KEGG   Homo sapiens (human): 2539Help
Entry
2539              CDS       T01001                                 

Gene name
G6PD, G6PD1
Definition
(RefSeq) glucose-6-phosphate dehydrogenase
  KO
K00036  glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00030  Pentose phosphate pathway
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa05230  Central carbon metabolism in cancer
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle)
hsa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
Disease
H00101  Other phagocyte defects
H00668  Anemia due to disorders of glutathione metabolism
H01375  Glucose 6-phosphate dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Carbohydrate metabolism
   00030 Pentose phosphate pathway
    2539 (G6PD)
  Metabolism of other amino acids
   00480 Glutathione metabolism
    2539 (G6PD)
 Human Diseases
  Cancers
   05230 Central carbon metabolism in cancer
    2539 (G6PD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.49  glucose-6-phosphate dehydrogenase (NADP+)
     2539 (G6PD)
    1.1.1.363  glucose-6-phosphate dehydrogenase [NAD(P)+]
     2539 (G6PD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   2539 (G6PD)
  Exosomal proteins of colorectal cancer cells
   2539 (G6PD)
  Exosomal proteins of bladder cancer cells
   2539 (G6PD)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: G6PD_C G6PD_N
Motif
Other DBs
NCBI-GeneID: 2539
NCBI-ProteinID: NP_001035810
OMIM: 305900
HGNC: 4057
Ensembl: ENSG00000160211
Vega: OTTHUMG00000024237
Pharos: P11413(Tchem)
UniProt: P11413
Structure
PDB: 

Position
Xq28
AA seq 515 aa AA seqDB search
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
NT seq 1548 nt NT seq  +upstreamnt  +downstreamnt
atggcagagcaggtggccctgagccggacccaggtgtgcgggatcctgcgggaagagctt
ttccagggcgatgccttccatcagtcggatacacacatattcatcatcatgggtgcatcg
ggtgacctggccaagaagaagatctaccccaccatctggtggctgttccgggatggcctt
ctgcccgaaaacaccttcatcgtgggctatgcccgttcccgcctcacagtggctgacatc
cgcaaacagagtgagcccttcttcaaggccaccccagaggagaagctcaagctggaggac
ttctttgcccgcaactcctatgtggctggccagtacgatgatgcagcctcctaccagcgc
ctcaacagccacatgaatgccctccacctggggtcacaggccaaccgcctcttctacctg
gccttgcccccgaccgtctacgaggccgtcaccaagaacattcacgagtcctgcatgagc
cagataggctggaaccgcatcatcgtggagaagcccttcgggagggacctgcagagctct
gaccggctgtccaaccacatctcctccctgttccgtgaggaccagatctaccgcatcgac
cactacctgggcaaggagatggtgcagaacctcatggtgctgagatttgccaacaggatc
ttcggccccatctggaaccgggacaacatcgcctgcgttatcctcaccttcaaggagccc
tttggcactgagggtcgcgggggctatttcgatgaatttgggatcatccgggacgtgatg
cagaaccacctactgcagatgctgtgtctggtggccatggagaagcccgcctccaccaac
tcagatgacgtccgtgatgagaaggtcaaggtgttgaaatgcatctcagaggtgcaggcc
aacaatgtggtcctgggccagtacgtggggaaccccgatggagagggcgaggccaccaaa
gggtacctggacgaccccacggtgccccgcgggtccaccaccgccacttttgcagccgtc
gtcctctatgtggagaatgagaggtgggatggggtgcccttcatcctgcgctgcggcaag
gccctgaacgagcgcaaggccgaggtgaggctgcagttccatgatgtggccggcgacatc
ttccaccagcagtgcaagcgcaacgagctggtgatccgcgtgcagcccaacgaggccgtg
tacaccaagatgatgaccaagaagccgggcatgttcttcaaccccgaggagtcggagctg
gacctgacctacggcaacagatacaagaacgtgaagctccctgacgcctatgagcgcctc
atcctggacgtcttctgcgggagccagatgcacttcgtgcgcagcgacgagctccgtgag
gcctggcgtattttcaccccactgctgcaccagattgagctggagaagcccaagcccatc
ccctatatttatggcagccgaggccccacggaggcagacgagctgatgaagagagtgggt
ttccagtatgagggcacctacaagtgggtgaacccccacaagctctga

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