KEGG   Homo sapiens (human): 2564
Entry
2564              CDS       T01001                                 

Gene name
GABRE
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit epsilon
  KO
K05185  gamma-aminobutyric acid receptor subunit epsilon
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP/US> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP/US>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2564 (GABRE)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2564 (GABRE)
   04723 Retrograde endocannabinoid signaling
    2564 (GABRE)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2564 (GABRE)
   05033 Nicotine addiction
    2564 (GABRE)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2564 (GABRE)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2564 (GABRE)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb
Other DBs
NCBI-GeneID: 2564
NCBI-ProteinID: NP_004952
OMIM: 300093
HGNC: 4085
Ensembl: ENSG00000102287
Vega: OTTHUMG00000024176
Pharos: P78334(Tclin)
UniProt: P78334
Position
Xq28
AA seq 506 aa
MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE
TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI
IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD
GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW
KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW
IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV
LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER
PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL
DNYSRVVFPVTFFFFNVLYWLVCLNL
NT seq 1521 nt   +upstreamnt  +downstreamnt
atgttgtccaaagttcttccagtcctcctaggcatcttattgatcctccagtcgagggtc
gagggacctcagactgaatcaaagaatgaagcctcttcccgtgatgttgtctatggcccc
cagccccagcctctggaaaatcagctcctctctgaggaaacaaagtcaactgagactgag
actgggagcagagttggcaaactgccagaagcctctcgcatcctgaacactatcctgagt
aattatgaccacaaactgcgccctggcattggagagaagcccactgtggtcactgttgag
atctccgtcaacagccttggtcctctctctatcctagacatggaatacaccattgacatc
atcttctcccagacctggtacgacgaacgcctctgttacaacgacacctttgagtctctt
gttctgaatggcaatgtggtgagccagctatggatcccggacaccttttttaggaattct
aagaggacccacgagcatgagatcaccatgcccaaccagatggtccgcatctacaaggat
ggcaaggtgttgtacacaattaggatgaccattgatgccggatgctcactccacatgctc
agatttccaatggattctcactcttgccctctatctttctctagcttttcctatcctgag
aatgagatgatctacaagtgggaaaatttcaagcttgaaatcaatgagaagaactcctgg
aagctcttccagtttgattttacaggagtgagcaacaaaactgaaataatcacaacccca
gttggtgacttcatggtcatgacgattttcttcaatgtgagcaggcggtttggctatgtt
gcctttcaaaactatgtcccttcttccgtgaccacgatgctctcctgggtttccttttgg
atcaagacagagtctgctccagcccggacctctctagggatcacctctgttctgaccatg
accacgttgggcaccttttctcgtaagaatttcccgcgtgtctcctatatcacagccttg
gatttctatatcgccatctgcttcgtcttctgcttctgcgctctgttggagtttgctgtg
ctcaacttcctgatctacaaccagacaaaagcccatgcttctcctaaactccgccatcct
cgtatcaatagccgtgcccatgcccgtacccgtgcacgttcccgagcctgtgcccgccaa
catcaggaagcttttgtgtgccagattgtcaccactgagggaagtgatggagaggagcgc
ccgtcttgctcagcccagcagccccctagcccaggtagccctgagggtccccgcagcctc
tgctccaagctggcctgctgtgagtggtgcaagcgttttaagaagtacttctgcatggtc
cccgattgtgagggcagtacctggcagcagggccgcctctgcatccatgtctaccgcctg
gataactactcgagagttgttttcccagtgactttcttcttcttcaatgtgctctactgg
cttgtttgccttaacttgtag

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