KEGG   Homo sapiens (human): 2912Help
Entry
2912              CDS       T01001                                 

Gene name
GRM2, GLUR2, GPRC1B, MGLUR2, mGlu2
Definition
(RefSeq) glutamate metabotropic receptor 2
  KO
K04605  metabotropic glutamate receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05030  Cocaine addiction
Drug target
Eglumegad  
Eglumetad (DG01987): D03966 D08908
Pomaglumetad methionil (DG02201): D09949 D10896
Talaglumetad hydrochloride: D09008
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2912 (GRM2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2912 (GRM2)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2912 (GRM2)
 09160 Human Diseases
  09165 Substance dependence
   05030 Cocaine addiction
    2912 (GRM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2912 (GRM2)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2912 (GRM2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ANF_receptor 7tm_3 NCD3G
Motif
Other DBs
NCBI-GeneID: 2912
NCBI-ProteinID: NP_000830
OMIM: 604099
HGNC: 4594
Ensembl: ENSG00000164082
Vega: OTTHUMG00000156902
Pharos: Q14416(Tchem)
UniProt: Q14416
Structure
PDB: 

Position
3p21.2
AA seq 872 aa AA seqDB search
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
NT seq 2619 nt NT seq  +upstreamnt  +downstreamnt
atgggatcgctgcttgcgctcctggcactgctgctgctgtggggtgctgtggctgagggc
ccagccaagaaggtgctgaccctggagggagacttggtgctgggtgggctgttcccagtg
caccagaagggcggcccagcagaggactgtggtcctgtcaatgagcaccgtggcatccag
cgcctggaggccatgctttttgcactggaccgcatcaaccgtgacccgcacctgctgcct
ggcgtgcgcctgggtgcacacatcctcgacagttgctccaaggacacacatgcgctggag
caggcactggactttgtgcgtgcctcactcagccgtggtgctgatggctcacgccacatc
tgccccgacggctcttatgcgacccatggtgatgctcccactgccatcactggtgttatt
ggcggttcctacagtgatgtctccatccaggtggccaacctcttgaggctatttcagatc
ccacagattagctacgcctctaccagtgccaagctgagtgacaagtcccgctatgactac
tttgcccgcacagtgcctcctgacttcttccaagccaaggccatggctgagattctccgc
ttcttcaactggacctatgtgtccactgtggcgtctgagggcgactatggcgagacaggc
attgaggcctttgagctagaggctcgtgcccgcaacatctgtgtggccacctcggagaaa
gtgggccgtgccatgagccgcgcggcctttgagggtgtggtgcgagccctgctgcagaag
cccagtgcccgcgtggctgtcctgttcacccgttctgaggatgcccgggagctgcttgct
gccagccagcgcctcaatgccagcttcacctgggtggccagtgatggttggggggccctg
gagagtgtggtggcaggcagtgagggggctgctgagggtgctatcaccatcgagctggcc
tcctaccccatcagtgactttgcctcctacttccagagcctggacccttggaacaacagc
cggaacccctggttccgtgaattctgggagcagaggttccgctgcagcttccggcagcga
gactgcgcagcccactctctccgggctgtgccctttgagcaggagtccaagatcatgttt
gtggtcaatgcagtgtacgccatggcccatgcgctccacaacatgcaccgtgccctctgc
cccaacaccacccggctctgtgacgcgatgcggccagttaacgggcgccgcctctacaag
gactttgtgctcaacgtcaagtttgatgccccctttcgcccagctgacacccacaatgag
gtccgctttgaccgctttggtgatggtattggccgctacaacatcttcacctatctgcgt
gcaggcagtgggcgctatcgctaccagaaggtgggctactgggcagaaggcttgactctg
gacaccagcctcatcccatgggcctcaccctcagccggccccctgcccgcctctcgctgc
agtgagccctgcctccagaatgaggtgaagagtgtgcagccgggcgaagtctgctgctgg
ctctgcattccgtgccagccctatgagtaccgattggacgaattcacttgcgctgattgt
ggcctgggctactggcccaatgccagcctgactggctgcttcgaactgccccaggagtac
atccgctggggcgatgcctgggctgtgggacctgtcaccatcgcctgcctcggtgccctg
gccaccctctttgtgctgggtgtctttgtgcggcacaatgccacaccagtggtcaaggcc
tcaggtcgggagctctgctacatcctgctgggtggtgtcttcctctgctactgcatgacc
ttcatcttcattgccaagccatccacggcagtgtgtaccttacggcgtcttggtttgggc
actgccttctctgtctgctactcagccctgctcaccaagaccaaccgcattgcacgcatc
ttcggtggggcccgggagggtgcccagcggccacgcttcatcagtcctgcctcacaggtg
gccatctgcctggcacttatctcgggccagctgctcatcgtggtcgcctggctggtggtg
gaggcaccgggcacaggcaaggagacagcccccgaacggcgggaggtggtgacactgcgc
tgcaaccaccgcgatgcaagtatgttgggctcgctggcctacaatgtgctcctcatcgcg
ctctgcacgctttatgccttcaagactcgcaagtgccccgaaaacttcaacgaggccaag
ttcattggcttcaccatgtacaccacctgcatcatctggctggcattcctgcccatcttc
tatgtcacctccagtgactaccgggtacagaccaccaccatgtgcgtgtcagtcagcctc
agcggctccgtggtgcttggctgcctctttgcgcccaagctgcacatcatcctcttccag
ccgcagaagaacgtggttagccaccgggcacccaccagccgctttggcagtgctgctgcc
agggccagctccagccttggccaagggtctggctcccagtttgtccccactgtttgcaat
ggccgtgaggtggtggactcgacaacgtcatcgctttga

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