KEGG   Homo sapiens (human): 2539
Entry
2539              CDS       T01001                                 

Gene name
G6PD, G6PD1
Definition
(RefSeq) glucose-6-phosphate dehydrogenase
  KO
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00030  Pentose phosphate pathway
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa05230  Central carbon metabolism in cancer
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle)
hsa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
Network
nt06026  Glutathione biosynthesis
  Element
N00905  NADP+ reduction
N00906  G6PD deficiency in NADP+ reduction
Disease
H00101  Other phagocyte defects
H00668  Anemia due to disorders of glutathione metabolism
H01375  Glucose 6-phosphate dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    2539 (G6PD)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    2539 (G6PD)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    2539 (G6PD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2539 (G6PD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.49  glucose-6-phosphate dehydrogenase (NADP+)
     2539 (G6PD)
    1.1.1.363  glucose-6-phosphate dehydrogenase [NAD(P)+]
     2539 (G6PD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   2539 (G6PD)
  Exosomal proteins of colorectal cancer cells
   2539 (G6PD)
  Exosomal proteins of bladder cancer cells
   2539 (G6PD)
SSDB
Motif
Pfam: G6PD_C G6PD_N
Other DBs
NCBI-GeneID: 2539
NCBI-ProteinID: NP_001035810
OMIM: 305900
HGNC: 4057
Ensembl: ENSG00000160211
Vega: OTTHUMG00000024237
Pharos: P11413(Tchem)
UniProt: P11413 A0A384NL00
Structure
PDB: 

Position
Xq28
AA seq 515 aa
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
NT seq 1548 nt   +upstreamnt  +downstreamnt
atggcagagcaggtggccctgagccggacccaggtgtgcgggatcctgcgggaagagctt
ttccagggcgatgccttccatcagtcggatacacacatattcatcatcatgggtgcatcg
ggtgacctggccaagaagaagatctaccccaccatctggtggctgttccgggatggcctt
ctgcccgaaaacaccttcatcgtgggctatgcccgttcccgcctcacagtggctgacatc
cgcaaacagagtgagcccttcttcaaggccaccccagaggagaagctcaagctggaggac
ttctttgcccgcaactcctatgtggctggccagtacgatgatgcagcctcctaccagcgc
ctcaacagccacatgaatgccctccacctggggtcacaggccaaccgcctcttctacctg
gccttgcccccgaccgtctacgaggccgtcaccaagaacattcacgagtcctgcatgagc
cagataggctggaaccgcatcatcgtggagaagcccttcgggagggacctgcagagctct
gaccggctgtccaaccacatctcctccctgttccgtgaggaccagatctaccgcatcgac
cactacctgggcaaggagatggtgcagaacctcatggtgctgagatttgccaacaggatc
ttcggccccatctggaaccgggacaacatcgcctgcgttatcctcaccttcaaggagccc
tttggcactgagggtcgcgggggctatttcgatgaatttgggatcatccgggacgtgatg
cagaaccacctactgcagatgctgtgtctggtggccatggagaagcccgcctccaccaac
tcagatgacgtccgtgatgagaaggtcaaggtgttgaaatgcatctcagaggtgcaggcc
aacaatgtggtcctgggccagtacgtggggaaccccgatggagagggcgaggccaccaaa
gggtacctggacgaccccacggtgccccgcgggtccaccaccgccacttttgcagccgtc
gtcctctatgtggagaatgagaggtgggatggggtgcccttcatcctgcgctgcggcaag
gccctgaacgagcgcaaggccgaggtgaggctgcagttccatgatgtggccggcgacatc
ttccaccagcagtgcaagcgcaacgagctggtgatccgcgtgcagcccaacgaggccgtg
tacaccaagatgatgaccaagaagccgggcatgttcttcaaccccgaggagtcggagctg
gacctgacctacggcaacagatacaagaacgtgaagctccctgacgcctatgagcgcctc
atcctggacgtcttctgcgggagccagatgcacttcgtgcgcagcgacgagctccgtgag
gcctggcgtattttcaccccactgctgcaccagattgagctggagaagcccaagcccatc
ccctatatttatggcagccgaggccccacggaggcagacgagctgatgaagagagtgggt
ttccagtatgagggcacctacaagtgggtgaacccccacaagctctga

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