KEGG   Homo sapiens (human): 2530
Entry
2530              CDS       T01001                                 

Gene name
FUT8, CDGF, CDGF1
Definition
(RefSeq) fucosyltransferase 8
  KO
K00717  glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00510  N-Glycan biosynthesis
hsa00513  Various types of N-glycan biosynthesis
hsa00533  Glycosaminoglycan biosynthesis - keratan sulfate
hsa01100  Metabolic pathways
hsa05202  Transcriptional misregulation in cancer
Module
hsa_M00075  N-glycan biosynthesis, complex type
Network
nt06015  N-Glycan biosynthesis
nt06240  Transcription
  Element
N00120  MLL-ENL fusion to transcriptional activation
N00820  N-Glycan biosynthesis
N00821  B4GALT1 deficiency in N-glycan biosynthesis
Disease
H02451  Congenital disorder of glycosylation with defective fucosylation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    2530 (FUT8)
   00513 Various types of N-glycan biosynthesis
    2530 (FUT8)
   00533 Glycosaminoglycan biosynthesis - keratan sulfate
    2530 (FUT8)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    2530 (FUT8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases [BR:hsa01003]
    2530 (FUT8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.68  glycoprotein 6-alpha-L-fucosyltransferase
     2530 (FUT8)
Glycosyltransferases [BR:hsa01003]
 Glycan extension
  N-Glycan
   2530 (FUT8)
SSDB
Motif
Pfam: FUT8_N_cat SH3_9 SH3_1 NodZ Wtap SKI
Other DBs
NCBI-GeneID: 2530
NCBI-ProteinID: NP_835368
OMIM: 602589
HGNC: 4019
Ensembl: ENSG00000033170
Vega: OTTHUMG00000142818
Pharos: Q9BYC5(Tbio)
UniProt: Q9BYC5 Q546E0 A8K8P8
Structure
PDB: 
2DE0

Position
14q23.3
AA seq 575 aa
MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDL
RRMAESLRIPEGPIDQGPAIGRVRVLEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIE
NGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLGHHERSIMTDLYYLSQTDGAGDWR
EKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRT
LILESQNWRYATGGWETVFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPR
PPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVI
GVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPSLLKEAKTK
YPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQ
TLHPDASANFHSLDDIYYFGGQNAHNQIAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYS
KGVNRKLGRTGLYPSYKVREKIETVKYPTYPEAEK
NT seq 1728 nt   +upstreamnt  +downstreamnt
atgcggccatggactggttcctggcgttggattatgctcattctttttgcctgggggacc
ttgctgttttatataggtggtcacttggtacgagataatgaccatcctgatcactctagc
cgagaactgtccaagattctggcaaagcttgaacgcttaaaacaacagaatgaagacttg
aggcgaatggccgaatctctccggataccagaaggccctattgatcaggggccagctata
ggaagagtacgcgttttagaagagcagcttgttaaggccaaagaacagattgaaaattac
aagaaacagaccagaaatggtctggggaaggatcatgaaatcctgaggaggaggattgaa
aatggagctaaagagctctggtttttcctacagagtgaattgaagaaattaaagaactta
gaaggaaatgaactccaaagacatgcagatgaatttcttttggatttaggacatcatgaa
aggtctataatgacggatctatactacctcagtcagacagatggagcaggtgattggcgg
gaaaaagaggccaaagatctgacagaactggttcagcggagaataacatatcttcagaat
cccaaggactgcagcaaagccaaaaagctggtgtgtaatatcaacaaaggctgtggctat
ggctgtcagctccatcatgtggtctactgcttcatgattgcatatggcacccagcgaaca
ctcatcttggaatctcagaattggcgctatgctactggtggatgggagactgtatttagg
cctgtaagtgagacatgcacagacagatctggcatctccactggacactggtcaggtgaa
gtgaaggacaaaaatgttcaagtggtcgagcttcccattgtagacagtcttcatccccgt
cctccatatttacccttggctgtaccagaagacctcgcagatcgacttgtacgagtgcat
ggtgaccctgcagtgtggtgggtgtctcagtttgtcaaatacttgatccgcccacagcct
tggctagaaaaagaaatagaagaagccaccaagaagcttggcttcaaacatccagttatt
ggagtccatgtcagacgcacagacaaagtgggaacagaagctgccttccatcccattgaa
gagtacatggtgcatgttgaagaacattttcagcttcttgcacgcagaatgcaagtggac
aaaaaaagagtgtatttggccacagatgacccttctttattaaaggaggcaaaaacaaag
taccccaattatgaatttattagtgataactctatttcctggtcagctggactgcacaat
cgatacacagaaaattcacttcgtggagtgatcctggatatacattttctctctcaggca
gacttcctagtgtgtactttttcatcccaggtctgtcgagttgcttatgaaattatgcaa
acactacatcctgatgcctctgcaaacttccattctttagatgacatctactattttggg
ggccagaatgcccacaatcaaattgccatttatgctcaccaaccccgaactgcagatgaa
attcccatggaacctggagatatcattggtgtggctggaaatcattgggatggctattct
aaaggtgtcaacaggaaattgggaaggacgggcctatatccctcctacaaagttcgagag
aagatagaaacggtcaagtaccccacatatcctgaggctgagaaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (15)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (62)   
   RefSeq(nuc) (14)   
   GenBank (24)   
   EMBL (24)   
Protein domain (6)   
   Pfam (6)   
All databases (115)   

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