KEGG   Homo sapiens (human): 26227Help
Entry
26227             CDS       T01001                                 

Gene name
PHGDH, 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
Definition
(RefSeq) phosphoglycerate dehydrogenase
  KO
K00058  D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
Module
hsa_M00020  Serine biosynthesis, glycerate-3P => serine
Disease
H01079  3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency
H02117  Neu-Laxova syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    26227 (PHGDH)
   00270 Cysteine and methionine metabolism
    26227 (PHGDH)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    26227 (PHGDH)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.95  phosphoglycerate dehydrogenase
     26227 (PHGDH)
    1.1.1.399  2-oxoglutarate reductase
     26227 (PHGDH)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   26227 (PHGDH)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 2-Hacid_dh_C 2-Hacid_dh
Motif
Other DBs
NCBI-GeneID: 26227
NCBI-ProteinID: NP_006614
OMIM: 606879
HGNC: 8923
Ensembl: ENSG00000092621
Vega: OTTHUMG00000012100
Pharos: O43175(Tbio)
UniProt: O43175
Structure
PDB: 

Position
1p12
AA seq 533 aa AA seqDB search
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
NT seq 1602 nt NT seq  +upstreamnt  +downstreamnt
atggcttttgcaaatctgcggaaagtgctcatcagtgacagcctggacccttgctgccgg
aagatcttgcaagatggagggctgcaggtggtggaaaagcagaaccttagcaaagaggag
ctgatagcggagctgcaggactgtgaaggccttattgttcgctctgccaccaaggtgacc
gctgatgtcatcaacgcagctgagaaactccaggtggtgggcagggctggcacaggtgtg
gacaatgtggatctggaggccgcaacaaggaagggcatcttggttatgaacacccccaat
gggaacagcctcagtgccgcagaactcacttgtggaatgatcatgtgcctggccaggcag
attccccaggcgacggcttcgatgaaggacggcaaatgggagcggaagaagttcatggga
acagagctgaatggaaagaccctgggaattcttggcctgggcaggattgggagagaggta
gctacccggatgcagtcctttgggatgaagactatagggtatgaccccatcatttcccca
gaggtctcggcctcctttggtgttcagcagctgcccctggaggagatctggcctctctgt
gatttcatcactgtgcacactcctctcctgccctccacgacaggcttgctgaatgacaac
acctttgcccagtgcaagaagggggtgcgtgtggtgaactgtgcccgtggagggatcgtg
gacgaaggcgccctgctccgggccctgcagtctggccagtgtgccggggctgcactggac
gtgtttacggaagagccgccacgggaccgggccttggtggaccatgagaatgtcatcagc
tgtccccacctgggtgccagcaccaaggaggctcagagccgctgtggggaggaaattgct
gttcagttcgtggacatggtgaaggggaaatctctcacgggggttgtgaatgcccaggcc
cttaccagtgccttctctccacacaccaagccttggattggtctggcagaagctctgggg
acactgatgcgagcctgggctgggtcccccaaagggaccatccaggtgataacacaggga
acatccctgaagaatgctgggaactgcctaagccccgcagtcattgtcggcctcctgaaa
gaggcttccaagcaggcggatgtgaacttggtgaacgctaagctgctggtgaaagaggct
ggcctcaatgtcaccacctcccacagccctgctgcaccaggggagcaaggcttcggggaa
tgcctcctggccgtggccctggcaggcgccccttaccaggctgtgggcttggtccaaggc
actacgcctgtactgcaggggctcaatggagctgtcttcaggccagaagtgcctctccgc
agggacctgcccctgctcctattccggactcagacctctgaccctgcaatgctgcctacc
atgattggcctcctggcagaggcaggcgtgcggctgctgtcctaccagacttcactggtg
tcagatggggagacctggcacgtcatgggcatctcctccttgctgcccagcctggaagcg
tggaagcagcatgtgactgaagccttccagttccacttctaa

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