KEGG   Homo sapiens (human): 2904
Entry
2904              CDS       T01001                                 
Symbol
GRIN2B, DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2B
  KO
K05210  glutamate receptor ionotropic, NMDA 2B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06544  Neuroactive ligand signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01880  GRM1/5-interacting scaffold proteins
Disease
H00606  Early infantile epileptic encephalopathy
H00773  Autosomal dominant intellectual developmental disorder
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Besonprodil: D03100
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Neramexane mesylate: D05145
Nevadistinel: D12553
Onfasprodil: D12787
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Rislenemdaz: D11340
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Traxoprodil mesylate: D06204
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2904 (GRIN2B)
   04015 Rap1 signaling pathway
    2904 (GRIN2B)
   04020 Calcium signaling pathway
    2904 (GRIN2B)
   04024 cAMP signaling pathway
    2904 (GRIN2B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2904 (GRIN2B)
   04082 Neuroactive ligand signaling
    2904 (GRIN2B)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2904 (GRIN2B)
   04728 Dopaminergic synapse
    2904 (GRIN2B)
   04720 Long-term potentiation
    2904 (GRIN2B)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2904 (GRIN2B)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2904 (GRIN2B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2904 (GRIN2B)
   05014 Amyotrophic lateral sclerosis
    2904 (GRIN2B)
   05016 Huntington disease
    2904 (GRIN2B)
   05017 Spinocerebellar ataxia
    2904 (GRIN2B)
   05020 Prion disease
    2904 (GRIN2B)
   05022 Pathways of neurodegeneration - multiple diseases
    2904 (GRIN2B)
  09165 Substance dependence
   05030 Cocaine addiction
    2904 (GRIN2B)
   05031 Amphetamine addiction
    2904 (GRIN2B)
   05033 Nicotine addiction
    2904 (GRIN2B)
   05034 Alcoholism
    2904 (GRIN2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2904 (GRIN2B)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2904 (GRIN2B)
SSDB
Motif
Pfam: NMDAR2_C Lig_chan Lig_chan-Glu_bd ANF_receptor SBP_bac_3
Other DBs
NCBI-GeneID: 2904
NCBI-ProteinID: NP_000825
OMIM: 138252
HGNC: 4586
Ensembl: ENSG00000273079
UniProt: Q13224 A0A8D9PHB2
Structure
Position
12:complement(13537337..13982134)
AA seq 1484 aa
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
NT seq 4455 nt   +upstreamnt  +downstreamnt
atgaagcccagagcggagtgctgttctcccaagttctggttggtgttggccgtcctggcc
gtgtcaggcagcagagctcgttctcagaagagcccccccagcattggcattgctgtcatc
ctcgtgggcacttccgacgaggtggccatcaaggatgcccacgagaaagatgatttccac
catctctccgtggtaccccgggtggaactggtagccatgaatgagaccgacccaaagagc
atcatcacccgcatctgtgatctcatgtctgaccggaagatccagggggtggtgtttgct
gatgacacagaccaggaagccatcgcccagatcctcgatttcatttcagcacagactctc
acccccatcctgggcatccacgggggctcctctatgataatggcagataaggatgaatcc
tccatgttcttccagtttggcccatcaattgaacagcaagcttccgtaatgctcaacatc
atggaagaatatgactggtacatcttttctatcgtcaccacctatttccctggctaccag
gactttgtaaacaagatccgcagcaccattgagaatagctttgtgggctgggagctagag
gaggtcctcctactggacatgtccctggacgatggagattctaagatccagaatcagctc
aagaaacttcaaagccccatcattcttctttactgtaccaaggaagaagccacctacatc
tttgaagtggccaactcagtagggctgactggctatggctacacgtggatcgtgcccagt
ctggtggcaggggatacagacacagtgcctgcggagttccccactgggctcatctctgta
tcatatgatgaatgggactatggcctccccgccagagtgagagatggaattgccataatc
accactgctgcttctgacatgctgtctgagcacagcttcatccctgagcccaaaagcagt
tgttacaacacccacgagaagagaatctaccagtccaatatgctaaataggtatctgatc
aatgtcacttttgaggggaggaatttgtccttcagtgaagatggctaccagatgcacccg
aaactggtgataattcttctgaacaaggagaggaagtgggaaagggtggggaagtggaaa
gacaagtccctgcagatgaagtactatgtgtggccccgaatgtgtccagagactgaagag
caggaggatgaccatctgagcattgtgaccctggaggaggcaccatttgtcattgtggaa
agtgtggaccctctgagtggaacctgcatgaggaacacagtcccctgccaaaaacgcata
gtcactgagaataaaacagacgaggagccgggttacatcaaaaaatgctgcaaggggttc
tgtattgacatccttaagaaaatttctaaatctgtgaagttcacctatgacctttacctg
gttaccaatggcaagcatgggaagaaaatcaatggaacctggaatggtatgattggagag
gtggtcatgaagagggcctacatggcagtgggctcactcaccatcaatgaggaacgatcg
gaggtggtcgacttctctgtgcccttcatagagacaggcatcagtgtcatggtgtcacgc
agcaatgggactgtctcaccttctgccttcttagagccattcagcgctgacgtatgggtg
atgatgtttgtgatgctgctcatcgtctcagccgtggctgtctttgtctttgagtacttc
agccctgtgggttataacaggtgcctcgctgatggcagagagcctggtggaccctctttc
accatcggcaaagctatttggttgctctggggtctggtgtttaacaactccgtacctgtg
cagaacccaaaggggaccacctccaagatcatggtgtcagtgtgggccttctttgctgtc
atcttcctggccagctacactgccaacttagctgccttcatgatccaagaggaatatgtg
gaccaggtttctggcctgagcgacaaaaagttccagagacctaatgacttctcaccccct
ttccgctttgggaccgtgcccaacggcagcacagagagaaatattcgcaataactatgca
gaaatgcatgcctacatgggaaagttcaaccagaggggtgtagatgatgcattgctctcc
ctgaaaacagggaaactggatgccttcatctatgatgcagcagtgctgaactatatggca
ggcagagatgaaggctgcaagctggtgaccattggcagtgggaaggtctttgcttccact
ggctatggcattgccatccaaaaagattctgggtggaagcgccaggtggaccttgctatc
ctgcagctctttggagatggggagatggaagaactggaagctctctggctcactggcatt
tgtcacaatgagaagaatgaggtcatgagcagccagctggacattgacaacatggcaggg
gtcttctacatgttgggggcggccatggctctcagcctcatcaccttcatctgcgaacac
cttttctattggcagttccgacattgctttatgggtgtctgttctggcaagcctggcatg
gtcttctccatcagcagaggtatctacagctgcatccatggggtggcgatcgaggagcgc
cagtctgtaatgaactcccccaccgcaaccatgaacaacacacactccaacatcctgcgc
ctgctgcgcacggccaagaacatggctaacctgtctggtgtgaatggctcaccgcagagc
gccctggacttcatccgacgggagtcatccgtctatgacatctcagagcaccgccgcagc
ttcacgcattctgactgcaaatcctacaacaacccgccctgtgaggagaacctcttcagt
gactacatcagtgaggtagagagaacgttcgggaacctgcagctgaaggacagcaacgtg
taccaagatcactaccaccatcaccaccggccccatagtattggcagtgccagctccatc
gatgggctctacgactgtgacaacccacccttcaccacccagtccaggtccatcagcaag
aagcccctggacatcggcctcccctcctccaagcacagccagctcagtgacctgtacggc
aaattctccttcaagagcgaccgctacagtggccacgacgacttgatccgctccgatgtc
tctgacatctcaacccacaccgtcacctatgggaacatcgagggcaatgccgccaagagg
cgtaagcagcaatataaggacagcctgaagaagcggcctgcctcggccaagtcccgcagg
gagtttgacgagatcgagctggcctaccgtcgccgaccgccccgctcccctgaccacaag
cgctacttcagggacaaggaagggctacgggacttctacctggaccagttccgaacaaag
gagaactcaccccactgggagcacgtagacctgaccgacatctacaaggagcggagtgat
gactttaagcgcgactccgtcagcggaggagggccctgtaccaacaggtctcacatcaag
cacgggacgggcgacaaacacggcgtggtcagcggggtacctgcaccttgggagaagaac
ctgaccaacgtggagtgggaggaccggtccgggggcaacttctgccgcagctgtccctcc
aagctgcacaactactccacgacggtgacgggtcagaactcgggcaggcaggcgtgcatc
cggtgtgaggcttgcaagaaagcaggcaacctgtatgacatcagtgaggacaactccctg
caggaactggaccagccggctgccccagtggcggtgacgtcaaacgcctccaccactaag
taccctcagagcccgactaattccaaggcccagaagaagaaccggaacaaactgcgccgg
cagcactcctacgacaccttcgtggacctgcagaaggaagaagccgccctggccccgcgc
agcgtaagcctgaaagacaagggccgattcatggatgggagcccctacgcccacatgttt
gagatgtcagctggcgagagcacctttgccaacaacaagtcctcagtgcccactgccgga
catcaccaccacaacaaccccggcggcgggtacatgctcagcaagtcgctctaccctgac
cgggtcacgcaaaaccctttcatccccacttttggggacgaccagtgcttgctccatggc
agcaaatcctacttcttcaggcagcccacggtggcgggggcgtcgaaagccaggccggac
ttccgggcccttgtcaccaacaagccggtggtctcggcccttcatggggccgtgccagcc
cgtttccagaaggacatctgtatagggaaccagtccaacccctgtgtgcctaacaacaaa
aaccccagggctttcaatggctccagcaatgggcatgtttatgagaaactttctagtatt
gagtctgatgtctga

  All links  
Disease (3)   
   OMIM (3)   
Gene (19)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (33)   
   RefSeq(nuc) (9)   
   GenBank (12)   
   EMBL (12)   
3D Structure (15)   
   PDB (15)   
Protein domain (5)   
   Pfam (5)   
All databases (87)   

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