KEGG   Homo sapiens (human): 284
Entry
284               CDS       T01001                                 
Symbol
ANGPT1, AGP1, AGPT, AGPT-1, ANG1, HAE5
Name
(RefSeq) angiopoietin 1
  KO
K05465  angiopoietin 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05323  Rheumatoid arthritis
Network
nt06526  MAPK signaling
nt06530  PI3K signaling
  Element
N01592  GF-RTK-RAS-ERK signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
Disease
H01006  Hereditary angioedema
Drug target
Trebananib: D10177
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    284 (ANGPT1)
   04014 Ras signaling pathway
    284 (ANGPT1)
   04015 Rap1 signaling pathway
    284 (ANGPT1)
   04066 HIF-1 signaling pathway
    284 (ANGPT1)
   04151 PI3K-Akt signaling pathway
    284 (ANGPT1)
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    284 (ANGPT1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    284 (ANGPT1)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Growth factors (RTK binding)
   284 (ANGPT1)
SSDB
Motif
Pfam: Fibrinogen_C
Other DBs
NCBI-GeneID: 284
NCBI-ProteinID: NP_001137
OMIM: 601667
HGNC: 484
Ensembl: ENSG00000154188
UniProt: Q15389
Structure
Position
8:complement(107249482..107497918)
AA seq 498 aa
MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTD
QYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAV
QNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQ
TNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRA
TTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIY
TIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNE
FIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLIL
HGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFK
GPSYSLRSTTMMIRPLDF
NT seq 1497 nt   +upstreamnt  +downstreamnt
atgacagttttcctttcctttgctttcctcgctgccattctgactcacatagggtgcagc
aatcagcgccgaagtccagaaaacagtgggagaagatataaccggattcaacatgggcaa
tgtgcctacactttcattcttccagaacacgatggcaactgtcgtgagagtacgacagac
cagtacaacacaaacgctctgcagagagatgctccacacgtggaaccggatttctcttcc
cagaaacttcaacatctggaacatgtgatggaaaattatactcagtggctgcaaaaactt
gagaattacattgtggaaaacatgaagtcggagatggcccagatacagcagaatgcagtt
cagaaccacacggctaccatgctggagataggaaccagcctcctctctcagactgcagag
cagaccagaaagctgacagatgttgagacccaggtactaaatcaaacttctcgacttgag
atacagctgctggagaattcattatccacctacaagctagagaagcaacttcttcaacag
acaaatgaaatcttgaagatccatgaaaaaaacagtttattagaacataaaatcttagaa
atggaaggaaaacacaaggaagagttggacaccttaaaggaagagaaagagaaccttcaa
ggcttggttactcgtcaaacatatataatccaggagctggaaaagcaattaaacagagct
accaccaacaacagtgtccttcagaagcagcaactggagctgatggacacagtccacaac
cttgtcaatctttgcactaaagaaggtgttttactaaagggaggaaaaagagaggaagag
aaaccatttagagactgtgcagatgtatatcaagctggttttaataaaagtggaatctac
actatttatattaataatatgccagaacccaaaaaggtgttttgcaatatggatgtcaat
gggggaggttggactgtaatacaacatcgtgaagatggaagtctagatttccaaagaggc
tggaaggaatataaaatgggttttggaaatccctccggtgaatattggctggggaatgag
tttatttttgccattaccagtcagaggcagtacatgctaagaattgagttaatggactgg
gaagggaaccgagcctattcacagtatgacagattccacataggaaatgaaaagcaaaac
tataggttgtatttaaaaggtcacactgggacagcaggaaaacagagcagcctgatctta
cacggtgctgatttcagcactaaagatgctgataatgacaactgtatgtgcaaatgtgcc
ctcatgttaacaggaggatggtggtttgatgcttgtggcccctccaatctaaatggaatg
ttctatactgcgggacaaaaccatggaaaactgaatgggataaagtggcactacttcaaa
gggcccagttactccttacgttccacaactatgatgattcgacctttagatttttga

  All links  
Disease (2)   
   OMIM (2)   
Gene (15)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (36)   
   RefSeq(nuc) (6)   
   GenBank (15)   
   EMBL (15)   
3D Structure (3)   
   PDB (3)   
Protein domain (1)   
   Pfam (1)   
All databases (64)   

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