KEGG   Homo sapiens (human): 2905
Entry
2905              CDS       T01001                                 
Symbol
GRIN2C, GluN2C, NMDAR2C, NR2C
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2C
  KO
K05211  glutamate receptor ionotropic, NMDA 2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01880  GRM1/5-interacting scaffold proteins
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2905 (GRIN2C)
   04024 cAMP signaling pathway
    2905 (GRIN2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2905 (GRIN2C)
   04082 Neuroactive ligand signaling
    2905 (GRIN2C)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2905 (GRIN2C)
   04720 Long-term potentiation
    2905 (GRIN2C)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2905 (GRIN2C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2905 (GRIN2C)
   05014 Amyotrophic lateral sclerosis
    2905 (GRIN2C)
   05017 Spinocerebellar ataxia
    2905 (GRIN2C)
   05020 Prion disease
    2905 (GRIN2C)
   05022 Pathways of neurodegeneration - multiple diseases
    2905 (GRIN2C)
  09165 Substance dependence
   05030 Cocaine addiction
    2905 (GRIN2C)
   05031 Amphetamine addiction
    2905 (GRIN2C)
   05033 Nicotine addiction
    2905 (GRIN2C)
   05034 Alcoholism
    2905 (GRIN2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2905 (GRIN2C)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2905 (GRIN2C)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd ANF_receptor SBP_bac_3 NMDAR2_C DUF63
Other DBs
NCBI-GeneID: 2905
NCBI-ProteinID: NP_000826
OMIM: 138254
HGNC: 4587
Ensembl: ENSG00000161509
UniProt: Q14957 A0A8D9PH81 O15398
Structure
Position
17:complement(74842023..74861532)
AA seq 1233 aa
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
NT seq 3702 nt   +upstreamnt  +downstreamnt
atgggtggggccctggggccggccctgttgctcacctcgctcttcggtgcctgggcaggg
ctgggtccggggcagggcgagcagggcatgacggtggccgtggtgtttagcagctcaggg
ccgccccaggcccagttccgtgcccgcctcaccccccagagcttcctggacctacccctg
gagatccagccgctcacagttggggtcaacaccaccaaccccagcagcctcctcacccag
atctgcggcctcctgggtgctgcccacgtccacggcattgtctttgaggacaacgtggac
accgaggcggtggcccagatccttgacttcatctcctcccagacccatgtgcccatcctc
agcatcagcggaggctctgctgtggtcctcacccccaaggagccgggctccgccttcctg
cagctgggcgtgtccctggagcagcagctgcaggtgctgttcaaggtgctggaagagtac
gactggagcgccttcgccgtcatcaccagcctgcacccgggccacgcgctcttcctggag
ggcgtgcgcgccgtcgccgacgccagccacgtgagttggcggctgctggacgtggtcacg
ctggagctgggcccgggagggccgcgcgcgcgcacgcagcgcctgctgcgccagctcgac
gcgcccgtgtttgtggcctactgctcgcgcgaggaggccgaggtgctcttcgccgaggcg
gcgcaggccggtctggtggggcccggccacgtgtggctggtgcccaacctggcgctgggc
agcaccgatgcgccccccgccaccttccccgtgggcctcatcagcgtcgtcaccgagagc
tggcgcctcagcctgcgccagaaggtgcgcgacggcgtggccattctggccctgggcgcc
cacagctactggcgccagcatggaaccctgccagccccggccggggactgccgtgttcac
cctgggcccgtcagccctgcccgggaggccttctacaggcacctactgaatgtcacctgg
gagggccgagacttctccttcagccctggtgggtacctggtccagcccaccatggtggtg
atcgccctcaaccggcaccgcctctgggagatggtggggcgctgggagcatggcgtccta
tacatgaagtaccccgtgtggcctcgctacagtgcctctctgcagcctgtggtggacagt
cggcacctgacggtggccacgctggaagagcggccctttgtcatcgtggagagccctgac
cctggcacaggaggctgtgtccccaacaccgtgccctgccgcaggcagagcaaccacacc
ttcagcagcggggacgtggccccctacaccaagctctgctgtaagggattctgcatcgac
atcctcaagaagctggccagagtggtcaaattctcctacgacctgtacctggtgaccaac
ggcaagcatggcaagcgggtgcgcggcgtatggaacggcatgattggggaggtgtactac
aagcgggcagacatggccatcggctccctcaccatcaatgaggaacgctccgagatcgta
gacttctctgtaccctttgtggagacgggcatcagtgtgatggtggctcgcagcaatggc
accgtctccccctcggccttcttggagccatatagccctgcagtgtgggtgatgatgttt
gtcatgtgcctcactgtggtggccatcaccgtcttcatgttcgagtacttcagccctgtc
agctacaaccagaacctcaccagaggcaagaagtccgggggcccagctttcactatcggc
aagtccgtgtggctgctgtgggcgctggtcttcaacaactcagtgcccatcgagaacccg
cggggcaccaccagcaagatcatggttctggtctgggccttctttgctgtcatcttcctc
gccagctacacggccaacctggccgccttcatgatccaagagcaatacatcgacactgtg
tcgggcctcagtgacaagaagtttcagcggcctcaagatcagtacccacctttccgcttc
ggcacggtgcccaacggcagcacggagcggaacatccgcagtaactaccgtgacatgcac
acccacatggtcaagttcaaccagcgctcggtggaggacgcgctcaccagcctcaagatg
gggaagctggatgccttcatctatgatgctgctgtcctcaactacatggcaggcaaggac
gagggctgcaagctggtcaccattgggtctggcaaggtctttgctaccactggctacggc
atcgccatgcagaaggactcccactggaagcgggccatagacctggcgctcttgcagttc
ctgggggacggagagacacagaaactggagacagtgtggctctcagggatctgccagaat
gagaagaacgaggtgatgagcagcaagctggacatcgacaacatggcaggcgtcttctac
atgctgctggtggccatggggctggccctgctggtcttcgcctgggagcacctggtctac
tggaagctgcgccactcggtgcccaactcatcccagctggacttcctgctggctttcagc
aggggcatctacagctgcttcagcggggtgcagagcctcgccagcccaccgcggcaggcc
agcccggacctcacggccagctcggcccaggccagcgtgctcaagatgctgcaggcagcc
cgcgacatggtgaccacggcgggcgtaagcagctccctggaccgcgccactcgcaccatc
gagaattggggtggcggccgccgtgcgcccccaccgtccccctgcccgaccccgcggtct
ggccccagcccatgcctgcccacccccgacccgcccccagagccgagccccacgggctgg
ggaccgccagacgggggtcgcgcggcgcttgtgcgcagggctccgcagcccccgggccgc
cccccgacgccggggccgcccctgtccgacgtctcccgagtgtcgcgccgcccagcctgg
gaggcgcggtggccggtgcggaccgggcactgcgggaggcacctctcggcctccgagcgg
cccctgtcgcccgcgcgctgtcactacagctcctttcctcgagccgaccgatccggccgc
cccttcctcccgctcttcccggagctggaggacctgccgctgctcggtccggagcagctg
gcccggcgggaggccctgctgcacgcggcctgggcccggggctcgcgcccgcgtcacgct
tccctgcccagctccgtggccgaggccttcgctcggcccagctcgctgcccgctgggtgc
accggccccgcctgcgcccgccccgacggccactcggcctgcaggcgcttggcgcaggcg
cagtcgatgtgcttgccgatctaccgggaggcctgccaggagggcgagcaggcaggggcc
cccgcctggcagcacagacagcacgtctgcctgcacgcccacgcccacctgccattttgc
tggggggctgtctgtcctcaccttccaccctgtgccagccacggctcctggctctccggg
gcctgggggcctctggggcacaggggcaggactctggggctgggcacaggctacagagac
agtgggggactggacgagatcagcagggtagcccgtgggacgcaaggcttcccgggaccc
tgcacctggagacggatctccagtctggagtcagaagtgtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (78)   
   RefGene (71)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (20)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (49)   
   RefSeq(nuc) (17)   
   GenBank (16)   
   EMBL (16)   
3D Structure (6)   
   PDB (6)   
Protein domain (6)   
   Pfam (6)   
All databases (160)   

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