KEGG   Homo sapiens (human): 2677
Entry
2677              CDS       T01001                                 
Symbol
GGCX, VKCFD1
Name
(RefSeq) vitamin K-dependent gamma-carboxylase isoform 1
  KO
K10106  vitamin K-dependent gamma-carboxylase [EC:4.1.1.90]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Disease
H00560  Pseudoxanthoma elasticum
H00995  Combined deficiency of vitamin K-dependent clotting factors
H01205  Coumarin resistance
Drug target
Anisindione: D07457
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    2677 (GGCX)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.90  peptidyl-glutamate 4-carboxylase
     2677 (GGCX)
SSDB
Motif
Pfam: HTTM VKGC_lumenal_dom Cupin_2 Ppnp
Other DBs
NCBI-GeneID: 2677
NCBI-ProteinID: NP_000812
OMIM: 137167
HGNC: 4247
Ensembl: ENSP00000233838.3
UniProt: P38435
Structure
Position
2:complement(85544720..85561493)
AA seq 758 aa
MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTD
PASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYT
IMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYW
SVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSP
FKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFS
YVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRH
QLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRT
GELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQR
IFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHL
ENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYM
YVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFL
RRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEV
TYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF
NT seq 2277 nt   +upstreamnt  +downstreamnt
atggcggtgtctgccgggtccgcgcggacctcgcccagctcagataaagtacagaaagac
aaggctgaactgatctcagggcccaggcaggacagccgaatagggaaactcttgggtttt
gagtggacagatttgtccagttggcggaggctggtgaccctgctgaatcgaccaacggac
cctgcaagcttagctgtctttcgttttctttttgggttcttgatggtgctagacattccc
caggagcgggggctcagctctctggaccggaaataccttgatgggctggatgtgtgccgc
ttccccttgctggatgccctacgcccactgccacttgactggatgtatcttgtctacacc
atcatgtttctgggggcactgggcatgatgctgggcctgtgctaccggataagctgtgtg
ttattcctgctgccatactggtatgtgtttctcctggacaagacatcatggaacaaccac
tcctatctgtatgggttgttggcctttcagctaacattcatggatgcaaaccactactgg
tctgtggacggtctgctgaatgcccataggaggaatgcccacgtgcccctttggaactat
gcagtgctccgtggccagatcttcattgtgtacttcattgcgggtgtgaaaaagctggat
gcagactgggttgaaggctattccatggaatatttgtcccggcactggctcttcagtccc
ttcaaactgctgttgtctgaggagctgactagcctgctggtcgtgcactggggtgggctg
ctgcttgacctctcagctggtttcctgctcttttttgatgtctcaagatccattggcctg
ttctttgtgtcctacttccactgcatgaattcccagcttttcagcattggtatgttctcc
tacgtcatgctggccagcagccctctcttctgctcccctgagtggcctcggaagctggtg
tcctactgcccccgaaggttgcaacaactgttgcccctcaaggcagcccctcagcccagt
gtttcctgtgtgtataagaggagccggggcaaaagtggccagaagccagggctgcgccat
cagctgggagctgccttcaccctgctctacctcctggagcagctattcctgccctattct
cattttctcacccagggctataacaactggacaaatgggctgtatggctattcctgggac
atgatggtgcactcccgctcccaccagcacgtgaagatcacctaccgtgatggccgcact
ggcgaactgggctaccttaaccctggggtatttacacagagtcggcgatggaaggatcat
gcagacatgctgaagcaatatgccacttgcctgagccgcctgcttcccaagtataatgtc
actgagccccagatctactttgatatttgggtctccatcaatgaccgcttccagcagagg
atttttgaccctcgtgtggacatcgtgcaggccgcttggtcaccctttcagcgcacatcc
tgggtgcaaccactcttgatggacctgtctccctggagggccaagttacaggaaatcaag
agcagcctagacaaccacactgaggtggtcttcattgcagatttccctggactgcacttg
gagaattttgtgagtgaagacctgggcaacactagcatccagctgctgcagggggaagtg
actgtggagcttgtggcagaacagaagaaccagactcttcgagagggagaaaaaatgcag
ttgcctgctggtgagtaccataaggtgtatacgacatcacctagcccttcttgctacatg
tacgtctatgtcaacactacagagcttgcactggagcaagacctggcatatctgcaagaa
ttaaaggaaaaggtggagaatggaagtgaaacagggcctctacccccagagctgcagcct
ctgttggaaggggaagtaaaagggggccctgagccaacacctctggttcagacctttctt
agacgccaacaaaggctccaggagattgaacgccggcgaaatactcctttccatgagcga
ttcttccgcttcttgttgcgaaagctctatgtctttcgccgcagcttcctgatgacttgt
atctcacttcgaaatctgatattaggccgtccttccctggagcagctggcccaggaggtg
acttatgcaaacttgagaccctttgaggcagttggagaactgaatccctcaaacacggat
tcttcacattctaatcctcctgagtcaaatcctgatcctgtccactcagagttctga

  All links  
Disease (3)   
   OMIM (3)   
Gene (16)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (25)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (57)   
   RefSeq(nuc) (23)   
   GenBank (17)   
   EMBL (17)   
3D Structure (10)   
   PDB (10)   
Protein domain (4)   
   Pfam (4)   
All databases (115)   

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