KEGG   Homo sapiens (human): 2908
Entry
2908              CDS       T01001                                 

Gene name
NR3C1, GCCR, GCR, GCRST, GR, GRL
Definition
(RefSeq) nuclear receptor subfamily 3 group C member 1
  KO
K05771  glucocorticoid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Network
nt06310  CRH-ACTH-cortisol signaling
  Element
N00924  Glucocorticoid receptor signaling pathway
N00925  Mutation-inactivated NR3C1 to glucocorticoid receptor signaling pathway
Disease
H01702  Glucocorticoid resistance syndrome
H01709  Glucocorticoid-induced osteonecrosis
Drug target
Alclometasone (DG00415): D01820<JP/US> D07116
Amcinonide: D01387<JP/US>
Beclometasone (DG00097): D00689<JP/US> D07495 D11572<US>
Betamethasone (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01402 D01637<JP/US> D02032<JP> D02286
Budesonide: D00246<JP/US>
Ciclesonide: D01703<JP/US>
Clobetasol (DG00422): D01272<JP/US> D07715
Clobetasone (DG00411): D01273<JP> D07717
Clocortolone (DG00416): D02287<US> D03541 D07719
Cloprednol: D03561
Cortisone (DG00509): D00973<JP/US> D07749
Cortivazol: D03594
Dagrocorat: D10617
Deflazacort: D03671<US>
Deprodone propionate: D01434<JP>
Descinolone acetonide: D03691
Desonide: D03696<US>
Desoximetasone: D03697<US>
Dexamethasone (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D02174 D02591 D02592 D07073<JP> D07796 D07797 D07798 D07799 D07800 D07801 D07802
Dichlorisone (DG02936): D07814 D07815
Diflorasone (DG00418): D01327<JP/US> D07827
Diflucortolone (DG00417): D01764<JP> D03812 D03813
Difluprednate: D01266<JP/US>
Exicorilant: D11665
Fluclorolone: D04201
Fludroxycortide: D00328<JP/US>
Flumetasone (DG00412): D01464 D04208
Flunisolide (DG01040): D00324<US> D04214
Fluocinolone acetonide: D01825<JP/US>
Fluocinonide: D00325<JP/US>
Fluocortin (DG00413): D04217 D07972
Fluocortolone (DG00295): D04218 D04219 D07973
Fluorometholone (DG00294): D01367<JP/US> D04221<US>
Flupamesone: D07975
Fluprednidene (DG00414): D07201 D07980
Fluprednisolone (DG02888): D04227 D04228
Fluticasone (DG00420): D01708<JP/US> D06315<JP/US> D07981
Formocortal: D04244
Fosdagrocorat: D10634
Halcinonide: D01308<US>
Halometasone: D07202
Halopredone (DG01376): D01743 D08036
Hydrocortisone (DG00012): D00088<JP/US> D00165<US> D00976 D00977<JP> D00978<JP/US> D01442 D01619<JP/US> D01886<JP/US> D02288<US> D04467 D06876 D09796
Loteprednol (DG01127): D01689<US> D08147
Mapracorat: D10136
Medrysone: D02289
Meprednisone: D06673
Methylprednisolone (DG00410): D00407<JP/US> D00751<JP/US> D00979<JP/US> D05000 D05001 D05002 D07203
Mifepristone: D00585<US>
Miricorilant: D11667
Mometasone (DG00419): D00690<JP/US> D03325<JP/US> D08227
Nivazol: D05194
Paramethasone (DG00508): D01229 D07464
Prednicarbate: D05601<US>
Prednisolone (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D00982 D01239<JP> D01998 D02156 D03301<JP> D08412 D08413 D08414 D08415
Prednisone (DG00094): D00473<US> D08416
Prednival: D05603
Prednylidene: D07230
Proligestone: D08429
Relacorilant: D11336
Resocortol (DG01545): D05719 D08476
Rimexolone: D05729
Ticabesone propionate: D06135
Tipredane: D06161
Tixocortol (DG00096): D06171 D08610
Tralonide: D06201
Triamcinolone (DG00010): D00385<JP> D00983<JP/US> D00984 D00985 D06216
Ulobetasol (DG00421): D04409<US> D08660
Vamorolone: D11000
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2908 (NR3C1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2908 (NR3C1)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2908 (NR3C1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    2908 (NR3C1)
Nuclear receptors [BR:hsa03310]
 3. Estrogen like
  3C. 3-Ketosteroid receptor
   2908 (NR3C1)
SSDB
Motif
Pfam: GCR Hormone_recep zf-C4
Other DBs
NCBI-GeneID: 2908
NCBI-ProteinID: NP_000167
OMIM: 138040
HGNC: 7978
Ensembl: ENSG00000113580
Vega: OTTHUMG00000129677
Pharos: P04150(Tclin)
UniProt: P04150 F1D8N4
Structure
PDB: 

Position
5q31.3
AA seq 777 aa
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
NT seq 2334 nt   +upstreamnt  +downstreamnt
atggactccaaagaatcattaactcctggtagagaagaaaaccccagcagtgtgcttgct
caggagaggggagatgtgatggacttctataaaaccctaagaggaggagctactgtgaag
gtttctgcgtcttcaccctcactggctgtcgcttctcaatcagactccaagcagcgaaga
cttttggttgattttccaaaaggctcagtaagcaatgcgcagcagccagatctgtccaaa
gcagtttcactctcaatgggactgtatatgggagagacagaaacaaaagtgatgggaaat
gacctgggattcccacagcagggccaaatcagcctttcctcgggggaaacagacttaaag
cttttggaagaaagcattgcaaacctcaataggtcgaccagtgttccagagaaccccaag
agttcagcatccactgctgtgtctgctgcccccacagagaaggagtttccaaaaactcac
tctgatgtatcttcagaacagcaacatttgaagggccagactggcaccaacggtggcaat
gtgaaattgtataccacagaccaaagcacctttgacattttgcaggatttggagttttct
tctgggtccccaggtaaagagacgaatgagagtccttggagatcagacctgttgatagat
gaaaactgtttgctttctcctctggcgggagaagacgattcattccttttggaaggaaac
tcgaatgaggactgcaagcctctcattttaccggacactaaacccaaaattaaggataat
ggagatctggttttgtcaagccccagtaatgtaacactgccccaagtgaaaacagaaaaa
gaagatttcatcgaactctgcacccctggggtaattaagcaagagaaactgggcacagtt
tactgtcaggcaagctttcctggagcaaatataattggtaataaaatgtctgccatttct
gttcatggtgtgagtacctctggaggacagatgtaccactatgacatgaatacagcatcc
ctttctcaacagcaggatcagaagcctatttttaatgtcattccaccaattcccgttggt
tccgaaaattggaataggtgccaaggatctggagatgacaacttgacttctctggggact
ctgaacttccctggtcgaacagttttttctaatggctattcaagccccagcatgagacca
gatgtaagctctcctccatccagctcctcaacagcaacaacaggaccacctcccaaactc
tgcctggtgtgctctgatgaagcttcaggatgtcattatggagtcttaacttgtggaagc
tgtaaagttttcttcaaaagagcagtggaaggacagcacaattacctatgtgctggaagg
aatgattgcatcatcgataaaattcgaagaaaaaactgcccagcatgccgctatcgaaaa
tgtcttcaggctggaatgaacctggaagctcgaaaaacaaagaaaaaaataaaaggaatt
cagcaggccactacaggagtctcacaagaaacctctgaaaatcctggtaacaaaacaata
gttcctgcaacgttaccacaactcacccctaccctggtgtcactgttggaggttattgaa
cctgaagtgttatatgcaggatatgatagctctgttccagactcaacttggaggatcatg
actacgctcaacatgttaggagggcggcaagtgattgcagcagtgaaatgggcaaaggca
ataccaggtttcaggaacttacacctggatgaccaaatgaccctactgcagtactcctgg
atgtttcttatggcatttgctctggggtggagatcatatagacaatcaagtgcaaacctg
ctgtgttttgctcctgatctgattattaatgagcagagaatgactctaccctgcatgtac
gaccaatgtaaacacatgctgtatgtttcctctgagttacacaggcttcaggtatcttat
gaagagtatctctgtatgaaaaccttactgcttctctcttcagttcctaaggacggtctg
aagagccaagagctatttgatgaaattagaatgacctacatcaaagagctaggaaaagcc
attgtcaagagggaaggaaactccagccagaactggcagcggttttatcaactgacaaaa
ctcttggattctatgcatgaagtggttgaaaatctccttaactattgcttccaaacattt
ttggataagaccatgagtattgaattccccgagatgttagctgaaatcatcaccaatcag
ataccaaaatattcaaatggaaatatcaaaaaacttctgtttcatcaaaagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Drug (154)   
   KEGG DRUG (154)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   PRONIT (16)   
   VEGA (1)   
Protein sequence (27)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (93)   
   RefSeq(nuc) (25)   
   GenBank (34)   
   EMBL (34)   
Protein domain (3)   
   Pfam (3)   
All databases (322)   

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