KEGG   Homo sapiens (human): 2538
Entry
2538              CDS       T01001                                 
Symbol
G6PC1, G6PC, G6PT, G6Pase, GSD1, GSD1a
Name
(RefSeq) glucose-6-phosphatase catalytic subunit 1 isoform 1
  KO
K01084  glucose-6-phosphatase [EC:3.1.3.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00052  Galactose metabolism
hsa00500  Starch and sucrose metabolism
hsa01100  Metabolic pathways
hsa04068  FoxO signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04931  Insulin resistance
hsa04973  Carbohydrate digestion and absorption
Network
nt06017  Glycogen metabolism
  Element
N00718  Glycogen degradation
Disease
H00069  Glycogen storage disease
H01760  Hepatic glycogen storage disease
H01939  Glycogen storage disease type I
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    2538 (G6PC1)
   00052 Galactose metabolism
    2538 (G6PC1)
   00500 Starch and sucrose metabolism
    2538 (G6PC1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    2538 (G6PC1)
   04151 PI3K-Akt signaling pathway
    2538 (G6PC1)
   04152 AMPK signaling pathway
    2538 (G6PC1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    2538 (G6PC1)
   04922 Glucagon signaling pathway
    2538 (G6PC1)
   04920 Adipocytokine signaling pathway
    2538 (G6PC1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    2538 (G6PC1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    2538 (G6PC1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.9  glucose-6-phosphatase
     2538 (G6PC1)
SSDB
Motif
Pfam: PAP2 ATPase_gene1 DUF373
Other DBs
NCBI-GeneID: 2538
NCBI-ProteinID: NP_000142
OMIM: 613742
HGNC: 4056
Ensembl: ENSP00000253801.1
UniProt: P35575
Structure
Position
17:42900799..42914438
AA seq 357 aa
MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK
LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA
MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ
VVAGVLSGIAVAETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK
AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV
ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL
NT seq 1074 nt   +upstreamnt  +downstreamnt
atggaggaaggaatgaatgttctccatgactttgggatccagtcaacacattacctccag
gtgaattaccaagactcccaggactggttcatcttggtgtccgtgatcgcagacctcagg
aatgccttctacgtcctcttccccatctggttccatcttcaggaagctgtgggcattaaa
ctcctttgggtagctgtgattggagactggctcaacctcgtctttaagtggattctcttt
ggacagcgtccatactggtgggttttggatactgactactacagcaacacttccgtgccc
ctgataaagcagttccctgtaacctgtgagactggaccagggagcccctctggccatgcc
atgggcacagcaggtgtatactacgtgatggtcacatctactctttccatctttcaggga
aagataaagccgacctacagatttcggtgcttgaatgtcattttgtggttgggattctgg
gctgtgcagctgaatgtctgtctgtcacgaatctaccttgctgctcattttcctcatcaa
gttgttgctggagtcctgtcaggcattgctgttgcagaaactttcagccacatccacagc
atctataatgccagcctcaagaaatattttctcattaccttcttcctgttcagcttcgcc
atcggattttatctgctgctcaagggactgggtgtagacctcctgtggactctggagaaa
gcccagaggtggtgcgagcagccagaatgggtccacattgacaccacaccctttgccagc
ctcctcaagaacctgggcacgctctttggcctggggctggctctcaactccagcatgtac
agggagagctgcaaggggaaactcagcaagtggctcccattccgcctcagctctattgta
gcctccctcgtcctcctgcacgtctttgactccttgaaacccccatcccaagtcgagctg
gtcttctacgtcttgtccttctgcaagagtgcggtagtgcccctggcatccgtcagtgtc
atcccctactgcctcgcccaggtcctgggccagccgcacaagaagtcgttgtaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (13)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (14)   
   RefSeq(nuc) (2)   
   GenBank (6)   
   EMBL (6)   
3D Structure (6)   
   PDB (6)   
Protein domain (3)   
   Pfam (3)   
All databases (42)   

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