KEGG   Homo sapiens (human): 2934
Entry
2934              CDS       T01001                                 

Gene name
GSN, ADF, AGEL
Definition
(RefSeq) gelsolin
  KO
K05768  gelsolin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05203  Viral carcinogenesis
Disease
H02322  Amyloidosis, Finnish type
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    2934 (GSN)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    2934 (GSN)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    2934 (GSN)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    2934 (GSN)
   04147 Exosome [BR:hsa04147]
    2934 (GSN)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Gelsolin / villin
     2934 (GSN)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2934 (GSN)
SSDB
Motif
Pfam: Gelsolin
Other DBs
NCBI-GeneID: 2934
NCBI-ProteinID: NP_000168
OMIM: 137350
HGNC: 4620
Ensembl: ENSG00000148180
Vega: OTTHUMG00000020584
Pharos: P06396(Tbio)
UniProt: P06396 A0A384MEF1
Structure
PDB: 

Position
9q33.2
AA seq 782 aa
MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPNSMVVEHPEFL
KAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNEC
SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV
PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA
TQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKL
YKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALK
TASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERV
PFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY
RHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFG
GKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPS
AAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDK
KMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEK
TEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAEL
AA
NT seq 2349 nt   +upstreamnt  +downstreamnt
atggctccgcaccgccccgcgcccgcgctgctttgcgcgctgtccctggcgctgtgcgcg
ctgtcgctgcccgtccgcgcggccactgcgtcgcggggggcgtcccaggcgggggcgccc
caggggcgggtgcccgaggcgcggcccaacagcatggtggtggaacaccccgagttcctc
aaggcagggaaggagcctggcctgcagatctggcgtgtggagaagttcgatctggtgccc
gtgcccaccaacctttatggagacttcttcacgggcgacgcctacgtcatcctgaagaca
gtgcagctgaggaacggaaatctgcagtatgacctccactactggctgggcaatgagtgc
agccaggatgagagcggggcggccgccatctttaccgtgcagctggatgactacctgaac
ggccgggccgtgcagcaccgtgaggtccagggcttcgagtcggccaccttcctaggctac
ttcaagtctggcctgaagtacaagaaaggaggtgtggcatcaggattcaagcacgtggta
cccaacgaggtggtggtgcagagactcttccaggtcaaagggcggcgtgtggtccgtgcc
accgaggtacctgtgtcctgggagagcttcaacaatggcgactgcttcatcctggacctg
ggcaacaacatccaccagtggtgtggttccaacagcaatcggtatgaaagactgaaggcc
acacaggtgtccaagggcatccgggacaacgagcggagtggccgggcccgagtgcacgtg
tctgaggagggcactgagcccgaggcgatgctccaggtgctgggccccaagccggctctg
cctgcaggtaccgaggacaccgccaaggaggatgcggccaaccgcaagctggccaagctc
tacaaggtctccaatggtgcagggaccatgtccgtctccctcgtggctgatgagaacccc
ttcgcccagggggccctgaagtcagaggactgcttcatcctggaccacggcaaagatggg
aaaatctttgtctggaaaggcaagcaggcaaacacggaggagaggaaggctgccctcaaa
acagcctctgacttcatcaccaagatggactaccccaagcagactcaggtctcggtcctt
cctgagggcggtgagaccccactgttcaagcagttcttcaagaactggcgggacccagac
cagacagatggcctgggcttgtcctacctttccagccatatcgccaacgtggagcgggtg
cccttcgacgccgccaccctgcacacctccactgccatggccgcccagcacggcatggat
gacgatggcacaggccagaaacagatctggagaatcgaaggttccaacaaggtgcccgtg
gaccctgccacatatggacagttctatggaggcgacagctacatcattctgtacaactac
cgccatggtggccgccaggggcagataatctataactggcagggtgcccagtctacccag
gatgaggtcgctgcatctgccatcctgactgctcagctggatgaggagctgggaggtacc
cctgtccagagccgtgtggtccaaggcaaggagcccgcccacctcatgagcctgtttggt
gggaagcccatgatcatctacaagggcggcacctcccgcgagggcgggcagacagcccct
gccagcacccgcctcttccaggtccgcgccaacagcgctggagccacccgggctgttgag
gtattgcctaaggctggtgcactgaactccaacgatgcctttgttctgaaaaccccctca
gccgcctacctgtgggtgggtacaggagccagcgaggcagagaagacgggggcccaggag
ctgctcagggtgctgcgggcccaacctgtgcaggtggcagaaggcagcgagccagatggc
ttctgggaggccctgggcgggaaggctgcctaccgcacatccccacggctgaaggacaag
aagatggatgcccatcctcctcgcctctttgcctgctccaacaagattggacgttttgtg
atcgaagaggttcctggtgagctcatgcaggaagacctggcaacggatgacgtcatgctt
ctggacacctgggaccaggtctttgtctgggttggaaaggattctcaagaagaagaaaag
acagaagccttgacttctgctaagcggtacatcgagacggacccagccaatcgggatcgg
cggacgcccatcaccgtggtgaagcaaggctttgagcctccctcctttgtgggctggttc
cttggctgggatgatgattactggtctgtggaccccttggacagggccatggctgagctg
gctgcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   PROTHERM (4)   
   VEGA (1)   
Protein sequence (49)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (46)   
DNA sequence (107)   
   RefSeq(nuc) (47)   
   GenBank (30)   
   EMBL (30)   
Protein domain (1)   
   Pfam (1)   
All databases (190)   

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KEGG   Homo sapiens (human): 85477
Entry
85477             CDS       T01001                                 

Gene name
SCIN
Definition
(RefSeq) scinderin
  KO
K05768  gelsolin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    85477 (SCIN)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    85477 (SCIN)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    85477 (SCIN)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    85477 (SCIN)
   04147 Exosome [BR:hsa04147]
    85477 (SCIN)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Gelsolin / villin
     85477 (SCIN)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   85477 (SCIN)
SSDB
Motif
Pfam: Gelsolin
Other DBs
NCBI-GeneID: 85477
NCBI-ProteinID: NP_001106177
OMIM: 613416
HGNC: 21695
Ensembl: ENSG00000006747
Vega: OTTHUMG00000152385
Pharos: Q9Y6U3(Tbio)
UniProt: Q9Y6U3
Structure
PDB: 
5A1M 5A1K 3FG6

Position
7p21.3
AA seq 715 aa
MARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTY
HLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAG
GVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGS
SCNKYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDII
ADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKD
ANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVY
VTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFY
GGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPV
HLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDV
FVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQ
TSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGK
DANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
NT seq 2148 nt   +upstreamnt  +downstreamnt
atggcgcgggagctataccacgaagagttcgcccgggcgggcaagcaggcggggctgcag
gtctggaggattgagaagctggagctggtgcccgtgccccagagcgctcacggcgacttc
tacgtcggggatgcctacctggtgctgcacacggccaagacgagccgaggcttcacctac
cacctgcacttctggctcggaaaggagtgttcccaggatgaaagcacagctgctgccatc
ttcactgttcagatggatgactatttgggtggcaagccagtgcagaatagagaacttcaa
ggatatgagtctaatgactttgttagctatttcaaaggcggtctgaaatacaaggctgga
ggcgtggcatctggattaaatcatgttcttacgaacgacctgacagccaagaggctccta
catgtgaagggtcgtagagtggtgagagccacagaagttccccttagctgggacagtttc
aacaagggtgactgcttcatcattgaccttggcaccgaaatttatcagtggtgtggttcc
tcgtgcaacaaatatgaacgtctgaaggcaaaccaggtagctactggcattcggtacaat
gaaaggaaaggaaggtctgaactaattgtcgtggaagaaggaagtgaaccctcagaactt
ataaaggtcttaggggaaaagccagagcttccagatggaggtgatgatgatgacattata
gcagacataagtaacaggaaaatggctaaactatacatggtttcagatgcaagtggctcc
atgagagtgactgtggtggcagaagaaaaccccttctcaatggcaatgctgctgtctgaa
gaatgctttattttggaccacggggctgccaaacaaattttcgtatggaaaggtaaagat
gctaatccccaagagaggaaggctgcaatgaagacagctgaagaatttctacagcaaatg
aattattccaagaatacccaaattcaagttcttccagaaggaggtgaaacaccaatcttc
aaacagttttttaaggactggagagataaagatcagagtgatggcttcgggaaagtttat
gtcacagagaaagtggctcaaataaaacaaattccctttgatgcctcaaaattacacagt
tctccgcagatggcagcccagcacaatatggtggatgatggttctggcaaagtggagatt
tggcgtgtagaaaacaatggtaggatccaagttgaccaaaactcatatggtgaattctat
ggtggtgactgctacatcatactctacacctatcccagaggacagattatctacacgtgg
caaggagcaaatgccacacgagatgagctgacaacatctgcgttcctgactgttcagttg
gatcggtcccttggaggacaggctgtgcagatccgagtctcccaaggcaaagagcctgtt
cacctactgagtttgttcaaagacaaaccgctcattatttacaagaatggaacatcaaag
aaaggaggtcaggcacctgctccccctacacgcctctttcaagtccggagaaacctggca
tctatcaccagaattgtggaggttgatgttgatgcaaattcactgaattctaacgatgtt
tttgtcctgaaactgccacaaaatagtggctacatctgggtaggaaaaggtgctagccag
gaggaggagaaaggagcagagtatgtagcaagtgtcctaaagtgcaaaaccttaaggatc
caagaaggcgaggagccagaggagttctggaattcccttggagggaaaaaagactaccag
acctcaccactactggaaacccaggctgaagaccatccacctcggctttacggctgctct
aacaaaactggaagatttgttattgaagagattccaggagagttcacccaggatgattta
gctgaagatgatgtcatgttactagatgcttgggaacagatatttatttggattggcaaa
gatgctaatgaagttgagaaaaaagaatctctgaagtctgccaaaatgtaccttgagaca
gacccttctggaagagacaagaggacaccaattgtcatcataaaacagggccatgagcca
cccacattcacaggctggttcctgggctgggattccagcaagtggtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (24)   
   RefSeq(nuc) (4)   
   GenBank (10)   
   EMBL (10)   
Protein domain (1)   
   Pfam (1)   
All databases (52)   

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