KEGG T01001: 2557

Homo sapiens (human): 2557

Entry

2557              CDS       T01001

Symbol

GABRA4

Name

(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha4

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

D02594

Adinazolam (DG00911):

D02770 D02771

Adipiplon:

D08840

Alpidem:

D02833

Alprazolam:

D00225<JP/US>

Aminobutyric acid:

D00058<JP>

Amobarbital (DG00916):

D00555<JP> D02252

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

D11149<US>

Bromazepam:

D01245<JP>

Brotizolam:

D01744<JP>

Butabarbital (DG01308):

D00699 D03180

Butobarbital:

D02618

Cenobamate:

D11150<US>

Chlordiazepoxide (DG00908):

D00267<JP> D00693<US>

Cinolazepam:

D07328

Clobazam:

D01253<JP/US>

Clonazepam:

D00280<JP/US>

Clotiazepam:

D01328<JP>

Cloxazolam:

D01268<JP>

Darigabat:

D12146

Delorazepam:

D07784

Dextofisopam:

D03737

Diazepam:

D00293<JP/US>

Estazolam:

D00311<JP/US>

Eszopiclone:

D02624<JP/US>

Ethyl loflazepate:

D01293<JP>

Etizolam:

D01514<JP>

Fludiazepam:

D01354<JP>

Flumazenil:

D00697<JP/US>

Flunitrazepam:

D01230<JP>

Flurazepam (DG00919):

D00329 D00695<US> D01408<JP>

Flutazolam:

D01286<JP>

Flutoprazepam:

D01279<JP>

Gaboxadol:

Ganaxolone:

Glutethimide:

Halazepam:

Haloxazolam:

D01758<JP>

Hexobarbital:

D01071

Indiplon:

D02640

Iomazenil:

D02283<JP>

Ketazolam:

D04650

Levotofisopam:

D04721

Loprazolam (DG00921):

D07326 D08145

Lorazepam:

D00365<JP/US>

Lormetazepam:

D01657<JP>

Medazepam (DG00909):

D01292<JP> D04882

Meprobamate:

D00376<US>

Metharbital:

D01382

Methylphenobarbital:

D00700

Mexazolam:

D01316<JP>

Midazolam (DG00920):

D00550<JP/US> D00696<US> D05028

Nimetazepam:

D01593

Nitrazepam:

D00531<JP>

Nordazepam:

D08283

Ocinaplon:

D02617

Oxazepam:

D00464<US>

Oxazolam:

D01278<JP>

Pagoclone:

D02616

Panadiplon:

D05346

Pazinaclone:

D05378

Pentobarbital (DG00915):

D00499 D00500<US> D02253<JP>

Phenobarbital (DG00845):

D00506<JP> D00701<JP> D08356

Potassium clorazepate (DG01218):

D00694<JP/US> D03562

Prazepam:

D00470

Propofol (DG00797):

D00549<JP/US> D04257

Quazepam:

D00457<JP/US>

Remimazolam (DG03105):

D10194<JP/US> D11788

Rilmazafone (DG01307):

D01564<JP> D08481

Sarmazenil:

D08507

Secobarbital (DG00917):

D00430 D01310<JP>

Suritozole:

D05980

Talbutal:

D06887

Temazepam:

D00370<US>

Thiamylal (DG01377):

D00713<JP> D06106

Thiopental (DG00790):

D00714<JP>

Tofisopam:

D01254<JP>

Topiramate:

D00537<JP/US>

Triazolam:

D00387<JP/US>

Zolpidem (DG00922):

D00706<JP/US> D08690

Zopiclone:

D01372<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2557 (GABRA4)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2557 (GABRA4)
   04723 Retrograde endocannabinoid signaling
    2557 (GABRA4)
  09157 Sensory system
   04742 Taste transduction
    2557 (GABRA4)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2557 (GABRA4)
   05033 Nicotine addiction
    2557 (GABRA4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2557 (GABRA4)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2557 (GABRA4)

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb OAD_gamma

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P48169(Tclin)

UniProt:

P48169 X5D7F5

Position

4:complement(46918900..46993581)

AA seq 554 aa
MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ
EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES
SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG
SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV
YLSKDTMEKSESLM

NT seq 1665 nt +upstreamnt +downstreamnt
atggtttctgccaagaaggtacccgcgatcgctctgtccgccggggtcagtttcgccctc
ctgcgcttcctgtgcctggcggtttgtttaaacgaatccccaggacagaaccaaaaggag
gagaaattgtgcacagaaaatttcacccgcatcctggacagtttgctcgatggttatgac
aacaggctgcgtcctggatttgggggtcctgttacagaagtgaaaactgacatatatgtc
accagctttggacctgtttctgatgttgaaatggaatacacaatggatgtgttcttcagg
cagacatggattgacaaaagattaaaatatgacggccccattgaaattttgagattgaac
aatatgatggtaacgaaagtgtggacccctgatactttcttcaggaatggaaagaaatct
gtctcacataatatgacagctccaaataagctttttagaattatgagaaatggtactatt
ttatacacaatgagactcaccataagtgcggagtgtcccatgagattggtggattttccc
atggatggtcatgcatgccctttgaaattcgggagttatgcctatccaaagagtgagatg
atctatacctggacaaaaggtcctgagaaatcagttgaagttccgaaggagtcttccagc
ttagttcaatatgatttgattgggcaaaccgtatcaagtgaaaccatcaaatcaattacg
ggtgaatatattgttatgacggtttacttccacctcagacggaagatgggttattttatg
attcagacctatattccgtgcattatgacagtgattctttctcaagtttcattttggata
aataaagaatcagttcccgctaggactgtatttggaataacaactgtcctcaccatgacc
acactaagcatcagtgcacgacattctttgcccaaagtgtcctatgctaccgccatggac
tggttcatagctgtctgctttgcttttgtattttcggcccttatcgagtttgctgctgtc
aactatttcaccaatattcaaatggaaaaagccaaaaggaagacatcaaagccccctcag
gaagttcccgctgctccagtgcagagagagaagcatcctgaagcccctctgcagaataca
aatgccaatttgaacatgagaaaaagaacaaatgctttggttcactctgaatctgatgtt
ggcaacagaactgaggtgggaaaccattcaagcaaatcttccacagttgttcaagaatct
tctaaaggcacacctcggtcttacttagcttccagtccaaacccattcagccgtgcaaat
gcagctgaaaccatatctgcagcaagagcacttccatctgcttctcctacttctatccga
actggatatatgcctcgaaaggcttcagttggatctgcttctactcgtcacgtgtttgga
tcaagactgcagaggataaagaccacagttaataccataggggctactgggaagttgtca
gctactcctcctccatcggctccaccaccttctggatctggcacaagtaaaatagacaaa
tatgcccgtattctctttccagtcacatttggggcatttaacatggtttattgggttgtt
tatttatctaaggacactatggagaaatcagaaagtctaatgtaa

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