KEGG   Homo sapiens (human): 2642
Entry
2642              CDS       T01001                                 

Gene name
GCGR, GGR, GL-R
Definition
(RefSeq) glucagon receptor
  KO
K04583  glucagon receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04922  Glucagon signaling pathway
Drug target
Crotedumab: D11230
Dasiglucagon: D11359
Glucagon (DG00511): D00116<JP/US> D02118<US>
Volagidemab: D11614
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2642 (GCGR)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    2642 (GCGR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2642 (GCGR)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Pancreatic peptide
   Glucagon
    2642 (GCGR)
SSDB
Motif
Pfam: 7tm_2 HRM Dicty_CAR VSP
Other DBs
NCBI-GeneID: 2642
NCBI-ProteinID: NP_000151
OMIM: 138033
HGNC: 4192
Ensembl: ENSG00000215644
Vega: OTTHUMG00000177914
Pharos: P47871(Tclin)
UniProt: P47871
Structure
PDB: 
4ERS 4LF3

Position
17q25.3
AA seq 477 aa
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
NT seq 1434 nt   +upstreamnt  +downstreamnt
atgcccccctgccagccacagcgacccctgctgctgttgctgctgctgctggcctgccag
ccacaggtcccctccgctcaggtgatggacttcctgtttgagaagtggaagctctacggt
gaccagtgtcaccacaacctgagcctgctgccccctcccacggagctggtgtgcaacaga
accttcgacaagtattcctgctggccggacacccccgccaataccacggccaacatctcc
tgcccctggtacctgccttggcaccacaaagtgcaacaccgcttcgtgttcaagagatgc
gggcccgacggtcagtgggtgcgtggaccccgggggcagccttggcgtgatgcctcccag
tgccagatggatggcgaggagattgaggtccagaaggaggtggccaagatgtacagcagc
ttccaggtgatgtacacagtgggctacagcctgtccctgggggccctgctcctcgccttg
gccatcctggggggcctcagcaagctgcactgcacccgcaatgccatccacgcgaatctg
tttgcgtccttcgtgctgaaagccagctccgtgctggtcattgatgggctgctcaggacc
cgctacagccagaaaattggcgacgacctcagtgtcagcacctggctcagtgatggagcg
gtggctggctgccgtgtggccgcggtgttcatgcaatatggcatcgtggccaactactgc
tggctgctggtggagggcctgtacctgcacaacctgctgggcctggccaccctccccgag
aggagcttcttcagcctctacctgggcatcggctggggtgcccccatgctgttcgtcgtc
ccctgggcagtggtcaagtgtctgttcgagaacgtccagtgctggaccagcaatgacaac
atgggcttctggtggatcctgcggttccccgtcttcctggccatcctgatcaacttcttc
atcttcgtccgcatcgttcagctgctcgtggccaagctgcgggcacggcagatgcaccac
acagactacaagttccggctggccaagtccacgctgaccctcatccctctgctgggcgtc
cacgaagtggtcttcgccttcgtgacggacgagcacgcccagggcaccctgcgctccgcc
aagctcttcttcgacctcttcctcagctccttccagggcctgctggtggctgtcctctac
tgcttcctcaacaaggaggtgcagtcggagctgcggcggcgttggcaccgctggcgcctg
ggcaaagtgctatgggaggagcggaacaccagcaaccacagggcctcatcttcgcccggc
cacggccctcccagcaaggagctgcagtttgggaggggtggtggcagccaggattcatct
gcggagacccccttggctggtggcctccctagattggctgagagccccttctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (21)   
   RefSeq(nuc) (5)   
   GenBank (8)   
   EMBL (8)   
Protein domain (4)   
   Pfam (4)   
All databases (64)   

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