KEGG   Homo sapiens (human): 27102
Entry
27102             CDS       T01001                                 

Gene name
EIF2AK1, HCR, HRI, LEMSPAD, hHRI
Definition
(RefSeq) eukaryotic translation initiation factor 2 alpha kinase 1
  KO
K16194  eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa05160  Hepatitis C
hsa05162  Measles
hsa05168  Herpes simplex virus 1 infection
Disease
H02457  Developmental delay, leukoencephalopathy, and neurologic decompensation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    27102 (EIF2AK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    27102 (EIF2AK1)
   05162 Measles
    27102 (EIF2AK1)
   05168 Herpes simplex virus 1 infection
    27102 (EIF2AK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    27102 (EIF2AK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     27102 (EIF2AK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   27102 (EIF2AK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo APH PKcGMP_CC
Other DBs
NCBI-GeneID: 27102
NCBI-ProteinID: NP_055228
OMIM: 613635
HGNC: 24921
Ensembl: ENSG00000086232
Vega: OTTHUMG00000090689
Pharos: Q9BQI3(Tchem)
UniProt: Q9BQI3 A0A024QZU1
Position
7p22.1
AA seq 630 aa
MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
NT seq 1893 nt   +upstreamnt  +downstreamnt
atgcaggggggcaactccggggtccgcaagcgcgaagaggagggcgacggggctggggct
gtggctgcgccgccggccatcgactttcccgccgagggcccggaccccgaatatgacgaa
tctgatgttccagcagaaatccaggtgttaaaagaacccctacaacagccaaccttccct
tttgcagttgcaaaccaactcttgctggtttctttgctggagcacttgagccacgtgcat
gaaccaaacccacttcgttcaagacaggtgtttaagctactttgccagacgtttatcaaa
atggggctgctgtcttctttcacttgtagtgacgagtttagctcattgagactacatcac
aacagagctattactcacttaatgaggtctgctaaagagagagttcgtcaggatccttgt
gaggatatttctcgtatccagaaaatcagatcaagggaagtagccttggaagcacaaact
tcacgttacttaaatgaatttgaagaacttgccatcttaggaaaaggtggatacggaaga
gtatacaaggtcaggaataaattagatggtcagtattatgcaataaaaaaaatcctgatt
aagggtgcaactaaaacagtttgcatgaaggtcctacgggaagtgaaggtgctggcaggt
cttcagcaccccaatattgttggctatcacaccgcgtggatagaacatgttcatgtgatt
cagccacgagcagacagagctgccattgagttgccatctctggaagtgctctccgaccag
gaagaggacagagagcaatgtggtgttaaaaatgatgaaagtagcagctcatccattatc
tttgctgagcccaccccagaaaaagaaaaacgctttggagaatctgacactgaaaatcag
aataacaagtcggtgaagtacaccaccaatttagtcataagagaatctggtgaacttgag
tcgaccctggagctccaggaaaatggcttggctggtttgtctgccagttcaattgtggaa
cagcagctgccactcaggcgtaattcccacctagaggagagtttcacatccaccgaagaa
tcttccgaagaaaatgtcaactttttgggtcagacagaggcacagtaccacctgatgctg
cacatccagatgcagctgtgtgagctctcgctgtgggattggatagtcgagagaaacaag
cggggccgggagtatgtggacgagtctgcctgtccttatgttatggccaatgttgcaaca
aaaatttttcaagaattggtagaaggtgtgttttacatacataacatgggaattgtgcac
cgagatctgaagccaagaaatatttttcttcatggccctgatcagcaagtaaaaatagga
gactttggtctggcctgcacagacatcctacagaagaacacagactggaccaacagaaac
gggaagagaacaccaacacatacgtccagagtgggtacttgtctgtacgcttcacccgaa
cagttggaaggatctgagtatgatgccaagtcagatatgtacagcttgggtgtggtcctg
ctagagctctttcagccgtttggaacagaaatggagcgagcagaagttctaacaggttta
agaactggtcagttgccggaatccctccgtaaaaggtgtccagtgcaagccaagtatatc
cagcacttaacgagaaggaactcatcgcagagaccatctgccattcagctgctgcagagt
gaacttttccaaaattctggaaatgttaacctcaccctacagatgaagataatagagcaa
gaaaaagaaattgcagaactaaagaagcagctaaacctcctttctcaagacaaaggggtg
agggatgacggaaaggatgggggcgtgggatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (3)   
   GenBank (14)   
   EMBL (14)   
Protein domain (5)   
   Pfam (5)   
All databases (84)   

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