KEGG   Homo sapiens (human): 27102Help
Entry
27102             CDS       T01001                                 

Gene name
EIF2AK1, HCR, HRI
Definition
(RefSeq) eukaryotic translation initiation factor 2 alpha kinase 1
  KO
K16194  eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa05160  Hepatitis C
hsa05162  Measles
hsa05168  Herpes simplex virus 1 infection
Network
nt06122  IFN signaling (viruses)
nt06163  Hepatitis C virus (HCV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06222  IFN signaling
nt06263  Hepatocellular carcinoma
  Element
N00270  HCV Core to IFN signaling pathway
N00575  HSV ICP27 to IFN signaling pathway
N00576  HSV UL41/UL13 to IFN signaling pathway
N00577  HSV UL41 to IFN signaling pathway
N00578  HSV UL41 to IFN signaling pathway
N00694  MV V/P/C to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    27102 (EIF2AK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    27102 (EIF2AK1)
   05160 Hepatitis C
    27102 (EIF2AK1)
   05168 Herpes simplex virus 1 infection
    27102 (EIF2AK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    27102 (EIF2AK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     27102 (EIF2AK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   27102 (EIF2AK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Kdo APH SlyX PKcGMP_CC
Motif
Other DBs
NCBI-GeneID: 27102
NCBI-ProteinID: NP_055228
OMIM: 613635
HGNC: 24921
Ensembl: ENSG00000086232
Vega: OTTHUMG00000090689
Pharos: Q9BQI3(Tchem)
UniProt: Q9BQI3 A0A024QZU1
Position
7p22.1
AA seq 630 aa AA seqDB search
MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
NT seq 1893 nt NT seq  +upstreamnt  +downstreamnt
atgcaggggggcaactccggggtccgcaagcgcgaagaggagggcgacggggctggggct
gtggctgcgccgccggccatcgactttcccgccgagggcccggaccccgaatatgacgaa
tctgatgttccagcagaaatccaggtgttaaaagaacccctacaacagccaaccttccct
tttgcagttgcaaaccaactcttgctggtttctttgctggagcacttgagccacgtgcat
gaaccaaacccacttcgttcaagacaggtgtttaagctactttgccagacgtttatcaaa
atggggctgctgtcttctttcacttgtagtgacgagtttagctcattgagactacatcac
aacagagctattactcacttaatgaggtctgctaaagagagagttcgtcaggatccttgt
gaggatatttctcgtatccagaaaatcagatcaagggaagtagccttggaagcacaaact
tcacgttacttaaatgaatttgaagaacttgccatcttaggaaaaggtggatacggaaga
gtatacaaggtcaggaataaattagatggtcagtattatgcaataaaaaaaatcctgatt
aagggtgcaactaaaacagtttgcatgaaggtcctacgggaagtgaaggtgctggcaggt
cttcagcaccccaatattgttggctatcacaccgcgtggatagaacatgttcatgtgatt
cagccacgagcagacagagctgccattgagttgccatctctggaagtgctctccgaccag
gaagaggacagagagcaatgtggtgttaaaaatgatgaaagtagcagctcatccattatc
tttgctgagcccaccccagaaaaagaaaaacgctttggagaatctgacactgaaaatcag
aataacaagtcggtgaagtacaccaccaatttagtcataagagaatctggtgaacttgag
tcgaccctggagctccaggaaaatggcttggctggtttgtctgccagttcaattgtggaa
cagcagctgccactcaggcgtaattcccacctagaggagagtttcacatccaccgaagaa
tcttccgaagaaaatgtcaactttttgggtcagacagaggcacagtaccacctgatgctg
cacatccagatgcagctgtgtgagctctcgctgtgggattggatagtcgagagaaacaag
cggggccgggagtatgtggacgagtctgcctgtccttatgttatggccaatgttgcaaca
aaaatttttcaagaattggtagaaggtgtgttttacatacataacatgggaattgtgcac
cgagatctgaagccaagaaatatttttcttcatggccctgatcagcaagtaaaaatagga
gactttggtctggcctgcacagacatcctacagaagaacacagactggaccaacagaaac
gggaagagaacaccaacacatacgtccagagtgggtacttgtctgtacgcttcacccgaa
cagttggaaggatctgagtatgatgccaagtcagatatgtacagcttgggtgtggtcctg
ctagagctctttcagccgtttggaacagaaatggagcgagcagaagttctaacaggttta
agaactggtcagttgccggaatccctccgtaaaaggtgtccagtgcaagccaagtatatc
cagcacttaacgagaaggaactcatcgcagagaccatctgccattcagctgctgcagagt
gaacttttccaaaattctggaaatgttaacctcaccctacagatgaagataatagagcaa
gaaaaagaaattgcagaactaaagaagcagctaaacctcctttctcaagacaaaggggtg
agggatgacggaaaggatgggggcgtgggatga

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