KEGG   Homo sapiens (human): 2908Help
Entry
2908              CDS       T01001                                 

Gene name
NR3C1, GCCR, GCR, GCRST, GR, GRL
Definition
(RefSeq) nuclear receptor subfamily 3 group C member 1
  KO
K05771  glucocorticoid receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Network
nt06310  CRH-ACTH-cortisol signaling
  Element
N00924  Glucocorticoid receptor signaling pathway
N00925  Mutation-inactivated NR3C1 to glucocorticoid receptor signaling pathway
Disease
H01702  Glucocorticoid resistance syndrome
H01709  Glucocorticoid-induced osteonecrosis
Drug target
Alclometasone (DG00415): D01820 D07116
Amcinonide: D01387
Beclometasone (DG00097): D00689 D07495 D11572
Betamethasone (DG00095): D00244 D00972 D01357 D01402 D01637 D02032 D02286
Budesonide: D00246
Ciclesonide: D01703
Clobetasol (DG00422): D01272 D07715
Clobetasone (DG00411): D01273 D07717
Clocortolone (DG00416): D02287 D03541 D07719
Cloprednol: D03561
Cortisone (DG00509): D00973 D07749
Cortivazol: D03594
Dagrocorat: D10617
Deflazacort: D03671
Deprodone propionate: D01434
Descinolone acetonide: D03691
Desonide: D03696
Desoximetasone: D03697
Dexamethasone (DG00011): D00292 D00975 D01510 D01615 D01632 D01948 D02174 D02591 D02592 D07073 D07796 D07797 D07798 D07799 D07800 D07801 D07802
Dichlorisone (DG02936): D07814 D07815
Diflorasone (DG00418): D01327 D07827
Diflucortolone (DG00417): D01764 D03812 D03813
Difluprednate: D01266
Exicorilant: D11665
Fluclorolone: D04201
Fludroxycortide: D00328
Flumetasone (DG00412): D01464 D04208
Flunisolide (DG01040): D00324 D04214
Fluocinolone acetonide: D01825
Fluocinonide: D00325
Fluocortin (DG00413): D04217 D07972
Fluocortolone (DG00295): D04218 D04219 D07973
Fluorometholone (DG00294): D01367 D04221
Flupamesone: D07975
Fluprednidene (DG00414): D07201 D07980
Fluprednisolone (DG02888): D04227 D04228
Fluticasone (DG00420): D01708 D06315 D07981
Formocortal: D04244
Fosdagrocorat: D10634
Halcinonide: D01308
Halometasone: D07202
Halopredone (DG01376): D01743 D08036
Hydrocortisone (DG00012): D00088 D00165 D00976 D00977 D00978 D01442 D01619 D01886 D02288 D04467 D06876 D09796
Loteprednol (DG01127): D01689 D08147
Mapracorat: D10136
Medrysone: D02289
Meprednisone: D06673
Methylprednisolone (DG00410): D00407 D00751 D00979 D05000 D05001 D05002 D07203
Mifepristone: D00585
Miricorilant: D11667
Mometasone (DG00419): D00690 D03325 D08227
Nivazol: D05194
Paramethasone (DG00508): D01229 D07464
Prednicarbate: D05601
Prednisolone (DG00093): D00472 D00980 D00981 D00982 D01239 D01998 D02156 D03301 D08412 D08413 D08414 D08415
Prednisone (DG00094): D00473 D08416
Prednival: D05603
Prednylidene: D07230
Proligestone: D08429
Relacorilant: D11336
Resocortol (DG01545): D05719 D08476
Rimexolone: D05729
Ticabesone propionate: D06135
Tipredane: D06161
Tixocortol (DG00096): D06171 D08610
Tralonide: D06201
Triamcinolone (DG00010): D00385 D00983 D00984 D00985 D06216
Ulobetasol (DG00421): D04409 D08660
Vamorolone: D11000
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2908 (NR3C1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2908 (NR3C1)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2908 (NR3C1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 estrogen-like
    2908 (NR3C1)
Nuclear receptors [BR:hsa03310]
 3. Estrogen like
  3C. 3-Ketosteroid receptor
   2908 (NR3C1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: GCR Hormone_recep zf-C4
Motif
Other DBs
NCBI-GeneID: 2908
NCBI-ProteinID: NP_000167
OMIM: 138040
HGNC: 7978
Ensembl: ENSG00000113580
Vega: OTTHUMG00000129677
Pharos: P04150(Tclin)
UniProt: P04150 F1D8N4
Structure
PDB: 

Position
5q31.3
AA seq 777 aa AA seqDB search
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
NT seq 2334 nt NT seq  +upstreamnt  +downstreamnt
atggactccaaagaatcattaactcctggtagagaagaaaaccccagcagtgtgcttgct
caggagaggggagatgtgatggacttctataaaaccctaagaggaggagctactgtgaag
gtttctgcgtcttcaccctcactggctgtcgcttctcaatcagactccaagcagcgaaga
cttttggttgattttccaaaaggctcagtaagcaatgcgcagcagccagatctgtccaaa
gcagtttcactctcaatgggactgtatatgggagagacagaaacaaaagtgatgggaaat
gacctgggattcccacagcagggccaaatcagcctttcctcgggggaaacagacttaaag
cttttggaagaaagcattgcaaacctcaataggtcgaccagtgttccagagaaccccaag
agttcagcatccactgctgtgtctgctgcccccacagagaaggagtttccaaaaactcac
tctgatgtatcttcagaacagcaacatttgaagggccagactggcaccaacggtggcaat
gtgaaattgtataccacagaccaaagcacctttgacattttgcaggatttggagttttct
tctgggtccccaggtaaagagacgaatgagagtccttggagatcagacctgttgatagat
gaaaactgtttgctttctcctctggcgggagaagacgattcattccttttggaaggaaac
tcgaatgaggactgcaagcctctcattttaccggacactaaacccaaaattaaggataat
ggagatctggttttgtcaagccccagtaatgtaacactgccccaagtgaaaacagaaaaa
gaagatttcatcgaactctgcacccctggggtaattaagcaagagaaactgggcacagtt
tactgtcaggcaagctttcctggagcaaatataattggtaataaaatgtctgccatttct
gttcatggtgtgagtacctctggaggacagatgtaccactatgacatgaatacagcatcc
ctttctcaacagcaggatcagaagcctatttttaatgtcattccaccaattcccgttggt
tccgaaaattggaataggtgccaaggatctggagatgacaacttgacttctctggggact
ctgaacttccctggtcgaacagttttttctaatggctattcaagccccagcatgagacca
gatgtaagctctcctccatccagctcctcaacagcaacaacaggaccacctcccaaactc
tgcctggtgtgctctgatgaagcttcaggatgtcattatggagtcttaacttgtggaagc
tgtaaagttttcttcaaaagagcagtggaaggacagcacaattacctatgtgctggaagg
aatgattgcatcatcgataaaattcgaagaaaaaactgcccagcatgccgctatcgaaaa
tgtcttcaggctggaatgaacctggaagctcgaaaaacaaagaaaaaaataaaaggaatt
cagcaggccactacaggagtctcacaagaaacctctgaaaatcctggtaacaaaacaata
gttcctgcaacgttaccacaactcacccctaccctggtgtcactgttggaggttattgaa
cctgaagtgttatatgcaggatatgatagctctgttccagactcaacttggaggatcatg
actacgctcaacatgttaggagggcggcaagtgattgcagcagtgaaatgggcaaaggca
ataccaggtttcaggaacttacacctggatgaccaaatgaccctactgcagtactcctgg
atgtttcttatggcatttgctctggggtggagatcatatagacaatcaagtgcaaacctg
ctgtgttttgctcctgatctgattattaatgagcagagaatgactctaccctgcatgtac
gaccaatgtaaacacatgctgtatgtttcctctgagttacacaggcttcaggtatcttat
gaagagtatctctgtatgaaaaccttactgcttctctcttcagttcctaaggacggtctg
aagagccaagagctatttgatgaaattagaatgacctacatcaaagagctaggaaaagcc
attgtcaagagggaaggaaactccagccagaactggcagcggttttatcaactgacaaaa
ctcttggattctatgcatgaagtggttgaaaatctccttaactattgcttccaaacattt
ttggataagaccatgagtattgaattccccgagatgttagctgaaatcatcaccaatcag
ataccaaaatattcaaatggaaatatcaaaaaacttctgtttcatcaaaagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Drug (154)   
   KEGG DRUG (154)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PHAROS (1)   
   PRONIT (16)   
   VEGA (1)   
Protein sequence (27)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (93)   
   RefSeq(nuc) (25)   
   GenBank (34)   
   EMBL (34)   
Protein domain (3)   
   Pfam (3)   
All databases (322)   

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