KEGG   Homo sapiens (human): 27161
Entry
27161             CDS       T01001                                 
Symbol
AGO2, CASC7, EIF2C2, LESKRES, LINC00980, PPD, Q10
Name
(RefSeq) argonaute RISC catalytic component 2
  KO
K11593  eukaryotic translation initiation factor 2C
Organism
hsa  Homo sapiens (human)
Disease
H02651  Lessel-Kreienkamp syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    27161 (AGO2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    27161 (AGO2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     27161 (AGO2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    27161 (AGO2)
   RNA interference (RNAi) pathway
    RITS (RNA-induced transcriptional silencing) complex
     27161 (AGO2)
   microRNA pathway
    RISC loading complex
     27161 (AGO2)
SSDB
Motif
Pfam: Piwi ArgoN ArgoMid PAZ ArgoL1 ArgoL2
Other DBs
NCBI-GeneID: 27161
NCBI-ProteinID: NP_036286
OMIM: 606229
HGNC: 3263
Ensembl: ENSG00000123908
UniProt: Q9UKV8
Structure
Position
8:complement(140520156..140642313)
AA seq 859 aa
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRS
FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
TSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVL
GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQ
ALAKAVQVHQDTLRTMYFA
NT seq 2580 nt   +upstreamnt  +downstreamnt
atgtactcgggagccggccccgcacttgcacctcctgcgccgccgccccccatccaagga
tatgccttcaagcctccacctagacccgactttgggacctccgggagaacaatcaaatta
caggccaatttcttcgaaatggacatccccaaaattgacatctatcattatgaattggat
atcaagccagagaagtgcccgaggagagttaacagggaaatcgtggaacacatggtccag
cactttaaaacacagatctttggggatcggaagcccgtgtttgacggcaggaagaatcta
tacacagccatgccccttccgattgggagggacaaggtggagctggaggtcacgctgcca
ggagaaggcaaggatcgcatcttcaaggtgtccatcaagtgggtgtcctgcgtgagcttg
caggcgttacacgatgcactttcagggcggctgcccagcgtcccttttgagacgatccag
gccctggacgtggtcatgaggcacttgccatccatgaggtacacccccgtgggccgctcc
ttcttcaccgcgtccgaaggctgctctaaccctcttggcgggggccgagaagtgtggttt
ggcttccatcagtccgtccggccttctctctggaaaatgatgctgaatattgatgtgtca
gcaacagcgttttacaaggcacagccagtaatcgagtttgtttgtgaagttttggatttt
aaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaa
gaaattaaaggtctaaaggtggagataacgcactgtgggcagatgaagaggaagtaccgc
gtctgcaatgtgacccggcggcccgccagtcaccaaacattcccgctgcagcaggagagc
gggcagacggtggagtgcacggtggcccagtatttcaaggacaggcacaagttggttctg
cgctacccccacctcccatgtttacaagtcggacaggagcagaaacacacctaccttccc
ctggaggtctgtaacattgtggcaggacaaagatgtattaaaaaattaacggacaatcag
acctcaaccatgatcagagcgactgctaggtcggcgcccgatcggcaagaagagattagc
aaattgatgcgaagtgcaagtttcaacacagatccatacgtccgtgaatttggaatcatg
gtcaaagatgagatgacagacgtgactgggcgggtgctgcagccgccctccatcctctac
gggggcaggaataaagctattgcgacccctgtccagggcgtctgggacatgcggaacaag
cagttccacacgggcatcgagatcaaggtgtgggccattgcgtgcttcgccccccagcgc
cagtgcacggaagtccatctgaagtccttcacagagcagctcagaaagatctcgagagac
gccggcatgcccatccagggccagccgtgcttctgcaaatacgcgcagggggcggacagc
gtggagcccatgttccggcacctgaagaacacgtatgcgggcctgcagctggtggtggtc
atcctgcccggcaagacgcccgtgtacgccgaggtcaagcgcgtgggagacacggtgctg
gggatggccacgcagtgcgtgcagatgaagaacgtgcagaggaccacgccacagaccctg
tccaacctctgcctgaagatcaacgtcaagctgggaggcgtgaacaacatcctgctgccc
cagggcaggccgccggtgttccagcagcccgtcatctttctgggagcagacgtcactcac
ccccccgccggggatgggaagaagccctccattgccgccgtggtgggcagcatggacgcc
caccccaatcgctactgcgccaccgtgcgcgtgcagcagcaccggcaggagatcatacaa
gacctggccgccatggtccgcgagctcctcatccagttctacaagtccacgcgcttcaag
cccacccgcatcatcttctaccgcgacggtgtctctgaaggccagttccagcaggttctc
caccacgagttgctggccatccgtgaggcctgtatcaagctagaaaaagactaccagccc
gggatcaccttcatcgtggtgcagaagaggcaccacacccggctcttctgcactgacaag
aacgagcgggttgggaaaagtggaaacattccagcaggcacgactgtggacacgaaaatc
acccaccccaccgagttcgacttctacctgtgtagtcacgctggcatccaggggacaagc
aggccttcgcactatcacgtcctctgggacgacaatcgtttctcctctgatgagctgcag
atcctaacctaccagctgtgtcacacctacgtgcgctgcacacgctccgtgtccatccca
gcgccagcatactacgctcacctggtggccttccgggccaggtaccacctggtggataag
gaacatgacagtgctgaaggaagccatacctctgggcagagtaacgggcgagaccaccaa
gcactggccaaggcggtccaggttcaccaagacactctgcgcaccatgtactttgcttga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (44)   
   RefSeq(nuc) (12)   
   GenBank (16)   
   EMBL (16)   
3D Structure (44)   
   PDB (44)   
Protein domain (6)   
   Pfam (6)   
All databases (149)   

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