KEGG   Homo sapiens (human): 246
Entry
246               CDS       T01001                                 

Symbol
ALOX15, 12-LOX, 15-LOX, 15-LOX-1, LOG15
Name
(RefSeq) arachidonate 15-lipoxygenase
  KO
K00460  arachidonate 15-lipoxygenase [EC:1.13.11.33]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa01100  Metabolic pathways
hsa04216  Ferroptosis
hsa04217  Necroptosis
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    246 (ALOX15)
   00591 Linoleic acid metabolism
    246 (ALOX15)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    246 (ALOX15)
   04217 Necroptosis
    246 (ALOX15)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    246 (ALOX15)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.33  arachidonate 15-lipoxygenase
     246 (ALOX15)
SSDB
Motif
Pfam: Lipoxygenase PLAT
Other DBs
NCBI-GeneID: 246
NCBI-ProteinID: NP_001131
OMIM: 152392
HGNC: 433
Ensembl: ENSG00000161905
Vega: OTTHUMG00000090746
Pharos: P16050(Tchem)
UniProt: P16050
Position
17p13.2
AA seq 662 aa
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
NT seq 1989 nt   +upstreamnt  +downstreamnt
atgggtctctaccgcatccgcgtgtccactggggcctcgctctatgccggttccaacaac
caggtgcagctgtggctggtcggccagcacggggaggcggcgctcgggaagcgactgtgg
cccgcacggggcaaggagacagaactcaaggtggaagtaccggagtatctggggccgctg
ctgtttgtgaaactgcgcaaacggcacctccttaaggacgacgcctggttctgcaactgg
atctctgtgcagggccccggagccggggacgaggtcaggttcccttgttaccgctgggtg
gagggcaacggcgtcctgagcctgcctgaaggcaccggccgcactgtgggcgaggaccct
cagggcctgttccagaaacaccgggaagaagagctggaagagagaaggaagttgtaccgg
tggggaaactggaaggacgggttaattctgaatatggctggggccaaactatatgacctc
cctgtggatgagcgatttctggaagacaagagagttgactttgaggtttcgctggccaag
gggctggccgacctcgctatcaaagactctctaaatgttctgacttgctggaaggatcta
gatgacttcaaccggattttctggtgtggtcagagcaagctggctgagcgcgtgcgggac
tcctggaaggaagatgccttatttgggtaccagtttcttaatggcgccaaccccgtggtg
ctgaggcgctctgctcaccttcctgctcgcctagtgttccctccaggcatggaggaactg
caggcccagctggagaaggagctggagggaggcacactgttcgaagctgacttctccctg
ctggatgggatcaaggccaacgtcattctctgtagccagcagcacctggctgcccctcta
gtcatgctgaaattgcagcctgatgggaaactcttgcccatggtcatccagctccagctg
ccccgcacaggatccccaccacctccccttttcttgcctacggatcccccaatggcctgg
cttctggccaaatgctgggtgcgcagctctgacttccagctccatgagctgcagtctcat
cttctgaggggacacttgatggctgaggtcattgttgtggccaccatgaggtgcctgccg
tcgatacatcctatcttcaagcttataattccccacctgcgatacaccctggaaattaac
gtccgggccaggactgggctggtctctgacatgggaattttcgaccagataatgagcact
ggtgggggaggccacgtgcagctgctcaagcaagctggagccttcctaacctacagctcc
ttctgtccccctgatgacttggccgaccgggggctcctgggagtgaagtcttccttctat
gcccaagatgcgctgcggctctgggaaatcatctatcggtatgtggaaggaatcgtgagt
ctccactataagacagacgtggctgtgaaagacgacccagagctgcagacctggtgtcga
gagatcactgaaatcgggctgcaaggggcccaggaccgagggtttcctgtctctttacag
gctcgggaccaggtttgccactttgtcaccatgtgtatcttcacctgcaccggccaacac
gcctctgtgcacctgggccagctggactggtactcttgggtgcctaatgcaccctgcacg
atgcggctgcccccgccaaccaccaaggatgcaacgctggagacagtgatggcgacactg
cccaacttccaccaggcttctctccagatgtccatcacttggcagctgggcagacgccag
cccgttatggtggctgtgggccagcatgaggaggagtatttttcgggccctgagcctaag
gctgtgctgaagaagttcagggaggagctggctgccctggataaggaaattgagatccgg
aatgcaaagctggacatgccctacgagtacctgcggcccagcgtggtggaaaacagtgtg
gccatctaa

KEGG   Homo sapiens (human): 247
Entry
247               CDS       T01001                                 

Symbol
ALOX15B, 15-LOX-2
Name
(RefSeq) arachidonate 15-lipoxygenase type B
  KO
K08022  arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    247 (ALOX15B)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    247 (ALOX15B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.33  arachidonate 15-lipoxygenase
     247 (ALOX15B)
    1.13.11.-  
     247 (ALOX15B)
SSDB
Motif
Pfam: Lipoxygenase PLAT DNA_pol3_tau_4
Other DBs
NCBI-GeneID: 247
NCBI-ProteinID: NP_001132
OMIM: 603697
HGNC: 434
Ensembl: ENSG00000179593
Vega: OTTHUMG00000108181
Pharos: O15296(Tchem)
UniProt: O15296
Structure
PDB: 
4NRE

Position
17p13.1
AA seq 676 aa
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL
PYTYLDPPLIENSVSI
NT seq 2031 nt   +upstreamnt  +downstreamnt
atggccgagttcagggtcagggtgtccaccggagaagccttcggggctggcacatgggac
aaagtgtctgtcagcatcgtggggacccggggagagagccccccactgcccctggacaat
ctcggcaaggagttcactgcgggcgctgaggaggacttccaggtgacgctcccggaggac
gtaggccgagtgctgctgctgcgcgtgcacaaggcgcccccagtgctgcccctgctgggg
cccctggccccggatgcctggttctgccgctggttccagctgacaccgccgcggggcggc
cacctcctcttcccctgctaccagtggctggagggggcggggaccctggtgctgcaggag
ggtacagccaaggtgtcctgggcagaccaccaccctgtgctccagcaacagcgccaggag
gagcttcaggcccggcaggagatgtaccagtggaaggcttacaacccaggttggcctcac
tgcctggatgaaaagacagtggaagacttggagctcaatatcaaatactccacagccaag
aatgccaacttttatctacaggctggctctgcttttgcagagatgaaaatcaaggggttg
ctggaccgcaaggggctctggaggagtctgaatgagatgaaaaggatcttcaacttccgg
aggaccccagcagctgagcacgcatttgagcactggcaggaggacgccttcttcgcctcc
cagttcctgaatggtctcaaccctgtcctgatccgccgctgtcactacctcccaaagaac
ttccccgtcactgatgccatggtggcctcagtgttgggtcctgggaccagcttgcaggct
gagctagagaagggctccctgttcttggtggatcacggcatcctctctggcatccagacc
aatgtcattaatgggaagcctcagttctctgcggccccaatgaccctgctataccagagc
ccaggctgcgggccgctgctgcctctcgccatccagctcagccagacccccggcccaaac
agccccatcttcctgcccactgatgacaagtgggactggttgctggccaagacctgggtg
cgcaatgccgagttctccttccatgaggccctcacgcacctgctgcactcacatctgctg
cctgaggtcttcaccctggctaccctgcgtcagctgccccactgccaccctctcttcaag
ctgctgatcccgcacacccgatacaccctgcacatcaacacactcgcccgggagctgctt
atcgtgccagggcaggtggtggacaggtccacaggcatcggcattgaaggcttctctgag
ttgatacagaggaacatgaagcagctgaactattctctcctgtgtctgcctgaggatatc
cggacccgaggagttgaagacatcccaggctactactaccgtgatgatgggatgcagatc
tggggtgcagtggaacgctttgtctctgaaatcatcggtatctactacccaagtgatgag
tctgtccaagatgacagagagctccaggcctgggtcagagagatcttctccaagggcttc
ctaaaccaggagagctcaggtataccctcctcactggagacccgggaagccctggtgcag
tatgtcaccatggtgatattcacctgctccgccaagcatgcggctgtcagtgcagggcag
tttgactcctgtgcttggatgcccaacctgccacccagcatgcagctgccaccacccacc
tccaaaggcctggcaacatgcgagggcttcatagccaccctcccacctgtcaatgccaca
tgtgatgtcatccttgctctctggttgctgagcaaggagcctggagaccaaaggcccctg
ggcacctatccggatgagcacttcacagaggaggcccctcggcggagcatcgccaccttc
cagagccgcctggcccagatctcgaggggcatccaggagcggaaccagggcctggtgctg
ccctacacctacctagaccctcccctcatcgagaacagcgtctccatctaa

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