KEGG   Homo sapiens (human): 2692
Entry
2692              CDS       T01001                                 
Symbol
GHRHR, GHRFR, GRFR, IGHD1B, IGHD4
Name
(RefSeq) growth hormone-releasing hormone receptor precursor
  KO
K04584  growth hormone releasing hormone receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04935  Growth hormone synthesis, secretion and action
Network
nt06324  GHRH-GH-IGF signaling
  Element
N00910  GHRHR-PKA-GH signaling pathway
Disease
H00254  Growth hormone deficiency
H02035  Isolated growth hormone deficiency
Drug target
Ibutamoren mesylate: D04491
Sermorelin (DG00494): D02117 D08509
Somatorelin (DG01168): D03326 D08523
Tesamorelin (DG00495): D06655 D09015<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2692 (GHRHR)
   04081 Hormone signaling
    2692 (GHRHR)
 09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    2692 (GHRHR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2692 (GHRHR)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Hypothalamic hormone
   Growth hormone-releasing hormone (GHRH)
    2692 (GHRHR)
SSDB
Motif
Pfam: 7tm_2 HRM Dicty_CAR
Other DBs
NCBI-GeneID: 2692
NCBI-ProteinID: NP_000814
OMIM: 139191
HGNC: 4266
Ensembl: ENSP00000320180.2
UniProt: Q02643 A0A090N8Y6
Structure
Position
7:30963953..30979528
AA seq 423 aa
MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWD
GLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLA
EEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVF
LKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRR
AFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLF
LNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPL
ELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLT
SMC
NT seq 1272 nt   +upstreamnt  +downstreamnt
atggaccgccggatgtggggggcccacgtcttctgcgtgttgagcccgttaccgaccgta
ttgggccacatgcacccagaatgtgacttcatcacccagctgagagaggatgagagtgcc
tgtctacaagcagcagaggagatgcccaacaccaccctgggctgccctgcgacctgggat
gggctgctgtgctggccaacggcaggctctggcgagtgggtcaccctcccctgcccggat
ttcttctctcacttcagctcagagtcaggggctgtgaaacgggattgtactatcactggc
tggtctgagccctttccaccttaccctgtggcctgccctgtgcctctggagctgctggct
gaggaggaatcttacttctccacagtgaagattatctacaccgtgggccatagcatctct
attgtagccctcttcgtggccatcaccatcctggttgctctcaggaggctccactgcccc
cggaactacgtccacacccagctgttcaccacttttatcctcaaggcgggagctgtgttc
ctgaaggatgctgcccttttccacagcgacgacactgaccactgcagcttctccactgtt
ctatgcaaggtctctgtggccgcctcccatttcgccaccatgaccaacttcagctggctg
ttggcagaagccgtctacctgaactgcctcctggcctccacctcccccagctcaaggaga
gccttctggtggctggttctcgctggctgggggctgcccgtgctcttcactggcacgtgg
gtgagctgcaaactggccttcgaggacatcgcgtgctgggacctggacgacacctccccc
tactggtggatcatcaaagggcccattgtcctctcggtcggggtgaactttgggcttttt
ctcaatattatccgcatcctggtgaggaaactggagccagctcagggcagcctccatacc
cagtctcagtattggcgtctctccaagtcgacacttttcctgatcccactctttggaatt
cactacatcatcttcaacttcctgccagacaatgctggcctgggcatccgcctccccctg
gagctgggactgggttccttccagggcttcattgttgccatcctctactgcttcctcaac
caagaggtgaggactgagatctcacggaagtggcatggccatgaccctgagcttctgcca
gcctggaggacccgtgctaagtggaccacgccttcccgctcggcggcaaaggtgctgaca
tctatgtgctag

  All links  
Disease (2)   
   OMIM (2)   
Gene (10)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (53)   

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