KEGG   Homo sapiens (human): 26060
Entry
26060             CDS       T01001                                 
Symbol
APPL1, APPL, DIP13alpha, MODY14
Name
(RefSeq) DCC-interacting protein 13-alpha
  KO
K08733  DCC-interacting protein 13 alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04081  Hormone signaling
hsa04211  Longevity regulating pathway
hsa04920  Adipocytokine signaling pathway
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
Network
nt06231  Apoptosis (cancer)
nt06260  Colorectal cancer
nt06325  Hormone/cytokine signaling
  Element
N00101  DCC-apoptotic pathway
N00102  Loss of DCC to DCC-apoptotic pathway
N01788  ADIPOQ-ADIPOR signaling pathway
Disease
H00410  Maturity onset diabetes of the young (MODY)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    26060 (APPL1)
 09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    26060 (APPL1)
  09149 Aging
   04211 Longevity regulating pathway
    26060 (APPL1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    26060 (APPL1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    26060 (APPL1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    26060 (APPL1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    26060 (APPL1)
SSDB
Motif
Pfam: BAR_3 PID PH BAR SOS1_NGEF_PH PH_9 Gemin6
Other DBs
NCBI-GeneID: 26060
NCBI-ProteinID: NP_036228
OMIM: 604299
HGNC: 24035
Ensembl: ENSP00000288266.3
UniProt: Q9UKG1
Structure
Position
3:57227729..57273471
AA seq 709 aa
MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHL
TSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKE
RDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMH
YFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREM
DSDIETMQQTIEDLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQ
FYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESK
KDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPAAGQSRP
PTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTN
PFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRM
TESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLS
SVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIE
KDLEEQSRLIAASSRPNQASSEGQFVVLSSSQSEESDLGEGGKKRESEA
NT seq 2130 nt   +upstreamnt  +downstreamnt
atgccggggatcgacaagctgcccatcgaggagacgctggaggacagcccgcagacaagg
tctttactaggtgtatttgaagaagatgccacagctatttccaactatatgaaccagttg
tatcaagctatgcatcggatttatgatgcacagaatgaattaagtgcagcaacacacctg
acctcaaaacttttaaaagaatatgaaaaacagcgttttccattgggaggtgatgatgaa
gttatgagctctacattgcaacagttttcaaaagttatagatgagcttagctcttgtcat
gcagtgctttcaactcaacttgctgatgccatgatgttccccattacccagtttaaagaa
agagatctgaaagaaatactaacattaaaggaagtatttcagattgcaagtaatgatcat
gatgctgcgattaatagatatagccgtttatcaaaaaaaagagaaaatgacaaggtgaag
tatgaagtaacagaagatgtgtacacatccagaaagaaacaacaccagaccatgatgcat
tatttttgtgcattaaatactcttcagtacaagaagaaaatagcattgttagaacctcta
cttgggtacatgcaagctcagataagtttctttaagatgggttctgaaaatcttaatgaa
caactggaagaatttttagctaatattggaacaagcgttcagaatgttcgcagggaaatg
gacagtgatatagagaccatgcaacagacaatagaggatttggaagtagccagtgatccc
ttatatgtgcctgacccagaccccaccaaatttcctgttaatcgaaatttaacccgaaag
gctggataccttaatgctaggaataaaacaggcttggtgtcatctacctgggacagacag
ttttacttcacgcagggtggaaatttaatgagtcaggcccgtggggatgtagcaggaggc
ctggccatggacatagacaactgttcagtgatggctgtggactgtgaagacagacgatat
tgttttcagatcacctctttcgatggaaaaaaatcttcaattttgcaagcagagagtaaa
aaagatcatgaagagtggatctgtacaataaacaacatatctaaacaaatatacttaagt
gaaaatccagaggaaactgctgcacgagtaaatcaatcagctctggaagctgtcactcct
tccccatctttccagcagaggcacgagagcctgcggccagcagcaggacaatctcggcca
ccgacagctcgaaccagcagttcaggatccttaggatctgagtctacaaatttggctgcc
ctctctctagattctcttgttgccccagacaccccaatacagtttgacataatttctcct
gtgtgtgaagatcagcctggccaggcaaaagcctttggccagggaggcaggcgtacaaat
ccatttggagaatctggaggaagtacaaaatctgaaactgaagattctattcttcatcag
ttatttattgtccgattccttggttcaatggaggtgaaatcagatgaccatccagatgtt
gtttatgaaactatgcgccaaatcttagctgcccgggccatccataacatctttcgtatg
acagaatcgcatttattagtcacttgtgactgtttaaagttaattgatccacagacacaa
gttacaaggctcacgtttccattaccttgtgtagttttgtatgctacacaccaggaaaat
aagcgcctttttggatttgttcttcggacatcaagcgggagaagtgaaagtaatctgtca
tcagtctgctatatatttgagtcaaacaatgagggggaaaagatatgtgattctgttgga
ctggcaaaacagatagctttgcatgctgaactggatcgtagggcatcagaaaaacaaaaa
gaaatagagagagtaaaagagaagcaacagaaagaactcaataaacaaaaacagattgaa
aaggacttggaagaacaaagtcggttgatagctgcttccagtagaccaaaccaagccagt
agtgaggggcagtttgttgtccttagcagtagccagtcagaagagagtgatttgggagaa
ggaggaaagaagagagaatcagaagcataa

  All links  
Disease (2)   
   OMIM (2)   
Gene (14)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (19)   
   RefSeq(nuc) (3)   
   GenBank (8)   
   EMBL (8)   
3D Structure (8)   
   PDB (8)   
Protein domain (7)   
   Pfam (7)   
All databases (55)   

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