KEGG   Homo sapiens (human): 290
Entry
290               CDS       T01001                                 
Symbol
ANPEP, AP-M, AP-N, APN, CD13, GP150, LAP1, P150, PEPN, hAPN
Name
(RefSeq) aminopeptidase N precursor
  KO
K11140  aminopeptidase N [EC:3.4.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa04614  Renin-angiotensin system
hsa04640  Hematopoietic cell lineage
Drug target
Tosedostat: D10026
Ubenimex: D00087<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    290 (ANPEP)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    290 (ANPEP)
  09152 Endocrine system
   04614 Renin-angiotensin system
    290 (ANPEP)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    290 (ANPEP)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    290 (ANPEP)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    290 (ANPEP)
   04090 CD molecules [BR:hsa04090]
    290 (ANPEP)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.11  Aminopeptidases
    3.4.11.2  membrane alanyl aminopeptidase
     290 (ANPEP)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M1
   290 (ANPEP)
Membrane trafficking [BR:hsa04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    290 (ANPEP)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   290 (ANPEP)
CD molecules [BR:hsa04090]
 Proteins
  290 (ANPEP)
SSDB
Motif
Pfam: ERAP1_C Peptidase_M1 Peptidase_M1_N DUF5700 Aminopep BSP DUF6968
Other DBs
NCBI-GeneID: 290
NCBI-ProteinID: NP_001141
OMIM: 151530
HGNC: 500
Ensembl: ENSP00000300060.6
UniProt: P15144 Q59E93
Structure
Position
15:complement(89784895..89814852)
AA seq 967 aa
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
WFTENSK
NT seq 2904 nt   +upstreamnt  +downstreamnt
atggccaagggcttctatatttccaagtccctgggcatcctggggatcctcctgggcgtg
gcagccgtgtgcacaatcatcgcactgtcagtggtgtactcccaggagaagaacaagaac
gccaacagctcccccgtggcctccaccaccccgtccgcctcagccaccaccaaccccgcc
tcggccaccaccttggaccaaagtaaagcgtggaatcgttaccgcctccccaacacgctg
aaacccgattcctaccgggtgacgctgagaccgtacctcacccccaatgacaggggcctg
tacgtttttaagggctccagcaccgtccgtttcacctgcaaggaggccactgacgtcatc
atcatccacagcaagaagctcaactacaccctcagccaggggcacagggtggtcctgcgt
ggtgtgggaggctcccagccccccgacattgacaagactgagctggtggagcccaccgag
tacctggtggtgcacctcaagggctccctggtgaaggacagccagtatgagatggacagc
gagttcgagggggagttggcagatgacctggcgggcttctaccgcagcgagtacatggag
ggcaatgtcagaaaggtggtggccactacacagatgcaggctgcagatgcccggaagtcc
ttcccatgcttcgatgagccggccatgaaggccgagttcaacatcacgcttatccacccc
aaggacctgacagccctgtccaacatgcttcccaaaggtcccagcaccccacttccagaa
gaccccaactggaatgtcactgagttccacaccacgcccaagatgtccacgtacttgctg
gccttcattgtcagtgagttcgactacgtggagaagcaggcatccaatggtgtcttgatc
cggatctgggcccggcccagtgccattgcggcgggccacggcgattatgccctgaacgtg
acgggccccatccttaacttctttgctggtcattatgacacaccctacccactcccaaaa
tcagaccagattggcctgccagacttcaacgccggcgccatggagaactggggactggtg
acctaccgggagaactccctgctgttcgaccccctgtcctcctccagcagcaacaaggag
cgggtggtcactgtgattgctcatgagctggcccaccagtggttcgggaacctggtgacc
atagagtggtggaatgacctgtggctgaacgagggcttcgcctcctacgtggagtacctg
ggtgctgactatgcggagcccacctggaacttgaaagacctcatggtgctgaatgatgtg
taccgcgtgatggcagtggatgcactggcctcctcccacccgctgtccacacccgcctcg
gagatcaacacgccggcccagatcagtgagctgtttgacgccatctcctacagcaagggc
gcctcagtcctcaggatgctctccagcttcctgtccgaggacgtattcaagcagggcctg
gcgtcctacctccacacctttgcctaccagaacaccatctacctgaacctgtgggaccac
ctgcaggaggctgtgaacaaccggtccatccaactccccaccaccgtgcgggacatcatg
aaccgctggaccctgcagatgggcttcccggtcatcacggtggataccagcacggggacc
ctttcccaggagcacttcctccttgaccccgattccaatgttacccgcccctcagaattc
aactacgtgtggattgtgcccatcacatccatcagagatggcagacagcagcaggactac
tggctgatagatgtaagagcccagaacgatctcttcagcacatcaggcaatgagtgggtc
ctgctgaacctcaatgtgacgggctattaccgggtgaactacgacgaagagaactggagg
aagattcagactcagctgcagagagaccactcggccatccctgtcatcaatcgggcacag
atcattaatgacgccttcaacctggccagtgcccataaggtccctgtcactctggcgctg
aacaacaccctcttcctgattgaagagagacagtacatgccctgggaggccgccctgagc
agcctgagctacttcaagctcatgtttgaccgctccgaggtctatggccccatgaagaac
tacctgaagaagcaggtcacacccctcttcattcacttcagaaataataccaacaactgg
agggagatcccagaaaacctgatggaccagtacagcgaggttaatgccatcagcaccgcc
tgctccaacggagttccagagtgtgaggagatggtctctggccttttcaagcagtggatg
gagaaccccaataataacccgatccaccccaacctgcggtccaccgtctactgcaacgct
atcgcccagggcggggaggaggagtgggacttcgcctgggagcagttccgaaatgccaca
ctggtcaatgaggctgacaagctccgggcagccctggcctgcagcaaagagttgtggatc
ctgaacaggtacctgagctacaccctgaacccggacttaatccggaagcaggacgccacc
tctaccatcatcagcattaccaacaacgtcattgggcaaggtctggtctgggactttgtc
cagagcaactggaagaagctttttaacgattatggtggtggctcgttctccttctccaac
ctcatccaggcagtgacacgacgattctccaccgagtatgagctgcagcagctggagcag
ttcaagaaggacaacgaggaaacaggcttcggctcaggcacccgggccctggagcaagcc
ctggagaagacgaaagccaacatcaagtgggtgaaggagaacaaggaggtggtgctccag
tggttcacagaaaacagcaaatag

  All links  
Disease (1)   
   OMIM (1)   
Gene (37)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (17)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (21)   
   RefSeq(nuc) (3)   
   GenBank (9)   
   EMBL (9)   
3D Structure (16)   
   PDB (16)   
Protein domain (7)   
   Pfam (7)   
All databases (88)   

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