KEGG T01001: 2564

Homo sapiens (human): 2564

Entry

2564              CDS       T01001

Symbol

GABRE

Name

(RefSeq) gamma-aminobutyric acid type A receptor subunit epsilon

K05185

gamma-aminobutyric acid receptor subunit epsilon

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

D02594

Adinazolam (DG00911):

D02770 D02771

Adipiplon:

D08840

Alpidem:

D02833

Alprazolam:

D00225<JP/US>

Aminobutyric acid:

D00058<JP>

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

Bromazepam:

D01245<JP>

Brotizolam:

D01744<JP>

Butabarbital (DG01308):

D00699 D03180

Butobarbital:

D02618

Cenobamate:

D11150<US>

Chlordiazepoxide (DG00908):

D00267<JP> D00693<US>

Cinolazepam:

D07328

Cipepofol:

D12449

Clobazam:

D01253<JP/US>

Clonazepam:

D00280<JP/US>

Clotiazepam:

D01328<JP>

Cloxazolam:

D01268<JP>

Darigabat:

D12146

Delorazepam:

D07784

Dextofisopam:

D03737

Diazepam:

D00293<JP/US>

Estazolam:

D00311<JP/US>

Eszopiclone:

D02624<JP/US>

Ethyl loflazepate:

D01293<JP>

Etizolam:

D01514<JP>

Fludiazepam:

D01354

Flumazenil:

D00697<JP/US>

Flunitrazepam:

D01230<JP>

Flurazepam (DG00919):

D00329 D00695<US> D01408<JP>

Flutazolam:

D01286

Flutoprazepam:

D01279

Gaboxadol:

D04282

Ganaxolone:

D04300<US>

Glutethimide:

D00532

Halazepam:

D00338

Haloxazolam:

D01758<JP>

Hexobarbital:

D01071

Indiplon:

D02640

Iomazenil:

D02283<JP>

Ketazolam:

D04650

Levotofisopam:

D04721

Loprazolam (DG00921):

D07326 D08145

Lorazepam:

D00365<JP/US>

Lormetazepam:

D01657<JP>

Medazepam (DG00909):

D01292<JP> D04882

Meprobamate:

D00376<US>

Metharbital:

D01382

Methylphenobarbital:

D00700

Mexazolam:

D01316<JP>

Midazolam (DG00920):

D00550<JP/US> D00696<US> D05028

Nimetazepam:

D01593

Nitrazepam:

D00531<JP>

Nordazepam:

D08283

Ocinaplon:

D02617

Oxazepam:

D00464<US>

Oxazolam:

D01278<JP>

Pagoclone:

D02616

Panadiplon:

D05346

Pazinaclone:

D05378

Pentobarbital (DG00915):

D00499 D00500<US> D02253<JP>

Phenobarbital (DG00845):

D00506<JP> D00701<JP/US> D08356

Potassium clorazepate (DG01218):

D00694<JP/US> D03562

Prazepam:

D00470

Propofol (DG00797):

D00549<JP/US> D04257

Quazepam:

D00457<JP/US>

Remimazolam (DG03105):

D10194<JP/US> D11788

Rilmazafone (DG01307):

D01564<JP> D08481

Sarmazenil:

D08507

Secobarbital (DG00917):

D00430 D01310

Suritozole:

D05980

Talbutal:

D06887

Temazepam:

D00370<US>

Thiamylal (DG01377):

D00713<JP> D06106

Thiopental (DG00790):

D00714<JP>

Tofisopam:

D01254<JP>

Topiramate:

D00537<JP/US>

Triazolam:

D00387<JP/US>

Zolpidem (DG00922):

D00706<JP/US> D08690

Zopiclone:

D01372<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2564 (GABRE)
   04082 Neuroactive ligand signaling
    2564 (GABRE)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2564 (GABRE)
   04723 Retrograde endocannabinoid signaling
    2564 (GABRE)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2564 (GABRE)
   05033 Nicotine addiction
    2564 (GABRE)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2564 (GABRE)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2564 (GABRE)

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

X:complement(151953124..151974676)

AA seq 506 aa
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE
TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI
IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD
GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW
KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW
IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV
LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER
PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL
DNYSRVVFPVTFFFFNVLYWLVCLNL

NT seq 1521 nt +upstreamnt +downstreamnt
atgttgtccaaagttcttccagtcctcctaggcatcttattgatcctccagtcgagggtc
gagggacctcagactgaatcaaagaatgaagcctcttcccgtgatgttgtctatggcccc
cagccccagcctctggaaaatcagctcctctctgaggaaacaaagtcaactgagactgag
actgggagcagagttggcaaactgccagaagcctctcgcatcctgaacactatcctgagt
aattatgaccacaaactgcgccctggcattggagagaagcccactgtggtcactgttgag
atctccgtcaacagccttggtcctctctctatcctagacatggaatacaccattgacatc
atcttctcccagacctggtacgacgaacgcctctgttacaacgacacctttgagtctctt
gttctgaatggcaatgtggtgagccagctatggatcccggacaccttttttaggaattct
aagaggacccacgagcatgagatcaccatgcccaaccagatggtccgcatctacaaggat
ggcaaggtgttgtacacaattaggatgaccattgatgccggatgctcactccacatgctc
agatttccaatggattctcactcttgccctctatctttctctagcttttcctatcctgag
aatgagatgatctacaagtgggaaaatttcaagcttgaaatcaatgagaagaactcctgg
aagctcttccagtttgattttacaggagtgagcaacaaaactgaaataatcacaacccca
gttggtgacttcatggtcatgacgattttcttcaatgtgagcaggcggtttggctatgtt
gcctttcaaaactatgtcccttcttccgtgaccacgatgctctcctgggtttccttttgg
atcaagacagagtctgctccagcccggacctctctagggatcacctctgttctgaccatg
accacgttgggcaccttttctcgtaagaatttcccgcgtgtctcctatatcacagccttg
gatttctatatcgccatctgcttcgtcttctgcttctgcgctctgttggagtttgctgtg
ctcaacttcctgatctacaaccagacaaaagcccatgcttctcctaaactccgccatcct
cgtatcaatagccgtgcccatgcccgtacccgtgcacgttcccgagcctgtgcccgccaa
catcaggaagcttttgtgtgccagattgtcaccactgagggaagtgatggagaggagcgc
ccgtcttgctcagcccagcagccccctagcccaggtagccctgagggtccccgcagcctc
tgctccaagctggcctgctgtgagtggtgcaagcgttttaagaagtacttctgcatggtc
cccgattgtgagggcagtacctggcagcagggccgcctctgcatccatgtctaccgcctg
gataactactcgagagttgttttcccagtgactttcttcttcttcaatgtgctctactgg
cttgtttgccttaacttgtag

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