctcagataatgagtacttctacgttgatttcagagaatatgaatatgat
ctcaaatgggagtttccaagagaaaatttagagtttgggaaggtactaggatcaggtgct
tttggaaaagtgatgaacgcaacagcttatggaattagcaaaacaggagtctcaatccag
gttgccgtcaaaatgctgaaagaaaaagcagacagctctgaaagagaggcactcatgtca
gaactcaagatgatgacccagctgggaagccacgagaatattgtgaacctgctgggggcg
tgcacactgtcaggaccaatttacttgatttttgaatactgttgctatggtgatcttctc
aactatctaagaagtaaaagagaaaaatttcacaggacttggacagagattttcaaggaa
cacaatttcagtttttaccccactttccaatcacatccaaattccagcatgcctggttca
agagaagttcagatacacccggactcggatcaaatctcagggcttcatgggaattcattt
cactctgaagatgaaattgaatatgaaaaccaaaaaaggctggaagaagaggaggacttg
aatgtgcttacatttgaagatcttctttgctttgcatatcaagttgccaaaggaatggaa
tttctggaatttaagtcgtgtgttcacagagacctggccgccaggaacgtgcttgtcacc
cacgggaaagtggtgaagatatgtgactttggattggctcgagatatcatgagtgattcc
aactatgttgtcaggggcaatgcccgtctgcctgtaaaatggatggcccccgaaagcctg
tttgaaggcatctacaccattaagagtgatgtctggtcatatggaatattactgtgggaa
atcttctcacttggtgtgaatccttaccctggcattccggttgatgctaacttctacaaa
ctgattcaaaatggatttaaaatggatcagccattttatgctacagaagaaatatacatt
ataatgcaatcctgctgggcttttgactcaaggaaacggccatccttccctaatttgact
tcgtttttaggatgtcagctggcagatgcagaagaagcgatgtatcagaatgtggatggc
cgtgtttcggaatgtcctcacacctaccaaaacaggcgacctttcagcagagagatggat
ttggggctactctctccgcaggctcaggtcgaagattcgtag

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