KEGG   Homo sapiens (human): 29126
Entry
29126             CDS       T01001                                 
Symbol
CD274, ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1
Name
(RefSeq) CD274 molecule
  KO
K06745  programmed cell death 1 ligand 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecule (CAM) interaction
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
Disease
H02540  Infantile-onset multisystem autoimmune disease
Drug target
Atezolizumab: D10773<JP/US>
Avelumab: D10817<JP/US>
Bintrafusp alfa: D11893
Cosibelimab: D11946<US>
Danburstotug: D12349
Durvalumab: D10808<JP/US>
Enristomig: D12561
Envafolimab: D13233
Inbakicept: D11747
Lodapolimab: D11532
Pimivalimab: D12143
Socazolimab: D12344
Sugemalimab: D12750
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecule (CAM) interaction
    29126 (CD274)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    29126 (CD274)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    29126 (CD274)
CD molecules [BR:hsa04090]
 Proteins
  29126 (CD274)
SSDB
Motif
Pfam: Ig_3 C2-set_2 I-set ig V-set Ig_2 C2-set_3 C1-set Ig_VEGFR-1-like_5th Ig_PDGFR_d4 aBig_2 DUF6941 Zwei_Ig_N StrH_N
Other DBs
NCBI-GeneID: 29126
NCBI-ProteinID: NP_054862
OMIM: 605402
HGNC: 17635
Ensembl: ENSG00000120217
UniProt: Q9NZQ7
Structure
Position
9:5450542..5470554
AA seq 290 aa
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
NT seq 873 nt   +upstreamnt  +downstreamnt
atgaggatatttgctgtctttatattcatgacctactggcatttgctgaacgcatttact
gtcacggttcccaaggacctatatgtggtagagtatggtagcaatatgacaattgaatgc
aaattcccagtagaaaaacaattagacctggctgcactaattgtctattgggaaatggag
gataagaacattattcaatttgtgcatggagaggaagacctgaaggttcagcatagtagc
tacagacagagggcccggctgttgaaggaccagctctccctgggaaatgctgcacttcag
atcacagatgtgaaattgcaggatgcaggggtgtaccgctgcatgatcagctatggtggt
gccgactacaagcgaattactgtgaaagtcaatgccccatacaacaaaatcaaccaaaga
attttggttgtggatccagtcacctctgaacatgaactgacatgtcaggctgagggctac
cccaaggccgaagtcatctggacaagcagtgaccatcaagtcctgagtggtaagaccacc
accaccaattccaagagagaggagaagcttttcaatgtgaccagcacactgagaatcaac
acaacaactaatgagattttctactgcacttttaggagattagatcctgaggaaaaccat
acagctgaattggtcatcccagaactacctctggcacatcctccaaatgaaaggactcac
ttggtaattctgggagccatcttattatgccttggtgtagcactgacattcatcttccgt
ttaagaaaagggagaatgatggatgtgaaaaaatgtggcatccaagatacaaactcaaag
aagcaaagtgatacacatttggaggagacgtaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (9)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (40)   
   RefSeq(nuc) (6)   
   GenBank (17)   
   EMBL (17)   
3D Structure (65)   
   PDB (65)   
Protein domain (14)   
   Pfam (14)   
All databases (137)   

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