KEGG   Homo sapiens (human): 23291
Entry
23291             CDS       T01001                                 
Symbol
FBXW11, BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos, NEDJED
Name
(RefSeq) F-box and WD repeat domain containing 11
  KO
K03362  F-box and WD-40 domain protein 1/11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04114  Oocyte meiosis
hsa04120  Ubiquitin mediated proteolysis
hsa04218  Cellular senescence
hsa04310  Wnt signaling pathway
hsa04340  Hedgehog signaling pathway
hsa04390  Hippo signaling pathway
hsa04710  Circadian rhythm
hsa05131  Shigellosis
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06182  Shigella
nt06516  TNF signaling
  Element
N00942  Shigella OspG to TNF-NFKB signaling pathway
Disease
H02715  Neurodevelopmental disorder with defects of ubiquitin-proteasome system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    23291 (FBXW11)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    23291 (FBXW11)
   04340 Hedgehog signaling pathway
    23291 (FBXW11)
   04390 Hippo signaling pathway
    23291 (FBXW11)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    23291 (FBXW11)
   04218 Cellular senescence
    23291 (FBXW11)
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    23291 (FBXW11)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    23291 (FBXW11)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    23291 (FBXW11)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    23291 (FBXW11)
   03036 Chromosome and associated proteins [BR:hsa03036]
    23291 (FBXW11)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   SCF complex
    Target recognizing subunit (F-box)
     23291 (FBXW11)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     23291 (FBXW11)
SSDB
Motif
Pfam: WD40 Beta-prop_TEP1_2nd WD40_Prp19 WD40_CDC20-Fz WD40_WDHD1_1st Beta-prop_TEP1_C EIF3I WD40_MABP1-WDR62_2nd Beta-TrCP_D Beta-prop_SCAP Beta-prop_WDR75_1st Beta-prop_EML Beta-prop_EML_2 WDR55 Beta-prop_CAF1B_HIR1 Beta-prop_WDR90_POC16_2nd Beta-prop_EIPR1 ANAPC4_WD40 F-box-like Beta-prop_DCAF12 WDR90_beta-prop_4th Beta-prop_IP5PC_F WD40_MABP1-WDR62_1st Beta-prop_RIG_2nd Beta-prop_SPT8 NBCH_WD40 Beta-prop_DCAF4 WD40_like Beta-prop_IFT140_1st Beta-prop_HPS5 F-box Beta-prop_WDR11_2nd WD40_RFWD3 Beta-prop_Nup120_160 Beta-prop_VPS8 Beta-prop_WDR19_1st Nucleoporin_N WD40_2 DUF1513 DUF4508 HEAT_ATR
Other DBs
NCBI-GeneID: 23291
NCBI-ProteinID: NP_036432
OMIM: 605651
HGNC: 13607
Ensembl: ENSG00000072803
UniProt: Q9UKB1
Structure
Position
5:complement(171861549..172006638)
AA seq 542 aa
MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVS
RKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFI
TALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKG
LSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENS
KGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDS
TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLV
GHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGS
SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA
STLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYI
SR
NT seq 1629 nt   +upstreamnt  +downstreamnt
atggagcccgactcggtgattgaggacaagaccatcgagctcatgtgttctgtgccaagg
tctttgtggctaggctgcgccaacctggtagagagcatgtgcgcactgagttgcctgcag
agcatgcccagtgtcagatgtctccagataagtaatggaacatcatctgtgatcgtctcc
agaaagaggccatcagaaggaaactatcaaaaagaaaaagacttgtgtattaaatatttt
gaccagtggtctgaatcagatcaagtggaatttgtggaacatcttatttcacgaatgtgt
cattatcagcatggacatattaactcttacctgaagcccatgttgcagcgggactttatt
accgctttaccagagcaaggcttagatcacatagcagaaaacattctttcgtacctggat
gccaggtctctgtgtgcagcagagctggtatgtaaagaatggcagcgagtgatctcagaa
ggaatgctttggaagaagctgattgaacgaatggtacgcactgatcccctatggaaagga
ctttcagaaagaagagggtgggatcagtacctgtttaaaaacagacccacagatggccct
ccaaattcattttataggtcattatacccaaagattatccaggatatagagactatagaa
tctaactggcggtgtggacgacacaacttgcagaggattcagtgccgctctgaaaatagt
aaaggtgtctactgtttacagtacgatgatgaaaaaattatcagtggcctacgagataat
tctattaagatatgggataaaaccagcctggaatgtttgaaagtgttaacaggacacaca
ggctctgtcctctgtctgcagtatgatgagcgtgtcattgtaactggctcttcagattct
acggtgagagtgtgggatgtgaacacgggtgaagttcttaacacattgatccaccacaat
gaggctgtattgcacttacgcttcagcaatggactgatggtgacctgttccaaggaccgc
tccattgctgtgtgggacatggcttctgcgaccgacatcactttacgccgtgtcctggtt
ggccaccgggctgccgtcaatgtagtagactttgacgacaagtacatcgtgtctgcctct
ggtgacaggaccatcaaagtctggagcacgagcacctgtgaatttgttcgtactctcaat
gggcacaagcggggcattgcctgtctccagtacagggatcgcctggttgttagtggatca
tcagataataccattaggctctgggatattgaatgtggtgcctgtttaagagtcctagag
ggacatgaagaattggtccgatgcatccggtttgataacaagaggattgtcagtggggcc
tatgatgggaaaattaaagtttgggacttgcaagctgctcttgaccctcgagccccagca
agcacattgtgtttgcgcacattggtggaacattctggacgtgtgtttcggctccagttt
gatgagtttcagatcatcagcagctcccatgatgacactattttgatttgggatttctta
aatgtgcctcccagtgcccagaatgagacccgttctccctccagaacatacacttacatc
tctagataa

  All links  
Disease (2)   
   OMIM (2)   
Gene (44)   
   RefGene (37)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (18)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (32)   
   RefSeq(nuc) (16)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (41)   
   Pfam (41)   
All databases (138)   

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