KEGG   Homo sapiens (human): 23498
Entry
23498             CDS       T01001                                 
Symbol
HAAO, 3-HAO, HAO, VCRL1, h3HAO
Name
(RefSeq) 3-hydroxyanthranilate 3,4-dioxygenase
  KO
K00452  3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
Disease
H02087  Vertebral, cardiac, renal, and limb defects syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    23498 (HAAO)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.6  3-hydroxyanthranilate 3,4-dioxygenase
     23498 (HAAO)
SSDB
Motif
Pfam: 3-HAO Cupin_2 AraC_binding Cupin_1 JmjC_2
Other DBs
NCBI-GeneID: 23498
NCBI-ProteinID: NP_036337
OMIM: 604521
HGNC: 4796
Ensembl: ENSG00000162882
UniProt: P46952
Structure
Position
2:complement(42767089..42792583)
AA seq 286 aa
MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEG
DMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYV
GDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEP
MSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVT
MGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG
NT seq 861 nt   +upstreamnt  +downstreamnt
atggagcgccgcctgggagtgagggcctgggtgaaggagaaccggggctccttccagccc
ccggtctgcaacaagctcatgcaccaggagcagctcaaagtcatgttcatcggaggcccc
aacaccaggaaggactatcacatcgaagagggtgaagaggtattttaccagctggaggga
gacatggttctccgagtcctggagcaagggaaacaccgggatgtggtcattcggcaggga
gagatattcctcctgcctgccagggtgccccactcaccacagaggtttgccaacaccgtg
gggctggtggttgagcgaaggcggctggagaccgagctagatgggctcaggtactatgtg
ggcgacaccatggacgttctgtttgagaagtggttctactgcaaggacctcggcacgcag
ttggcccccatcatccaggagttcttcagctctgagcagtacagaacaggaaagcccatc
cctgaccagctgctcaaggagccaccattccctctgagcacacgatccatcatggagccc
atgtccctggatgcctggctggacagccaccacagggagctgcaggcaggcacaccactc
agcctgtttggggacacctatgagacccaggtgatcgcctatgggcaaggcagcagcgaa
ggcctgagacagaatgtggacgtgtggctgtggcagctggagggctcctcggtggtgaca
atggggggacggcgcctgagcctggcccctgatgacagcctcctggtgctagctgggacc
tcgtatgcctgggagcgaacacaaggctctgtggccctgtctgtgacccaggaccctgcc
tgcaagaagcccctggggtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (17)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (19)   
   RefSeq(nuc) (5)   
   GenBank (7)   
   EMBL (7)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (53)   

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