KEGG   Homo sapiens (human): 2917
Entry
2917              CDS       T01001                                 
Symbol
GRM7, GLUR7, GPRC1G, MGLU7, MGLUR7, NEDSHBA, PPP1R87
Name
(RefSeq) glutamate metabotropic receptor 7
  KO
K04609  metabotropic glutamate receptor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04072  Phospholipase D signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04724  Glutamatergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01879  Glutamate-GRM-GNAI/O signaling pathway
Disease
H02705  Neurodevelopmental disorder with glutamatergic synapse dysfunction
H02886  Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    2917 (GRM7)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2917 (GRM7)
   04082 Neuroactive ligand signaling
    2917 (GRM7)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2917 (GRM7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    2917 (GRM7)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2917 (GRM7)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     2917 (GRM7)
G protein-coupled receptors [BR:hsa04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   2917 (GRM7)
SSDB
Motif
Pfam: ANF_receptor 7tm_3 NCD3G Peripla_BP_6 FtrD-like
Other DBs
NCBI-GeneID: 2917
NCBI-ProteinID: NP_000835
OMIM: 604101
HGNC: 4599
Ensembl: ENSG00000196277
UniProt: Q14831 B2R693 Q59G95
Structure
Position
3:6861115..7741533
AA seq 915 aa
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
NT seq 2748 nt   +upstreamnt  +downstreamnt
atggtccagctgaggaagctgctccgcgtcctgactttgatgaagttcccctgctgcgtg
ctggaggtgctcctgtgcgcgctggcggcggcggcgcgcggccaggagatgtacgccccg
cactcaatccggatcgagggggacgtcaccctcggggggctgttccccgtgcacgccaag
ggtcccagcggagtgccctgcggcgacatcaagagggaaaacgggatccacaggctggaa
gcgatgctctacgccctggaccagatcaacagtgatcccaacctactgcccaacgtgacg
ctgggcgcgcggatcctggacacttgttccagggacacttacgcgctcgaacagtcgctt
actttcgtccaggcgctcatccagaaggacacctccgacgtgcgctgcaccaacggcgaa
ccgccggttttcgtcaagccggagaaagtagttggagtgattggggcttcggggagttcg
gtctccatcatggtagccaacatcctgaggctcttccagatcccccagattagttatgca
tcaacggcacccgagctaagtgatgaccggcgctatgacttcttctctcgcgtggtgcca
cccgattccttccaagcccaggccatggtagacattgtaaaggccctaggctggaattat
gtgtctaccctcgcatcggaaggaagttatggagagaaaggtgtggagtccttcacgcag
atttccaaagaggcaggtggactctgcattgcccagtccgtgagaatcccccaggaacgc
aaagacaggaccattgactttgatagaattatcaaacagctcctggacacccccaactcc
agggccgtcgtgatttttgccaacgatgaggatataaagcagatccttgcagcagccaaa
agagctgaccaagttggccattttctttgggtgggatcagacagctggggatccaaaata
aacccactgcaccagcatgaagatatcgcagaaggggccatcaccattcagcccaagcga
gccacggtggaagggtttgatgcctactttacgtcccgtacacttgaaaacaacagaaga
aatgtatggtttgccgaatactgggaggaaaacttcaactgcaagttgacgattagtggg
tcaaaaaaagaagacacagatcgcaaatgcacaggacaggagagaattggaaaagattcc
aactatgagcaggagggtaaagtccagttcgtgattgacgcagtctatgctatggctcac
gcccttcaccacatgaacaaggatctctgtgctgactaccggggtgtctgcccagagatg
gagcaagctggaggcaagaagttgctgaagtatatacgcaatgttaatttcaatggtagt
gctggcactccagtgatgtttaacaagaacggggatgcacctgggcgttatgacatcttt
cagtaccagaccacaaacaccagcaacccgggttaccgtctgatcgggcagtggacagac
gaacttcagctcaatatagaagacatgcagtggggtaaaggagtccgagagatacccgcc
tcagtgtgcacactaccatgtaagccaggacagagaaagaagacacagaaaggaactcct
tgctgttggacctgtgagccttgcgatggttaccagtaccagtttgatgagatgacatgc
cagcattgcccctatgaccagaggcccaatgaaaatcgaaccggatgccaggatattccc
atcatcaaactggagtggcactccccctgggctgtgattcctgtcttcctggcaatgttg
gggatcattgccaccatctttgtcatggccactttcatccgctacaatgacacgcccatt
gtccgggcatctgggcgggaactcagctatgttcttttgacgggcatctttctttgctac
atcatcactttcctgatgattgccaaaccagatgtggcagtgtgttctttccggcgagtt
ttcttgggcttgggtatgtgcatcagttatgcagccctcttgacgaaaacaaatcggatt
tatcgcatatttgagcagggcaagaaatcagtaacagctcccagactcataagcccaaca
tcacaactggcaatcacttccagtttaatatcagttcagcttctaggggtgttcatttgg
tttggtgttgatccacccaacatcatcatagactatgatgaacacaagacaatgaaccct
gagcaagccagaggggttctcaagtgtgacattacagatctccaaatcatttgctccttg
ggatatagcattcttctcatggtcacatgtactgtgtatgccatcaagactcggggtgta
cccgagaattttaacgaagccaagcccattggattcactatgtacacgacatgtatagta
tggcttgccttcattccaattttttttggcaccgctcaatcagcggaaaagctctacata
caaactaccacgcttacaatctccatgaacctaagtgcatcagtggcgctggggatgcta
tacatgccgaaagtgtacatcatcattttccaccctgaactcaatgtccagaaacggaag
cgaagcttcaaggcggtagtcacagcagccaccatgtcatcgaggctgtcacacaaaccc
agtgacagacccaacggtgaggcaaagaccgagctctgtgaaaacgtagacccaaacagc
cctgctgcaaaaaagaagtatgtcagttataataacctggttatctaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (14)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (16)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (33)   
   RefSeq(nuc) (15)   
   GenBank (9)   
   EMBL (9)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (74)   

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