KEGG   Homo sapiens (human): 2356
Entry
2356              CDS       T01001                                 

Gene name
FPGS
Definition
(RefSeq) folylpolyglutamate synthase
  KO
K01930  folylpolyglutamate synthase [EC:6.3.2.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    2356 (FPGS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    2356 (FPGS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.17  tetrahydrofolate synthase
     2356 (FPGS)
SSDB
Motif
Pfam: Mur_ligase_C
Other DBs
NCBI-GeneID: 2356
NCBI-ProteinID: NP_004948
OMIM: 136510
HGNC: 3824
Ensembl: ENSG00000136877
Vega: OTTHUMG00000020716
Pharos: Q05932(Tchem)
UniProt: Q05932
Position
9q34.11
AA seq 587 aa
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq 1764 nt   +upstreamnt  +downstreamnt
atgtcgcgggcgcggagccacctgcgcgccgctctattcctggcagcggcgtctgcgcgc
ggcataacgacccaggtcgcggcgcggcggggcttgagcgcgtggccggtgccgcaggag
ccgagcatggagtaccaggatgccgtgcgcatgctcaataccctgcagaccaatgccggc
tacctggagcaggtgaagcgccagcggggtgaccctcagacacagttggaagccatggaa
ctgtacctggcacggagtgggctgcaggtggaggacttggaccggctgaacatcatccac
gtcactgggacgaaggggaagggctccacctgtgccttcacggaatgtatcctccgaagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggttcgggagcggatc
cgcatcaatgggcagcccatcagtcctgagctcttcaccaagtacttctggcgcctctac
caccggctggaggagaccaaggatggcagctgtgtctccatgcccccctacttccgcttc
ctgacactcatggccttccacgtcttcctccaagagaaggtggacctggcagtggtggag
gtgggcattggcggggcttatgactgcaccaacatcatcaggaagcctgtggtgtgcgga
gtctcctctcttggcatcgaccacaccagcctcctgggggatacggtggagaagatcgca
tggcagaaagggggcatctttaagcaaggtgtccctgccttcactgtgctccaacctgaa
ggtcccctggcagtgctgagggaccgagcccagcagatctcatgtcctctatacctgtgt
ccgatgctggaggccctcgaggaaggggggccgccgctgaccctgggcctggagggggag
caccagcggtccaacgccgccttggccttgcagctggcccactgctggctgcagcggcag
gaccgccatggtgctggggagccaaaggcatccaggccagggctcctgtggcagctgccc
ctggcacctgtgttccagcccacatcccacatgcggctcgggcttcggaacacggagtgg
ccgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggtgcgcac
accgccagcagcgcgcaggcctgcgtgcgctggttccgccaggcgctgcagggccgcgag
aggccgagcggtggccccgaggttcgagtcttgctcttcaatgctaccggggaccgggac
ccggcggccctgctgaagctgctgcagccctgccagtttgactatgccgtcttctgccct
aacctgacagaggtgtcatccacaggcaacgcagaccaacagaacttcacagtgacactg
gaccaggtcctgctccgctgcctggaacaccagcagcactggaaccacctggacgaagag
caggccagcccggacctctggagtgcccccagcccagagcccggtgggtccgcatccctg
cttctggcgccccacccaccccacacctgcagtgccagctccctcgtcttcagctgcatt
tcacatgccttgcaatggatcagccaaggccgagaccccatcttccagccacctagtccc
ccaaagggcctcctcacccaccctgtggctcacagtggggccagcatactccgtgaggct
gctgccatccatgtgctagtcactggcagcctgcacctggtgggtggtgtcctgaagctg
ctggagcccgcactgtcccagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (44)   
   RefSeq(nuc) (10)   
   GenBank (17)   
   EMBL (17)   
Protein domain (1)   
   Pfam (1)   
All databases (95)   

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