KEGG   Homo sapiens (human): 2932
Entry
2932              CDS       T01001                                 

Symbol
GSK3B
Name
(RefSeq) glycogen synthase kinase 3 beta
  KO
K03083  glycogen synthase kinase 3 beta [EC:2.7.11.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04012  ErbB signaling pathway
hsa04062  Chemokine signaling pathway
hsa04110  Cell cycle
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04310  Wnt signaling pathway
hsa04340  Hedgehog signaling pathway
hsa04360  Axon guidance
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04657  IL-17 signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04728  Dopaminergic synapse
hsa04910  Insulin signaling pathway
hsa04916  Melanogenesis
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05131  Shigellosis
hsa05135  Yersinia infection
hsa05160  Hepatitis C
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
Network
nt06114  PI3K signaling (viruses)
nt06115  WNT signaling (viruses and bacteria)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06169  Measles virus (MV)
nt06215  WNT signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06419  Microtubule-based transport
nt06460  Alzheimer disease
nt06465  Prion disease
  Element
N00056  Wnt signaling pathway
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N00175  KSHV LANA to Wnt signaling pathway
N00242  Mutation-inactivated AXIN to Wnt signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N01017  Mutation-caused aberrant PSEN1 to anterograde axonal transport
N01202  Oligomeric conformation PrPc to anterograde axonal transport
N01403  Zn to anterograde axonal transport
Drug target
Laduviglusib: D12196
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    2932 (GSK3B)
   04310 Wnt signaling pathway
    2932 (GSK3B)
   04340 Hedgehog signaling pathway
    2932 (GSK3B)
   04390 Hippo signaling pathway
    2932 (GSK3B)
   04151 PI3K-Akt signaling pathway
    2932 (GSK3B)
   04150 mTOR signaling pathway
    2932 (GSK3B)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    2932 (GSK3B)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    2932 (GSK3B)
   04550 Signaling pathways regulating pluripotency of stem cells
    2932 (GSK3B)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    2932 (GSK3B)
   04657 IL-17 signaling pathway
    2932 (GSK3B)
   04662 B cell receptor signaling pathway
    2932 (GSK3B)
   04062 Chemokine signaling pathway
    2932 (GSK3B)
  09152 Endocrine system
   04910 Insulin signaling pathway
    2932 (GSK3B)
   04917 Prolactin signaling pathway
    2932 (GSK3B)
   04935 Growth hormone synthesis, secretion and action
    2932 (GSK3B)
   04919 Thyroid hormone signaling pathway
    2932 (GSK3B)
   04916 Melanogenesis
    2932 (GSK3B)
  09156 Nervous system
   04728 Dopaminergic synapse
    2932 (GSK3B)
   04722 Neurotrophin signaling pathway
    2932 (GSK3B)
  09158 Development and regeneration
   04360 Axon guidance
    2932 (GSK3B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    2932 (GSK3B)
  09162 Cancer: specific types
   05210 Colorectal cancer
    2932 (GSK3B)
   05225 Hepatocellular carcinoma
    2932 (GSK3B)
   05226 Gastric cancer
    2932 (GSK3B)
   05217 Basal cell carcinoma
    2932 (GSK3B)
   05215 Prostate cancer
    2932 (GSK3B)
   05213 Endometrial cancer
    2932 (GSK3B)
   05224 Breast cancer
    2932 (GSK3B)
  09172 Infectious disease: viral
   05160 Hepatitis C
    2932 (GSK3B)
   05162 Measles
    2932 (GSK3B)
   05163 Human cytomegalovirus infection
    2932 (GSK3B)
   05167 Kaposi sarcoma-associated herpesvirus infection
    2932 (GSK3B)
   05165 Human papillomavirus infection
    2932 (GSK3B)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    2932 (GSK3B)
   05135 Yersinia infection
    2932 (GSK3B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2932 (GSK3B)
   05020 Prion disease
    2932 (GSK3B)
   05022 Pathways of neurodegeneration - multiple diseases
    2932 (GSK3B)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    2932 (GSK3B)
   05415 Diabetic cardiomyopathy
    2932 (GSK3B)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    2932 (GSK3B)
   04932 Non-alcoholic fatty liver disease
    2932 (GSK3B)
   04931 Insulin resistance
    2932 (GSK3B)
   04934 Cushing syndrome
    2932 (GSK3B)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    2932 (GSK3B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2932 (GSK3B)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    2932 (GSK3B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.26  tau-protein kinase
     2932 (GSK3B)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  GSK family [OT]
   2932 (GSK3B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    2932 (GSK3B)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kinase-like APH Kdo
Other DBs
NCBI-GeneID: 2932
NCBI-ProteinID: NP_001139628
OMIM: 605004
HGNC: 4617
Ensembl: ENSG00000082701
Vega: OTTHUMG00000133765
Pharos: P49841(Tclin)
UniProt: P49841 Q6FI27
Structure
Position
3:complement(119821321..120095823)
AA seq 420 aa
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
NT seq 1263 nt   +upstreamnt  +downstreamnt
atgtcagggcggcccagaaccacctcctttgcggagagctgcaagccggtgcagcagcct
tcagcttttggcagcatgaaagttagcagagacaaggacggcagcaaggtgacaacagtg
gtggcaactcctgggcagggtccagacaggccacaagaagtcagctatacagacactaaa
gtgattggaaatggatcatttggtgtggtatatcaagccaaactttgtgattcaggagaa
ctggtcgccatcaagaaagtattgcaggacaagagatttaagaatcgagagctccagatc
atgagaaagctagatcactgtaacatagtccgattgcgttatttcttctactccagtggt
gagaagaaagatgaggtctatcttaatctggtgctggactatgttccggaaacagtatac
agagttgccagacactatagtcgagccaaacagacgctccctgtgatttatgtcaagttg
tatatgtatcagctgttccgaagtttagcctatatccattcctttggaatctgccatcgg
gatattaaaccgcagaacctcttgttggatcctgatactgctgtattaaaactctgtgac
tttggaagtgcaaagcagctggtccgaggagaacccaatgtttcgtatatctgttctcgg
tactatagggcaccagagttgatctttggagccactgattatacctctagtatagatgta
tggtctgctggctgtgtgttggctgagctgttactaggacaaccaatatttccaggggat
agtggtgtggatcagttggtagaaataatcaaggtcctgggaactccaacaagggagcaa
atcagagaaatgaacccaaactacacagaatttaaattccctcaaattaaggcacatcct
tggactaaggtcttccgaccccgaactccaccggaggcaattgcactgtgtagccgtctg
ctggagtatacaccaactgcccgactaacaccactggaagcttgtgcacattcatttttt
gatgaattacgggacccaaatgtcaaactaccaaatgggcgagacacacctgcactcttc
aacttcaccactcaagaactgtcaagtaatccacctctggctaccatccttattcctcct
catgctcggattcaagcagctgcttcaacccccacaaatgccacagcagcgtcagatgct
aatactggagaccgtggacagaccaataatgctgcttctgcatcagcttccaactccacc
tga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (46)   
   KEGG PATHWAY (46)   
Network (11)   
   KEGG NETWORK (11)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (27)   
   RefSeq(nuc) (5)   
   GenBank (11)   
   EMBL (11)   
3D Structure (89)   
   PDB (89)   
Protein domain (6)   
   Pfam (6)   
All databases (223)   

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