KEGG   Homo sapiens (human): 2558Help
Entry
2558              CDS       T01001                                 

Gene name
GABRA5
Definition
(RefSeq) gamma-aminobutyric acid type A receptor alpha5 subunit
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225
Aminobutyric acid: D00058
Amobarbital (DG00916): D00555 D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149
Bromazepam: D01245
Brotizolam: D01744
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Chlordiazepoxide (DG00908): D00267 D00693
Cinolazepam: D07328
Clobazam: D01253
Clonazepam: D00280
Clotiazepam: D01328
Cloxazolam: D01268
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293
Estazolam: D00311
Eszopiclone: D02624
Ethyl loflazepate: D01293
Etizolam: D01514
Fludiazepam: D01354
Flumazenil: D00697
Flunitrazepam: D01230
Flurazepam (DG00919): D00329 D00695 D01408
Flutazolam: D01286
Flutoprazepam: D01279
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365
Lormetazepam: D01657
Medazepam (DG00909): D01292 D04882
Meprobamate: D00376
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316
Midazolam (DG00920): D00550 D00696 D05028
Nimetazepam: D01593
Nitrazepam: D00531
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464
Oxazolam: D01278
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500 D02253
Phenobarbital (DG00845): D00506 D00701 D08356
Potassium clorazepate (DG01218): D00694 D03562
Prazepam: D00470
Propofol (DG00797): D00549 D04257
Quazepam: D00457
Remimazolam besilate: D10194
Rilmazafone (DG01307): D01564 D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370
Thiamylal (DG01377): D00713 D06106
Thiopental (DG00790): D00714
Tofisopam: D01254
Topiramate: D00537
Triazolam: D00387
Zolpidem (DG00922): D00706 D08690
Zopiclone: D01372
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2558 (GABRA5)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2558 (GABRA5)
   04723 Retrograde endocannabinoid signaling
    2558 (GABRA5)
  09157 Sensory system
   04742 Taste transduction
    2558 (GABRA5)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2558 (GABRA5)
   05033 Nicotine addiction
    2558 (GABRA5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2558 (GABRA5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2558 (GABRA5)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Neur_chan_LBD Neur_chan_memb CytochromB561_N
Motif
Other DBs
NCBI-GeneID: 2558
NCBI-ProteinID: NP_000801
OMIM: 137142
HGNC: 4079
Ensembl: ENSG00000186297
Vega: OTTHUMG00000171824
Pharos: P31644(Tclin)
UniProt: P31644
Structure
PDB: 

Position
15q12
AA seq 462 aa AA seqDB search
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY
DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL
NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF
PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS
TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM
TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA
KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
NT seq 1389 nt NT seq  +upstreamnt  +downstreamnt
atggacaatggaatgttctctggttttatcatgatcaaaaacctccttctcttttgtatt
tccatgaacttatccagtcactttggcttttcacagatgccaaccagttcagtgaaagat
gagaccaatgacaacatcacgatatttaccaggatcttggatgggctcttggatggctac
gacaacagacttcggcccgggctgggagagcgcatcactcaggtgaggaccgacatctac
gtcaccagcttcggcccggtgtccgacacggaaatggagtacaccatagacgtgtttttc
cgacaaagctggaaagatgaaaggcttcggtttaaggggcccatgcagcgcctccctctc
aacaacctccttgccagcaagatctggaccccagacacgttcttccacaacgggaagaag
tccatcgctcacaacatgaccacgcccaacaagctgctgcggctggaggacgacggcacc
ctgctctacaccatgcgcttgaccatctctgcagagtgccccatgcagcttgaggacttc
ccgatggatgcgcacgcttgccctctgaaatttggcagctatgcgtaccctaattctgaa
gtcgtttacgtctggaccaacggctccaccaagtcggtggtggtggcggaagatggctcc
agactgaaccagtaccacctgatggggcagacggtgggcactgagaacatcagcaccagc
acaggcgaatacacaatcatgacagctcacttccacctgaaaaggaagattggctacttt
gtcatccagacctaccttccctgcataatgaccgtgatcttatcacaggtgtccttttgg
ctgaaccgggaatcagtcccagccaggacagtttttggggtcaccacggtgctgaccatg
acgaccctcagcatcagcgccaggaactctctgcccaaagtggcctacgccaccgccatg
gactggttcatagccgtgtgctatgccttcgtcttctcggcgctgatagagtttgccacg
gtcaattactttaccaagagaggctgggcctgggatggcaaaaaagccttggaagcagcc
aagatcaagaaaaagcgtgaagtcatactaaataagtcaacaaacgcttttacaactggg
aagatgtctcaccccccaaacattccgaaggaacagaccccagcagggacgtcgaataca
acctcagtctcagtaaaaccctctgaagagaagacttctgaaagcaaaaagacttacaac
agtatcagcaaaattgacaaaatgtcccgaatcgtattcccagtcttgttcggcactttc
aacttagtttactgggcaacgtatttgaatagggagccggtgataaaaggagccgcctct
ccaaaataa

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