KEGG   Homo sapiens (human): 267
Entry
267               CDS       T01001                                 
Symbol
AMFR, GP78, RNF45, SPG89
Name
(RefSeq) autocrine motility factor receptor
  KO
K10636  E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
Disease
H00266  Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    267 (AMFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    267 (AMFR)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    267 (AMFR)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.36  RING-type E3 ubiquitin transferase (cysteine targeting)
     267 (AMFR)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    267 (AMFR)
  Multi subunit type E3
   ERAD complex
    267 (AMFR)
   LMBR1L-GP78-UBAC2 complex
    267 (AMFR)
SSDB
Motif
Pfam: G2BR zf-RING_2 zf-C3HC4_2 CUE zf-C3HC4 zf-RING_11 zf-C3HC4_3 zf-ANAPC11 zf-RING_UBOX zf-rbx1 zf-RING_5 zf-RING_16 Prok-RING_4 zf-C3HC4_4 zf_RING_Vps8 zf-RING_Vps41
Other DBs
NCBI-GeneID: 267
NCBI-ProteinID: NP_001135
OMIM: 603243
HGNC: 463
Ensembl: ENSG00000159461
UniProt: Q9UKV5
Structure
Position
16:complement(56361452..56425545)
AA seq 643 aa
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP
ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD
KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH
LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY
LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH
FFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDL
QLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLD
LSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNK
SSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
NT seq 1932 nt   +upstreamnt  +downstreamnt
atgccgctgctcttcctcgagcgcttcccctggcccagcctccgcacctacacgggcctc
agcggcctggccctgctgggcaccatcatcagcgcctaccgcgcgctcagccagcccgag
gccggccccggcgagccggaccagctaacggcctcgctgcagcctgagccgccggcgccc
gcccggccgagcgccgggggaccccgggcccgcgatgtggcccagtacctgctctcagac
agcctcttcgtgtgggttctagtaaataccgcttgctgtgttttgatgttggtggctaag
ctcatccagtgtattgtgtttggccctcttcgagtgagtgagagacagcatctcaaagac
aaattttggaattttattttctacaagttcattttcatctttggtgtgctgaatgtccag
acagtggaagaggtggtcatgtggtgcctctggtttgccggacttgtctttctgcacctg
atggttcagctctgcaaggatcgatttgaatatctttccttctcgcccaccacgccgatg
agcagccacggtcgagtcctgtccctgttggttgccatgctgctttcctgctgtggactg
gcggccgtctgctccatcaccggctacacccacggaatgcacaccttggctttcatggct
gcagagtctcttcttgtgacagtgaggactgctcatgtgattttacgatacgtaattcac
ctctgggacctcaaccacgaagggacgtgggaaggaaaggggacgtatgtctattacaca
gactttgtcatggagctcactctcctgtccctggacctcatgcaccatattcacatgttg
ttatttggcaacatctggttatccatggccagcctggtcatctttatgcagctgcgttac
ctgtttcatgaggtgcaacgtcgaattcgtcggcacaagaactatctacgtgtggttgga
aacatggaggccaggtttgcagttgcaactccagaggagctggctgtcaacaatgacgac
tgtgccatctgttgggactccatgcaggctgcgcggaaactgccctgtggacatcttttc
cacaactcctgtcttcgttcctggctagaacaagacacctcctgtccaacatgcagaatg
tctcttaatattgccgacaataatcgtgtcagggaagaacatcaaggagagaacttggat
gagaatttggttcctgtagcagcagccgaagggagacctcgcttaaaccaacacaatcac
ttcttccatttcgatgggtctcggattgcgagctggctgccgagtttttcggttgaagtg
atgcacaccaccaacattcttggcattacgcaggccagcaactcccagctcaatgcaatg
gctcatcagattcaagagatgtttccccaggttccataccatctggtactgcaggacctc
cagctgacacgctcagttgaaataacaacagacaatattttagaaggacggattcaagta
ccttttcctacacagcggtcagatagcatcagacctgcattgaacagtcctgtggaaagg
ccaagcagtgaccaggaagagggagaaacttctgctcagaccgagcgtgtgccactggac
ctcagtcctcgcctggaggagacgctggacttcggcgaggtggaagtggagcccagtgag
gtggaagacttcgaggctcgtgggagccgcttctccaagtctgctgatgagagacagcgc
atgctggtgcagcgtaaggacgaactcctccagcaagctcgcaaacgtttcttgaacaaa
agttctgaagatgatgcggcctcagagagcttcctcccctcggaaggtgcgtcctctgac
cccgtgaccctgcgtcgaaggatgctggctgccgccgcggaacggaggcttcagaagcag
cagacctcctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (16)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (50)   
   RefSeq(nuc) (6)   
   GenBank (22)   
   EMBL (22)   
3D Structure (13)   
   PDB (13)   
Protein domain (16)   
   Pfam (16)   
All databases (104)   

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