| Entry |
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| Gene name |
PYCARD, ASC, CARD5, TMS, TMS-1, TMS1
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| Definition |
(RefSeq) PYD and CARD domain containing
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| KO |
| K12799 | apoptosis-associated speck-like protein containing a CARD |
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| Organism |
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| Pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04625 | C-type lectin receptor signaling pathway |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Network |
nt06139 NLR signaling (viruses and bacteria) nt06170 Influenza A virus (IAV) |
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| Element |
| N00742 | NLRP3 Inflammasome signaling pathway |
| N00743 | IAV NS1 to NLRP3 inflammasome signaling pathway |
| N00864 | Yersinia YopK to NLRP3 Inflammasome signaling pathway |
| N00865 | Yersinia YopK to NLRC4 Inflammasome signaling pathway |
| N00866 | Yersinia YopM to Pyrin Inflammasome signaling pathway |
| N00867 | NLRC4 Inflammasome signaling pathway |
| N00868 | Pyrin Inflammasome signaling pathway |
| N00933 | Escherichia NleA to NLRP3 inflammasome signaling pathway |
| N00934 | Non-canonical inflammasome signaling pathway |
| N00948 | Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway |
| N00949 | Shigella IpaB to NLRC4 Inflammasome signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
29108 (PYCARD)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
29108 (PYCARD)
04623 Cytosolic DNA-sensing pathway
29108 (PYCARD)
04625 C-type lectin receptor signaling pathway
29108 (PYCARD)
09160 Human Diseases
09172 Infectious disease: viral
05164 Influenza A
29108 (PYCARD)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
29108 (PYCARD)
05132 Salmonella infection
29108 (PYCARD)
05131 Shigellosis
29108 (PYCARD)
05135 Yersinia infection
29108 (PYCARD)
05133 Pertussis
29108 (PYCARD)
05134 Legionellosis
29108 (PYCARD)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
29108 (PYCARD)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
PDB: |
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| Position |
16p11.2
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| AA seq |
195 aa
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
LRESQSYLVEDLERS |
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| NT seq |
588 nt +upstreamnt +downstreamnt
atggggcgcgcgcgcgacgccatcctggatgcgctggagaacctgaccgccgaggagctc
aagaagttcaagctgaagctgctgtcggtgccgctgcgcgagggctacgggcgcatcccg
cggggcgcgctgctgtccatggacgccttggacctcaccgacaagctggtcagcttctac
ctggagacctacggcgccgagctcaccgctaacgtgctgcgcgacatgggcctgcaggag
atggccgggcagctgcaggcggccacgcaccagggctctggagccgcgccagctgggatc
caggcccctcctcagtcggcagccaagccaggcctgcactttatagaccagcaccgggct
gcgcttatcgcgagggtcacaaacgttgagtggctgctggatgctctgtacgggaaggtc
ctgacggatgagcagtaccaggcagtgcgggccgagcccaccaacccaagcaagatgcgg
aagctcttcagtttcacaccagcctggaactggacctgcaaggacttgctcctccaggcc
ctaagggagtcccagtcctacctggtggaggacctggagcggagctga |
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