KEGG   Homo sapiens (human): 2642
Entry
2642              CDS       T01001                                 
Symbol
GCGR, GGR, GL-R, MVAH
Name
(RefSeq) glucagon receptor
  KO
K04583  glucagon receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04922  Glucagon signaling pathway
Disease
H02787  Mahvash disease
Drug target
Crotedumab: D11230
Dasiglucagon (DG03173): D11359 D12314<US>
Glucagon (DG00511): D00116<JP/US> D02118<US>
Mazdutide: D12225
Pemvidutide: D12861
Retatrutide: D12430
Survodutide: D12898
Volagidemab: D11614
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2642 (GCGR)
   04081 Hormone signaling
    2642 (GCGR)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    2642 (GCGR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2642 (GCGR)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Pancreatic peptide
   Glucagon
    2642 (GCGR)
SSDB
Motif
Pfam: 7tm_2 HRM Dicty_CAR VSP
Other DBs
NCBI-GeneID: 2642
NCBI-ProteinID: NP_000151
OMIM: 138033
HGNC: 4192
Ensembl: ENSG00000215644
UniProt: P47871
Structure
Position
17:81804150..81814008
AA seq 477 aa
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
NT seq 1434 nt   +upstreamnt  +downstreamnt
atgcccccctgccagccacagcgacccctgctgctgttgctgctgctgctggcctgccag
ccacaggtcccctccgctcaggtgatggacttcctgtttgagaagtggaagctctacggt
gaccagtgtcaccacaacctgagcctgctgccccctcccacggagctggtgtgcaacaga
accttcgacaagtattcctgctggccggacacccccgccaataccacggccaacatctcc
tgcccctggtacctgccttggcaccacaaagtgcaacaccgcttcgtgttcaagagatgc
gggcccgacggtcagtgggtgcgtggaccccgggggcagccttggcgtgatgcctcccag
tgccagatggatggcgaggagattgaggtccagaaggaggtggccaagatgtacagcagc
ttccaggtgatgtacacagtgggctacagcctgtccctgggggccctgctcctcgccttg
gccatcctggggggcctcagcaagctgcactgcacccgcaatgccatccacgcgaatctg
tttgcgtccttcgtgctgaaagccagctccgtgctggtcattgatgggctgctcaggacc
cgctacagccagaaaattggcgacgacctcagtgtcagcacctggctcagtgatggagcg
gtggctggctgccgtgtggccgcggtgttcatgcaatatggcatcgtggccaactactgc
tggctgctggtggagggcctgtacctgcacaacctgctgggcctggccaccctccccgag
aggagcttcttcagcctctacctgggcatcggctggggtgcccccatgctgttcgtcgtc
ccctgggcagtggtcaagtgtctgttcgagaacgtccagtgctggaccagcaatgacaac
atgggcttctggtggatcctgcggttccccgtcttcctggccatcctgatcaacttcttc
atcttcgtccgcatcgttcagctgctcgtggccaagctgcgggcacggcagatgcaccac
acagactacaagttccggctggccaagtccacgctgaccctcatccctctgctgggcgtc
cacgaagtggtcttcgccttcgtgacggacgagcacgcccagggcaccctgcgctccgcc
aagctcttcttcgacctcttcctcagctccttccagggcctgctggtggctgtcctctac
tgcttcctcaacaaggaggtgcagtcggagctgcggcggcgttggcaccgctggcgcctg
ggcaaagtgctatgggaggagcggaacaccagcaaccacagggcctcatcttcgcccggc
cacggccctcccagcaaggagctgcagtttgggaggggtggtggcagccaggattcatct
gcggagacccccttggctggtggcctccctagattggctgagagccccttctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (18)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (24)   
   RefSeq(nuc) (8)   
   GenBank (8)   
   EMBL (8)   
3D Structure (20)   
   PDB (20)   
Protein domain (4)   
   Pfam (4)   
All databases (78)   

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