KEGG   Homo sapiens (human): 2736Help
Entry
2736              CDS       T01001                                 

Gene name
GLI2, CJS, HPE9, PHS2, THP1, THP2
Definition
(RefSeq) GLI family zinc finger 2
  KO
K16798  zinc finger protein GLI2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
hsa04390  Hippo signaling pathway
hsa05200  Pathways in cancer
hsa05217  Basal cell carcinoma
Network
nt06217  HH signaling
nt06269  Basal cell carcinoma
  Element
N00010  Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017  Mutation-activated SMO to Hedgehog signaling pathway
N00062  Hedgehog signaling pathway
Disease
H00267  Holoprosencephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    2736 (GLI2)
   04390 Hippo signaling pathway
    2736 (GLI2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2736 (GLI2)
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    2736 (GLI2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2736 (GLI2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 developmental/cell cycle regulators, GLI-like
    2736 (GLI2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: zf-C2H2 zf-H2C2_2 zf-C2H2_4 FOXP-CC
Motif
Other DBs
NCBI-GeneID: 2736
NCBI-ProteinID: NP_005261
OMIM: 165230
HGNC: 4318
Ensembl: ENSG00000074047
Vega: OTTHUMG00000153741
Pharos: P10070(Tchem)
UniProt: P10070 Q1PSW9 Q59FV5
Position
2q14.2
AA seq 1586 aa AA seqDB search
METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHA
PLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHP
YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQM
TLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD
ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL
SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSES
AVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKED
LDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTRE
QKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGC
NKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR
NDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGA
QSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLR
KHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPA
GLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASP
LGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGP
PPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHE
APGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLA
RGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDE
GTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKN
NMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDS
TQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTIS
GALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQS
YPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPT
GRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAP
DHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTV
DSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGI
SNMAVGDMSSMLTSLAEESKFLNMMT
NT seq 4761 nt NT seq  +upstreamnt  +downstreamnt
atggagacgtctgcctcagccactgcctccgagaagcaagaagccaaaagtgggatcctg
gaggccgctggcttccccgacccgggtaaaaaggcctctcctttggtggtggctgcagcg
gcagcagcagcggtagctgcccaaggagtgccgcagcatctcttgccaccattccatgcg
cccctaccgattgacatgcgacaccaggaaggaaggtaccattacgagcctcattctgtc
cacggtgtgcacgggccccctgccctcagcggcagccctgtcatctctgacatctccttg
atccggctttccccgcacccggctggccctggggagtcccccttcaacgccccccacccg
tacgtgaacccccacatggagcactacctccgttctgtgcacagcagccccacgctctcc
atgatctctgcagccaggggcctcagccccgctgatgtggcccaggagcaccttaaggag
aggggactgtttggccttcctgctccaggcaccaccccctcagactattaccaccagatg
accctcgtggcaggccaccccgcgccctacggggacctgctgatgcagagcgggggcgct
gccagcgcaccccatctccacgactacctcaaccccgtggacgtgtcccgtttctccagc
ccgcgggtgacgccccgcctgagccgcaagcgggcgctgtccatctccccactctcagac
gccagcctggacctgcagcggatgatccgcacctcacccaactcgctagtggcctacatc
aacaactcccgaagcagctcggcggccagcggttcctacgggcatctgtcagcgggtgcc
ctcagcccagccttcaccttcccccaccccatcaaccccgtggcctaccagcagattctg
agccagcagaggggtctggggtcagcctttggacacacaccacccctgatccagccctca
cccaccttcctggcccagcagcccatggccctcacctccatcaatgccacgcccacccag
ctcagcagcagcagcaactgtctgagtgacaccaaccagaacaagcagagcagtgagtcg
gccgtcagcagcaccgtcaaccctgtcgccattcacaagcgcagcaaggtcaagaccgag
cctgagggcctgcggccggcctcccctctggcgctgacgcagggccaggtgtctggacac
ggctcatgtgggtgtgcccttcccctctcccaggagcagctggctgacctcaaggaagat
ctggacagggatgactgtaagcaggaggctgaggtggtcatctatgagaccaactgccac
tgggaagactgcaccaaggagtacgacacccaggagcagctggtgcatcacatcaacaac
gagcacatccacggggagaagaaggagtttgtgtgccgctggcaggcctgcacgcgggag
cagaagcccttcaaggcgcagtacatgctggtggtgcacatgcggcgacacacgggcgag
aagccccacaagtgcacgttcgagggctgctcgaaggcctactcccgcctggagaacctg
aagacacacctgcggtcccacaccggggagaagccatatgtgtgtgagcacgagggctgc
aacaaagccttctccaacgcctcggaccgcgccaagcaccagaatcgcacccactccaac
gagaaaccctacatctgcaagatcccaggctgcaccaagagatacacagaccccagctct
ctccggaagcatgtgaaaacggtccacggcccagatgcccacgtcaccaagaagcagcgc
aatgacgtgcacctccgcacaccgctgctcaaagagaatggggacagtgaggccggcacg
gagcctggcggcccagagagcaccgaggccagcagcaccagccaggccgtggaggactgc
ctgcacgtcagagccatcaagaccgagagctccgggctgtgtcagtccagccccggggcc
cagtcgtcctgcagcagcgagccctctcctctgggcagtgcccccaacaatgacagtggc
gtggagatgccggggacggggcccgggagcctgggagacctgacggcactggatgacaca
cccccaggggccgacacctcagccctggctgccccctccgctggtggcctccagctgcgc
aaacacatgaccaccatgcaccggttcgagcagctcaagaaggagaagctcaagtcactc
aaggattcctgctcatgggccgggccgactccacacacgcggaacaccaagctgcctccc
ctcccgggaagtggctccatcctggaaaacttcagtggcagtgggggcggcgggcccgcg
gggctgctgccgaacccgcggctgtcggagctgtccgcgagcgaggtgaccatgctgagc
cagctgcaggagcgccgcgacagctccaccagcacggtcagctcggcctacaccgtgagc
cgccgctcctccggcatctccccctacttctccagccgccgctccagcgaggcctcgccc
ctgggcgccggccgcccgcacaacgcgagctccgctgactcctacgaccccatctccacg
gacgcgtcgcggcgctcgagcgaggccagccagtgcagcggcggctccgggctgctcaac
ctcacgccggcgcagcagtacagcctgcgggccaagtacgcggcagccactggcggcccc
ccgcccactccgctgccgggcctggagcgcatgagcctgcggaccaggctggcgctgctg
gacgcgcccgagcgcacgctgcccgccggctgcccacgcccactggggccgcggcgtggc
agcgacgggccgacctatggccacggccacgcgggggctgcgcccgccttcccccacgag
gctccaggcggcggagccaggcgggccagcgaccctgtgcggcggcccgatgccctgtcc
ctgccgcgggtgcagcgcttccacagcacccacaacgtgaaccccggcccgctgccgccc
tgtgccgacaggcgaggcctccgcctgcagagccacccgagcaccgacggcggcctggcc
cgcggcgcctactcgccccggccgcctagcatcagcgagaacgtggcgatggaggccgtg
gcggcaggagtggacggcgcggggcccgaggccgacctggggctgccggaggacgacctg
gtgcttccagacgacgtggtgcagtacatcaaggcgcacgccagtggcgctctggacgag
ggcaccgggcaggtgtatcccacggaaagcactggcttctctgacaaccccagactaccc
agcccggggctgcacggccagcgcaggatggtggctgcggactccaacgtgggcccctcc
gcccctatgctgggaggatgccagttaggctttggggcgccctccagcctgaacaaaaat
aacatgcctgtgcagtggaatgaggtgagctccggcaccgtagacgccctggccagccag
gtgaagcctccaccctttcctcagggcaacctggcggtggtgcagcagaagcctgccttt
ggccagtacccgggctacagtccgcaaggcctacaggctagccctgggggcctggacagc
acgcagccacacctgcagccccgcagcggagccccctcccagggcatccccagggtaaac
tacatgcagcagctgcgacagccagtggcaggcagccagtgtcctggcatgactaccact
atgagcccccatgcctgctatggccaagtccacccccagctgagccccagcaccatcagt
ggggccctcaaccagttcccccaatcctgcagcaacatgccagccaagccagggcatctg
gggcaccctcagcagacagaagtggcacctgaccccaccacgatgggcaatcgccacagg
gaacttggggtccccgattcagccctggctggagtgccaccacctcacccagtccagagc
tacccacagcagagccatcacctggcagcctccatgagccaggagggctaccaccaggtc
cccagccttctgcctgcccgccagcctggcttcatggagccccaaacaggcccgatgggg
gtggctacagcaggctttggcctagtgcagccccggcctcccctcgagcccagccccact
ggccgccaccgtggggtacgtgctgtgcagcagcagctggcctacgccagggccacaggc
catgccatggctgccatgccgtccagtcaggaaacagcagaggctgtgcccaagggagcg
atgggcaacatggggtcggtgcctccccagccgcctccgcaggacgcaggtggggccccg
gaccacagcatgctctactactacggccagatccacatgtacgaacaggatggaggcctg
gagaacctcgggagctgccaggtcatgcggtcccagccaccacagccacaggcctgtcag
gacagcatccagccccagcccttgccctcaccaggggtcaaccaggtgtccagcactgtg
gactcccagctcctggaggccccccagattgacttcgatgccatcatggatgatggcgat
cactcgagtttgttctcgggtgctctgagccccagcctcctccacagcctctcccagaac
tcctcccgcctcaccaccccccgaaactccttgaccctgccctccatccccgcaggcatc
agcaacatggctgtcggggacatgagctccatgctcaccagcctcgccgaggagagcaag
ttcctgaacatgatgacctag

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