KEGG   Homo sapiens (human): 2912
Entry
2912              CDS       T01001                                 
Symbol
GRM2, GLUR2, GPRC1B, MGLUR2, mGlu2
Name
(RefSeq) glutamate metabotropic receptor 2
  KO
K04605  metabotropic glutamate receptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
hsa05030  Cocaine addiction
Network
nt06544  Neuroactive ligand signaling
  Element
N01879  Glutamate-GRM-GNAI/O signaling pathway
Drug target
Eglumegad  
Eglumetad (DG01987): D03966 D08908
Pomaglumetad methionil (DG02201): D09949 D10896
Talaglumetad hydrochloride: D09008
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2912 (GRM2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2912 (GRM2)
   04082 Neuroactive ligand signaling
    2912 (GRM2)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2912 (GRM2)
 09160 Human Diseases
  09165 Substance dependence
   05030 Cocaine addiction
    2912 (GRM2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2912 (GRM2)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2912 (GRM2)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G
Other DBs
NCBI-GeneID: 2912
NCBI-ProteinID: NP_000830
OMIM: 604099
HGNC: 4594
Ensembl: ENSG00000164082
UniProt: Q14416
Structure
Position
3:51707068..51718613
AA seq 872 aa
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
NT seq 2619 nt   +upstreamnt  +downstreamnt
atgggatcgctgcttgcgctcctggcactgctgctgctgtggggtgctgtggctgagggc
ccagccaagaaggtgctgaccctggagggagacttggtgctgggtgggctgttcccagtg
caccagaagggcggcccagcagaggactgtggtcctgtcaatgagcaccgtggcatccag
cgcctggaggccatgctttttgcactggaccgcatcaaccgtgacccgcacctgctgcct
ggcgtgcgcctgggtgcacacatcctcgacagttgctccaaggacacacatgcgctggag
caggcactggactttgtgcgtgcctcactcagccgtggtgctgatggctcacgccacatc
tgccccgacggctcttatgcgacccatggtgatgctcccactgccatcactggtgttatt
ggcggttcctacagtgatgtctccatccaggtggccaacctcttgaggctatttcagatc
ccacagattagctacgcctctaccagtgccaagctgagtgacaagtcccgctatgactac
tttgcccgcacagtgcctcctgacttcttccaagccaaggccatggctgagattctccgc
ttcttcaactggacctatgtgtccactgtggcgtctgagggcgactatggcgagacaggc
attgaggcctttgagctagaggctcgtgcccgcaacatctgtgtggccacctcggagaaa
gtgggccgtgccatgagccgcgcggcctttgagggtgtggtgcgagccctgctgcagaag
cccagtgcccgcgtggctgtcctgttcacccgttctgaggatgcccgggagctgcttgct
gccagccagcgcctcaatgccagcttcacctgggtggccagtgatggttggggggccctg
gagagtgtggtggcaggcagtgagggggctgctgagggtgctatcaccatcgagctggcc
tcctaccccatcagtgactttgcctcctacttccagagcctggacccttggaacaacagc
cggaacccctggttccgtgaattctgggagcagaggttccgctgcagcttccggcagcga
gactgcgcagcccactctctccgggctgtgccctttgagcaggagtccaagatcatgttt
gtggtcaatgcagtgtacgccatggcccatgcgctccacaacatgcaccgtgccctctgc
cccaacaccacccggctctgtgacgcgatgcggccagttaacgggcgccgcctctacaag
gactttgtgctcaacgtcaagtttgatgccccctttcgcccagctgacacccacaatgag
gtccgctttgaccgctttggtgatggtattggccgctacaacatcttcacctatctgcgt
gcaggcagtgggcgctatcgctaccagaaggtgggctactgggcagaaggcttgactctg
gacaccagcctcatcccatgggcctcaccctcagccggccccctgcccgcctctcgctgc
agtgagccctgcctccagaatgaggtgaagagtgtgcagccgggcgaagtctgctgctgg
ctctgcattccgtgccagccctatgagtaccgattggacgaattcacttgcgctgattgt
ggcctgggctactggcccaatgccagcctgactggctgcttcgaactgccccaggagtac
atccgctggggcgatgcctgggctgtgggacctgtcaccatcgcctgcctcggtgccctg
gccaccctctttgtgctgggtgtctttgtgcggcacaatgccacaccagtggtcaaggcc
tcaggtcgggagctctgctacatcctgctgggtggtgtcttcctctgctactgcatgacc
ttcatcttcattgccaagccatccacggcagtgtgtaccttacggcgtcttggtttgggc
actgccttctctgtctgctactcagccctgctcaccaagaccaaccgcattgcacgcatc
ttcggtggggcccgggagggtgcccagcggccacgcttcatcagtcctgcctcacaggtg
gccatctgcctggcacttatctcgggccagctgctcatcgtggtcgcctggctggtggtg
gaggcaccgggcacaggcaaggagacagcccccgaacggcgggaggtggtgacactgcgc
tgcaaccaccgcgatgcaagtatgttgggctcgctggcctacaatgtgctcctcatcgcg
ctctgcacgctttatgccttcaagactcgcaagtgccccgaaaacttcaacgaggccaag
ttcattggcttcaccatgtacaccacctgcatcatctggctggcattcctgcccatcttc
tatgtcacctccagtgactaccgggtacagaccaccaccatgtgcgtgtcagtcagcctc
agcggctccgtggtgcttggctgcctctttgcgcccaagctgcacatcatcctcttccag
ccgcagaagaacgtggttagccaccgggcacccaccagccgctttggcagtgctgctgcc
agggccagctccagccttggccaagggtctggctcccagtttgtccccactgtttgcaat
ggccgtgaggtggtggactcgacaacgtcatcgctttga

  All links  
Disease (1)   
   OMIM (1)   
Gene (11)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (27)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (25)   
DNA sequence (54)   
   RefSeq(nuc) (26)   
   GenBank (14)   
   EMBL (14)   
3D Structure (29)   
   PDB (29)   
Protein domain (3)   
   Pfam (3)   
All databases (125)   

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